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Pancreatic Neoplasms: HELP
Articles by Y. Z. Chen
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Y. Z. Chen wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Mitochondrial tRNALeu(CUN) A12307G variant may not be associated pancreatic cancer. 2016

Li, Y / Huang, A W / Chen, Y Z / Yang, W J / Zhou, M T / Sun, H W. ·Department of Operating Room, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. · Department of Surgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. ·Genet Mol Res · Pubmed #27323166.

ABSTRACT: Mitochondrial DNA mutations that lead to mitochondrial dysfunction have long been proposed to play important roles in the development of pancreatic cancer. Of these, alterations to mitochondrial tRNA genes constitute the largest group. Most recently, a variation at position 12307 in the gene encoding tRNA(Leu(CUN)) has been reported to be associated with this disease. However, the molecular mechanism underlying this relationship remains poorly understood. To assess this association, we evaluated this variant by evolutionary conservation analysis, measurements of allelic frequencies among control subjects, and use of several bioinformatic tools to estimate potential structural and functional alterations. We found this residue to have a high conservation index; however, the presence of the A12307G variation in control subjects revealed by a literature search suggested it to be common in human populations. Moreover, RNAfold results showed that this variant did not alter the secondary structure of tRNA(Leu(CUN)). Through the application of a pathogenicity scoring system, this variant was determined to be a "neutral polymorphism," with a score of only 4 points based on current data. Thus, the contribution of the A12307G variant to pancreatic cancer needs to be addressed in further experimental studies.

2 Article Distribution and clinical significance of tumour-associated macrophages in pancreatic ductal adenocarcinoma: a retrospective analysis in China. 2015

Chen, S J / Zhang, Q B / Zeng, L J / Lian, G D / Li, J J / Qian, C C / Chen, Y Z / Chen, Y T / Huang, K H. ·Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, PR China. ; Department of Gastroenterology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, PR China. · Department of Gastroenterology, Lihuili Hospital of Ningbo Medical Center, Ningbo, PR China. · Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, PR China. ·Curr Oncol · Pubmed #25684992.

ABSTRACT: BACKGROUND: We aimed to characterize the localization and prognostic significance of tumour-associated macrophages (tams) in pancreatic ductal adenocarcinoma (pdac). METHODS: Tumour specimens from 70 patients with pdac and inflammatory specimens from 13 patients with chronic pancreatitis were collected and analyzed for tam and M2 macrophage counts by immunohistochemistry. Correlations between tam distributions and clinicopathologic features were determined. RESULTS: Immunohistochemical analysis showed that tam and M2 macrophage counts were higher in tissues from pdac than from chronic pancreatitis. The tams and M2 macrophages both infiltrated more into peritumour. Both macrophage types were positively associated with lymph node metastasis (p = 0.041 for tams in peritumour, p = 0.013 for M2 macrophages in introtumour, p = 0.006 for M2 macrophage in peritumour). In addition, abdominal pain was significantly more frequent in pdac patients with a greater tams count. The survival rate was much lower in patients having high infiltration by M2 macrophages than in those having low infiltration. CONCLUSIONS: The tam count might be associated with neural invasion in pdac, and M2 macrophages might play an important role in lymph node metastasis. Higher counts of either macrophage type were associated with increased risk of lymph node metastasis, and the M2 macrophage count could potentially be a marker for evaluating prognosis.