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Pancreatic Neoplasms: HELP
Articles by Rong Fu
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Rong Fu wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells. 2016

Xu, Qianqian / Fu, Rong / Yin, Guoxiao / Liu, Xiulan / Liu, Yang / Xiang, Ming. ·Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. · Synergy Innovation Center of Biological Peptide Antidiabetics of Hubei Province, School of Life Science, Wuchang University of Technology, Wuhan 430223, China. · Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: xiangming@mails.tjmu.edu.cn. ·Gene · Pubmed #26719042.

ABSTRACT: We previously reported that regenerating islet-derived protein 3 alpha (REG3A) exacerbates pancreatic malignancies. The mechanism of this effect has not been clearly elucidated. Here we first identified key differentially expressed genes (DEGs) and signal pathways in the pancreatic cancer cell line SW1990, compared to two control cell lines, by microarray analysis. We then identified key genes and pathways regulated by REG3A or the cytokine IL6 in SW1990 cells. Afterwards, these DEGs induced by REG3A or IL6 were subjected to KEGG pathway enrichment analysis and GO function analysis by the DAVID online tool. Ultimately, we constructed protein-protein interaction networks among the DEGs by Cytoscape. Among the three pancreatic cell lines, SW1990 exhibited highly deterioration with the activation of genes and pathways related to proliferation, survival, angiogenesis, and invasion. As a result, 50 DEGs enriched in 11 pathways were identified in REG3A-treated SW1990 cells, and 28 DEGs enriched in 9 pathways were detected in IL6-treated cells. Overall, results of microarray analysis followed by qRT-PCR and Western blotting suggest that REG3A regulates pancreatic cell growth by increasing the expression of at least 8 genes: JAK1, STAT3, IL10, FOXM1, KRAS, MYC, CyclinD1, and c-fos; and activation of at least 4 signal pathways: TGFβ, PDGF, angiogenesis and RAS. Similar results were obtained with IL6 treatment. Regulation network analysis confirmed the cell growth related DEGs, and further uncovered three transcription factor families with immune functions regulated by REG3A.

2 Article Association of body mass index and risk of death from pancreas cancer in Asians: findings from the Asia Cohort Consortium. 2013

Lin, Yingsong / Fu, Rong / Grant, Eric / Chen, Yu / Lee, Jung Eun / Gupta, Prakash C / Ramadas, Kunnambath / Inoue, Manami / Tsugane, Shoichiro / Gao, Yu-Tang / Tamakoshi, Akiko / Shu, Xiao-Ou / Ozasa, Kotaro / Tsuji, Ichiro / Kakizaki, Masako / Tanaka, Hideo / Chen, Chien-Jen / Yoo, Keun-Young / Ahn, Yoon-Ok / Ahsan, Habibul / Pednekar, Mangesh S / Sauvaget, Catherine / Sasazuki, Shizuka / Yang, Gong / Xiang, Yong-Bing / Ohishi, Waka / Watanabe, Takashi / Nishino, Yoshikazu / Matsuo, Keitaro / You, San-Lin / Park, Sue K / Kim, Dong-Hyun / Parvez, Faruque / Rolland, Betsy / McLerran, Dale / Sinha, Rashmi / Boffetta, Paolo / Zheng, Wei / Thornquist, Mark / Feng, Ziding / Kang, Daehee / Potter, John D. ·Department of Public Health, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan. linys@aichi-med-u.ac.jp ·Eur J Cancer Prev · Pubmed #23044748.

ABSTRACT: We aimed to examine the association between BMI and the risk of death from pancreas cancer in a pooled analysis of data from the Asia Cohort Consortium. The data for this pooled analysis included 883 529 men and women from 16 cohort studies in Asian countries. Cox proportional-hazards models were used to estimate the hazard ratios and 95% confidence intervals for pancreas cancer mortality in relation to BMI. Seven predefined BMI categories (<18.5, 18.5-19.9, 20.0-22.4, 22.5-24.9, 25.0-27.4, 27.5-29.9, ≥ 30) were used in the analysis, with BMI of 22.5-24.9 serving as the reference group. The multivariable analyses were adjusted for known risk factors, including age, smoking, and a history of diabetes. We found no statistically significant overall association between each BMI category and the risk of death from pancreas cancer in all Asians, and obesity was unrelated to the risk of mortality in both East Asians and South Asians. Age, smoking, and a history of diabetes did not modify the association between BMI and the risk of death from pancreas cancer. In planned subgroup analyses among East Asians, an increased risk of death from pancreas cancer among those with a BMI less than 18.5 was observed for individuals with a history of diabetes; hazard ratio=2.01 (95% confidence interval: 1.01-4.00) (P for interaction=0.07). The data do not support an association between BMI and the risk of death from pancreas cancer in these Asian populations.