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Hearing Disorders: HELP
Articles from Milan area
Based on 191 articles published since 2010

These are the 191 published articles about Hearing Disorders that originated from Milan area during 2010-2020.
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8
1 Editorial Autoimmunity and Otolaryngology Diseases. 2018

Ralli, Massimo / Di Stadio, Arianna / De Virgilio, Armando / Croce, Adelchi / de Vincentiis, Marco. ·Department of Sense Organs, Sapienza University of Rome, Rome, Italy. · San Camillo Hospital IRCCS, Venice, Italy. · Humanitas Clinical and Research Center, Via Alessandro Manzoni, 56-20089 Rozzano, Italy. · Department of Otolaryngology, Università Gabriele d'Annunzio Chieti, Italy. · Department Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy. ·J Immunol Res · Pubmed #30402505.

ABSTRACT: -- No abstract --

2 Editorial Encouraging postnatal cytomegalovirus (CMV) screening: the time is NOW for universal screening! 2017

Ronchi, Andrea / Shimamura, Masako / Malhotra, Prashant S / Sánchez, Pablo J. ·a Neonatal Intensive Care Unit, Department of Clinical Sciences and Community Health , Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano , Milan , Italy. · b Division of Pediatric Infectious Diseases, Department of Pediatrics, Center for Vaccines and Immunity , The Research Institute at Nationwide Children's Hospital, Nationwide Children's Hospital, The Ohio State University College of Medicine , Columbus , OH , USA. · c Department of Pediatric Otolaryngology-Head and Neck Surgery , Nationwide Children's Hospital, The Ohio State University College of Medicine , Columbus , OH , USA. · d Divisions of Neonatology and Pediatric Infectious Diseases, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital ; Nationwide Children's Hospital, The Ohio State University College of Medicine , Columbus , OH , USA. ·Expert Rev Anti Infect Ther · Pubmed #28277819.

ABSTRACT: -- No abstract --

3 Review ATP1A3-related disorders: An update. 2018

Carecchio, Miryam / Zorzi, Giovanna / Ragona, Francesca / Zibordi, Federica / Nardocci, Nardo. ·Department of Pediatric Neurology, IRCCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, 20131 Milan, Italy; Molecular Neurogenetics Unit, IRCCS Foundation Carlo Besta Neurological Institute, Via L. Temolo 4, 20126 Milan, Italy; Department of Medicine and Surgery, PhD Programme in Molecular and Translational Medicine, Milan Bicocca University, Via Cadore 48, 20900 Monza, Italy. · Department of Pediatric Neurology, IRCCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, 20131 Milan, Italy. · Department of Pediatric Neurology, IRCCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, 20131 Milan, Italy. Electronic address: nardo.nardocci@istituto-besta.it. ·Eur J Paediatr Neurol · Pubmed #29291920.

ABSTRACT: Alternating Hemiplegia of Childhood (AHC), Rapid-onset Dystonia Parkinsonism (RDP) and CAPOS syndrome (cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss) are three distinct, yet partially overlapping clinical syndromes that have long been thought to be allelic disorders. From 2004 to 2012, both autosomal dominant and de novo mutations in ATP1A3 have been detected in patients affected by these three conditions. Growing evidence suggests that AHC, RDP and CAPOS syndrome are part of a large and continuously expanding clinical spectrum and share some recurrent clinical features, such as abrupt-onset, asymmetric anatomical distribution and the presence of triggering factors, which are highly suggestive of ATP1A3 mutations. In this review, we will highlight the main clinical and genetic features of ATP1A3-related disorders focussing on shared and distinct features that can be helpful in clinical practice to individuate mutation carriers.

4 Review [Renal diseases related to MYH9 disorders]. 2017

Galeano, Dario / Zanoli, Luca / L'Imperio, Vincenzo / Fatuzzo, Pasquale / Granata, Antonio. ·UOC Nefrologia e Dialisi, P.O. San Giovanni di Dio, Agrigento, Italia. · Scuola di Specializzazione in Nefrologia, Dipartimento di Medicina Clinica e Sperimentale, Università di Catania, A.O.U. Policlinico-Vittorio Emanuele, Catania. · Anatomia Patologica, Dipartimento di Chirurgia e Medicina Traslazionale, Università di Milano Bicocca. ·G Ital Nefrol · Pubmed #28682562.

ABSTRACT: Mutations in MYH9 gene encoding the nonmuscle myosin heavy chain IIA (NMMHC-IIA) are related to a number of rare autosomal-dominant disorders which has been known as May-Hegglin disease, Sebastian syndrome, Fechtner syndrome and Epstein syndrome. Their common clinical features are congenital macrothrombocytopaenia and polymorphonuclear inclusion bodies, in addition to a variable risk of developing proteinuria, chronic kidney disease progressing toward end stage, sensorineural deafness and presenile cataracts. The term MYH9 related disease (MYH9-RD) describes the variable expression of a single illness encompassing all previously mentioned hereditary disorders. Renal involvement in MYH9- RD has been observed in 30% of patients. Mutant MYH9 protein, expressed in podocytes, mesangial and tubular cells, plays a main role in foot process effacement and in development of nephropathy. Interestingly, the MYH9 gene is currently under investigation also for his possible contribution to many other non-hereditary glomerulopathies such as focal global glomerulosclerosis (hypertensive nephrosclerosis), idiopathic focal segmental glomerulosclerosis, C1q nephropathy and HIV-associated nephropathy. In this review we are aimed to describe renal diseases related to MYH9 disorders, from the hereditary disease to the acquired disorders, in which MYH9-gene acts as a "renal failure susceptibility gene".

