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Hearing Disorders: HELP
Articles from Beijing Municipality
Based on 566 articles published since 2010
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These are the 566 published articles about Hearing Disorders that originated from Beijing Municipality during 2010-2020.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · 11 · 12 · 13 · 14 · 15 · 16 · 17 · 18 · 19 · 20
1 Editorial Hearing loss and auditory plasticity. 2017

Sun, Wei / Yang, Shiming / Liu, Ke / Salvi, Richard J. ·Center for Hearing & Deafness, Department of Communicative Disorders and Science, State University of New York at Buffalo, Buffalo, NY, USA. · Department of Otolaryngology, Head and Neck Surgery, Chinese PLA General Hospital, Beijing, PR China. · Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China. ·Hear Res · Pubmed #28434581.

ABSTRACT: -- No abstract --

2 Review [Advances in the relevance of laryngopharyngeal reflux and tinnitus]. 2019

Chen, N S / Zhao, Y X / Ma, X / Yu, L S. ·Department of Otorhinolaryngology, Peking University People's Hospital, Beijing 100044, China. ·Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi · Pubmed #31315368.

ABSTRACT: Tinnitus is the most common symptom in otorhinolaryngology. In the past, tinnitus was often localized in the auditory system lesions, causing a great amount of idiopathic tinnitus patients inadequately treated. At present, it is believed that the pathogenesis of tinnitus not only originates from auditory system itself, but also participates in systemic disorders. In recent years, investigating in the effects of laryngopharyngeal reflux on tinnitus is undergoing rapid progress. This review highlights the current state of relationship between laryngopharyngeal reflux and tinnitus, which may provide a new systemic insight into diagnosis and treatment on tinnitus as well as laryngopharyngeal reflux.

3 Review Simultaneous repair of cerebrospinal fluid otorrhea and cochlear implantation in two patients with recurrent meningitis and severe inner ear malformation. 2019

Chen, Biao / Shi, Ying / Gong, Yue / Chen, Jingyuan / Li, Yongxin. ·Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, PR China. · Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, PR China. Electronic address: entlyx@sina.com. ·Int J Pediatr Otorhinolaryngol · Pubmed #31195308.

ABSTRACT: OBJECTIVES: To investigate the outcomes of simultaneous cochlear implantation and repair of a cerebrospinal fluid (CSF) leak in two patients with inner ear malformations following meningitis. METHODS: In this retrospective study and review of the literature, two patients with recurrent meningitis and severe inner ear malformation underwent cochlear implantation via the round window, and repair of CSF otorrhea via a transmastoid lateral semicircular canal approach. Both patients were treated with antibiotics for 7 days after the surgery. RESULTS: Neither patient has exhibited evidence of CSF otorrhea 1 year after surgical repair. Categorical Auditory Performance (CAP) scores and the Speech Intelligibility Ratings (SIRs) were obtained before and 1 year after surgery: the scores were 0 versus 4 and 0 versus 2, respectively. Vestibular function tests of both patients were reviewed and were normal. CONCLUSION: Simultaneous repair of CSF otorrhea and cochlear implantation in patients with recurrent meningitis and severe inner ear malformation can be regarded as safe and effective.

4 Review Endovascular treatment of V3 segment vertebro-vertebral arteriovenous fistula with Willis covered stent: Case report and literature review. 2019

Geng, Jiewen / Hu, Peng / Ma, Yongjie / Zhang, Peng / Zhang, Hongqi. ·Department of Neurosurgery, China International Neuroscience Institute, Beijing, China. ·Interv Neuroradiol · Pubmed #30165773.

ABSTRACT: A 46-year-old male presented to our hospital suffering from right mastoid pulsatile tinnitus secondary to traffic trauma. Digital subtraction angiography was remarkable for a vertebro-vertebral arteriovenous fistula fed by the right vertebral artery at the C1 level. Dual platelet therapy was administrated before and after the operation, then a Willis covered stent was deployed at the orifice of the fistula. Post-operative angiography showed proper stent localization but some contrast agent leaking from the fistula. Angiography performed 6 months post-operatively demonstrated no leak from the fistula and the patency of the right vertebral artery. This case demonstrated that an intracranial covered stent could be used as an alternative, successful treatment for vertebro-vertebral arteriovenous fistula.

