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Pancreatic Neoplasms: HELP
Articles by J. E. Doherty
Based on 1 article published since 2010
(Why 1 article?)
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Between 2010 and 2020, J. E. Doherty wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216. 2017

Mohelnikova-Duchonova, B / Kocik, M / Duchonova, B / Brynychova, V / Oliverius, M / Hlavsa, J / Honsova, E / Mazanec, J / Kala, Z / Ojima, I / Hughes, D J / Doherty, J E / Murray, H A / Crockard, M A / Lemstrova, R / Soucek, P. ·Department of Toxicogenomics, National Institute of Public Health, Prague, Czech Republic. · Department of Oncology, Palacky University Medical School and Teaching Hospital, Olomouc, Czech Republic. · Department of Transplantation Surgery, Institute of Clinical and Experimental Medicine, Prague, Czech Republic. · Palacky University, Olomouc, Czech Republic. · Charles University in Prague, Prague, Czech Republic. · Department of Surgery, University Hospital and Medical Faculty, Masaryk University, Brno, Czech Republic. · Department of Clinical and Transplantation Pathology, Institute of Clinical and Experimental Medicine, Prague, Czech Republic. · Department of Pathology, University Hospital and Medical Faculty, Masaryk University, Brno, Czech Republic. · Institute of Chemical Biology and Drug Discovery, State University of New York at Stony Brook, Stony Brook, NY, USA. · Department of Physiology &Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland. · Randox Laboratories, Crumlin, UK. ·Pharmacogenomics J · Pubmed #27573236.

ABSTRACT: The Hedgehog pathway is one of the major driver pathways in pancreatic ductal adenocarcinoma. This study investigated prognostic importance of Hedgehog signaling pathway in pancreatic cancer patients who underwent a radical resection. Tumors and adjacent non-neoplastic pancreatic tissues were obtained from 45 patients with histologically verified pancreatic cancer. The effect of experimental taxane chemotherapy on the expression of Hedgehog pathway was evaluated in vivo using a mouse xenograft model prepared using pancreatic cancer cell line Paca-44. Mice were treated by experimental Stony Brook Taxane SB-T-1216. The transcript profile of 34 Hedgehog pathway genes in patients and xenografts was assessed using quantitative PCR. The Hedgehog pathway was strongly overexpressed in pancreatic tumors and upregulation of SHH, IHH, HHAT and PTCH1 was associated with a trend toward decreased patient survival. No association of Hedgehog pathway expression with KRAS mutation status was found in tumors. Sonic hedgehog ligand was overexpressed, but all other downstream genes were downregulated by SB-T-1216 treatment in vivo. Suppression of HH pathway expression in vivo by taxane-based chemotherapy suggests a new mechanism of action for treatment of this aggressive tumor.