5 Review A review of new insights on the association between hearing loss and cognitive decline in ageing. 2016

Fortunato, S / Forli, F / Guglielmi, V / De Corso, E / Paludetti, G / Berrettini, S / Fetoni, A R. ·Otolaryngology Audiology and Phoniatric Unit, University of Pisa, Pisa, Italy; · Department of Neuroscience, Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy; · Department of Head and Neck Surgery - Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy. ·Acta Otorhinolaryngol Ital · Pubmed #27214827.

ABSTRACT: Age-related hearing loss (ARHL) has a multifactorial pathogenesis and it is an inevitable hearing impairment associated with reduction of communicative skills related to ageing. Increasing evidence has linked ARHL to more rapid progression of cognitive decline and incidental dementia. Many aspects of daily living of elderly people have been associated to hearing abilities, showing that hearing loss (HL) affects the quality of life, social relationships, motor skills, psychological aspects and function and morphology in specific brain areas. Epidemiological and clinical studies confirm the assumption of a relationship between these conditions. However, the mechanisms are still unclear and are reviewed herein. Long-term hearing deprivation of auditory inputs can impact cognitive performance by decreasing the quality of communication leading to social isolation and depression and facilitate dementia. On the contrary, the limited cognitive skills may reduce the cognitive resources available for auditory perception, increasing the effects of HL. In addition, hearing loss and cognitive decline may reflect a 'common cause' on the auditory pathway and brain. In fact, some pathogenetic factors are recongised in common microvascular disease factors such as diabetes, atherosclerosis and hypertension. Interdisciplinary efforts to investigate and address HL in the context of brain and cognitive ageing are needed. Surprisingly, few studies have been adressed on the effectiveness of hearing aids in changing the natural history of cognitive decline. Effective interventions with hearing aids or cochlear implant may improve social and emotional function, communication, cognitive function and positively impact quality of life. The aim of this review is to overview new insights on this challenging topic and provide new ideas for future research.

6 Review When flexibility is not necessarily a virtue: a review of hypermobility syndromes and chronic or recurrent musculoskeletal pain in children. 2015

Cattalini, Marco / Khubchandani, Raju / Cimaz, Rolando. ·Pediatric Clinic, University of Brescia and Spedali Civili di Brescia, Brescia, Italy. marco.cattalini@gmail.com. · Pediatric Rheumatology Clinic, Department of Paediatrics, Jaslok Hospital and Research Centre, Mumbai, India. rajukhubchandani@yahoo.co.in. · Anna Meyer Children's Hospital and University of Florence, Florence, Italy. rolando.cimaz@meyer.it. ·Pediatr Rheumatol Online J · Pubmed #26444669.

ABSTRACT: Chronic or recurrent musculoskeletal pain is a common complaint in children. Among the most common causes for this problem are different conditions associated with hypermobility. Pediatricians and allied professionals should be well aware of the characteristics of the different syndromes associated with hypermobility and facilitate early recognition and appropriate management. In this review we provide information on Benign Joint Hypermobility Syndrome, Ehlers-Danlos Syndrome, Marfan Syndrome, Loeys-Dietz syndrome and Stickler syndrome, and discuss their characteristics and clinical management.

7 Review Hearing loss and dementia in the aging population. 2014

Peracino, Andrea. ·Fondazione Giovanni Lorenzini Medical Science Foundation, Milan, Italy/Houston, Tex., USA. ·Audiol Neurootol · Pubmed #25733359.

ABSTRACT: For some years, policy makers and medical scientists have both begun to focus more on chronic noncommunicable diseases. It is well known that cardio-cerebrovascular disease, tumors, diabetes, and chronic obstructive pulmonary disease (COPD), are considered areas of major interest in many scientific projects and health programs. The economic impact of cardio-cerebrovascular disease in EU alone is more than EUR 200 billion, while tumors have an impact of EUR 150 billion. The direct and indirect cost of brain disorders exceeds EUR 700 billion a year. Among the brain disorders, the devastating impact of dementia on affected individuals and the burden imposed on their families and society has made prevention and treatment of dementia a public health priority. Interventions that could merely delay the onset of dementia by 1 year would result in a more than 10% decrease in the global prevalence of dementia in 2050. Unfortunately, there are no known interventions that currently have such effectiveness. The manifestations of age-related hearing loss in many older adults are subtle and, thus, hearing loss is often perceived as an unfortunate but inconsequential part of aging. Researchers report that hearing loss seems to speed up age-related cognitive decline. Researchers suggest that treating hearing loss more aggressively could help delay cognitive decline and dementia. Furthermore, there is an increasing interest in better understanding the pathophysiologic correlations between hearing loss and dementia. Hearing loss in older adults, in fact, is associated independently with poorer cognitive functioning, incident dementia, and falls. Further research investigating the basis of this connection as well as the pathomechanism of the two diseases will further our ability to treat dementia.

