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Pancreatic Neoplasms: HELP
Articles by G. Dan Ayers
Based on 1 article published since 2008
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Between 2008 and 2019, G. Dan Ayers wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Clinical Trial Dual Src and EGFR inhibition in combination with gemcitabine in advanced pancreatic cancer: phase I results : A phase I clinical trial. 2018

Cardin, Dana B / Goff, Laura W / Chan, Emily / Whisenant, Jennifer G / Dan Ayers, G / Takebe, Naoko / Arlinghaus, Lori R / Yankeelov, Thomas E / Berlin, Jordan / Merchant, Nipun. ·Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. dana.cardin@vanderbilt.edu. · Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. dana.cardin@vanderbilt.edu. · Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. · Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. · Amgen Inc., Thousand Oaks, CA, USA. · Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. · Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. · Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA. · Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA. · Institute for Computational and Engineering Sciences, Departments of Biomedical Engineering and Diagnostic Medicine, Livestrong Cancer Institutes, University of Texas, Austin, TX, USA. · Department of Surgery, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL, USA. ·Invest New Drugs · Pubmed #28990119.

ABSTRACT: Pancreatic adenocarcinoma remains a major therapeutic challenge, as the poor (<8%) 5-year survival rate has not improved over the last three decades. Our previous preclinical data showed cooperative attenuation of pancreatic tumor growth when dasatinib (Src inhibitor) was added to erlotinib (EGFR inhibitor) and gemcitabine. Thus, this study was designed to determine the maximum-tolerated dose of the triplet combination. Standard 3 + 3 dose escalation was used, starting with daily oral doses of 70 mg dasatinib and 100 mg erlotinib with gemcitabine on days 1, 8, and 15 (800 mg/m