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Pancreatic Neoplasms: HELP
Articles by Raffaella Bertè
Based on 2 articles published since 2010
(Why 2 articles?)

Between 2010 and 2020, Raffaella Bertè wrote the following 2 articles about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article Early palliative care and quality of life of advanced cancer patients-a multicenter randomized clinical trial. 2019

Franciosi, Vittorio / Maglietta, Giuseppe / Degli Esposti, Claudia / Caruso, Giuseppe / Cavanna, Luigi / Bertè, Raffaella / Bacchini, Gianpaolo / Bocchi, Letizia / Piva, Erico / Monfredo, Michela / Scafuri, Valentina / Di Cesare, Pamela / Melotti, Barbara / Sequino, Manuel / Rimanti, Anita / Binovi, Cinzia / Ghisoni, Francesco / Caminiti, Caterina. ·Medical Oncology Unit, University Hospital, Parma, Italy. vfranciosi@ao.pr.it. · Research and Innovation Unit, University Hospital, Parma, Italy. · Medical Oncology Unit, University Hospital, Bologna, Italy. · Medical Oncology Unit, University Hospital, Parma, Italy. · Medical Oncology Unit, General Hospital, Piacenza, Italy. · Palliative Care Unit, General Hospital, Piacenza, Italy. · Medical Oncology Unit, University Hospital, Ferrara, Italy. · Palliative Care Unit, General Hospital, Fidenza, Italy. ·Ann Palliat Med · Pubmed #30943735.

ABSTRACT: BACKGROUND: To compare quality of life (QoL) of patients receiving early palliative care (EPC) vs. standard oncologic care (SOC). METHODS: Pragmatic, multicenter, randomized trial at five University and Community Hospital Cancer Centers in Northern Italy. Advanced non-small cell lung, gastric, pancreatic and biliary tract cancer patients diagnosed within the previous 8 weeks. In the EPC arm, visits were performed systematically by a dedicated physician/nurse palliative care (PC) team, who assessed physical and psychosocial symptoms, and enacted the necessary services. In the SOC arm, PC visits were only carried out if requested. The primary outcome was the difference in the change of QoL [Functional Assessment of Cancer Therapy-General measure (FACT-G)] from baseline to 12 weeks in the two groups. RESULTS: From November 2014 to March 2016, 281 patients were enrolled (142 EPC, 139 SOC); 218 completed FACT-G at 12 weeks. Baseline demographic and clinical characteristics were similar for the two groups. Values of FACT-G at baseline and 12 weeks were 72.3 (SD 12.6) and 70.1 (SD 15.5) for patients enrolled in the EPC arm, vs. 71.7 (SD 14.7) and 69.6 (SD 15.5) for the SOC arm, but the change scores did not differ significantly between groups. In the multivariable analysis, adjusting for QoL at baseline, two potential prospective prognostic factors were statistically significant: lung cancer (P=0.03) and interaction of living without a partner and intervention arm (P=0.01). Dying within 6 months (P<0.001) was also statistically significant. CONCLUSIONS: In this study, EPC did not improve QoL in advanced cancer patients, but our findings highlight aspects which may guide future research on EPC.

2 Article Systematic versus on-demand early palliative care: results from a multicentre, randomised clinical trial. 2016

Maltoni, Marco / Scarpi, Emanuela / Dall'Agata, Monia / Zagonel, Vittorina / Bertè, Raffaella / Ferrari, Daris / Broglia, Chiara Maria / Bortolussi, Roberto / Trentin, Leonardo / Valgiusti, Martina / Pini, Sara / Farolfi, Alberto / Casadei Gardini, Andrea / Nanni, Oriana / Amadori, Dino / Anonymous6220876. ·Palliative Care Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)-IRCCS, Meldola, Italy. · Biostatistics and Clinical Trials Unit, IRST-IRCCS, Meldola, Italy. Electronic address: emanuela.scarpi@irst.emr.it. · Biostatistics and Clinical Trials Unit, IRST-IRCCS, Meldola, Italy. · Medical Oncology Unit 1, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy. · Palliative Care, Oncology Department, Guglielmo da Saliceto Hospital, Piacenza, Italy. · Palliative Care Unit, Oncology Department, Azienda Ospedaliera San Paolo, Milano, Italy. · Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. · Palliative Care and Pain Therapy Unit, Centro di Riferimento Oncologico di Aviano, IRCCS, Aviano, Italy. · Palliative Care and Pain Therapy Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy. · Medical Oncology Unit, IRST-IRCCS, Meldola, Italy. ·Eur J Cancer · Pubmed #27472648.

ABSTRACT: BACKGROUND: Early palliative care (EPC) in oncology has been shown to have a positive impact on clinical outcome, quality-of-care outcomes, and costs. However, the optimal way for activating EPC has yet to be defined. METHODS: This prospective, multicentre, randomised study was conducted on 207 outpatients with metastatic or locally advanced inoperable pancreatic cancer. Patients were randomised to receive 'standard cancer care plus on-demand EPC' (n = 100) or 'standard cancer care plus systematic EPC' (n = 107). Primary outcome was change in quality of life (QoL) evaluated through the Functional Assessment of Cancer Therapy - Hepatobiliary questionnaire between baseline (T0) and after 12 weeks (T1), in particular the integration of physical, functional, and Hepatic Cancer Subscale (HCS) combined in the Trial Outcome Index (TOI). Patient mood, survival, relatives' satisfaction with care, and indicators of aggressiveness of care were also evaluated. FINDINGS: The mean changes in TOI score and HCS score between T0 and T1 were -4.47 and -0.63, with a difference between groups of 3.83 (95% confidence interval [CI] 0.10-7.57) (p = 0.041), and -2.23 and 0.28 (difference between groups of 2.51, 95% CI 0.40-4.61, p = 0.013), in favour of interventional group. QoL scores at T1 of TOI scale and HCS were 84.4 versus 78.1 (p = 0.022) and 52.0 versus 48.2 (p = 0.008), respectively, for interventional and standard arm. Until February 2016, 143 (76.9%) of the 186 evaluable patients had died. There was no difference in overall survival between treatment arms. INTERPRETATIONS: Systematic EPC in advanced pancreatic cancer patients significantly improved QoL with respect to on-demand EPC.