8 Review Hearing loss and cognitive decline in older adults: questions and answers. 2014

Bernabei, Roberto / Bonuccelli, Ubaldo / Maggi, Stefania / Marengoni, Alessandra / Martini, Alessandro / Memo, Maurizio / Pecorelli, Sergio / Peracino, Andrea P / Quaranta, Nicola / Stella, Roberto / Lin, Frank R / Anonymous2740808. ·Department of Geriatrics, Neuroscience and Orthopaedics, Catholic University of the Sacred Heart, Rome, Italy. ·Aging Clin Exp Res · Pubmed #25281432.

ABSTRACT: The association between hearing impairment, the diagnosis of dementia, and the role of sensory therapy has been proposed for some time, but further research is needed. Current understanding of this association requires the commitment of those experts who can integrate experience and research from several fields to be able to understand the link from hearing to dementia. A workshop whose panelists included experts from many areas, ranging from ear, nose and throat (ENT) to dementia's specialists, was promoted and organized by the Giovanni Lorenzini Medical Science Foundation (Milan, Italy; Houston, TX, USA) to increase the awareness of the relationship between hearing loss and dementia, and included questions and comments following a presentation from the clinical researcher, Frank Lin, who has been evaluating the relationship between hearing loss and cognitive decline since 2009.

9 Review Platinum compounds in children with cancer: toxicity and clinical management. 2013

Ruggiero, Antonio / Trombatore, Giovanna / Triarico, Silvia / Arena, Roberta / Ferrara, Pietro / Scalzone, Maria / Pierri, Filomena / Riccardi, Riccardo. ·Division of Pediatric Oncology, Catholic University of Rome, Rome, Italy. ·Anticancer Drugs · Pubmed #23962902.

ABSTRACT: Platinum compounds are widely used in the treatment of pediatric tumors such as neuroblastoma, germ-cell tumors, osteosarcoma, retinoblastoma, hepatoblastoma, brain tumors (low-grade gliomas and medulloblastoma/PNET), and relapsed and refractory lymphomas. The three major platinum compounds (cisplatin, carboplatin, and oxaliplatin) have a similar pharmacokinetics profile and mechanism of action, but the differences in their chemical structure are responsible for their different antitumor activity and toxicity. In this review, we have described the main characteristics of cisplatin, carboplatin, and oxaliplatin, focusing on their toxic effects and possible strategies to prevent them to improve the clinical outcomes in pediatric cancer patients. The underlying mechanism of each platinum-related toxicity is shown together with the clinical manifestations. Furthermore, possible preventive strategies are suggested to reduce the negative impact of platinum compounds on the quality of life of children with cancer. Cisplatin seems to be mostly ototoxic and nephrotoxic, carboplatin mainly produces myelosuppression, whereas oxaliplatin induces predominantly peripheral sensory neurotoxicity. In contrast, nausea and vomiting can be linked to all platinum compounds, although cisplatin exerts the strongest emetic effect. A correct knowledge of pharmacokinetics and toxicological profile of platinum compounds may aid physicians prevent their toxicity on auditory, nervous, renal, and bone marrow function, improving the quality of life of pediatric cancer patients.

10 Review A systematic review and meta-analysis of the diagnostic accuracy of anti-heat shock protein 70 antibodies for the detection of autoimmune hearing loss. 2013

Ianuale, Carolina / Cadoni, Gabriella / De Feo, Emma / Liberati, Luca / Simo, Rachel Kamgaing / Paludetti, Gaetano / Ricciardi, Walter / Boccia, Stefania. ·Institute of Hygiene, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, Italy. ·Otol Neurotol · Pubmed #23295728.

ABSTRACT: OBJECTIVE: We reviewed case-control studies concerning the diagnostic accuracy of Heat Shock Protein 70 (Hsp-70) auto antibodies in the detection of immunomediated inner ear disease. MATERIALS AND METHODS: We searched for relevant articles published in English language on PubMed and Scopus up to December 2011. A quality assessment of the retrieved articles was performed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) 2 tool. Pooled data on the accuracy of the test were calculated, where possible. RESULTS: Three articles were deemed eligible. Among them, 2 evaluated the relationship between Hsp-70 and immunomediated inner ear disease by using the Western blot, whereas one report used the enzyme-linked immunosorbent assay method. Pooled sensitivity of Western blot test for Hsp-70 was 0.70 (95% confidence interval [CI], 0.59-0.80), with a large heterogeneity (I = 72.7%), and pooled specificity was 0.98 (95% CI, 0.87-1.00), with an I of 61.0%. Pooled positive likelihood ratios (LR) was 14.7 (95% CI, 2.1-104.1; I = 31.4%), and pooled negative LR was 0.32 (95% CI, 0.10-0.70; I = 78.8%). Sensitivity and specificity of enzyme-linked immunosorbent assay test for Hsp-70 auto antibodies was 0.85 (95% CI, 0.55-0.98) and 0.98 (95% CI, 0.86-1.00). Risk of bias was performed by using QUADAS 2 tool, with high scores obtained for patient selection and index test domains and low for the applicability criterion. DISCUSSION: This review shows that studies on autoimmune hearing loss diagnosis based on the detection of Hsp-70 autoantibodies used different inclusion and methodologic criteria and are affected from potential bias. Additional studies are actually required to identify an accurate laboratory diagnostic method for the autoimmune hearing loss.

