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Pancreatic Neoplasms: HELP
Articles by Gergana Bounova
Based on 1 article published since 2010
(Why 1 article?)
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Between 2010 and 2020, Gergana Bounova wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Pancreatic cancer organoids recapitulate disease and allow personalized drug screening. 2019

Driehuis, Else / van Hoeck, Arne / Moore, Kat / Kolders, Sigrid / Francies, Hayley E / Gulersonmez, M Can / Stigter, Edwin C A / Burgering, Boudewijn / Geurts, Veerle / Gracanin, Ana / Bounova, Gergana / Morsink, Folkert H / Vries, Robert / Boj, Sylvia / van Es, Johan / Offerhaus, G Johan A / Kranenburg, Onno / Garnett, Mathew J / Wessels, Lodewyk / Cuppen, Edwin / Brosens, Lodewijk A A / Clevers, Hans. ·Oncode Institute, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. · Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands. · Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands. · Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands. · Wellcome Sanger Institute, Hinxton CB10 1SA, United Kingdom. · Department of Molecular Cancer Research, Center Molecular Medicine, Oncode Institute, University Medical Center Utrecht, Utrecht 3584 CM, The Netherlands. · Hubrecht Organoid Technology, Utrecht 3584 CM, The Netherlands. · Department of Pathology, University Medical Center Utrecht, Utrecht 3584 CM, The Netherlands. · Utrecht Platform for Organoid Technology, Utrecht Medical Center Utrecht, Utrecht 3584 CM, The Netherlands. · Hartwig Medical Foundation, 1098 XH Amsterdam, The Netherlands. · Center for Personalized Cancer Treatment,University Medical Center Utrecht, Utrecht 3584 CM, The Netherlands. · Oncode Institute, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands; h.clevers@hubrecht.eu. · Princess Maxima Center, Utrecht 3584 CS, The Netherlands. ·Proc Natl Acad Sci U S A · Pubmed #31818951.

ABSTRACT: We report the derivation of 30 patient-derived organoid lines (PDOs) from tumors arising in the pancreas and distal bile duct. PDOs recapitulate tumor histology and contain genetic alterations typical of pancreatic cancer. In vitro testing of a panel of 76 therapeutic agents revealed sensitivities currently not exploited in the clinic, and underscores the importance of personalized approaches for effective cancer treatment. The PRMT5 inhibitor EZP015556, shown to target