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Pancreatic Neoplasms: HELP
Articles by Richard B. Hayes
Based on 6 articles published since 2010
(Why 6 articles?)
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Between 2010 and 2020, Richard Hayes wrote the following 6 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. 2018

Fan, Xiaozhou / Alekseyenko, Alexander V / Wu, Jing / Peters, Brandilyn A / Jacobs, Eric J / Gapstur, Susan M / Purdue, Mark P / Abnet, Christian C / Stolzenberg-Solomon, Rachael / Miller, George / Ravel, Jacques / Hayes, Richard B / Ahn, Jiyoung. ·Department of Population Health, New York University School of Medicine, New York, New York, USA. · Departments of Public Health Sciences and Oral Health Sciences, Biomedical Informatics Center, Program for Human Microbiome Research, Medical University of South Carolina, Charleston, South Carolina, USA. · Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA. · Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. · Department of Surgery, New York University School of Medicine, New York, New York, USA. · Department of Cell Biology, New York University School of Medicine, New York, New York, USA. · NYU Perlmutter Cancer Center, New York, New York, USA. · Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA. ·Gut · Pubmed #27742762.

ABSTRACT: OBJECTIVE: A history of periodontal disease and the presence of circulating antibodies to selected oral pathogens have been associated with increased risk of pancreatic cancer; however, direct relationships of oral microbes with pancreatic cancer have not been evaluated in prospective studies. We examine the relationship of oral microbiota with subsequent risk of pancreatic cancer in a large nested case-control study. DESIGN: We selected 361 incident adenocarcinoma of pancreas and 371 matched controls from two prospective cohort studies, the American Cancer Society Cancer Prevention Study II and the National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. From pre-diagnostic oral wash samples, we characterised the composition of the oral microbiota using bacterial 16S ribosomal RNA (16S rRNA) gene sequencing. The associations between oral microbiota and risk of pancreatic cancer, controlling for the random effect of cohorts and other covariates, were examined using traditional and L1-penalised least absolute shrinkage and selection operator logistic regression. RESULTS: Carriage of oral pathogens, CONCLUSIONS: This study provides supportive evidence that oral microbiota may play a role in the aetiology of pancreatic cancer.

2 Article Correlates of circulating 25-hydroxyvitamin D: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. 2010

McCullough, Marjorie L / Weinstein, Stephanie J / Freedman, D Michal / Helzlsouer, Kathy / Flanders, W Dana / Koenig, Karen / Kolonel, Laurence / Laden, Francine / Le Marchand, Loic / Purdue, Mark / Snyder, Kirk / Stevens, Victoria L / Stolzenberg-Solomon, Rachael / Virtamo, Jarmo / Yang, Gong / Yu, Kai / Zheng, Wei / Albanes, Demetrius / Ashby, Jason / Bertrand, Kimberly / Cai, Hui / Chen, Yu / Gallicchio, Lisa / Giovannucci, Edward / Jacobs, Eric J / Hankinson, Susan E / Hartge, Patricia / Hartmuller, Virginia / Harvey, Chinonye / Hayes, Richard B / Horst, Ronald L / Shu, Xiao-Ou. ·American Cancer Society, Atlanta, Georgia 30303-1002, USA. marji.mccullough@cancer.org ·Am J Epidemiol · Pubmed #20562191.

ABSTRACT: Low vitamin D status is common globally and is associated with multiple disease outcomes. Understanding the correlates of vitamin D status will help guide clinical practice, research, and interpretation of studies. Correlates of circulating 25-hydroxyvitamin D (25(OH)D) concentrations measured in a single laboratory were examined in 4,723 cancer-free men and women from 10 cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers, which covers a worldwide geographic area. Demographic and lifestyle characteristics were examined in relation to 25(OH)D using stepwise linear regression and polytomous logistic regression. The prevalence of 25(OH)D concentrations less than 25 nmol/L ranged from 3% to 36% across cohorts, and the prevalence of 25(OH)D concentrations less than 50 nmol/L ranged from 29% to 82%. Seasonal differences in circulating 25(OH)D were most marked among whites from northern latitudes. Statistically significant positive correlates of 25(OH)D included male sex, summer blood draw, vigorous physical activity, vitamin D intake, fish intake, multivitamin use, and calcium supplement use. Significant inverse correlates were body mass index, winter and spring blood draw, history of diabetes, sedentary behavior, smoking, and black race/ethnicity. Correlates varied somewhat within season, race/ethnicity, and sex. These findings help identify persons at risk for low vitamin D status for both clinical and research purposes.

