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Pancreatic Neoplasms: HELP
Articles by Signe Borgquist
Based on 3 articles published since 2010
(Why 3 articles?)
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Between 2010 and 2020, Signe Borgquist wrote the following 3 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Hormonal factors and pancreatic cancer risk in women: The Malmö Diet and Cancer Study. 2018

Andersson, Gustav / Borgquist, Signe / Jirström, Karin. ·Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden. · Clinical Trial Unit, Skåne University Hospital, Lund, Sweden. ·Int J Cancer · Pubmed #29424426.

ABSTRACT: The incidence of pancreatic cancer is leveling between sexes. Smoking, high age and heredity are established risk factors, but evidence regarding the influence of hormonal factors is unclear. In this study, we investigated the associations of reproductive factors, use of oral contraceptives (OC) and hormone replacement therapy (HRT) with pancreatic cancer risk in the Malmö Diet and Cancer Study, a prospective, population-based cohort encompassing 17,035 women. Up until 31 December 2015, 110 women were identified with incident pancreatic cancer through the Swedish Cancer Registry. Higher age at menarche was significantly associated with pancreatic cancer risk (age-adjusted [hazard ratio] HR = 1.17; 95% confidence interval [CI] 1.04-1.32, and fully adjusted HR = 1.17; 95% CI 1.04-1.32). Ever use of OC was not significantly associated with pancreatic cancer risk but ever use of HRT was significantly associated with a decreased risk of pancreatic cancer (age-adjusted HR = 0.47, 95% CI 0.23-0.97, and fully adjusted HR = 0.48, 95% CI 0.23-1.00), in particular use of estrogen-only regimen (age-adjusted HR = 0.21; 95% CI 0.05-0.87 and fully adjusted HR = 0.22; 95% CI 0.05-0.90). Age at menopause or first childbirth, parity and breastfeeding history were not significantly associated with pancreatic cancer risk. Collectively, these findings suggest a protective role of female hormones against pancreatic cancer. Further studies are needed, and potential modifying genetic factors and indirect hazardous effects of smoking should also be considered.

2 Article Pancreatic cancer risk in relation to sex, lifestyle factors, and pre-diagnostic anthropometry in the Malmö Diet and Cancer Study. 2016

Andersson, Gustav / Wennersten, Christoffer / Borgquist, Signe / Jirström, Karin. ·Division of Oncology and Pathology, Department of Clinical Sciences, Lund, Lund University, Skåne University Hospital, 221 85 Lund, Sweden. ·Biol Sex Differ · Pubmed #27980714.

ABSTRACT: BACKGROUND: Lifestyle factors may influence the risk of developing pancreatic cancer. Whereas cigarette smoking is an established risk factor, the effects of high alcohol intake and obesity are more uncertain. The aim of the present study was to examine the associations of pre-diagnostic anthropometry, alcohol consumption, and smoking habits with pancreatic cancer risk in a Swedish prospective, population-based cohort, with particular reference to potential sex differences. METHODS: The studied cohort consists of 28,098 participants, including all incident cases of pancreatic cancer, in the Malmö Diet and Cancer Study up until December 31, 2013 ( RESULTS: BMI was not a significant risk factor for pancreatic cancer, but a higher WHR was significantly associated with an increased risk in the entire cohort (hazard ratio (HR) 2.36, 95% confidence interval (CI) 1.28-4.35, CONCLUSIONS: WHR was the only pre-diagnostic anthropometric factor associated with pancreatic cancer risk, with no sex-related differences. Regular smoking was confirmed as a significant risk factor in both sexes, whereas occasional and passive smoking were significant risk factors only in women. Despite the lack of a significant interaction between smoking and sex in relation with pancreatic cancer risk, potential sex differences should be considered in future epidemiological studies.

3 Article Exposure to environmental tobacco smoke in childhood and incidence of cancer in adulthood in never smokers in the European Prospective Investigation into Cancer and Nutrition. 2011

Chuang, Shu-Chun / Gallo, Valentina / Michaud, Dominique / Overvad, Kim / Tjønneland, Anne / Clavel-Chapelon, Francoise / Romieu, Isabelle / Straif, Kurt / Palli, Domenico / Pala, Valeria / Tumino, Rosario / Sacerdote, Carlotta / Panico, Salvatore / Peeters, Petra H / Lund, Eiliv / Gram, Inger Torhild / Manjer, Jonas / Borgquist, Signe / Riboli, Elio / Vineis, Paolo. ·School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, W2 1PG, London, UK. s-c.chuang@imperial.ac.uk ·Cancer Causes Control · Pubmed #21279734.

ABSTRACT: The association between childhood environmental tobacco smoke (ETS) exposure and adult cancer risk is controversial; we examined this relationship in never smokers within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Over an average of 10 years, 8,372 cases of cancer were diagnosed in 112,430 never smokers in EPIC. Childhood ETS was self-reported by participants at baseline, along with other lifestyle factors. Hazard ratios (HR) for ETS exposure in childhood and their 95% confidence intervals (CI) were estimated by Cox proportional hazards models stratified by age, sex, and study center and adjusted for education, alcohol drinking, body mass index, physical activity, non-alcoholic energy intake, fruit and vegetable intake, and adulthood ETS exposure. Models were further adjusted for reproductive factors for female cancers, for meat intake for digestive system cancers, and for diabetes status for pancreatic cancer. No association was observed between childhood ETS exposure and overall cancer risks (HR = 0.97, 95% CI = 0.92-1.02), and for selected sites. The only exception was pancreatic cancer, as previously reported by Vrieling et al., among those who had been exposed daily in childhood (overall HR = 2.09, 95% CI = 1.14-3.84). In conclusion, childhood ETS exposure might not be a major risk factor for common cancers in adulthood.