Pick Topic
Review Topic
List Experts
Examine Expert
Save Expert
  Site Guide ··   
Pancreatic Neoplasms: HELP
Articles by Manuel Domínguez-Fraile
Based on 1 article published since 2010
(Why 1 article?)
||||

Between 2010 and 2020, Manuel Domínguez-Fraile wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Zeb1 in Stromal Myofibroblasts Promotes 2018

Sangrador, Irene / Molero, Xavier / Campbell, Fiona / Franch-Expósito, Sebastià / Rovira-Rigau, Maria / Samper, Esther / Domínguez-Fraile, Manuel / Fillat, Cristina / Castells, Antoni / Vaquero, Eva C. ·Gastrointestinal and pancreatic oncology research group, Hospital Clinic, Barcelona, CiberEHD, Spain. · Exocrine Pancreas Research Unit, Hospital Universitari Vall d'Hebron, Autonomous University of Barcelona, CiberEHD, Barcelona, Spain. · Department of Pathology, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, United Kingdom. · Gastroenterology Department, Hospital Clinic, IDIBAPS, CiberEHD, University of Barcelona, Barcelona, Spain. · Gene Therapy and Cancer, IDIBAPS, CiberER, University of Barcelona, Barcelona, Spain. · Institut de Malalties Digestives i Metabòliques, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain. · Gastrointestinal and pancreatic oncology research group, Hospital Clinic, Barcelona, CiberEHD, Spain. evaquero@comb.cat. ·Cancer Res · Pubmed #29490942.

ABSTRACT: The transcription factor Zeb1 has been identified as a crucial player in Kras-dependent oncogenesis. In pancreatic ductal adenocarcinoma (PDAC), Zeb1 is highly expressed in myofibroblasts and correlates with poor prognosis. As Kras mutations are key drivers in PDAC, we aimed here to assess the necessity of Zeb1 for Kras-driven PDAC and to define the role of Zeb1-expressing myofibroblasts in PDAC development. Genetically engineered mice with conditional pancreatic