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Pancreatic Neoplasms: HELP
Articles by Maria Luisa Friso
Based on 2 articles published since 2010
(Why 2 articles?)

Between 2010 and 2020, Maria L. Friso wrote the following 2 articles about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article Patterns of radiotherapy practice for pancreatic cancer: Results of the Gastrointestinal Radiation Oncology Study Group multi-institutional survey. 2015

Macchia, Gabriella / Sainato, Aldo / Talamini, Renato / Boz, Giovanni / Bacigalupo, Almalina / Caravatta, Luciana / Fiore, Michele / Friso, Maria Luisa / Fusco, Vincenzo / Lupattelli, Marco / Mantello, Giovanna / Mattiucci, Gian Carlo / Slim, Najla / Sciacero, Piera / Turri, Lucia / Valentini, Vincenzo / Morganti, Alessio Giuseppe / Genovesi, Domenico. ·Radiation Oncology Unit, Research and Care Foundation 'Giovanni Paolo II', Catholic University of Sacred Heart, Campobasso, Italy. · Radiation Oncology Unit, University Hospital, Pisa, Italy. · Epidemiology and Biostatistics Unit, Oncological Referral Center, Aviano, Italy. · Radiation Oncology Department, Oncological Referral Center, Aviano, Italy. · Radiation Oncology Unit, AOU IRCCS San Martino, IST National Cancer Research Institute, Genoa, Italy. · Radiation Oncology Department, 'A. Businco' Regional Oncological Hospital, Cagliari, Italy. · Radiation Oncology Unit, Campus Bio-Medico University Hospital, Rome, Italy. · Radiotherapy and Nuclear Medicine Unit, Veneto Institute of Oncology-IRCCS, Padua, Italy. · Radiation Oncology Unit, IRCCS CROB, Rionero in Vulture, Potenza, Italy. · Radiation Oncology Unit, 'S. Maria della Misericordia' Hospital, Perugia, Italy. · Radiation Oncology Unit, State Hospital, Ancona, Italy. · Radiation Oncology Department, 'A. Gemelli' Hospital, Catholic University of Sacred Heart, Rome, Italy. · Radiation Oncology Unit, 'San Raffaele' Hospital, Milan, Italy. · Radiation Oncology Unit, ASL TO4, General Hospital, Ivrea, Italy. · Radiation Oncology Unit, 'Maggiore della Carità' Hospital, Novara, Italy. · Radiation Oncology Unit, 'SS Annunziata' Hospital, 'G. D'Annunzio' University, Chieti, Italy. ·Oncol Rep · Pubmed #25955190.

ABSTRACT: No information is currently available regarding pancreatic cancer (PC) pattern of care in Italy. In the present study, a nationwide survey using a questionnaire was performed to enquire the local standards for PC diagnosis and radiotherapy treatment. Fifty-seven percent of 140 Italian centres completed questionnaire. The main causes of no radiotherapy indication were poor general condition (45%) and lack of guidelines (25%). Physicians (38%) employed neoadjuvant therapy in locally advanced PC patients, while in other centres (62%) adjuvant chemoradiation was administered. Adjuvant gemcitabine-based chemotherapy was selected as the treatment of choice by 59% of centres. Patients were treated mostly with doses of 50-54.9 Gy on the tumour (or bed) plus lymph nodes. A 3D-CRT technique was used in 81.2% of centres, while IMRT and IGRT were available in 61.2 and 48.7% of cases, respectively. Extensive variation exists with regard to patterns of care for PC in Italy. Nevertheless, cooperative studies emerging from this survey appeared beneficial.

2 Article Inter-observer variability of clinical target volume delineation in radiotherapy treatment of pancreatic cancer: a multi-institutional contouring experience. 2014

Caravatta, Luciana / Macchia, Gabriella / Mattiucci, Gian Carlo / Sainato, Aldo / Cernusco, Nunzia L V / Mantello, Giovanna / Di Tommaso, Monica / Trignani, Marianna / De Paoli, Antonino / Boz, Gianni / Friso, Maria L / Fusco, Vincenzo / Di Nicola, Marta / Morganti, Alessio G / Genovesi, Domenico. ·Radiation Oncology Department, "San Francesco" Hospital, Via Mannironi, 1, 08110 Nuoro, Italy. lcaravatta@hotmail.com. ·Radiat Oncol · Pubmed #25199768.

ABSTRACT: BACKGROUND: An observational multi-institutional study has been conducted aimed to evaluate the inter-observer variability in clinical target volume (CTV) delineation among different radiation oncologists in radiotherapy treatment of pancreatic cancer. METHODS: A multi-institutional contouring dummy-run of two different cases of pancreatic cancer treated by postoperative and preoperative radiotherapy (RT) was performed. Clinical history, diagnostics, and planning CT imaging were available on AIRO website (http://www.radioterapiaitalia.it). Participants were requested to delineate CTVs according to their skills and knowledge. Aiming to quantify interobserver variability of CTVs delineations, the total volume, craniocaudal, laterolateral, and anteroposterior diameters were calculated. Descriptive statistic was calculated. The 95% Confidence Interval (95% CI) for coefficient of variation (CV) was estimated. The Dice Similarity Index (DSI) was used to evaluate the spatial overlap accuracy of the different CTVs compared with the CTVs of a national reference Centre considered as a benchmark. The mean DSI (mDSI) was calculated and reported. RESULTS: A total of 18 radiation oncologists from different Institutes submitted the targets. Less variability was observed for the Elective CTV rather than the Boost CTV, in both cases. The estimated CV were 28.8% (95% CI: 21.2-45.0%) and 20.0% (95% CI: 14.9-30.6%) for the Elective CTV, in adjuvant (Case 1) and neoadjuvant (Case 2) case, respectively. The mDSI value was 0.68 for the Elective CTVs in both cases (range 0.19-0.79 in postoperative vs range 0.35-0.79 in preoperative case). The mDSI was increased to 0.71 (Case 1) and 0.72 (Case 2) if the observers with a worse agreement have been excluded. On the other hand, a CV of 42.4% (95% CI: 30.1-72.4%) and 63.8% (95% CI: 43.9-119.2%) with a mDSI value of 0.44 and 0.52, were calculated for the Boost CTV in Case 1 and Case 2, respectively. CONCLUSIONS: The CV and mDSI obtained values for Elective CTVs showed an acceptable agreement among participants either in postoperative as well in preoperative setting. Additional strategies to reduce the variability in Boost CTV delineation need to be found and promoted.