5 Review [Recent immunology research of Meniere's disease]. 2018

Guo, S Y / Zhang, Y / Liu, B. ·Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education , Beijing 100730, China. ·Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi · Pubmed #30585012.

ABSTRACT: Inner ear disease is characterized by tinnitus, deafness and vertigo. The pathogenesis remains unknown. In the past, it is considered to be related to vascular disease such as thrombus and hemadostenosis.However, more and more researches indicate that it may be associated with multiple factors mediated by allergy. This paper reviews some possible pathogenesis of Meniere disease, including type Ⅰ allergy, autoimmunity, circulating immune complex and immune genetic.

6 Review [The current status and applications of implantable bone-conduction devices]. 2018

Xia, J Y / Yu, Q N / Xi, X / Yang, B B. ·Department of Otorhinolaryngology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310002, China. · Department of Otorhinolaryngology, Shaoxing Keqiao Women and Children's Hospital, Zhejiang 312030, China. · Department of Otorhinolaryngology Head and Neck Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China. ·Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi · Pubmed #30032500.

ABSTRACT: Implantable bone-conduction devices are characterized by the fact that the vibration is transmitted through bone conduction. The technology and surgical techniques in the application of implantable bone-conduction devices have developed considerably in recent years, experiencing a transformation from percutaneous to transcutaneous implantation. This article reviewed current developments in the types, surgical indications, and complications, as well as compared between the various bone-conduction devices to provid references for clinical application.

7 Review [Characteristics of early hearing impairment in patients with diabetes mellitus]. 2018

Li, Y H / Liu, B. ·Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing 100005, China. ·Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi · Pubmed #29614558.

ABSTRACT: The early hearing loss in diabetic patients is not easy to be perceived, therefore, comprehensive and complete audiological examination is necessary. At present, hearing loss in diabetes patients characterized by high frequency decline, some of the examination for high frequency hearing loss such as speech audiometry and extended high frequency are applicated. In addition, electrophysiological techniques have also been rapidly developed in animal experiments. This review summarized the audiological characteristics in diabetes patients and progress in animal experiments, which provided the basis for early diagnosis and early treatment of hearing loss in diabetes mellitus.

8 Review [Middle ear teratoma in infant: report of three cases and review of the literatures]. 2018

Peng, Z / Wang, Z X / Xie, J / Wang, L E / Liu, Y / Gong, S S. ·Department of Otorhinolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijng 100050, China. ·Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi · Pubmed #29429175.

ABSTRACT:

9 Review Genetic basis of hearing loss in Spanish, Hispanic and Latino populations. 2018

Mittal, Rahul / Patel, Amit P / Nguyen, Desiree / Pan, Debbie R / Jhaveri, Vasanti M / Rudman, Jason R / Dharmaraja, Arjuna / Yan, Denise / Feng, Yong / Chapagain, Prem / Lee, David J / Blanton, Susan H / Liu, Xue Zhong. ·Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA. · Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, China. · Department of Physics and Biomolecular Sciences Institute, Florida International University, Miami, FL, USA. · Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. · Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA; Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA. · Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, China; Tsinghua University School of Medicine, Beijing 10084, China; Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address: xliu@med.miami.edu. ·Gene · Pubmed #29331482.

ABSTRACT: Hearing loss (HL) is the most common neurosensory disorder affecting humans. The screening, prevention and treatment of HL require a better understanding of the underlying molecular mechanisms. Genetic predisposition is one of the most common factors that leads to HL. Most HL studies include few Spanish, Hispanic and Latino participants, leaving a critical gap in our understanding about the prevalence, impact, unmet health care needs, and genetic factors associated with hearing impairment among Spanish, Hispanic and Latino populations. The few studies which have been performed show that the gene variants commonly associated with HL in non-Spanish and non-Hispanic populations are infrequently responsible for hearing impairment in Spanish as well as Hispanic and Latino populations (hereafter referred to as Hispanic). To design effective screening tools to detect HL in Spanish and Hispanic populations, studies must be conducted to determine the gene variants that are most commonly associated with hearing impairment in this racial/ethnic group. In this review article, we summarize gene variants and loci associated with HL in Spanish and Hispanic populations. Identifying new genetic variants associated with HL in Spanish and Hispanic populations will pave the way to develop effective screening tools and therapeutic strategies for HL.

