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Pancreatic Neoplasms: HELP
Articles by Kazuro Chiba
Based on 4 articles published since 2010
(Why 4 articles?)
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Between 2010 and 2020, Kazuro Chiba wrote the following 4 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Proposal for Endoscopic Ultrasonography Classification for Small Pancreatic Cancer. 2019

Terada, Shuzo / Kikuyama, Masataka / Kawaguchi, Shinya / Kanemoto, Hideyuki / Yokoi, Yoshihiro / Kamisawa, Terumi / Kuruma, Sawako / Chiba, Kazuro / Honda, Goro / Horiguchi, Shinichiro / Nakahodo, Jun. ·Department of Gastroenterology, Shizuoka General Hospital, Shizuoka 420-8527, Japan. m01060st@jichi.ac.jp. · Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-0021, Japan. kikuyama110@yahoo.co.jp. · Department of Gastroenterology, Shizuoka General Hospital, Shizuoka 420-8527, Japan. shinya-kawaguchi@i.shizuoka-pho.jp. · Department of Surgery, Shizuoka General Hospital, Shizuoka 420-8527, Japan. kanemot@gmail.com. · Department of Surgery, Shinshiro Municipal Hospital, Aichi 441-1387, Japan. y.yokoi@shinshirohp.jp. · Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-0021, Japan. kamisawa@cick.jp. · Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-0021, Japan. sawako@cick.jp. · Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-0021, Japan. kazuro_oruzak@yahoo.co.jp. · Department of Surgery, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo 113-0021, Japan. ghon@cick.jp. · Department of Pathology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo 113-0021, Japan. s.horiguchi@cick.jp. · Department of Human Pathology, Juntendo University, Tokyo 113-8421, Japan. nakajun58@yahoo.co.jp. ·Diagnostics (Basel) · Pubmed #30678056.

ABSTRACT: BACKGROUNDS: Endoscopic ultrasonography (EUS) is used to observe the stricture of the main pancreatic duct (MPD) and in diagnosing pancreatic cancer (PC). We investigate the findings on EUS by referring to the histopathological findings of resected specimens. MATERIALS AND METHODS: Six patients with carcinoma in situ (CIS) and 30 patients with invasive carcinoma of 20 mm or less were included. The preoperative EUS findings were classified as follows. A1: Simple stricture type-no findings around the stricture; A2: Hypoecho stricture type-localized hypoechoic area without demarcation around the stricture; A3: Tumor stricture type-tumor on the stricture; B: Dilation type-the dilation of the pancreatic duct without a downstream stricture; C: Parenchymal tumor type-tumor located apart from the MPD. RESULTS: Classes A1 and A2 consisted of 2 CISs, and 4 invasive carcinomas included two cases smaller than 5 mm in diameter. Most of the cancers classified as A3 or C were of invasive carcinoma larger than 5 mm in diameter. All cancers classified as B involved CIS. Serial pancreatic-juice aspiration cytologic examination (SPACE) was selected for all types of cases, with a sensitivity of 92.0%, while EUS-guided fine needle aspiration cytology (EUS-FNA) was only useful for invasive carcinoma, and its sensitivity was 66.7%. CONCLUSIONS: Stricture without a tumor could be a finding for invasive PC and pancreatic duct dilation without a downstream stricture could be a finding indicative of CIS. Carcinoma smaller than 5 mm in diameter could not be recognized by EUS. SPACE had a high sensitivity for diagnosing small PC.

2 Article Acute obstructive suppurative pancreatic ductitis (AOSPD) in pancreatic cancer treated by nasopancreatic drainage. 2018

Shimizuguchi, Ryoko / Kikuyama, Masataka / Kamisawa, Terumi / Kuruma, Sawako / Chiba, Kazuro. ·Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan. · Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan. kikuyama110@cick.jp. ·Clin J Gastroenterol · Pubmed #29464657.

ABSTRACT: An 80-year-old woman with pancreatic cancer was admitted with fever and abdominal pain. Blood examinations showed an elevated CRP level. On computed tomography (CT), a pancreatic tumor with a dilated upstream main pancreatic duct (MPD) was seen. Endoscopic retrograde cholangiopancreatography (ERCP) showed the strictured part of the MPD at the head of the pancreas with upstream dilatation. A nasopancreatic drainage tube was placed. Through the tube, purulent pancreatic juice was discharged and culture of the pancreatic juice grew Klebsiella pneumoniae. On the day after ERCP, the patient's condition and the laboratory results improved. The patient's disorder was diagnosed as acute obstructive suppurative pancreatitis with pancreatic cancer.

