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Pancreatic Neoplasms: HELP
Articles by Maria Gabriella Brizi
Based on 5 articles published since 2008
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Between 2008 and 2019, M. G. Brizi wrote the following 5 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Review Uptodate in the assessment and management of intraductal papillary mucinous neoplasms of the pancreas. 2017

Pagliari, D / Saviano, A / Serricchio, M L / Dal Lago, A A / Brizi, M G / Lanza, F / Manfredi, R / Gasbarrini, A / Attili, F. ·Department of Internal Medicine and Gastroenterology, Pancreatic Unit, Fondazione Policlinico Universitario "A. Gemelli", Catholic University of the Sacred Heart, School of Medicine, Rome, Italy. danilo.pagliari@gmail.com. ·Eur Rev Med Pharmacol Sci · Pubmed #28682431.

ABSTRACT: Intraductal Papillary Mucinous Neoplasms (IPMNs) are the most common cystic tumors of the pancreas and are considered premalignant lesions. IPMNs are characterized by the papillary growth of the ductal epithelium with rich mucin production, which is responsible for cystic segmental or diffuse dilatation of the main pancreatic duct (MPD) and/or its branches. According to the different involvement of pancreatic duct system, IPMNs are divided into main duct type (MD-IPMN), branch duct type (BD-IPMN), and mixed type (MT-IPMN). IPMNs may be incidentally discovered in asymptomatic patients, particularly in those with BD-IPMNs, when imaging studies are performed for unrelated indications. The increase in their frequency may reflect the combined effects of new diagnostic techniques, the improvement of radiologic exams and progress in the recognition of the pathology. MD-IPMNs present a higher risk of malignant progression than BD-IPMNs; as a consequence, all the guidelines strictly suggest the need of surgery for MD- and MT- IPMNs with MPD > 10 mm, while the management of BD-IPMNs is still controversial and depends on several cysts and patients features. The choice between non-operative and surgical management depends on the distinction between benign and invasive IPMN forms, assessment of malignancy risk, patient's wellness and its preferences. This manuscript revises the different guidelines for the management of IPMNs that have been published in different world countries: the international (Sendai 2006 and Fukuoka 2012), the 2013 European, the 2014 Italian, and finally the 2015 American guidelines. In summary, this review will integrate the recent insights in the combination of diagnostic techniques, such as Magnetic Resonance Imaging (MRI) and endoscopic ultrasound (EUS), pathology classification, and management of IPMNs.

2 Article Pancreatic neuroendocrine tumors in MEN1 disease: a mono-centric longitudinal and prognostic study. 2018

Chiloiro, S / Lanza, F / Bianchi, A / Schinzari, G / Brizi, M G / Giampietro, A / Rufini, V / Inzani, F / Giordano, A / Rindi, G / Pontecorvi, A / De Marinis, L. ·Department of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy. · Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy. · Department of Oncology, Catholic University of the Sacred Heart, Rome, Italy. · Department of Nuclear Medicine, Catholic University of the Sacred Heart, Rome, Italy. · Department of Anatomic Pathology, Catholic University of the Sacred Heart, Rome, Italy. · Department of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy. laurademarinis@yahoo.it. ·Endocrine · Pubmed #28567607.

ABSTRACT: PURPOSE: Multiple endocrine neoplasia type 1 (MEN1) is an inherited endocrine neoplastic syndrome associated with a greater risk of endocrine tumor development like pancreatic neuroendocrine tumors (p-NET), with different clinical characteristics from sporadic ones. This paper aims to compare clinical, hystological and morphological aspects of p-NET in patients affected from MEN1 (MEN1+) and not-affected ones (MEN1-). METHODS: We performed a retrospective observational study. Data was collected between December 2010 and December 2015, including patients with a histological diagnosis of p-NET and radiological imaging. We compared clinical, histological, radiological, and prognostic aspects of MEN+ p-NET with MEN-1 p-NET. RESULTS: Of the 45 patients enrolled, 13 MEN1+ and 21 MEN1- cases were analyzed. Frequency of not secreting p-NETs and insulin secreting p-NETs, histopathological grades and Ki67 expression were superimposable between MEN1+ and MEN1- patients. MEN1+ pNETs are more often multicentric compared to MEN1- pNETs. Frequency of liver and nodes metastatic spread was higher in MEN1- p-NET compared to MEN1+ p-NET. Analyzing p-NET according to the disease outcome, we found that recovered and stable p-NETs in MEN1+ patients, compared to MEN1- cases, are diagnosed at lower age (p = 0.04/p = 0.002) and that are more frequently multifocal lesions (p = 0.009/p = 0.002). CONCLUSIONS: In our study pNETs in MEN1+ and pNETs in MEN1- don't significantly differ for prognosis but only for clinical features. p-NET stage disease and prognosis can be positively influenced by early diagnosis and screening in index patients' first-degree relatives.

