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Pancreatic Neoplasms: HELP
Articles by Rim Chérif
Based on 6 articles published since 2010
(Why 6 articles?)
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Between 2010 and 2020, R. Cherif wrote the following 6 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Risk and Predictors of Postoperative Morbidity and Mortality After Pancreaticoduodenectomy for Pancreatic Neuroendocrine Neoplasms: A Comparative Study With Pancreatic Ductal Adenocarcinoma. 2019

Partelli, Stefano / Tamburrino, Domenico / Cherif, Rim / Muffatti, Francesca / Moggia, Elisabetta / Gaujoux, Sébastien / Sauvanet, Alain / Falconi, Massimo / Fusai, Giuseppe. ·Department of HPB and Liver Transplant Surgery, Royal Free Hospital, NHS Foundation Trust, London, United Kingdom. · Chirurgie Hépato-Bilio-Pancréatique, Beaujon Hospital, Paris. ·Pancreas · Pubmed #30946244.

ABSTRACT: OBJECTIVES: Pancreaticoduodenectomy (PD) is associated with a high risk of postoperative complications and mortality. The aim of this study was to compare postoperative morbidity after PD in patients undergoing resections for pancreatic neuroendocrine neoplasms (PanNENs) with patients undergoing the same resection for pancreatic ductal adenocarcinoma (PDAC). METHODS: Data of 566 patients from 3 European tertiary referral centers between 1998 and 2014 were considered. RESULTS: Overall, 566 patients (179 with PanNENs, 387 with PDAC) who underwent PD were analyzed. Patients with PanNENs were significantly younger (56 vs 64 years, P < 0.0001). The consistency of the pancreas was soft in 147 patients (82%) with PanNENs and in 162 patients (42%) with PDAC (P < 0.0001). Patients in the PanNENs group had a significantly higher rate of pancreatic fistula (P < 0.0001), bile leak (P = 0.004), abdominal collection (P = 0.017), and development of sepsis (P = 0.042). No differences in terms of overall postoperative complications, median length of stay, and in-hospital mortality were found. On multivariate analysis sex (male), PanNENs indication, blood transfusion, and a soft pancreatic texture were independent predictors of pancreatic fistula after PD. CONCLUSIONS: Pancreaticoduodenectomy for PanNENs is associated with higher rate of surgical-specific postoperative complications than those for PDAC.

2 Article Laparoscopic Pancreaticoduodenectomy with Reconstruction of the Portal Vein with the Parietal Peritoneum. 2016

Dokmak, Safi / Chérif, Rim / Duquesne, Igor / Delattre, Raphaêlle / Aussilhou, Béatrice / Soubrane, Olivier / Sauvanet, Alain. ·Department of HPB Surgery and Liver Transplantation, Beaujon Hopsital, Clichy, France. safi.dokmak@bjn.aphp.fr. · Department of HPB Surgery and Liver Transplantation, Beaujon Hopsital, Clichy, France. · Department of Anesthesia-Reanimation, Beaujon Hopsital, Clichy, France. ·Ann Surg Oncol · Pubmed #27038457.

ABSTRACT: INTRODUCTION: Laparoscopic pancreaticoduodenectomy (LPD) is increasingly used for resections of periampullary tumors, including pancreatic adenocarcinoma.1 LPD with venous resection-reconstruction (VRR) has already been performed with or without vascular graft.2 (,) 3 The parietal peritoneum (PP) was recently described for reconstruction of the mesenterico-portal vein, with excellent results.4 PATIENTS AND METHODS: Between April 2011 and May 2015, a total of 64 LPDs were performed in our department; however, only one patient underwent VRR. Compared with the open approach, full mobilization of the mesentery and right liver is not systematically carried out and, theoretically, vascular grafts may be more frequently needed with LPD. In this video, LPD for pancreatic adenocarcinoma with resection of the lateral right side of the portal vein (>25 mm) was performed. Reconstruction was achieved rapidly, as a lateral patch, with the falciform ligament. RESULTS: Surgery lasted 360 min, 60 min of portal vein occlusion, 200 ml of blood loss, and uneventful stay. Since 2010, the PP has been used as a lateral patch in 69 patients operated by open (n = 68) or laparoscopic approach (n = 1). Although handling and suturing can be difficult, no bleeding complications related to the PP were observed and the permeability rate was >95 %. CONCLUSION: LPD is still restricted to selected centers, with conflicting results regarding safety; however, venous resection may be required. We feel that with the laparoscopic approach, vascular grafts are more frequently needed and the PP has many advantages compared with an open approach, including easy access, unlimited size, and rapid harvesting.