11 Review Inherited neuropathies and deafness caused by a PMP22 point mutation: a case report and a review of the literature. 2013

Luigetti, Marco / Zollino, Marcella / Conti, Guido / Romano, Angela / Sabatelli, Mario. ·Institute of Neurology, Catholic University of the Sacred Heart, Largo F. Vito 1, 00168, Rome, Italy. ·Neurol Sci · Pubmed #23263778.

ABSTRACT: -- No abstract --

12 Review Should corticosteroids be used in bacterial meningitis in children? 2013

Esposito, Susanna / Semino, Margherita / Picciolli, Irene / Principi, Nicola. ·Pediatric Clinic, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. susanna.esposito@unimi.it ·Eur J Paediatr Neurol · Pubmed #22789668.

ABSTRACT: Bacterial meningitis is one of the most serious infections in infants and children, with considerable morbidity and mortality. Despite the spreading of conjugated vaccines against Haemophilus influenzae type b (Hib), the most important pneumococcal serotypes and serogroup C meningococcus has reduced the incidence of this infection in developed countries, it still remains a global public health problem and an important cause of mortality and disability. Whether corticosteroids should be used as a complementary therapy to antibacterials is still not clear because of the disparate findings from clinical trials and clinical evidence. The aim of this review is to analyze the available evidence on the impact of corticosteroid therapy in infants and children with bacterial meningitis in developed countries in order to define whether they should be added routinely in the empiric therapy of such disease. Our analysis concluded that in high-income countries dexamethasone has shown good results to prevent hearing loss in Hib meningitis if administered before or at the same time as the first dose of antibiotics. Dexamethasone should be evaluated in pneumococcal meningitis: it may be less beneficial in children with delayed presentation to medical attention and may be unfavourable in case of cephalosporin-resistant pneumococci. On the contrary, there is no evidence to recommend the use of corticosteroids in meningococcal meningitis. Further studies that take into account the epidemiologic changes of recent years, consider enrolment based on the onset of symptoms and evaluate outcomes such as hearing loss and neurologic sequelae with advanced techniques are urgently needed.

13 Review Congenital cytomegalovirus infection: current strategies and future perspectives. 2012

Buonsenso, D / Serranti, D / Gargiullo, L / Ceccarelli, M / Ranno, O / Valentini, P. ·Department of Pediatrics, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy. ·Eur Rev Med Pharmacol Sci · Pubmed #22953641.

ABSTRACT: INTRODUCTION: Cytomegalovirus is the most common cause of congenital infections in humans and it produces considerable morbidity in newborns. AIMS: The present study reviews current concepts on epidemiology, clinical manifestations, diagnosis, treatment, future strategies and prognosis of children with congenital cytomegalovirus infection. RESULTS: Congenital cytomegalovirus infection can be symptomatic or not at birth, but about 10-20% of them all will exhibit neurological damage when followed up. Sensorineural hearing loss is the most frequent long-term consequence and is not manifest invariably at birth or in the neonatal period but in many cases becomes clinically apparent in later childhood. There are growing evidences that newborns with symptomatic congenital cytomegalovirus infection would benefit from treatment with either ganciclovir or valganciclovir, the most widely studied drugs in this setting. It is not yet clear if children with asymptomatic or pauci-symptomatic infection at birth would benefit from treatment. DISCUSSION: Studies evaluating treatment and long-term follow-up of infants with both symptomatic and asymptomatic infection are necessary, in order to definitely evaluate the short and long-term effectiveness and safety of both ganciclovir and valganciclovir and to identify risk factors associated to the development of long-term sequelae. In this way it will be possible to select those children that might benefit for treatment.

14 Review Auditory processing in infancy: do early abnormalities predict disorders of language and cognitive development? 2011

Guzzetta, Francesco / Conti, Guido / Mercuri, Eugenio. ·Unit of Child Neurology and Psychiatry, Catholic University, Rome, Italy. fguzzetta@rm.unicatt.it ·Dev Med Child Neurol · Pubmed #21838818.

