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Pancreatic Neoplasms: HELP
Articles by Maria Michela D'Innocenzio
Based on 1 article published since 2010
(Why 1 article?)

Between 2010 and 2020, Maria Michela D'Innocenzio wrote the following article about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article Pancreatic cystic endocrine tumors: a different morphological entity associated with a less aggressive behavior. 2010

Boninsegna, Letizia / Partelli, Stefano / D'Innocenzio, Maria Michela / Capelli, Paola / Scarpa, Aldo / Bassi, Claudio / Pederzoli, Paolo / Falconi, Massimo. ·Department of Surgery, S. Cuore-Don Calabria Hospital, Negrar, Italy. ·Neuroendocrinology · Pubmed #20689265.

ABSTRACT: BACKGROUND: Cystic pancreatic endocrine tumors (CPETs) are rare lesions and their biological features have been scarcely investigated. AIM: To compare clinical and pathological features of resected non-functioning sporadic CPETs (NF-CPETs) with solid pancreatic endocrine tumors (SPETs) in a single-institution experience. METHODS: All patients with a pathologically confirmed diagnosis of sporadic non-functioning pancreatic endocrine tumors who underwent curative resection between 1990 and 2008 were included. A comparison of demographic, clinical and pathological characteristics between CPETs and SPETs was made. Univariate and multivariable analyses were performed to identify preoperative predictors of carcinoma (non-functioning pancreatic endocrine carcinoma). RESULTS: Twenty-one (11.5%) patients with a histological diagnosis of NF-CPET were identified. The median age was 60 years (IQR 46.5-73.5 years) and a diagnosis of carcinoma (non-functioning pancreatic endocrine carcinoma) was made in 3 (14.3%) cases. In the comparison with NF-SPETs, no differences were found in terms of gender (p = 0.75), age (p = 0.81), presenting symptoms (p = 0.43), localization of the tumors (p = 0.46) and type of resection (p = 0.31). The incidence of non-functioning pancreatic endocrine carcinoma was significantly lower in the NF-CPET versus the NF-SPET group (14.3 vs. 40.4%, p = 0.04). By univariate analysis, preoperative predictors of non-functioning pancreatic endocrine carcinoma included the presence of symptoms (OR 3.96, 95% CI 2.06-7.63) and an increase in the absolute value of radiological diameter (OR 1.05, 95% CI 1.03-1.07). A cystic morphology of the lesion turned out to be a negative predictor of carcinoma (OR 0.25, 95% CI 0.70-0.87). These results were confirmed by multivariable analysis. CONCLUSIONS: NF-CPETs have a measurable propensity to be benign. In those patients affected by small and asymptomatic NF-CPET a more conservative surgical approach or a follow-up policy could be considered.