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Pancreatic Neoplasms: HELP
Articles by Antonio Ferrández
Based on 5 articles published since 2008
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Between 2008 and 2019, A. Ferrández wrote the following 5 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Guideline [Recommendations for the diagnosis, staging and treatment of pre-malignant lesions and pancreatic adenocarcinoma]. 2016

Martin-Richard, Marta / Ginès, Angels / Ayuso, Juan Ramón / Sabater, Luis / Fabregat, Joan / Mendez, Ramiro / Fernández-Esparrach, Glòria / Molero, Xavier / Vaquero, Eva C / Cuatrecasas, Miriam / Ferrández, Antonio / Maurel, Joan / Anonymous3560884. ·Servicio de Oncología Médica, Hospital Sant Pau, Barcelona, España. Electronic address: mmartinri@santpau.cat. · Servicio de Gastroenterología, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Barcelona, España. · Servicio de Radiología, Hospital Clínic de Barcelona, Barcelona, España. · Servicio de Cirugía, Hospital Clínico Universitario de Valencia, Valencia, España. · Servicio de Cirugía, Hospital de Bellvitge, Barcelona, España. · Servicio de Radiología, Hospital Clínico San Carlos, Madrid, España. · Servicio de Gastroenterología, Hospital Vall d'Hebron, Barcelona, España. · Servicio de Anatomía Patológica, Hospital Clínic de Barcelona, Barcelona, España. · Servicio de Anatomía Patológica, Hospital Clínico Universitario de Valencia, Valencia, España. · Servicio de Oncología Médica, Translational Genomics and Targeted Therapeutics in Solid Tumors Group, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, España; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Barcelona, España. ·Med Clin (Barc) · Pubmed #27726847.

ABSTRACT: BACKGROUND AND OBJECTIVE: Clinical management of adenocarcinoma of the pancreas is complex, and requires a multidisciplinary approach. The same applies for the premalignant lesions that are increasingly being diagnosed. The current document is an update on the diagnosis and management of premalignant lesions and adenocarcinoma of the pancreas. PATIENTS AND METHODS: A conference to establish the basis of the literature review and manuscript redaction was organized by the Grupo Español Multidisciplinar en Cáncer Digestivo. Experts in the field from different specialties (Gastroenterology, Surgery, Radiology, Pathology, Medical Oncology and Radiation Oncology) met to prepare the present document. RESULTS: The current literature was reviewed and discussed, with subsequent deliberation on the evidence. CONCLUSIONS: Final recommendations were established in view of all the above.

2 Review Outcome quality standards in pancreatic oncologic surgery. 2014

Sabater, Luis / García-Granero, Alvaro / Escrig-Sos, Javier / Gómez-Mateo, Maria Del Carmen / Sastre, Juan / Ferrández, Antonio / Ortega, Joaquín. ·Department of Surgery, Hospital Clínico, University of Valencia, Valencia, Spain, luis.sabater@uv.es. ·Ann Surg Oncol · Pubmed #24390708.

ABSTRACT: PURPOSE: To identify quality indicators and establish acceptable quality limits (AQLs) in pancreatic oncologic surgery using a formal statistical methodology. METHODS: Indicators have been identified through systematic literature reviews and guidelines for pancreatic surgery. AQLs were determined for each indicator with confidence intervals of 99.8 and 95 % above and below the weighted average by sample size from the different series examined. RESULTS: Several indicators have been identified with the following results as AQLs: resectability rate >59 %; morbidity, mortality, and pancreatic fistula rate in pancreaticoduodenectomy <55, <5, and <16 %, respectively; morbidity, mortality, and fistula rate in distal pancreatectomy <53, <4, and <31 %, respectively; number of lymph nodes retrieved >15; R1 resection <46 %; survival at 1, 3, and 5 years >54, >19, and >8 %, respectively. CONCLUSIONS: A series of different indicators for quality surgical care outcome in pancreatic cancer, as well as their limits, have been determined according to a standard methodology.

3 Article Procedures and recommended times in the care process of the patient with pancreatic cancer: PAN-TIME consensus between scientific societies. 2017

Vera, R / Ferrández, A / Ferrer, C J / Flores, C / Joaquín, C / López, S / Martín, T / Martín, E / Marzo, M / Sarrión, A / Vaquero, E / Zapatero, A / Aparicio, J. ·Spanish Society of Medical Oncology, Madrid, Spain. ruth.vera.garcia@cfnavarra.es. · Spanish Society of Pathological Anatomy, Madrid, Spain. · Spanish Society of Radiation Oncology, Madrid, Spain. · Spanish Society of General and Family Physicians, Madrid, Spain. · Spanish Society of Endocrinology and Nutrition, Madrid, Spain. · Spanish Society of Surgical Oncology, Madrid, Spain. · Spanish Society of Medical Radiology/Spanish Society of Abdominal Radiology, Madrid, Spain. · Spanish Association of Surgeons, Madrid, Spain. · Spanish Society of Family and Community Medicine, Madrid, Spain. · Spanish Society of Primary Care Physicians, Madrid, Spain. · Spanish Association of Gastroenterology, Madrid, Spain. · Spanish Society of Internal Medicine, Madrid, Spain. · Spanish Society of Medical Oncology, Madrid, Spain. ·Clin Transl Oncol · Pubmed #28105537.