ABSTRACT: Increasing attention has been devoted to the maturation of sensory processing in the first year of life. While the development of cortical visual function has been thoroughly studied, much less information is available on auditory processing and its early disorders. The aim of this paper is to provide an overview of the assessment techniques for early auditory processing. While otoacoustic emissions and auditory brainstem responses are well-established tools for neonatal screening of hearing loss, there have been less consistent results for neurophysiological assessments of central auditory processing in clinical practice. Early auditory event-related potentials could provide valuable diagnostic information, but their use as a possible clinical screening method is still limited and should be further assessed. Behavioural tests are few and are greatly needed in young infants as they could provide a more easily used tool for detecting the preconditions of early cerebral auditory impairment.

15 Review Pathogenesis of presbycusis in animal models: a review. 2011

Fetoni, Anna R / Picciotti, Pasqualina M / Paludetti, Gaetano / Troiani, Diana. ·Institute of Otolaryngology, School of Medicine, Catholic University of Rome, Largo A. Gemelli, 8 00168 Rome, Italy. afetoni@rm.unicatt.it ·Exp Gerontol · Pubmed #21211561.

ABSTRACT: Presbycusis is the most common cause of hearing loss in aged subjects, reducing individual's communicative skills. Age related hearing loss can be defined as a progressive, bilateral, symmetrical hearing loss due to age related degeneration and it can be considered a multifactorial complex disorder, with both environmental and genetic factors contributing to the aetiology of the disease. The decline in hearing sensitivity caused by ageing is related to the damage at different levels of the auditory system (central and peripheral). Histologically, the aged cochlea shows degeneration of the stria vascularis, the sensorineural epithelium, and neurons of the central auditory pathways. The mechanisms responsible for age-associated hearing loss are still incompletely characterized. This work aims to give a broad overview of the scientific findings related to presbycusis, focusing mainly on experimental studies in animal models.

16 Clinical Trial Narrative abilities in early implanted children. 2015

Murri, Alessandra / Cuda, Domenico / Guerzoni, Letizia / Fabrizi, Enrico. ·Department of Otorhinolaryngology, Guglielmo da Saliceto Hospital (a.m., d.c., l.g.), Piacenza, Italy. · Department of Economics and Social Sciences, Università Cattolica del S. Cuore Piacenza (e.f.), Piacenza, Italy. ·Laryngoscope · Pubmed #25510218.

ABSTRACT: OBJECTIVES/HYPOTHESIS: To investigate the effect of age at cochlear implant activation on oral narrative ability in children implanted before 2.5 years of age and to examine the role of other variables (gender, parental education level, stimulation modality) in narrative skills. STUDY DESIGN: retrospective nonrandomized group study METHODS: Thirty children (21 females; 9 males) with congenital, bilateral severe-to-profound sensorineural hearing loss were included in this study. The mean age at cochlear implant activation was 14.7 months (standard deviation [SD] ± 5.3). The Renfrew Bus Story was used to analyze oral narrative skills at mean chronological age of 63 months (SD ± 0.2). RESULTS: The total information on the Renfrew Bus Story raw score ranged from 8 to 40, with a mean of 22.7 (SD ± 8.6). Children produced on average 7.5 words in a sentence (SD ± 1.5). The mean score for complexity was 2.2 (SD ± 1.5). Regression analysis revealed a highly significant and negative linear effect of age at cochlear implant activation on all outcomes. The mother's education level had a positive strong effect on sentence length but a weak effect on total information and complexity. The paternal education score had a weak influence on the sentence length. Gender, age at diagnosis, and stimulation modality were not correlated with the narrative outcomes. CONCLUSIONS: Early implanted children can develop narrative skills close to normal hearing children. The sociocultural context, expressed by maternal and paternal educational level, are positively related to the development of oral narrative.

17 Clinical Trial Influence of tinnitus sound therapy signals on the intelligibility of speech. 2011

Paglialonga, A / Fiocchi, S / Parazzini, M / Ravazzani, P / Tognola, G. ·CNR-Consiglio Nazionale delle Ricerche, Istituto di Ingegneria Biomedica (ISIB), c/o Politecnico di Milano, Milan, Italy. alessia.paglialonga@polimi.it ·J Laryngol Otol · Pubmed #21729434.

ABSTRACT: OBJECTIVE: To assess the influence on speech intelligibility of various signals used in tinnitus sound therapy. MATERIALS AND METHODS: We measured, in normal hearing subjects, the intelligibility of speech in the presence of three different sound therapy signals: wide-band noise, a recording of moving water, and a combination of tones. RESULTS: For a given level of stimulation, speech intelligibility was worst in the presence of wide-band noise, compared with the other sound therapy signals. When the stimulation level of the three different signals was increased, speech intelligibility deteriorated more rapidly with wide-band noise, compared with the other two signals. The combination of tones had the least influence on speech intelligibility. CONCLUSION: The use of different tinnitus sound therapy signals can lead to significantly different effects on the intelligibility of speech. The use of natural sound recordings or combinations of tones may provide the patient with more flexibility to change the stimulation level during treatment.

