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Pancreatic Neoplasms: HELP
Articles by Tatjana Antic
Based on 5 articles published since 2010
(Why 5 articles?)
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Between 2010 and 2020, Tatjana Antic wrote the following 5 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Solid pseudopapillary neoplasm (SPN) of the testis: Comprehensive mutational analysis of 6 testicular and 8 pancreatic SPNs. 2018

Michalova, Kvetoslava / Michal, Michael / Sedivcova, Monika / Kazakov, Dmitry V / Bacchi, Carlos / Antic, Tatjana / Miesbauerova, Marketa / Hes, Ondrej / Michal, Michal. ·Department of Pathology, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic. Electronic address: kveta.michalova@medima.cz. · Department of Pathology, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic. · Bioptical Laboratory, Ltd., Plzen 301 00, Czech Republic. · Department of Pathology, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic. · Consultoria em Patologia, Botucatu, SP, Brazil. · Department of Pathology, The University of Chicago, Chicago, USA. ·Ann Diagn Pathol · Pubmed #29705715.

ABSTRACT: BACKGROUND: Recently, we came with the theory of a possible relationship between a group of testicular and pancreatic tumors. We used one case of a pancreatic analogue solid pseudopapillary neoplasm of the testis composed partially of areas reminiscent of solid pseudopapillary neoplasm (SPN) of the pancreas and partially of structures identical to primary signet ring stromal tumor of the testis (PSRSTT) as a connecting link between these two entities. After demonstrating that PSRSTT and pancreatic analogue SPN of the testis share the same immunoprofile and genetic features characteristic for pancreatic SPN, we came to the conclusion that pancreatic analogue SPN of the testis and PSRSTT represent a morphological spectrum of a single entity and that both are related to the pancreatic SPN. DESIGN: The aim of this study is to present a series of 6 cases of testicular tumors, which lacked the signet ring cell component and were thus morphologically very similar to the SPN of the pancreas. The goal of this study is to compare the genetic background of these testicular tumors that are obviously related to the PSRSTT/pancreatic analogue SPN of the testis with the series of 8 pancreatic SPN. RESULTS: The mutational analysis revealed an oncogenic somatic mutation in the exon 3 of the CTNNB1 (β-catenin) gene in all analyzable (5/6) testicular and all pancreatic (8/8) tumors. The immunoprofile (positivity with β-catenin, CD10, vimentin, NSE, CD56, and negativity with inhibin, calretinin, chromogranin) was identical in all testicular and pancreatic tumors. CONCLUSION: This study expanded the morphological spectrum of the PSRSTT/pancreatic analogue SPN of the testis by adding 6 cases without the signet ring cell component. Considering the obvious analogy of PSRSTT/pancreatic analogue SPN of the testis/SPN of the testis and their relationship to the pancreatic SPN we propose the collective term "solid pseudopapillary neoplasm of the testis" for these tumors. The mutational profile of the SPN of the testis and pancreas was the same in both groups of tumors which we consider as a final proof that SPN of the testis is identical to the SPN of the pancreas.

2 Article Primary signet ring stromal tumor of the testis: a study of 13 cases indicating their phenotypic and genotypic analogy to pancreatic solid pseudopapillary neoplasm. 2017

Michalova, Kvetoslava / Michal, Michael / Kazakov, Dmitry V / Sedivcova, Monika / Hes, Ondrej / Hadravsky, Ladislav / Agaimy, Abbas / Tretiakova, Maria / Bacchi, Carlos / Hartmann, Arndt / Kuroda, Naoto / Bulimbasic, Stela / Coric, Marijana / Antic, Tatjana / Michal, Michal. ·Department of Pathology, Faculty of Medicine in Plzen, 30460, Charles University in Prague, 11636, Biopticka laborator s.r.o., Plzen, 30100, Czech Republic. Electronic address: kveta.michalova@biopticka.cz. · Department of Pathology, Faculty of Medicine in Plzen, 30460, Charles University in Prague, 11636, Biopticka laborator s.r.o., Plzen, 30100, Czech Republic; Biomedical Center, Faculty of Medicine in Plzen, 30460, Charles University, Czech Republic. · Department of Pathology, Faculty of Medicine in Plzen, 30460, Charles University in Prague, 11636, Biopticka laborator s.r.o., Plzen, 30100, Czech Republic. · Biopticka laborator s.r.o., Plzen, 30100, Czech Republic. · Department of Pathology, Charles University, 3rd Medical Faculty and Charles University Hospital Royal Vineyards, Prague, 10034, Czech Republic. · Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, 91054, Germany. · Department of Pathology, University of Washington, Seattle, 98195, USA. · Consultoria em Patologia, Botucatu, SP, 18602-010, Brazil. · Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, 780-8562, Japan. · Department of Pathology, University Hospital Centre, Zagreb, 100000, Croatia. · Department of Pathology, The University of Chicago, Chicago, 60637, USA. ·Hum Pathol · Pubmed #28739499.