10 Review [Research progress on the etiology of delayed-onset hearing loss in children]. 2017

Wang, X Y / Huang, L H / Du, Y T. ·Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing 100005, China. ·Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi · Pubmed #29050102.

ABSTRACT: Newborn hearing screening is an effective method for early detection of hearing loss, however, it is not able to detect delayed-onset hearing loss. By exploring the etiology of delayed-onset hearing loss in children, it can provide a clinical basis for early detection of delayed-onset hearing loss. Mutations in

11 Review The Advances in Hearing Rehabilitation and Cochlear Implants in China. 2017

Li, Jia-Nan / Chen, Si / Zhai, Lei / Han, Dong-Yi / Eshraghi, Adrien A / Feng, Yong / Yang, Shi-Ming / Liu, Xue-Zhong. ·1Department of Otolaryngology & Head and Neck Surgery, and Auditory Implantation Center, Chinese PLA General Hospital, Beijing, People's Republic of China; 2Department of Otolaryngology, University of Miami Ear Institute, Miami, Florida, USA; 3China Rehabilitation Research Center for Deaf Children, Beijing, People's Republic of China; 4Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China; and 5Tsinghua University School of Medicine, Beijing, People's Republic of China. ·Ear Hear · Pubmed #28471842.

ABSTRACT: Hearing loss (HL) is a common sensory impairment in humans, with significant economic and social impacts. With nearly 20% of the world's population, China has focused on economic development and health awareness to improve the care for its hearing-impaired population. Recently, the Chinese government has initiated national programs such as the China Disabled Persons Federation to fund prevention, treatment, and rehabilitation of hearing impairment. Newborn hearing screening and auditory rehabilitation programs in China have expanded exponentially with government support. While facing many challenges and overcoming obstacles, cochlear implantation (CI) programs in China have also experienced considerable growth. This review discusses the implementation of CI programs for HL in China and presents current HL data including epidemiology, newborn hearing screening, and determination of genetic etiologies. Sharing the experience in Chinese auditory rehabilitation and CI programs will shine a light on the developmental pathway of healthcare infrastructure to meet emerging needs of the hearing-impaired population in other developing countries.

12 Review Early detection of hearing impairment in patients with diabetes mellitus with otoacoustic emission. A systematic review and meta-analysis. 2017

Hao, Jin / Fu, Xinxing / Zhang, Chunfang / Zhang, Xuelian / Zhao, Shouqin / Li, Yongxin. ·a Department of Otolaryngology, Head and Neck Surgery , Beijing Tongren Hospital, Capital Medical University , Beijing , PR China. · b Beijing Institute of Otolaryngology, Key Laboratory of Otolaryngology, Head and Neck Surgery (Capital Medical University) , Ministry of Education , Beijing , PR China. · c Department of Bioinformatic , Wuerzburg University , Wuerzburg , Germany. · d Department of Endocrinology , Beijing Tongren Hospital, Capital Medical University , Beijing , PR China. ·Acta Otolaryngol · Pubmed #27632340.

ABSTRACT: CONCLUSIONS: The distortion product otoacoustic emission (DPOAE) amplitudes in diabetics were significantly lower than those in controls when pure tone audiometry (PTA) was within normal limits, implying cochlear function impairment in the early stage of diabetes mellitus. Retrocochlear damage was suggested by elongated wave latencies and the wave interval of auditory brainstem response (ABR) in diabetics. OBJECTIVES: This study aimed to systematically analyze the application of DPOAE in evaluation of the hearing function of diabetics. DATA SOURCES AND REVIEW METHODS: Eligible articles were identified through searches of nine different electronic databases. Two investigators reviewed the original articles independently, with pre-defined inclusion and exclusion criteria. Meta-analyses were conducted by using Metan module. RESULTS: There were seven articles eligible for the analysis. PTA thresholds were within normal limits in all diabetics at low-middle frequencies. The mean DPOAE amplitudes of diabetics were significantly lower than those of controls. The standardized mean difference (SMD) (95% CI) was -0.49 (-0.70, -0.27), -0.46 (-0.63, -0.30), and -0.60 (-0.77, -0.43) at 1, 2, and 4 kHz, respectively. The latencies of waves I, III, and V in diabetes were significantly longer than those of controls (0.43 (0.23, 0.64), 0.54 (0.33, 0.75), and 0.56 (0.35, 0.77), respectively). The wave interval I-V was significantly longer in diabetics (p < .001, 0.47 [0.24, 0.70]).