3 Article Circulating 25-hydroxyvitamin D and the risk of rarer cancers: Design and methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. 2010

Gallicchio, Lisa / Helzlsouer, Kathy J / Chow, Wong-Ho / Freedman, D Michal / Hankinson, Susan E / Hartge, Patricia / Hartmuller, Virginia / Harvey, Chinonye / Hayes, Richard B / Horst, Ronald L / Koenig, Karen L / Kolonel, Laurence N / Laden, Francine / McCullough, Marjorie L / Parisi, Dominick / Purdue, Mark P / Shu, Xiao-Ou / Snyder, Kirk / Stolzenberg-Solomon, Rachael Z / Tworoger, Shelley S / Varanasi, Arti / Virtamo, Jarmo / Wilkens, Lynne R / Xiang, Yong-Bing / Yu, Kai / Zeleniuch-Jacquotte, Anne / Zheng, Wei / Abnet, Christian C / Albanes, Demetrius / Bertrand, Kimberly / Weinstein, Stephanie J. ·Mercy Medical Center, Baltimore, Maryland 21202, USA. lgallic@mdmercy.com ·Am J Epidemiol · Pubmed #20562188.

ABSTRACT: The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP), a consortium of 10 prospective cohort studies from the United States, Finland, and China, was formed to examine the associations between circulating 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of rarer cancers. Cases (total n = 5,491) included incident primary endometrial (n = 830), kidney (n = 775), ovarian (n = 516), pancreatic (n = 952), and upper gastrointestinal tract (n = 1,065) cancers and non-Hodgkin lymphoma (n = 1,353) diagnosed in the participating cohorts. At least 1 control was matched to each case on age, date of blood collection (1974-2006), sex, and race/ethnicity (n = 6,714). Covariate data were obtained from each cohort in a standardized manner. The majority of the serum or plasma samples were assayed in a central laboratory using a direct, competitive chemiluminescence immunoassay on the DiaSorin LIAISON platform (DiaSorin, Inc., Stillwater, Minnesota). Masked quality control samples included serum standards from the US National Institute of Standards and Technology. Conditional logistic regression analyses were conducted using clinically defined cutpoints, with 50-<75 nmol/L as the reference category. Meta-analyses were also conducted using inverse-variance weights in random-effects models. This consortium approach permits estimation of the association between 25(OH)D and several rarer cancers with high accuracy and precision across a wide range of 25(OH)D concentrations.

4 Article Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. 2010

Stolzenberg-Solomon, Rachael Z / Jacobs, Eric J / Arslan, Alan A / Qi, Dai / Patel, Alpa V / Helzlsouer, Kathy J / Weinstein, Stephanie J / McCullough, Marjorie L / Purdue, Mark P / Shu, Xiao-Ou / Snyder, Kirk / Virtamo, Jarmo / Wilkins, Lynn R / Yu, Kai / Zeleniuch-Jacquotte, Anne / Zheng, Wei / Albanes, Demetrius / Cai, Qiuyin / Harvey, Chinonye / Hayes, Richard / Clipp, Sandra / Horst, Ronald L / Irish, Lonn / Koenig, Karen / Le Marchand, Loic / Kolonel, Laurence N. ·National Cancer Institute, Bethesda, Maryland 20852, USA. ·Am J Epidemiol · Pubmed #20562185.

ABSTRACT: Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin D (25(OH)D) concentrations (the best indicator of vitamin D derived from diet and sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study of participants from 8 cohorts within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) (1974-2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were associated with the development of pancreatic cancer. In total, 952 incident pancreatic adenocarcinoma cases occurred among participants (median follow-up, 6.5 years). Controls (n = 1,333) were matched to each case by cohort, age, sex, race/ethnicity, date of blood draw, and follow-up time. Conditional logistic regression analysis was used to calculate smoking-, body mass index-, and diabetes-adjusted odds ratios and 95% confidence intervals for pancreatic cancer. Clinically relevant 25(OH)D cutpoints were compared with a referent category of 50-<75 nmol/L. No significant associations were observed for participants with lower 25(OH)D status. However, a high 25(OH)D concentration (> or =100 nmol/L) was associated with a statistically significant 2-fold increase in pancreatic cancer risk overall (odds ratio = 2.12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered.

