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Pancreatic Neoplasms: HELP
Articles by Chiara Maria Broglia
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Chiara Maria Broglia wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Systematic versus on-demand early palliative care: A randomised clinical trial assessing quality of care and treatment aggressiveness near the end of life. 2016

Maltoni, Marco / Scarpi, Emanuela / Dall'Agata, Monia / Schiavon, Stefania / Biasini, Claudia / Codecà, Carla / Broglia, Chiara Maria / Sansoni, Elisabetta / Bortolussi, Roberto / Garetto, Ferdinando / Fioretto, Luisa / Cattaneo, Maria Teresa / Giacobino, Alice / Luzzani, Massimo / Luchena, Giovanna / Alquati, Sara / Quadrini, Silvia / Zagonel, Vittorina / Cavanna, Luigi / Ferrari, Daris / Pedrazzoli, Paolo / Frassineti, Giovanni Luca / Galiano, Antonella / Casadei Gardini, Andrea / Monti, Manlio / Nanni, Oriana / Anonymous8880886. ·Palliative Care Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, FC, Italy. · Unit of Biostatistics and Clinical Trials, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, FC, Italy. Electronic address: emanuela.scarpi@irst.emr.it. · Unit of Biostatistics and Clinical Trials, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, FC, Italy. · Pain Therapy and Palliative Care Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. · Medical Oncology Unit, Oncology-Hematology Department, Guglielmo da Saliceto Hospital, Piacenza, Italy. · Medical Oncology Unit, San Paolo Hospital, Milan, Italy. · Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. · Palliative Care and Pain Therapy Unit, Aviano National Cancer Institute, Aviano, Italy. · Medical Oncology Unit, Presidio Humanitas Gradenigo, Turin, Italy. · Medical Oncology Unit, Oncology Department, S. Maria Annunziata Hospital, Florence, Italy. · Palliative Care Unit, Oncology Department, L. Sacco Hospital, Milan, Italy. · Oncology Unit, Ospedale degli Infermi, Ponderano, BI, Italy. · Palliative Care, Department of Geriatric, Orthogeriatric and Rehabilitation Frailty Area, E.O. Galliera Hospitals, Genoa, Italy. · Oncology Unit, Sant'Anna Hospital, Como, Italy. · Palliative Care Unit, Arcispedale S. Maria Nuova - IRCCS, Reggio Emilia, Italy. · Oncology Unit, SS Trinità Hospital Sora, ASL Frosinone, Italy. · Department of Clinical and Experimental Oncology, Medical Oncology Unit 1, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. · Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, FC, Italy. ·Eur J Cancer · Pubmed #27821313.

ABSTRACT: AIM: Early palliative care (EPC) in oncology has shown sparse evidence of a positive impact on patient outcomes, quality of care outcomes and costs. PATIENTS AND METHODS: Data for this secondary analysis were taken from a trial of 207 outpatients with metastatic pancreatic cancer randomly assigned to receive standard cancer care plus on-demand EPC (standard arm) or standard cancer care plus systematic EPC (interventional arm). After 20 months' follow-up, 149 (80%) had died. Outcome measures were frequency, type and timing of chemotherapy administration, use of resources, place of death and overall survival. RESULTS: Some indices of end-of-life (EoL) aggressiveness had a favourable impact from systematic EPC. Interventional arm patients showed higher use of hospice services: a significantly longer median and mean period of hospice care (P = 0.025 for both indexes) and a significantly higher median and mean number of hospice admissions (both P < 0.010). In the experimental arm, chemotherapy was performed in the last 30 days of life in a significantly inferior rate with respect to control arm: 18.7% versus 27.8% (adjusted P = 0.036). Other non-significant differences were seen in favour of experimental arm. CONCLUSIONS: Systematic EPC showed a significant impact on some indicators of EoL treatment aggressiveness. These data, reinforced by multiple non-significant differences in most of the other items, suggest that quality of care is improved by this approach. This study is registered on ClinicalTrials.gov (NCT01996540).

2 Article Systematic versus on-demand early palliative care: results from a multicentre, randomised clinical trial. 2016

Maltoni, Marco / Scarpi, Emanuela / Dall'Agata, Monia / Zagonel, Vittorina / Bertè, Raffaella / Ferrari, Daris / Broglia, Chiara Maria / Bortolussi, Roberto / Trentin, Leonardo / Valgiusti, Martina / Pini, Sara / Farolfi, Alberto / Casadei Gardini, Andrea / Nanni, Oriana / Amadori, Dino / Anonymous6220876. ·Palliative Care Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)-IRCCS, Meldola, Italy. · Biostatistics and Clinical Trials Unit, IRST-IRCCS, Meldola, Italy. Electronic address: emanuela.scarpi@irst.emr.it. · Biostatistics and Clinical Trials Unit, IRST-IRCCS, Meldola, Italy. · Medical Oncology Unit 1, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy. · Palliative Care, Oncology Department, Guglielmo da Saliceto Hospital, Piacenza, Italy. · Palliative Care Unit, Oncology Department, Azienda Ospedaliera San Paolo, Milano, Italy. · Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. · Palliative Care and Pain Therapy Unit, Centro di Riferimento Oncologico di Aviano, IRCCS, Aviano, Italy. · Palliative Care and Pain Therapy Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy. · Medical Oncology Unit, IRST-IRCCS, Meldola, Italy. ·Eur J Cancer · Pubmed #27472648.

ABSTRACT: BACKGROUND: Early palliative care (EPC) in oncology has been shown to have a positive impact on clinical outcome, quality-of-care outcomes, and costs. However, the optimal way for activating EPC has yet to be defined. METHODS: This prospective, multicentre, randomised study was conducted on 207 outpatients with metastatic or locally advanced inoperable pancreatic cancer. Patients were randomised to receive 'standard cancer care plus on-demand EPC' (n = 100) or 'standard cancer care plus systematic EPC' (n = 107). Primary outcome was change in quality of life (QoL) evaluated through the Functional Assessment of Cancer Therapy - Hepatobiliary questionnaire between baseline (T0) and after 12 weeks (T1), in particular the integration of physical, functional, and Hepatic Cancer Subscale (HCS) combined in the Trial Outcome Index (TOI). Patient mood, survival, relatives' satisfaction with care, and indicators of aggressiveness of care were also evaluated. FINDINGS: The mean changes in TOI score and HCS score between T0 and T1 were -4.47 and -0.63, with a difference between groups of 3.83 (95% confidence interval [CI] 0.10-7.57) (p = 0.041), and -2.23 and 0.28 (difference between groups of 2.51, 95% CI 0.40-4.61, p = 0.013), in favour of interventional group. QoL scores at T1 of TOI scale and HCS were 84.4 versus 78.1 (p = 0.022) and 52.0 versus 48.2 (p = 0.008), respectively, for interventional and standard arm. Until February 2016, 143 (76.9%) of the 186 evaluable patients had died. There was no difference in overall survival between treatment arms. INTERPRETATIONS: Systematic EPC in advanced pancreatic cancer patients significantly improved QoL with respect to on-demand EPC.