13 Review [Effect of cochlear implantation on sound localization for patients with unilateral sensorineural hearing loss]. 2016

Liu, J F / Dai, J S / Wang, N Y. ·Department of Otorhinolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University; College of Otolaryngology, Capital Medical University; Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing 100020, China. ·Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi · Pubmed #27625137.

ABSTRACT: The aim of this review was to examine the current literature regarding application of cochlear implantation on patients with unilateral sensorineural hearing loss (USNHL) for improvement on sound localization. The literature were searched in the PubMed database with 'cochlear implantation AND single-sided deafness' or 'cochlear implantation AND unilateral deafness' as keywords. The publication date of the articles was up to 2015-2-12. A total of 12 articles were included. The results show that the ability of sound localization for most of the USNHL subjects (90%) with cochlear implantation was significantly improved than that without CI, which suggests that CI is a superior auditory rehabilitation treatment than BAHA and CROS hearing aids for patients with USNHL, because of the re-establishment of the benefits of binaural hearing. In addition, the benefit of CI for USNHL requires a period of auditory experience or training. About 30% subjects showed significantly improvement on sound localization ability after CI worked for three months. For most of the patients (90%), the sound localization ability improved after CI worked for six months. When CI worked for nine months, all the subjects would show improvement on sound localization ability. Sound localization of the USNHL subjects with a CI is based primarily on interaural level differences (ILD) while interaural time differences (ITD) provide little advantage or probably not perceptible at all. The younger subject suffers from USNHL, the stronger the plasticity of the auditory center shows, which results in more obvious degeneration of the affected side and adaptive enhancement of the contralateral side of the auditory pathway. Similarly, the longer duration of USNHL lead to more obvious degeneration of the affected side and adaptive enhancement of the contralateral side. An adaptive enhancement of auditory pathway corresponding to the healthy ear will rely more on the monaural spatial cues that available to the intact ear to improve the sound localization in the horizontal plane. Contrarily, the degeneration of auditory pathway corresponding to the USNHL may be limited to re-reorganize from auditory deprivation even after CI, which may increase the risk that a few subjects cannot re-establish the binaural benefits after CI. Therefore, patients with USNHL should accept CI as soon as possible to obtain good binaural benefits, especially for sound localization.

14 Review An uncommon case of lymphoplasmacytic lymphoma in cerebellopontine angle region: Case report with a literature review. 2016

Yan, Chengrui / Kong, Xiangyi / Yang, Lanshu / Ma, Wenbin. ·Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing, P. R. China. ·Medicine (Baltimore) · Pubmed #27559959.

ABSTRACT: In the central nervous system, cerebellopontine angle (CPA) lymphomas are rare; few cases have been reported. Lymphoplasmacytic lymphoma (LPL) in the CPA is rarer still, and often misdiagnosed as acoustic neuroma.We report a rare case of CPA LPL-a challenging diagnosis guided by clinical presentations, radiological signs, and postoperative pathological test.A 43-year-old woman presented with headaches. Her magnetic resonance imaging revealed an abnormal homogeneously enhancing mass in the left CPA. We present detailed analysis of her disease and review relevant literature.When surgically treated, her specimen showed a typical LPL histopathology pattern. After surgery, the patient's symptoms improved greatly, and she received chemotherapy.Despite its rarity, LPL should be considered in differential diagnoses of CPA lesions that mimic acoustic neuromas.

