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Pancreatic Neoplasms: HELP
Articles by Madeleine Bussemaker
Based on 1 article published since 2010
(Why 1 article?)
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Between 2010 and 2020, Madeleine Bussemaker wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Sonodynamic therapy combined with novel anti-cancer agents, sanguinarine and ginger root extract: Synergistic increase in toxicity in the presence of PANC-1 cells in vitro. 2018

Prescott, Matthew / Mitchell, James / Totti, Stella / Lee, Judy / Velliou, Eirini / Bussemaker, Madeleine. ·Bioprocess and Biochemical Engineering (BioProChem) Group, Department of Chemical Engineering, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom. · Sonochemistry Ultrasonics Research Group (SURG), Department of Chemical Engineering, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom. · Sonochemistry Ultrasonics Research Group (SURG), Department of Chemical Engineering, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom. Electronic address: m.bussemaker@surrey.ac.uk. ·Ultrason Sonochem · Pubmed #28533126.

ABSTRACT: The presence of ultrasound-induced cavitation in sonodynamic therapy (SDT) treatments has previously enhanced the activity and delivery of certain sonosensitisers in biological systems. The purpose of this work was to investigate the potential for two novel anti-cancer agents from natural derivatives, sanguinarine and ginger root extract (GRE), as sonosensitisers in an SDT treatment with in vitro PANC-1 cells. Both anti-cancer compounds had a dose-dependent cytotoxicity in the presence of PANC-1 cells. A range of six discreet ultrasound power-frequency configurations were tested and it was found that the cell death caused directly by ultrasound was likely due to the sonomechanical effects of cavitation. Combined treatment used dosages of 100μM sanguinarine or 1mM of GRE with 15s sonication at 500kHz and 10W. The sanguinarine-SDT and GRE-SDT treatments showed a 6% and 17% synergistic increase in observed cell death, respectively. Therefore both sanguinarine and GRE were found to be effective sonosensitisers and warrant further development for SDT, with a view to maximising the magnitude of synergistic increase in toxicity.