ABSTRACT: Primary signet ring stromal tumor of the testis (PSRSTT) is an extremely rare tumor described only twice in the literature. Pancreatic-analogue solid pseudopapillary neoplasm (SPN) of the testis is a recently reported entity with morphological overlap with PSRSTT. We reviewed our files to find all cases of PSRSTT to better characterize this entity. We studied 13 cases of PSRSTTs using histological, immunohistochemical (IHC), and molecular genetic methods and compared the results with pancreatic SPN. Grossly, the size of PSRSTTs ranged from 0.5 to 2 cm (mean 1.1). Microscopically, PSRSTTs predominantly showed a proliferation of low-grade epithelioid cells containing characteristic cytoplasmic vacuole dislodging the nucleus (signet ring cells) separated by fibrous septa into trabeculae and nests. The immunoprofile was characterized by immunoreactivity for β-catenin, cyclin D1 (nuclear positivity for both antibodies), CD10, vimentin, galectin-3, claudin 7, α-1-antitrypsin, CD56, and neuron-specific enolase and negativity for chromogranin, inhibin, calretinin, SF-1, NANOG, OCT3/4, and SALL4. In some cases, the IHC panel was restricted because of a limited amount of tissue. Molecular genetic analysis revealed mutations within exon 3 of the CTNNB1 encoding β-catenin in all analyzable cases. Based on histological similarities between pancreatic SPN and PSRSTT and their identical IHC and molecular genetic features, we assume that both neoplasms share the same pathogenesis, and thus, PSRSTT can be considered as a testicular analogue of pancreatic SPN.

3 Article The expression of FOXL2 in pancreatic, hepatobiliary, and renal tumors with ovarian-type stroma. 2014

Westerhoff, Maria / Tretiakova, Maria / Hart, John / Gwin, Katja / Liu, Xiuli / Zhou, Ming / Yeh, Matthew M / Antic, Tatjana. ·University of Washington Medical Center, Seattle, WA 98195. Electronic address: mwest2@uw.edu. · University of Washington Medical Center, Seattle, WA 98195. · University of Chicago Medical Center, Chicago, IL 60637. · Cleveland Clinic, Cleveland, OH 809835. · New York University, New York, NY 10012. ·Hum Pathol · Pubmed #24746205.

ABSTRACT: FOXL2, a gene encoding a member of the fork-head-winged-helix family of transcription factors, is one of the earliest expressed genes during female gonadal development. It is expressed in normal ovarian stroma and ovarian neoplasms with granulosa cell lineage. Nonovarian tumors such as pancreatic mucinous cystic neoplasms (PMCs), hepatobiliary cystadenomas (HBCs), and mixed epithelial and stromal tumor of the kidney (MEST) have ovarian-type stroma. Immunohistochemical staining with FOXL2, estrogen receptor, and progesterone receptor was performed on 21 PMCs, 13 HBCs, and 10 MESTs and assessed for nuclear immunohistochemical positivity in the tumor stroma. All cases of PMC and HBC demonstrated nuclear reactivity for FOXL2 in the subepithelial stromal cells. Ninety percent of MEST demonstrated nuclear FOXL2 positivity. Estrogen receptor nuclear positivity was demonstrated in 57% of PMC, 77% of HBC, and 80% of MEST. Progesterone receptor nuclear positivity was present in 67% of PMC, 100% of HBC, and 90% of MEST. Clinical information was available for 37 patients. Seventy-eight percent of the patients had a history of obesity, heavy alcohol use, or hormone-related therapy. The 2 male patients had histories significant for morbid obesity and chronic alcoholism. FOXL2 is expressed from the early stages of ovarian development and has been shown to be mandatory for normal ovarian function. We have shown that it is also expressed in the aberrant ovarian-type stroma characteristic of PMC, HBC, and MEST. Most of such patients, including the rare male patients, have risk factors for hormonal abnormalities such as obesity and hormonal replacement therapy.

4 Article Immunohistochemical analysis of E-cadherin and zeste homolog 2 expression in endoscopic ultrasound-guided fine-needle aspiration of pancreatic adenocarcinoma. 2013

Gao, Ling / Antic, Tatjana / Hyjek, Elizabeth / Gong, Can / Mueller, Jeffrey / Waxman, Irving / DeMay, Richard M / Reeves, Ward. ·Department of Pathology, The University of Chicago, Chicago, Illinois. ·Cancer Cytopathol · Pubmed #23674382.

ABSTRACT: BACKGROUND: Recent studies have demonstrated that partial or complete loss of E-cadherin (EC) and nuclear accumulation of zeste homolog 2 (EZH2) are hallmarks of poorly differentiated pancreatic adenocarcinoma (PAC). Depletion of EZH2 sensitizes cancer cells to chemotherapy in vitro. The objective of this study was to determine EC and EZH2 expression by immunohistochemistry (IHC) in samples obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) as potential biomarkers for treatment and disease prognosis. METHODS: Thirty-eight EUS-FNA samples from patients with a PAC diagnosis were analyzed by IHC for EC and EZH2 expression. Seven corresponding surgical resection specimens were included in the study. The intensity of EZH2 and EC expression in PAC and in normal gastrointestinal pick-ups (internal positive control) was scored by using a 4-tier grading system. RESULTS: EC demonstrated a focal, weak-to-moderate decrease in 24 PAC samples. Complete loss of EC expression was observed in the poorly differentiated areas represented by single tumor cells. The average staining intensity of EC in samples of poorly differentiated PAC was significantly lower than that of moderately differentiated PAC samples (P = .0005). EZH2 was variably positive in 31 of 38 PAC samples. The average staining intensity of EZH2 in moderately and poorly differentiated PACs did not differ significantly (P = .81). CONCLUSIONS: EC and EZH2 expression was determined reliably by IHC on paraffin sections of EUS-FNA cell block specimens. The current results were consistent with prior reports indicating a decrease or loss of EC expression in poorly differentiated PAC. However, EZH2 expression did not always correlate inversely with EC expression and was more heterogeneous.

5 Minor Cytological features of pancreatic intraductal tubulopapillary neoplasm and an unexpected immunohistochemical profile. 2014

Zhao, Lei / Hart, John / Xiao, Shu-Yuan / Antic, Tatjana. ·Department of Pathology, The University of Chicago, Chicago, IL, USA. ·Pathology · Pubmed #25393265.

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