3 Article Evaluation of the Added Value of Diffusion-Weighted Imaging to Conventional Magnetic Resonance Imaging in Pancreatic Neuroendocrine Tumors and Comparison With 68Ga-DOTANOC Positron Emission Tomography/Computed Tomography. 2016

Farchione, Alessandra / Rufini, Vittoria / Brizi, Maria Gabriella / Iacovazzo, Donato / Larghi, Alberto / Massara, Roberto Maria / Petrone, Gianluigi / Poscia, Andrea / Treglia, Giorgio / De Marinis, Laura / Giordano, Alessandro / Rindi, Guido / Bonomo, Lorenzo. ·From the Institutes of *Radiology and †Nuclear Medicine, Department of Radiological Sciences; ‡Division of Endocrinology; §Digestive Endoscopy Unit; ∥Institute of Pathology; and ¶Institute of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy; and #Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland. ·Pancreas · Pubmed #26418904.

ABSTRACT: OBJECTIVES: The aims of this study were to investigate the added value of diffusion-weighted imaging (DWI) in pancreatic neuroendocrine tumor (pNET) evaluation and to compare magnetic resonance imaging (MRI) to Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) results. METHODS: Morphological MRI (T2-weighted [T2-w] + contrast-enhanced [CE] T1-w) and DWI (T2-w + DWI) and Ga-DOTANOC PET/CT in 25 patients/30 pNETs were retrospectively evaluated. Per-patient and per-lesion detection rates (pDR and lDR, respectively) were calculated. Apparent diffusion coefficient values were compared among pNET and surrounding and normal pancreas (control group, 18 patients). Apparent diffusion coefficient and standardized uptake value (SUV) values were compared among different grading and staging groups. RESULTS: No statistically significant differences in PET/CT and MRI session detection rates were found (morphological MRI and DW-MRI, 88% pDR and 87% lDR; combined evaluation, 92% pDR and 90% lDR; Ga-DOTANOC PET/CT, 88% pDR and 80% lDR). Consensus reading (morphological/DW-MRI + PET/CT) improved pDR and lDR (100%). Apparent diffusion coefficient mean value was significantly lower compared with surrounding and normal parenchyma (P < 0.01). The apparent diffusion coefficient and SUV values of pNETs among different grading and staging groups were not statistically different. CONCLUSIONS: Conventional MRI, DW-MRI + T2-w sequences, and Ga-DOTANOC PET/CT can be alternative tools in pNET detection. Diffusion-weighted MRI could be valuable in patients with clinical suspicion but negative conventional imaging findings. However, the consensus reading of the 3 techniques seems the best approach.

4 Article Intraoperative radiation therapy in resected pancreatic carcinoma: long-term analysis. 2008

Valentini, Vincenzo / Morganti, Alessio G / Macchia, Gabriella / Mantini, Giovanna / Mattiucci, Gian C / Brizi, M Gabriella / Alfieri, Sergio / Bossola, Maurizio / Pacelli, Fabio / Sofo, Luigi / Doglietto, Giovanbattista / Cellini, Numa. ·Department of Radiotherapy, Policlinico Universitario A. Gemelli, Catholic University, Rome, Italy. ·Int J Radiat Oncol Biol Phys · Pubmed #18313525.

ABSTRACT: PURPOSE: The combination of external radiotherapy (RT) plus intraoperative radiotherapy (IORT) in patients with pancreatic cancer is still debated. This study presents long-term results (minimum follow-up, 102 months) for 26 patients undergoing integrated adjuvant RT (external RT+IORT). METHODS AND MATERIALS: From 1990 to 1995, a total of 17 patients with pancreatic cancer underwent IORT (10 Gy) and postoperative external RT (50.4 Gy). Preoperative "flash" RT was included for the last 9 patients. The liver and pancreatic head received 5 Gy (two 2.5-Gy fractions) the day before surgery. In the subsequent period (1996-1998), 9 patients underwent preoperative concomitant chemoradiation (39.6 Gy) with 5-fluorouracil, IORT (10 Gy), and adjuvant chemotherapy. RESULTS: Preoperative chemoradiation was completed in all patients, whereas postoperative therapy was completed in 13 of 17 patients. All 26 patients underwent pancreatectomy (25 R0 and one R1 resections). One patient died of postoperative complications (3.8%) not related to IORT. The 9 patients undergoing concomitant chemoradiation were candidates for adjuvant chemotherapy; however, only 4 of 9 underwent adjuvant chemotherapy. At last follow-up, 4 patients (15.4%) were alive and disease free. Disease recurrence was documented in 20 patients (76.9%). Sixteen patients (61.5%) showed distant metastasis, and 5 patients (19.2%) showed local recurrence. The incidence of local recurrence in R0 patients was 4 of 25 (16.0%). The overall 5-year survival rate was 15.4%. There was significant correlation with overall survival of tumor diameter (p=0.019). CONCLUSIONS: The incidence of local recurrence in this long follow-up series (19.2%) was definitely less than that reported in other studies of adjuvant RT (approximately 50%), suggesting a positive impact on local control of integrated adjuvant RT (IORT+external RT).

5 Minor Masking effect of chronic pancreatitis in the interpretation of somatostatin receptor positron emission tomography in pancreatic neuroendocrine tumors. 2013

Treglia, Giorgio / Farchione, Alessandra / Stefanelli, Antonella / Brizi, Maria Gabriella / Larghi, Alberto / Inzani, Frediano / Rindi, Guido / Rufini, Vittoria. · ·Pancreas · Pubmed #23591437.

ABSTRACT: -- No abstract --