15 Review Physiological functions and clinical implications of the N-end rule pathway. 2016

Liu, Yujiao / Liu, Chao / Dong, Wen / Li, Wei. ·College of Marine Life, Ocean University of China, Qingdao, 266003, China. · State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. · University of Chinese Academy of Sciences, Beijing, 100049, China. · College of Marine Life, Ocean University of China, Qingdao, 266003, China. wdong@ouc.edu.cn. · State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. leways@ioz.ac.cn. ·Front Med · Pubmed #27492620.

ABSTRACT: The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determination of a protein's half-life is dependent on its N-terminal residue. The N-terminal residue serves as the degradation signal of a protein and thus called N-degron. N-degron can be recognized and modifed by several steps of post-translational modifications, such as oxidation, deamination, arginylation or acetylation, it then polyubiquitinated by the N-recognin for degradation. The molecular basis of the N-end rule pathway has been elucidated and its physiological functions have been revealed in the past 30 years. This pathway is involved in several biological aspects, including transcription, differentiation, chromosomal segregation, genome stability, apoptosis, mitochondrial quality control, cardiovascular development, neurogenesis, carcinogenesis, and spermatogenesis. Disturbance of this pathway often causes the failure of these processes, resulting in some human diseases. This review summarized the physiological functions of the N-end rule pathway, introduced the related biological processes and diseases, with an emphasis on the inner link between this pathway and certain symptoms.

16 Review [Three applications and the challenge of the big data in otology]. 2016

Lei, Guanxiong / Li, Jianan / Shen, Weidong / Yang, Shiming. ·School of Medical, Nankai University, Tianjin 300071, China; Department of Otorhinolaryngology Head and Neck Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China. · Department of Otorhinolaryngology Head and Neck Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China. ·Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi · Pubmed #27033583.

ABSTRACT: With the expansion of human practical activities, more and more areas have suffered from big data problems. The emergence of big data requires people to update the research paradigm and develop new technical methods. This review discussed that big data might bring opportunities and challenges in the area of auditory implantation, the deafness genome, and auditory pathophysiology, and pointed out that we needed to find appropriate theories and methods to make this kind of expectation into reality.

17 Review Understanding auditory neuropathy spectrum disorder: a systematic review in transgenic mouse models. 2016

Wang, Li / Guan, Jing / Wang, Hongyang / Lan, Lan / Zhang, Qiujing / Zong, Liang / Du, Wan / Xiong, Wenping / Li, Fengjiao / Wu, Kaiwen / Wang, Dayong / Wang, Qiuju. ·Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China. · Medical College, Nankai University, Tianjin, 300071, China. · Institute of Otolaryngology, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, 100853, China. wqcr301@sina.com. ·Sci China Life Sci · Pubmed #26783139.

ABSTRACT: Auditory neuropathy spectrum disorder is a unique group of hearing dysfunctions characterized by preserved outer hair cell function and abnormal neural conduction of the auditory pathway. However, the pathogenic mechanism underlying this disorder is not clear. We therefore performed a systematic review of genetic mouse models with different gene mutations to provide a valuable tool for better understanding of the process and the possible molecular mechanisms. Of the 18 articles retrieved, nine met the required criteria. All biochemical, histological, and electrophysiological results were recorded for each of the mouse models, as was the transgenic technology. This review provides a summary of different mouse models that may play an important role in the diagnosis and management of auditory neuropathy spectrum disorder in the future.

18 Review Psychophysical and neural correlates of noised-induced tinnitus in animals: Intra- and inter-auditory and non-auditory brain structure studies. 2016

Zhang, Jinsheng / Luo, Hao / Pace, Edward / Li, Liang / Liu, Bin. ·Department of Otolaryngology-Head and Neck Surgery, Wayne State University, School of Medicine, 4201 Saint Antoine, Detroit, MI 48201, USA; Department of Communication Sciences & Disorders, Wayne State University, College of Liberal Arts & Sciences, 60 Farnsworth St., Detroit, MI 48202, USA. Electronic address: jinzhang@med.wayne.edu. · Department of Otolaryngology-Head and Neck Surgery, Wayne State University, School of Medicine, 4201 Saint Antoine, Detroit, MI 48201, USA. · Department of Psychology, McGovern Institute for Brain Research at PKU, Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing, 100080, China. ·Hear Res · Pubmed #26299842.