3 Article Intraductal papillary mucinous neoplasm of the pancreas and IgG4-related disease: a coincidental association. 2013

Tabata, Taku / Kamisawa, Terumi / Hara, Seiichi / Kuruma, Sawako / Chiba, Kazuro / Kuwata, Go / Fujiwara, Takashi / Egashira, Hideto / Koizumi, Satomi / Endo, Yuka / Koizumi, Koichi / Fujiwara, Junko / Arakawa, Takeo / Momma, Kumiko / Horiguchi, Shinichiro / Hishima, Tsunekazu / Kurata, Masanao / Honda, Goro / Kloppel, Gunter. ·Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan. ·Pancreatology · Pubmed #23890136.

ABSTRACT: BACKGROUND/AIMS: Coexistence of autoimmune pancreatitis (AIP) and pancreatic cancer, elevation of serum IgG4 levels in pancreatic cancer patients, and infiltration of IgG4-positive plasma cells in peritumorous pancreatitis have been described in a few reports. This study examined the relationship between intraductal papillary mucinous neoplasm (IPMN) of the pancreas and peritumorous IgG4-positive lymphoplasmacytic infiltrates. METHODS: Serum IgG4 levels were measured in 54 patients with IPMN (median 70 years, 26 males and 28 females; 13 main duct type and 41 branch duct type). Histological findings focusing on dense lymphoplasmacytic infiltration, storiform fibrosis, and obliterative phlebitis were reviewed, and immunostaining with IgG4 and IgG was performed in 23 surgically resected IPMN cases (18 main duct type and 5 branch duct type). The presence of IgG4-positive plasma cells >10/hpf and an IgG4-positive/IgG-positive plasma cell ratio >40% were considered significant. RESULTS: Serum IgG4 levels were elevated in 2 (4%) IPMN patients. Significant infiltration of IgG4-positive plasma cells was detected in 4 IPMN cases (17%). The IgG4-positive/IgG-positive plasma cell ratio was >40% in all 4 cases. In one case with a markedly elevated serum IgG4 level (624 mg/dL), typical lymphoplasmacytic sclerosing pancreatitis (AIP type 1) lesions surrounded the whole IPMN. In the 3 other cases, infiltration of IgG4-positive plasma cells with fibrosis was focally detected mainly in the periductal area around the IPMN. CONCLUSIONS: In a few patients with IPMNs, IgG4-positive plasma cell infiltration can occur in the peritumorous area. The association of an IPMN with AIP type 1-like changes seems to be exceptional and coincidental.

4 Article Pancreatic cancer causing acute pancreatitis: a comparative study with cancer patients without pancreatitis and pancreatitis patients without cancer. 2013

Minato, Yohei / Kamisawa, Terumi / Tabata, Taku / Hara, Seiichi / Kuruma, Sawako / Chiba, Kazuro / Kuwata, Go / Fujiwara, Takashi / Egashira, Hideto / Koizumi, Koichi / Saito, Itaru / Endo, Yuka / Koizumi, Satomi / Fujiwara, Junko / Arakawa, Takeo / Momma, Kumiko / Kurata, Masanao / Honda, Goro. ·Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan. ·J Hepatobiliary Pancreat Sci · Pubmed #23494612.

ABSTRACT: BACKGROUND/PURPOSE: Although pancreatic cancer produces upstream obstructive pancreatitis, acute pancreatitis is a less common manifestation of pancreatic cancer. This study aimed to clarify the subgroup of pancreatic cancer patients who present with an episode of acute pancreatitis (Group I) in comparison with a matched group of pancreatic cancer patients without pancreatitis (Group II) and another group of acute pancreatitis patients without pancreatic cancer (Group III). METHODS: This was a retrospective comparative study of 18 patients in Group I, 300 patients in Group II and 141 patients in Group III. RESULTS: The mean age of Group I was 63.7 years and the male to female ration was 1:0.3. Serum CA 19-9 levels were elevated in 80 %. The main pancreatic duct was incompletely obstructed in 7 patients. There were no significant differences in location of tumor, clinical stage, resection rate and survival months between Group I and II. Acute pancreatitis secondary to pancreatic cancer was more likely to be mild (94 vs. 72 %,p < 0.05) and relapsed (39 vs. 16 %,p < 0.05) compared with Group III. CONCLUSIONS: Anatomic evaluation of the pancreas should be performed in patients with acute pancreatitis with no obvious etiology, even if the pancreatitis is mild, to search for underlying malignancy.