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Pancreatic Neoplasms: HELP
Articles by Maria Chiara Ambrosetti
Based on 6 articles published since 2010
(Why 6 articles?)
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Between 2010 and 2020, M. C. Ambrosetti wrote the following 6 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Review Ultrasonography of the pancreas. 2012

Zamboni, Giulia A / Ambrosetti, Maria Chiara / D'Onofrio, Mirko / Pozzi Mucelli, Roberto. ·Istituto di Radiologia, Policlinico GB Rossi, Azienda Ospedaliera Universitaria Integrata Verona, P.le LA Scuro 10, 37134 Verona, Italy. gzamboni@hotmail.com ·Radiol Clin North Am · Pubmed #22560688.

ABSTRACT: Although the pancreas is often thought of as an organ that is difficult to explore using ultrasound (US), because of its deep retroperitoneal location, with the appropriate technique it can be studied successfully in most patients. In this article, the authors discuss the use of available US techniques in the diagnosis of the most common pancreatic diseases, the use of US intraoperatively, and the use of sonographic guidance for diagnostic and therapeutic procedures. The authors also briefly discuss the potential use of elastosonography techniques in the evaluation of pancreatic disease.

2 Article Solid Pseudopapillary Neoplasms of the Pancreas: Clinicopathologic and Radiologic Features According to Size. 2019

De Robertis, Riccardo / Marchegiani, Giovanni / Catania, Matteo / Ambrosetti, Maria Chiara / Capelli, Paola / Salvia, Roberto / D'Onofrio, Mirko. ·Department of Radiology, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale A. Stefani 1, 37126 Verona, Italy. · Department of Pancreatic Surgery, G. B. Rossi Hospital, University of Verona, Verona, Italy. · Department of Radiology, G. B. Rossi Hospital, University of Verona, Verona, Italy. · Department of Pathology, G. B. Rossi Hospital, University of Verona, Verona, Italy. ·AJR Am J Roentgenol · Pubmed #31310181.

ABSTRACT:

3 Article Correlation between appearance of the retroportal fat plane at preoperative CT and pathology findings in resected adenocarcinoma of the pancreatic head. 2019

Lombardo, F / Zamboni, G A / Bonatti, M / Chincarini, M / Ambrosetti, M C / Marchegiani, G / Malleo, G / Mansueto, G / Pozzi Mucelli, R. ·Department of Radiology, University of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy. Electronic address: fabio.lombardo@me.com. · Department of Radiology, University of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy. · Department of Radiology, Ospedale Centrale di Bolzano, Via L. Boehler 5, 39100 Bolzano, Italy. · Department of Surgery, University of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy. ·Clin Radiol · Pubmed #30691733.

ABSTRACT: AIM: To correlate the appearance of the retroportal fat plane at preoperative computed tomography (CT) and the pathology findings in resected adenocarcinoma of the pancreatic head (PDAC). MATERIAL AND METHODS: Forty-eight patients with resected PDAC of the pancreatic head were included (24 men, 24 women, mean age 63 years, median BMI 24.1). All patients underwent CT <30 days before surgery. The state of the retroperitoneal resection margin and the presence of lymphatic or perineural invasion were obtained from pathology reports. CT images were reviewed independently by two radiologists for assessment of the retroportal fat plane and graded in two categories (clear/effaced). Inter-reader discrepancies were solved in consensus. Interobserver agreement was calculated and Fisher's test was used to assess the correlation between CT and pathology findings. Visceral fat areas were measured and correlated with CT findings. RESULTS: A clear retroportal fat plane was significantly associated with a negative retroperitoneal margin at pathology with 100% specificity and PPV (p=0.0001). No association was observed between the appearance of the fat plane at CT and the presence of lymphatic or perineural invasion (p=ns). Interobserver agreement for retroportal fat plane evaluation was good (0.741). False-positive cases had a significantly lower visceral fat area than the correctly classified patients (p=0.0480). CONCLUSIONS: A clear retroportal fat plane is significantly associated with negative retroperitoneal resection margins at pathology. The lack of visceral adipose tissue can lead to overestimation of retroportal fat plane involvement at preoperative CT.