18 Article Medico-Legal aspects of an unusual complication from an ear swab test: was the procedure necessary? 2019

Ricci, Eleonora / Ronconi, Gianpaolo / Salini, Sara / Ferrara, Paola Emilia / De-Giorgio, Fabio. ·Istituto di Sanità Pubblica, sezione di Medicina Legale, Università Cattolica del S. Cuore di Roma, Italia. · Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia. ·Ig Sanita Pubbl · Pubmed #31887735.

ABSTRACT: A 65-year-old woman affected by chronic pruritus in both ears was referred by her family physician to a private laboratory to undergo an ear swab test for microbiological and cultural examination. During the procedure on the right side, the patient experienced sudden pain, immediately followed by auricular fullness and dizziness. The clinician performing the swab did not perform an otoscopy and did not administer any topical or general medications. A few days later, purulent discharge appeared. Follow-up showed tympanic membrane perforation and mixed severe hearing loss. Indications for ear swab tests are currently unclear, and complications deriving from this apparently simple procedure are seldom reported.

19 Article Hearing loss in very preterm infants: should we wait or treat? 2019

Frezza, S / Catenazzi, P / Gallus, R / Gallini, F / Fioretti, M / Anzivino, R / Corsello, M / Cota, F / Vento, G / Conti, G. ·Department of Woman and Child Health, Division of Neonatology, Institute of Otorhinolaryngology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy. · Department Head and Neck Surgery, Institute of Otorhinolaryngology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy. ·Acta Otorhinolaryngol Ital · Pubmed #31501617.

ABSTRACT: -- No abstract --

20 Article Migration, Work, and Health: Lessons Learned from a Clinical Case Series in a Northern Italy Public Hospital. 2019

Arici, Cecilia / Tamhid, Tishad / Porru, Stefano. ·Department of Diagnostics and Public Health, Section of Occupational Health, University of Verona, 37134 Verona, Italy. cecilia.arici@univr.it. · University Research Center "Integrated Models for Prevention and Protection in Environmental and Occupational Health", Universities of Verona, Brescia and Milano Bicocca, 37134 Verona, Italy. cecilia.arici@univr.it. · Postgraduate School of Occupational Medicine, University of Verona, 37134 Verona, Italy. · Department of Diagnostics and Public Health, Section of Occupational Health, University of Verona, 37134 Verona, Italy. · University Research Center "Integrated Models for Prevention and Protection in Environmental and Occupational Health", Universities of Verona, Brescia and Milano Bicocca, 37134 Verona, Italy. ·Int J Environ Res Public Health · Pubmed #31438461.

ABSTRACT: BACKGROUND: Migrant workers (MWs) generally perform dangerous jobs and have reduced access to occupational health (OH) care, therefore being prone to developing occupational diseases (OD). The aim of the work is to describe a case series of MWs and report on related outcomes for OH professionals. METHODS: A case series of 724 MWs, sent from January 2001 to June 2013 to a public OH unit for OD or fitness-for-work (FFW) evaluation, was entered in a dedicated database and elaborated for descriptive statistics with Microsoft Excel. RESULTS: MWs were mostly (75%) men, with a mean age of 40. They came mainly from Morocco, Senegal, Albania, Romania, and Pakistan. Main sectors of employment were manufacturing, metal industry, services, construction. OD were found in 210 cases, main diagnoses being: Lumbar disc and upper limb musculoskeletal disorders (51%), contact dermatitis (15%), allergic asthma (8%), noise-induced hearing loss (7%), tumors (3%), psychiatric disorders (2%). Moreover, 136 FFW judgements were formulated, with some limitations/restrictions expressed. Finally, a relevant prevalence of some chronic non-occupational diseases was found. CONCLUSIONS: MWs in Italy may suffer from OH inequalities. Qualified public OH professionals and occupational physicians in workplaces should have a proactive role to concretely meet MWs' health needs.

21 Article Diagnosis of congenital CMV infection via DBS samples testing and neonatal hearing screening: an observational study in Italy. 2019

Pellegrinelli, Laura / Galli, Cristina / Primache, Valeria / Alde', Mirko / Fagnani, Enrico / Di Berardino, Federica / Zanetti, Diego / Pariani, Elena / Ambrosetti, Umberto / Binda, Sandro. ·Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Carlo Pascal, 36, 20133, Milan, Italy. laura.pellegrinelli@unimi.it. · Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Carlo Pascal, 36, 20133, Milan, Italy. · Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, Italy. · U.O.S.D di Audiologia, Fondazione I.R.C.C.S. Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy. ·BMC Infect Dis · Pubmed #31331274.

