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Pancreatic Neoplasms: HELP
Articles by Peter Boyle
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Peter Boyle wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Incretin-Based Therapies and the Short-term Risk of Pancreatic Cancer: Results From Two Retrospective Cohort Studies. 2018

Boniol, Mathieu / Franchi, Matteo / Bota, Maria / Leclercq, Agn├Ęs / Guillaume, Joeri / van Damme, Nancy / Corrao, Giovanni / Autier, Philippe / Boyle, Peter. ·International Prevention Research Institute, Lyon, France. · Strathclyde Institute for Global Public Health at International Prevention Research Institute, Lyon, France. · Laboratory of Healthcare Research and Pharmacoepidemiology, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy. · InterMutualistic Agency, Brussels, Belgium. · Belgian Cancer Registry, Brussels, Belgium. · International Prevention Research Institute, Lyon, France philippe.autier@i-pri.org. ·Diabetes Care · Pubmed #29146599.

ABSTRACT: OBJECTIVE: Concerns have been raised about a possible increased risk of pancreatic cancer associated with incretin-based therapies. We examined the risk of pancreatic cancer among patients with diabetes prescribed incretin drugs. RESEARCH DESIGN AND METHODS: With the use of public health insurance databases of Belgium and the Lombardy Region, Italy, we created two retrospective cohorts that included adult patients who were first prescribed an incretin drug or another noninsulin antidiabetic drug (NIAD) from 1 July 2008 to 31 December 2013 in Belgium and from 1 January 2008 to 31 December 2012 in the Lombardy Region. The risk of pancreatic cancer was evaluated by multivariate-adjusted Cox models that included time-dependent variables. Adjusted hazard ratios (aHRs) from Belgium and Italy were pooled by using fixed-effects meta-analyses. RESULTS: The cohorts included 525,733 patients with diabetes treated with NIADs and 33,292 with incretin drugs. Results in both cohorts were similar. Eighty-five and 1,589 subjects who developed pancreatic cancer were registered among the incretin and NIAD new users, respectively, which represented an aHR of pancreatic cancer of 2.14 (95% CI 1.71-2.67) among those prescribed an incretin compared with an NIAD. The aHR with a drug use lag exposure of 6 months was 1.69 (1.24-2.32). The aHR decreased from 3.35 (2.32-4.84) in the first 3 months after the first incretin prescription to 2.12 (1.22-3.66) in months 3-5.9, 1.95 (1.20-3.16) in months 6-11.9, and 1.69 (1.12-2.55) after 12 months. Among those prescribed an NIAD, pancreatic cancer occurred mostly within the year after the first prescription. The risk of pancreatic cancer among patients subsequently prescribed insulin was 6.89 (6.05-7.85). CONCLUSIONS: The recent prescription of incretin therapy is associated with an increased risk of pancreatic cancer. The reason for such an increase is likely the consequence of an occult pancreatic cancer that provokes or aggravates diabetes. Studies are warranted for assessing the risk of pancreatic cancer associated with long-term use of incretin drugs.

2 Article Past medical history and pancreatic cancer risk: Results from a multicenter case-control study. 2010

Maisonneuve, Patrick / Lowenfels, Albert B / Bueno-de-Mesquita, H Bas / Ghadirian, Parviz / Baghurst, Peter A / Zatonski, Witold A / Miller, Anthony B / Duell, Eric J / Boffetta, Paolo / Boyle, Peter. ·European Institute of Oncology, Milan, Italy. ·Ann Epidemiol · Pubmed #20123159.

ABSTRACT: PURPOSE: To investigate risk factors that may be linked to pancreatic cancer. METHODS: We designed a multicenter population-based case-control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland. RESULTS: After adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23-9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18-74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60-2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56-12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50-0.82). CONCLUSIONS: Patients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancreatic cancer.