4 Article Solid non-functioning endocrine tumors of the pancreas: correlating computed tomography and pathology. 2017

Zamboni, Giulia A / Ambrosetti, Maria Chiara / Zivelonghi, Caterina / Lombardo, Fabio / Butturini, Giovanni / Cingarlini, Sara / Capelli, Paola / Pozzi Mucelli, Roberto. ·Istituto di Radiologia, DAI Patologia e Diagnostica, Policlinico GB Rossi, AOUI Verona, Verona, Italy. Electronic address: gzamboni@hotmail.com. · Istituto di Radiologia, DAI Patologia e Diagnostica, Policlinico GB Rossi, AOUI Verona, Verona, Italy. · Chirurgia Generale e Del Pancreas, DAI Chirurgia e Oncologia, Istituto Del Pancreas, Policlinico GB Rossi, AOUI Verona, Verona, Italy. · Oncologia Medica, DAI Chirurgia e Oncologia, Policlinico GB Rossi, AOUI Verona, Verona, Italy. · UOC Anatomia e Istologia Patologica, DAI Patologia e Diagnostica, Policlinico GB Rossi, AOUI Verona, Verona, Italy. ·HPB (Oxford) · Pubmed #28784262.

ABSTRACT: BACKGROUND: Since prognosis and treatment of pancreatic endocrine tumors (pNET) are based on tumor grade, contrast-enhanced multidetector computed tomography (MDCT) features of solid non-functioning pNETs were studied and correlated with pathology tumor grading. METHODS: MDCTs of diagnosed pNETs were reviewed retrospectively. Each tumor was analyzed for location, size, homogeneity, margins, arterial and venous phase enhancement, main pancreatic duct diameter, calcifications, vascular invasion, lymph-nodes enlargement, and liver metastases. RESULTS: Of 154 pNETs presenting between January 2000 and May 2016 with available histology from resected specimen or biopsy, there were 65 G1, 72 G2 and 17 G3 pNETs. Tumor diameter varied significantly between the three groups. Tumors >20 mm were more frequently malignant and non-homogeneous than smaller tumors. G1 tumors were more commonly hypervascular and G3 tumors more often non-hypervascular in the arterial phase. Arterial phase non-hyperdensity and tumor non-homogeneity had a higher rate of metastatic lesions. Vascular invasion correlated with presence of metastases and histological grade. G3 tumors were all >20 mm (p = 0.007), more often non-hypervascular in the arterial phase (p = 0.0025), and non-hyperdense in the venous phase (p = 0.009), and showed more often vascular invasion (p = 0.0198). CONCLUSION: CT correlated with tumor grade; differentiating low-grade and high-grade pNETs through routine CT imaging might improve patient management.

5 Article Distribution of liver metastases based on the site of primary pancreatic carcinoma. 2016

Ambrosetti, Maria Chiara / Zamboni, Giulia A / Mucelli, Roberto Pozzi. ·Istituto di Radiologia, Policlinico GB Rossi, Azienda Ospedaliera Universitaria Integrata di Verona, P. le LA Scuro 10, 37134, Verona, Italy. mchiara.ambrosetti@gmail.com. · Istituto di Radiologia, Policlinico GB Rossi, Azienda Ospedaliera Universitaria Integrata di Verona, P. le LA Scuro 10, 37134, Verona, Italy. ·Eur Radiol · Pubmed #26017740.

ABSTRACT: OBJECTIVES: To investigate whether the different location of pancreatic adenocarcinoma affects the lobar distribution of metastases to the liver. METHODS: From all patients who underwent multidetector computed tomography (MDCT) examinations for staging of pancreatic adenocarcinoma in the last 4 years we selected 80 patients (42 men, 38 women; mean age, 60.56 years) with liver metastases and a pancreatic adenocarcinoma of the head (group A, 40 patients; diameter, 32.41 ± 2.28 mm) or body-tail (group B, 40 patients; diameter, 52.21 ± 2.8 mm). We analysed tumour site, diameter, vascular invasion and number of metastases in each lobe of the liver. The total number of metastases was compared between the two groups with an unpaired t-test, while Fisher's test was used to compare the number of metastases within the two lobes. RESULTS: As expected, the number of liver metastases was higher in group B than in group A. The ratio of metastases in the right-to-left hemi-liver was 7.4:1 for group A compared with 3.3:1 for group B (p < 0.0001). CONCLUSIONS: Although the number of liver metastases is higher in the right lobe than in the left lobe in both groups, there is a significant difference in the ratio of metastases between the right and the left hemi-liver. This supports the existence of a streamline phenomenon and a selective lobar distribution of metastases within the liver. KEY POINTS: • Pancreatic adenocarcinoma presents with liver metastases in 40% of cases • The presence of liver metastases disqualifies the patient from curative surgery • The distribution of metastases within the liver depends on the site of pancreatic adenocarcinoma • The distribution of liver metastases is due to the streamline phenomenon.