ABSTRACT: BACKGROUND: Congenital Cytomegalovirus (cCMV) is the most common cause of non-genetic hearing loss in childhood. A newborn hearing screening program (NHSP) is currently running in Italy, but no universal cCMV nor statewide hearing-targeted CMV screening programs have been implemented yet. This observational monocentric study was aimed at estimating the rate of cCMV infections identified by CMV-DNA analysis on Dried Blood Spots (DBS) samples in deaf children identified via NHSP in Northern Italy in the period spanning from 2014 to 2018. METHODS: Children with a confirmed diagnosis of deafness and investigated for CMV-DNA by nucleic acid extraction and in-house polymerase-chain reaction (PCR) on stored newborns screening cards (DBS-test) were included in this study. Deafness was defined by a hearing threshold ≥20 decibel (dB HL) by Auditory Brainstem Responses (ABR); all investigated DBS samples were collected within 3 days of life. RESULTS: Overall, 82 children were included (median age: 3.4 months; lower-upper quartiles: 2-5.3 months; males: 60.9%). Most of them (70.7%) presented bilateral hearing loss with a symmetrical pattern in 79.3% of the cases. ABR thresholds were ≥ 70 dB HL (severe/profound deafness) in 46.5% of children. Among all tested children, 6.1% resulted positive for cCMV. The rate of severe/profound deafness was statistically higher in children with cCMV infection. CONCLUSIONS: The addition of DBS-test to the NHSP allowed the identification, in their first months of life, of a cCMV infection in 6.1% of children who had failed NHS. The introduction of a targeted CMV screening strategy could help clinicians in the differential diagnosis and in the babies' management. DBS samples can be considered a "universal newborns biobank": their storage site and duration should be the subject of political decision-making.

22 Article Hypothalamic malformations in patients with X-linked deafness and incomplete partition type 3. 2019

Siddiqui, Ata / D'Amico, Alessandra / Colafati, Giovanna Stefania / Cicala, Domenico / Talenti, Giacomo / Rajput, Kaukab / Pinelli, Lorenzo / D'Arco, Felice. ·Department of Neuroradiology, King's College Hospital, London, UK. · Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy. · Oncological Neuroradiology Unit, Department of Imaging, IRCCS Bambino Gesù Children's Hospital, Rome, Italy. · Neuroradiology Unit, Santobono-Pausilipon Children's Hospital, Naples, Italy. · Neuroradiology Unit, Verona University Hospital, Verona, Italy. · Cochlear Implant Department, Great Ormond Street Hospital, London, UK. · Neuroradiology Unit, Pediatric Neuroradiology Section, ASST Spedali Civili, Brescia, Italy. · Radiology Department, Great Ormond Street Hospital, Great Ormond St, London, WC1N3JH, UK. darcofel@gmail.com. ·Neuroradiology · Pubmed #31177298.

ABSTRACT: Patients with X-linked deafness carry mutations in the POU3F4 gene and have pathognomonic inner ear malformations characterised by symmetrical incomplete partition type 3 (absent modiolus and lamina spiralis but preserved interscalar septum in a normal-sized cochlea) and large internal auditory meatus (IAM) with an increased risk of gusher during stapes surgery. We describe a range of fairly characteristic malformations in the hypothalamus of some patients with this rare condition, ranging from subtle asymmetric appearance and thickening of the tuber cinereum to more marked hypothalamic enlargement. We discuss the role of POU3F4 in the normal development of both the inner ear and hypothalamus and the proposed pathophysiology of incomplete partition type 3.

23 Article The impact of intra-operative factors in otosclerosis outcomes: retrospective study in a tertiary centre. 2019

Quaranta, N / Piccininni, K / Romanello, M / Lucidi, D / Sergi, B. ·UOC Otorinolaringoiatria Universitaria, Azienda Ospedaliero-Universitaria Policlinico di Bari, Italy. · UOC Otorinolaringoiatria, Fondazione Policlinico A. Gemelli-IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy. ·Acta Otorhinolaryngol Ital · Pubmed #31131839.