3 Article Sporadic nonfunctioning pancreatic neuroendocrine tumors: prognostic significance of incidental diagnosis. 2014

Birnbaum, David Jérémie / Gaujoux, Sébastien / Cherif, Rim / Dokmak, Safi / Fuks, David / Couvelard, Anne / Vullierme, Marie-Pierre / Ronot, Maxime / Ruszniewski, Philippe / Belghiti, Jacques / Sauvanet, Alain. ·Department of Hepato-Pancreato-Biliary Surgery - Pôle des Maladies de l'Appareil Digestif (PMAD), AP-HP, hôpital Beaujon, Clichy, France. · Department of Hepato-Pancreato-Biliary Surgery - Pôle des Maladies de l'Appareil Digestif (PMAD), AP-HP, hôpital Beaujon, Clichy, France; Université Paris Diderot, Paris, France; Centre de Recherche Biomédicale Bichat Beaujon (CRB3)/INSERM U773, Institut National de la Santé et de la Recherche Médicale, Paris, France. · Department of Hepato-Pancreato-Biliary Surgery - Pôle des Maladies de l'Appareil Digestif (PMAD), AP-HP, hôpital Beaujon, Clichy, France; Université Paris Diderot, Paris, France. · Université Paris Diderot, Paris, France; Centre de Recherche Biomédicale Bichat Beaujon (CRB3)/INSERM U773, Institut National de la Santé et de la Recherche Médicale, Paris, France; Département of Pathology, AP-HP, hôpital Beaujon, Clichy, France. · Department of Radiology, AP-HP, hôpital Beaujon, Clichy, France. · Université Paris Diderot, Paris, France; Département of Pathology, AP-HP, hôpital Beaujon, Clichy, France; Department of Radiology, AP-HP, hôpital Beaujon, Clichy, France. · Université Paris Diderot, Paris, France; Centre de Recherche Biomédicale Bichat Beaujon (CRB3)/INSERM U773, Institut National de la Santé et de la Recherche Médicale, Paris, France; Department of Gastroenterology, Pôle des Maladies de l'Appareil Digestif (PMAD), AP-HP, hôpital Beaujon, Clichy, France. · Department of Hepato-Pancreato-Biliary Surgery - Pôle des Maladies de l'Appareil Digestif (PMAD), AP-HP, hôpital Beaujon, Clichy, France; Université Paris Diderot, Paris, France. Electronic address: alain.sauvanet@bjn.aphp.fr. ·Surgery · Pubmed #24238123.

ABSTRACT: BACKGROUND: Sporadic nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) are increasingly diagnosed as incidentalomas, and their resection is usually recommended. The prognostic significance of this diagnosis feature is poorly studied, and management of these tumors remains controversial. Clinical, pathologic characteristics and outcome of resected incidentally diagnosed NF-PNET (Inc) were compared with resected symptomatic NF-PNET (Symp) to better assess their biologic behavior and tailor their management. METHODS: From 1994 to 2010, 108 patients underwent resection for sporadic nonmetastatic NF-PNET. Diagnosis was considered as incidental in patients with no abdominal symptoms or symptoms unlikely to be related to tumor mass. Patients with Inc were compared with patients with Symp, regarding demographics, postoperative course, pathology, and disease-free survival (DFS). RESULTS: Of the 108 patients, 65 (61%) had incidentally diagnosed tumors. Pancreas-sparing pancreatectomies (enucleation/central pancreatectomy) were performed more frequently in Inc (62% vs 30%, P = .001). Inc tumors were more frequently <20 mm (65% vs 42%, P = .019), staged T1 (62% vs 33%, P = .0001), node negative (85% vs 60%; P = .005), and grade 1 (66% vs 33%, P = .0001). One postoperative death occurred in the Inc group, and postoperative morbidity was similar between the two groups (60% vs 65%, P = .59). DFS was substantially better in the Inc group (5-year DFS = 92% vs 82%, P = .0016). CONCLUSION: Incidentally diagnosed NF-PNETs are associated with less aggressive features compared with symptomatic lesions but cannot always be considered to be benign. Operative resection remains recommended for most. Incidentally diagnosed NF-PNET may be good candidates for pancreas-sparing pancreatectomies.

4 Article Pattern and clinical predictors of lymph node involvement in nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs). 2013

Partelli, Stefano / Gaujoux, Sebastien / Boninsegna, Letizia / Cherif, Rim / Crippa, Stefano / Couvelard, Anne / Scarpa, Aldo / Ruszniewski, Philippe / Sauvanet, Alain / Falconi, Massimo. ·Departments of Surgery and Pathology, University of Verona, Verona, Italy. ·JAMA Surg · Pubmed #23986355.