ABSTRACT: PURPOSE: Pancreatic cancer (PC) is a disease with bad prognosis. It is usually diagnosed at advanced stages and its treatment is complex. The aim of this consensus document was to provide recommendations by experts that would ameliorate PC diagnosis, reduce the time to treatment, and optimize PC management by interdisciplinary teams. METHODS: As a consensus method, we followed the modified Delphi methodology. A scientific committee of experts provided 40 statements that were submitted in two rounds to a panel of 87 specialists of 12 scientific societies. RESULTS: Agreement was reached for 39 of the 40 proposed statements (97.5%). CONCLUSIONS: Although a screening of the asymptomatic population is not a feasible option, special attention to potential symptoms during primary care could ameliorate early diagnostic. It is especially important to decrease the period until diagnostic tests are performed. This consensus could improve survival in PC patients by decreasing the time to diagnose and time to treatment and by the implementation of multidisciplinary teams.

4 Article Prognostic implications of the standardized study of resection margins in pancreatic cancers. 2014

Sabater, Luis / Gómez-Mateo, María del Carmen / López-Sebastián, Javier / Muñoz-Forner, Elena / Morera-Ocón, Francisco / Cervantes, Andrés / Roselló, Susana / Camps-Vilata, Bruno / Ferrández, Antonio / Ortega, Joaquín. ·Servicio de Cirugía General, Instituto de Investigación Sanitaria INCLIVA, Departamento de Cirugía, Universitat de València, Valencia, España. Electronic address: luis.sabater@uv.es. · Servicio de Anatomía Patológica, Instituto de Investigación Sanitaria INCLIVA, Departamento de Patología, Universitat de València, Valencia, España. · Servicio de Cirugía General, Hospital San Pablo Coquimbo, Coquimbo, Chile. · Servicio de Cirugía General, Instituto de Investigación Sanitaria INCLIVA, Departamento de Cirugía, Universitat de València, Valencia, España. · Servicio de Hematología y Oncología Médica, Instituto de Investigación Sanitaria INCLIVA, Universitat de València, Valencia, España. ·Cir Esp · Pubmed #24878428.

ABSTRACT: INTRODUCTION: Involvement of surgical resection margins is a fundamental prognostic factor in pancreatic oncological surgery. However, there is a lack of standardized histopathology definition. The aims of this study are to investigate the real rate of R1 resections when surgical specimens are evaluated according to a standardized protocol and to study its survival implications. PATIENTS Y METHODS: One hundred consecutive surgically resected patients with pancreatic ductal adenocarcinoma were included in the study. They were further divided in 2 groups: pre-protocol, evaluated before the introduction of the standardized protocol and post-protocol, analyzed with the standardized protocol. RESULTS: R0 resection rate in the pre-protocol group was 78%, falling to 47% after the introduction of the standardized protocol (p=0,003). The posterior retroperitoneal margin was the most frequently involved margin. In cases with tumors located at the pancreatic head and analyzed according to the standardized protocol R1 involvement negatively affected survival. Median survival in the R0 group was 22 months versus 16 in those with the margin involved (HR: 2.044; IC 95% 1,00-4,16; P=.043). CONCLUSIONS: Standardized evaluation of the retroperitoneal margins in pancreatic cancer increases the rate of R1 patients. In cases with pancreatic cancer located at the pancreatic head involvement of posterior retroperitoneal margin significantly decreases survival.

5 Article High microvessel density in pancreatic ductal adenocarcinoma is associated with high grade. 2013

Barău, Anca / Ruiz-Sauri, Amparo / Valencia, Gerardo / Gómez-Mateo, Maria Del Carmen / Sabater, Luis / Ferrandez, Antonio / Llombart-Bosch, Antonio. ·Department of Internal Medicine, Emergency County Hospital Craiova, University of Medicine and Pharmacy Craiova, Petru Rareş 2, Craiova, 200349, Romania. anca_barau@yahoo.com ·Virchows Arch · Pubmed #23579431.

ABSTRACT: The objectives of this work are to study angiogenesis in pancreatic ductal adenocarcinoma using computerized morphometric and image analysis and to compare the microvascular density in intratumoral and peritumoral areas and normal pancreatic tissue. Microvascular density was analyzed in 60 cases of pancreatic ductal adenocarcinoma and 30 samples of normal pancreatic tissue using an avidin-biotin immunoperoxidase technique with an anti-CD31 antibody. Microvascular density (MVD) was analyzed through digital microimaging and computerized analysis. The blood vessel density in the tumor was significantly higher than in peritumoral areas and in normal pancreatic tissue. Well differentiated pancreatic ductal adenocarcinomas contained higher MVD than poorly differentiated carcinomas. In pancreatic adenocarcinoma, MVD is higher than in peritumoral tissue or normal pancreatic tissue.