ABSTRACT: -- No abstract --

24 Article Surgery of the lateral skull base: a 50-year endeavour. 2019

Zanoletti, E / Mazzoni, A / Martini, A / Abbritti, R V / Albertini, R / Alexandre, E / Baro, V / Bartolini, S / Bernardeschi, D / Bivona, R / Bonali, M / Borghesi, I / Borsetto, D / Bovo, R / Breun, M / Calbucci, F / Carlson, M L / Caruso, A / Cayé-Thomasen, P / Cazzador, D / Champagne, P-O / Colangeli, R / Conte, G / D'Avella, D / Danesi, G / Deantonio, L / Denaro, L / Di Berardino, F / Draghi, R / Ebner, F H / Favaretto, N / Ferri, G / Fioravanti, A / Froelich, S / Giannuzzi, A / Girasoli, L / Grossardt, B R / Guidi, M / Hagen, R / Hanakita, S / Hardy, D G / Iglesias, V C / Jefferies, S / Jia, H / Kalamarides, M / Kanaan, I N / Krengli, M / Landi, A / Lauda, L / Lepera, D / Lieber, S / Lloyd, S L K / Lovato, A / Maccarrone, F / Macfarlane, R / Magnan, J / Magnoni, L / Marchioni, D / Marinelli, J P / Marioni, G / Mastronardi, V / Matthies, C / Moffat, D A / Munari, S / Nardone, M / Pareschi, R / Pavone, C / Piccirillo, E / Piras, G / Presutti, L / Restivo, G / Reznitsky, M / Roca, E / Russo, A / Sanna, M / Sartori, L / Scheich, M / Shehata-Dieler, W / Soloperto, D / Sorrentino, F / Sterkers, O / Taibah, A / Tatagiba, M / Tealdo, G / Vlad, D / Wu, H / Zanetti, D. ·Department of Neuroscience DNS, Otolaryngology Section, Padova University, Padova, Italy. · Department of Neurosurgery, Lariboisière Hospital, University of Paris Diderot, Paris, France. · Gruppo Otologico, Piacenza-Rome, Italy. · Academic Neurosurgery, Department of Neuroscience DNS, University of Padova Medical School, Padova, Italy. · Neurosurgery, Bellaria Hospital, Bologna, Italy. · AP-HP, Groupe Hôspital-Universitaire Pitié-Salpêtrière, Neuro-Sensory Surgical Department and NF2 Rare Disease Centre, Paris, France. · Sorbonne Université, Paris, France. · ENT and Skull-Base Surgery Department, Department of Neurosciences, Ospedale Papa Giovanni XXIII, Bergamo, Italy. · Otolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Italy. · Neurosurgery, Maria Cecilia Hospital, Cotignola (RA), Italy. · Department of Neurosurgery, Julius Maximilians University Hospital Würzburg, Bavaria, Germany. · Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA. · Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA. · The Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. · Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. · Department of Neuroscience DNS, Section of Human Anatomy, Padova University, Padova, Italy. · Department of Neuroradiology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano, Italy. · Department of Radiation Oncology, University Hospital Maggiore della Carità, Novara, Italy. · Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy. · Unit of Audiology, Department of Clinical Sciences and Community Health, University of Milano, Italy. · Department of Surgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano, Italy. · Department of Neurosurgery, Eberhard Karls University Tübingen, Germany. · Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. · Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, "Julius-Maximilians" University Hospital of Würzburg, Bavaria, Germany. · Department of Neurosurgery, Cambridge University Hospital, Cambridge, UK. · Oncology Department, Cambridge University Hospital, Cambridge, UK. · Department of Otolaryngology Head and Neck Surgery, Shanghai Ninh People's Hospital, Shanghai Jiatong University School of Medicine, China. · Department of Neurosciences, King Faisal Specialist Hospital & Research Center, Alfaisal University, College of Medicine, Riyadh, KSA. · ENT & Skull-Base Department, Ospedale Nuovo di Legnano, Legnano (MI), Italy. · Department of Neuro-Otology and Skull-Base Surgery Manchester Royal Infirmary, Manchester, UK. · Department of Neuroscience DNS, Audiology Unit, Padova University, Treviso, Italy. · University Aix-Marseille, France. · Otolaryngology-Head and Neck Surgery Department, University Hospital of Verona, Italy. · Mayo Clinic School of Medicine, Rochester, MN, USA. · Department of Neuro-otology and Skull Base Surgery, Cambridge University Hospital, Cambridge, UK. · ENT Department, Treviglio (BG), Italy. ·Acta Otorhinolaryngol Ital · Pubmed #31130732.

ABSTRACT: -- No abstract --

25 Article A new bone conduction hearing aid to predict hearing outcome with an active implanted device. 2019

Canale, Andrea / Boggio, Valeria / Albera, Andrea / Ravera, Mattia / Caranzano, Federico / Lacilla, Michelangelo / Albera, Roberto. ·Otolaryngology Division, Department of Surgical Sciences, University of Turin, Via Genova 3, 10126, Turin, Italy. andrea.canale@unito.it. · Otolaryngology Division, Department of Surgical Sciences, University of Turin, Via Genova 3, 10126, Turin, Italy. · Department of Otolaryngology, San Giuseppe Hospital, University of Milan, Milan, Italy. ·Eur Arch Otorhinolaryngol · Pubmed #31053966.

ABSTRACT: PURPOSE: We compared our historical medium-term data obtained with an active semi-implanted bone conduction device and the hearing results of a new passive bone conduction hearing device to determine its predictive value for the hearing results with the semi-implanted device. METHODS: The study sample was 15 patients with an active bone conduction implant (mean follow-up 26 months). Pure tone audiometry was performed with headphones, sound field speech audiometry was conducted unaided, and free-field speech audiometry was carried out with both the active bone conduction system and the passive device switched off. RESULTS: As compared with the unaided condition, speech reception was significantly improved with both devices. Comparison of speech reception threshold at 100% of word recognition showed no difference between the active and the passive device. At lower intensity the difference in speech perception was significant in the patients with monaural fitting (group A) and was non-statistically significant in those with binaural fitting (group B); the speech reception threshold at 50% of word recognition was 26.00 dB (± 10.22) with the active implant and 30.50 dB (± 7.98) with the passive device in group A (p = 0.047) and 24.00 dB (± 5.48) and 29.00 dB (± 2.24) in group B (p = 0.052), respectively. CONCLUSIONS: The hearing outcome after active bone conduction implant was comparable to published data. Compared with the unaided condition, speech recognition was significantly improved with the passive device. The device may also provide value to predict the hearing outcome with the implanted device, especially at higher intensities. LEVEL OF EVIDENCE: IV.