ABSTRACT: IMPORTANCE: Nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs) are often indolent neoplasms without lymph node (LN) metastasis at diagnosis. Therefore, in patients with low risk of LN metastasis, the extent of surgery and lymphadenectomy could be limited and follow-up adjusted to the very low risk of relapse. OBJECTIVE: To construct a predicting model to assess the risk of pN+ prior to surgical resection for NF-PanNETs using preoperative retrievable variables. DESIGN: Retrospective review using multiple logistic regression analysis to construct predictive model of pN+ based on preoperatively available data. SETTING: The combined prospective databases of the Surgical Departments of the University of Verona, Verona, Italy, and Beaujon Hospital, Clichy, France, were queried for clinical and pathological data. PARTICIPANTS: All patients with resected (R0 or R1), pathologically confirmed NF-PanNETs between January 1, 1993 and December 31, 2009. MAIN OUTCOME AND MEASURE: Risk of lymph node metastases in patients with pancreatic neuroendocrine tumors. RESULTS: Among 181 patients, nodal metastases were reported in 55 patients (30%) and were associated with decreased 5-year disease-free survival (70% vs 97%, P < .001). Multivariable analysis showed that independent factors associated with nodal metastasis were radiological nodal status (rN) (odds ratio [OR], 5.58; P < .001) and tumor grade (NET-G2 vs NET-G1: OR, 4.87; P < .001) (first model). When the tumor grade was excluded, rN (OR, 4.73; P = .001) and radiological tumor size larger than 4 cm (OR, 2.67; P = .03) were independent predictors of nodal metastasis (second model). The area under the receiver operating characteristic curve for the first and second models were 80% and 74%, respectively. CONCLUSIONS AND RELEVANCE: Patients with NF-PanNET-G1 have a very low risk of pN+ in the absence of radiological signs of node involvement. When preoperative grading assessment is not achieved, the radiological size of the lesion is a powerful alternative predictor of pN+. The risk of pathological nodal involvement in patients with NF-PanNETs can be accurately estimated by a clinical predictive model.

5 Article Enucleation of pancreatic lesions through laparotomy. 2012

Cherif, R / Gaujoux, S / Sauvanet, A. ·Service de Chirurgie Hépato-Pancréato-Biliaire, Pôle des Maladies de l'Appareil Digestif (PMAD), Hôpital Beaujon, AP-HP, Université Paris-VII, 100, boulevard du Général-Leclerc, 92110 Clichy, France. ·J Visc Surg · Pubmed #23168088.

ABSTRACT: -- No abstract --

6 Article Parenchyma-sparing resections for pancreatic neuroendocrine tumors. 2012

Cherif, Rim / Gaujoux, Sébastien / Couvelard, Anne / Dokmak, Safi / Vuillerme, Marie-Pierre / Ruszniewski, Philippe / Belghiti, Jacques / Sauvanet, Alain. ·Department of Hepato-Pancreato-Biliary Surgery, Pôle des Maladies de l'Appareil Digestif (PMAD), AP-HP, hôpital Beaujon, 100, Bd du Général Leclerc, Clichy 92110, France. ·J Gastrointest Surg · Pubmed #22911124.

ABSTRACT: BACKGROUND: Parenchyma-sparing pancreatectomy (PSP), including enucleation and central pancreatectomy, has been investigated as an alternative to standard resection for pancreatic endocrine neoplasm, but the benefit/risk of these procedures remains little known. METHODS: From 1998 to 2010, among 197 patients operated for well-differentiated pancreatic neuroendocrine tumors, 67 underwent PSP (45 enucleations and 22 central pancreatectomies) and 66 standard resections (35 pancreaticoduodenectomies and 31 distal pancreatectomies) for a tumor below 4 cm, without synchronous distant metastasis. Groups were compared regarding postoperative morbidity, mortality, long-term pancreatic function, and survival calculated using the Kaplan-Meier method. RESULTS: Tumors operated by PSP had a median size of 15 mm, were mainly incidentally diagnosed (n = 46, 69 %), and nonfunctioning (n = 55, 82 %). Overall morbidity rate was higher after PSP than standard resection (SR) (76 vs 58 %, p = 0.0028), including more frequent pancreatic fistulas (69 vs 42 %, p = 0.003). Postoperative diabetes was less frequent following PSP than pancreaticoduodenectomy (5 vs 21 %; p = 0.022) but equivalent to the one observed after distal pancreatectomy (4 %, p = 1). Exocrine insufficiency was significantly less frequent after PSP than SR (3 vs 32 %; p < 0.0001). The overall and recurrence-free 5-year survival after PSP for nonfunctioning tumors was 96 and 98 %, respectively. CONCLUSION: In selected patients, with small and low-grade tumors, PSP are associated with excellent overall and recurrence-free survivals. These procedures are associated with an increased postoperative morbidity but an excellent postoperative pancreatic function. Therefore, they should be considered as a valid therapeutic option in selected well-differentiated pancreatic neuroendocrine tumors.