6 Article Single-energy low-voltage arterial phase MDCT scanning increases conspicuity of adenocarcinoma of the pancreas. 2014

Zamboni, Giulia A / Ambrosetti, Maria Chiara / Guariglia, Stefania / Cavedon, Carlo / Pozzi Mucelli, Roberto. ·Istituto di Radiologia, Policlinico GB Rossi, Azienda Ospedaliera Universitaria Integrata di Verona, P.le LA Scuro 10, 37134 Verona, Italy. Electronic address: gzamboni@hotmail.com. · Istituto di Radiologia, Policlinico GB Rossi, Azienda Ospedaliera Universitaria Integrata di Verona, P.le LA Scuro 10, 37134 Verona, Italy. Electronic address: mchiara.ambrosetti@gmail.com. · U.O. di Fisica Sanitaria, Azienda Ospedaliera Universitaria Integrata di Verona, P.le Stefani 1, 37126 Verona, Italy. Electronic address: guariglia@gmail.com. · U.O. di Fisica Sanitaria, Azienda Ospedaliera Universitaria Integrata di Verona, P.le Stefani 1, 37126 Verona, Italy. Electronic address: carlo.cavedon@ospedaleuniverona.it. · Istituto di Radiologia, Policlinico GB Rossi, Azienda Ospedaliera Universitaria Integrata di Verona, P.le LA Scuro 10, 37134 Verona, Italy. Electronic address: roberto.pozzimucelli@univr.it. ·Eur J Radiol · Pubmed #24447420.

ABSTRACT: PURPOSE: To test a single-energy low-voltage CT protocol for pancreatic adenocarcinoma. METHODS AND MATERIALS: A total of 30 patients with pathology-proven pancreatic adenocarcinoma underwent 64-row MDCT with arterial phase at 80 kV and were compared to a similar group of 30 patients scanned with a 120 kV protocol. Scans were compared for quantitative image parameters (attenuation and standard deviation in the pancreas, tumor, aorta), CTDI and DLP using an unpaired t-test. Image noise values for each protocol (SD of the psoas) were compared using an unpaired t-test. Effective dose was calculated for each protocol. CNR (=conspicuity/SDnoise) and FOM (CNR2/ED) were calculated. The Catphan600 phantom was used to evaluate image non-uniformity, noise, spatial resolution, and low contrast detectability. RESULTS: Mean patient weight was 68 kg in the study group and 73 kg in the control group (p=0.0355), while patient diameters at the celiac axis were not significantly different. Mean attenuation was significantly higher at 80 kV in the aorta (517.5±116.4 vs 290.3±76.4 HU) and normal pancreas (154.0±39.95 vs 90.02±19.01 HU) (all p<0.0001), while no significant difference was observed for adenocarcinoma (61.43±35.61 vs 47.45±18.95; p=n.s.). CTDI and DLP were significantly lower at 80 kV (6.00±0.90 mGy vs 10.24±2.93 mGy, and 180.4±35.49 mGy cm vs 383.8±117 mGy cm, respectively; all p<0.0001). Tumor conspicuity (HUpancreas-HUtumor) was significantly higher at 80 kV (94.2±39.3 vs 39.5±22 HU; p<0.0001). Mean image noise was significantly higher at 80kV (28.32±10.06 vs 19.7±7.1HU; p<0.0001). Effective dose was significantly lower at 80 kV (1.984±0.39 vs 5.75±1.75 mSv; p<0.0001). The total DLP for the exam was 1024±31.86 mGy cm for the 80 kV protocol and 1357±62.60 mGy cm for the 120 kV protocol (p<0.0001). Phantoms showed higher non-uniformity, slightly higher noise, slightly lower MTF (50%) and slightly higher percentage contrast for the 80 kV protocol. CONCLUSION: Single-source 80 kV pancreatic phase scanning results in higher conspicuity of pancreatic adenocarcinoma and FOM and in significant dose reduction while maintaining acceptable image quality.