5 Article Available carbohydrates, glycemic load, and pancreatic cancer: is there a link? 2010

Meinhold, Cari L / Dodd, Kevin W / Jiao, Li / Flood, Andrew / Shikany, James M / Genkinger, Jeanine M / Hayes, Richard B / Stolzenberg-Solomon, Rachael Z. ·National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA. ·Am J Epidemiol · Pubmed #20452999.

ABSTRACT: High-carbohydrate diets have been linked to pancreatic cancer risk in case-control studies, but prospective studies have shown mostly null results. The authors investigated the associations of glycemic load, glycemic index, and carbohydrate intake with pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Dietary intake was assessed by using a self-administered questionnaire. Between 1998 and 2006 (median follow-up = 6.5 years), 266 incident, confirmed pancreatic cancers were identified among 109,175 participants. Hazards ratios and 95% confidence intervals were adjusted for sex, smoking, body mass index, and total energy. Overall, elevated risks for pancreatic cancer were observed in the 90th versus 10th percentile of glycemic load (hazards ratio (HR) = 1.45, 95% confidence interval (CI): 1.05, 2.00), available carbohydrate (HR = 1.47, 95% CI: 1.05, 2.06), and sucrose (HR = 1.37, 95% CI: 0.99, 1.89) intake. The positive association for available carbohydrate intake was observed during the first 4 years of follow-up (HR(<2 years) = 2.60, 95% CI: 1.34, 5.06; HR(2-<4 years) = 1.94, 95% CI: 1.06, 3.55) but not subsequently (HR = 0.86, 95% CI: 0.52, 1.44); the opposite pattern was observed for total fat and saturated fat intake. Rather than being causal, the short-term increase in pancreatic cancer risk associated with high available carbohydrate and low fat intake may be capturing dietary changes associated with subclinical disease.

6 Article Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts. 2010

Jiao, Li / Berrington de Gonzalez, Amy / Hartge, Patricia / Pfeiffer, Ruth M / Park, Yikyung / Freedman, D Michal / Gail, Mitchell H / Alavanja, Michael C R / Albanes, Demetrius / Beane Freeman, Laura E / Chow, Wong-Ho / Huang, Wen-Yi / Hayes, Richard B / Hoppin, Jane A / Ji, Bu-Tian / Leitzmann, Michael F / Linet, Martha S / Meinhold, Cari L / Schairer, Catherine / Schatzkin, Arthur / Virtamo, Jarmo / Weinstein, Stephanie J / Zheng, Wei / Stolzenberg-Solomon, Rachael Z. ·Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. jiao@bcm.edu ·Cancer Causes Control · Pubmed #20383573.

ABSTRACT: OBJECTIVE: To investigate whether the positive association of body mass index (BMI, kg/m(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes. METHODS: In a pooled analysis of primary data of seven prospective cohorts including 458,070 men and 485,689 women, we identified 2,454 patients with incident pancreatic cancer during an average 6.9 years of follow-up. Cox proportional hazard regression models were used in data analysis. RESULTS: In a random-effects meta-analysis, for every 5 kg/m(2) increment in BMI, the summary relative risk (RR) was 1.06 (95% confidence interval (CI) 0.99-1.13) for men and 1.12 (95% CI 1.05-1.19) for women. The aggregate analysis showed that compared with normal weight (BMI: 18.5 to <25), the adjusted RR was 1.13 (95% CI 1.03-1.23) for overweight (BMI: 25 to <30) and 1.19 (95% CI 1.05-1.35) for obesity class I (BMI: 30 to <35). Tests of interactions of BMI effects by other risk factors were not statistically significant. Every 5 kg/m(2) increment in BMI was associated with an increased risk of pancreatic cancer among never and former smokers, but not among current smokers (P-interaction = 0.08). CONCLUSION: The present evidence suggests that a high BMI is an independent risk factor of pancreatic cancer.