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Pancreatic Neoplasms: HELP
Articles by Anders Engeland
Based on 1 article published since 2010
(Why 1 article?)
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Between 2010 and 2020, Anders Engeland wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Metabolic factors and the risk of pancreatic cancer: a prospective analysis of almost 580,000 men and women in the Metabolic Syndrome and Cancer Project. 2010

Johansen, Dorthe / Stocks, Tanja / Jonsson, Håkan / Lindkvist, Björn / Björge, Tone / Concin, Hans / Almquist, Martin / Häggström, Christel / Engeland, Anders / Ulmer, Hanno / Hallmans, Göran / Selmer, Randi / Nagel, Gabriele / Tretli, Steinar / Stattin, Pär / Manjer, Jonas. ·Department of Surgery, Lund University, Malmö, Sweden. dorthe.johansen@med.lu.se ·Cancer Epidemiol Biomarkers Prev · Pubmed #20826833.

ABSTRACT: BACKGROUND: The aim of this study was to investigate the association between factors in metabolic syndrome (MetS; single and combined) and the risk of pancreatic cancer. METHODS: The Metabolic Syndrome and Cancer Project is a pooled cohort containing data on body mass index, blood pressure, and blood levels of glucose, cholesterol, and triglycerides. During follow-up, 862 individuals were diagnosed with pancreatic cancer. Cox proportional hazards analysis was used to calculate relative risks (RR) with 95% confidence intervals using the above-mentioned factors categorized into quintiles and transformed into z-scores. All z-scores were summarized and a second z-transformation creating a composite z-score for MetS was done. All risk estimates were calibrated to correct for a regression dilution bias. RESULTS: The trend over quintiles was positively associated with the risk of pancreatic cancer for mid-blood pressure (mid-BP) and glucose in men and for body mass index, mid-BP, and glucose in women. The z-score for the adjusted mid-BP (RR, 1.10; 1.01-1.20) and the calibrated z-score for glucose (RR, 1.37; 1.14-1.34) were positively associated with pancreatic cancer in men. In women, a positive association was found for calibrated z-scores for mid-BP (RR, 1.34; 1.08-1.66), for the calibrated z-score for glucose (RR, 1.98; 1.41-2.76), and for the composite z-score for MetS (RR, 1.58; 1.34-1.87). CONCLUSION: Our study adds further evidence to a possible link between abnormal glucose metabolism and risk of pancreatic cancer. IMPACT: To our knowledge, this is the first study on MetS and pancreatic cancer using prediagnostic measurements of the examined factors.