ABSTRACT: Tinnitus, a ringing in the ear or head without an external sound source, is a prevalent health problem. It is often associated with a number of limbic-associated disorders such as anxiety, sleep disturbance, and emotional distress. Thus, to investigate tinnitus, it is important to consider both auditory and non-auditory brain structures. This paper summarizes the psychophysical, immunocytochemical and electrophysiological evidence found in rats or hamsters with behavioral evidence of tinnitus. Behaviorally, we tested for tinnitus using a conditioned suppression/avoidance paradigm, gap detection acoustic reflex behavioral paradigm, and our newly developed conditioned licking suppression paradigm. Our new tinnitus behavioral paradigm requires relatively short baseline training, examines frequency specification of tinnitus perception, and achieves sensitive tinnitus testing at an individual level. To test for tinnitus-related anxiety and cognitive impairment, we used the elevated plus maze and Morris water maze. Our results showed that not all animals with tinnitus demonstrate anxiety and cognitive impairment. Immunocytochemically, we found that animals with tinnitus manifested increased Fos-like immunoreactivity (FLI) in both auditory and non-auditory structures. The manner in which FLI appeared suggests that lower brainstem structures may be involved in acute tinnitus whereas the midbrain and cortex are involved in more chronic tinnitus. Meanwhile, animals with tinnitus also manifested increased FLI in non-auditory brain structures that are involved in autonomic reactions, stress, arousal and attention. Electrophysiologically, we found that rats with tinnitus developed increased spontaneous firing in the auditory cortex (AC) and amygdala (AMG), as well as intra- and inter-AC and AMG neurosynchrony, which demonstrate that tinnitus may be actively produced and maintained by the interactions between the AC and AMG.

19 Review The application of genome editing in studying hearing loss. 2015

Zou, Bing / Mittal, Rahul / Grati, M'hamed / Lu, Zhongmin / Shu, Yilai / Tao, Yong / Feng, Youg / Xie, Dinghua / Kong, Weijia / Yang, Shiming / Chen, Zheng-Yi / Liu, Xuezhong. ·Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. · Department of Biology, University of Miami, Miami, FL 33146, USA. · Department of Otology and Laryngology, Harvard Medical School and Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston 02114, USA; Department of Otology and Skull Base Surgery, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China. · Department of Otology and Laryngology, Harvard Medical School and Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston 02114, USA; Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. · Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China. · Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital Central South University, Changsha, Hunan, China. · Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. · Department of Otolaryngology-Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China. · Department of Otology and Laryngology, Harvard Medical School and Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston 02114, USA. Electronic address: zheng-yi_chen@meei.harvard.edu. · Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital Central South University, Changsha, Hunan, China; Department of Otolaryngology-Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China. Electronic address: xliu@med.miami.edu. ·Hear Res · Pubmed #25987504.

ABSTRACT: Targeted genome editing mediated by clustered, regularly interspaced, short palindromic repeat (CRISPR)/CRISPR-associated nuclease 9 (Cas9) technology has emerged as one of the most powerful tools to study gene functions, and with potential to treat genetic disorders. Hearing loss is one of the most common sensory disorders, affecting approximately 1 in 500 newborns with no treatment. Mutations of inner ear genes contribute to the largest portion of genetic deafness. The simplicity and robustness of CRISPR/Cas9-directed genome editing in human cells and model organisms such as zebrafish, mice and primates make it a promising technology in hearing research. With CRISPR/Cas9 technology, functions of inner ear genes can be studied efficiently by the disruption of normal gene alleles through non-homologous-end-joining (NHEJ) mechanism. For genetic hearing loss, CRISPR/Cas9 has potential to repair gene mutations by homology-directed-repair (HDR) or to disrupt dominant mutations by NHEJ, which could restore hearing. Our recent work has shown CRISPR/Cas9-mediated genome editing can be efficiently performed in the mammalian inner ear in vivo. Thus, application of CRISPR/Cas9 in hearing research will open up new avenues for understanding the pathology of genetic hearing loss and provide new routes in the development of treatment to restore hearing. In this review, we describe major methodologies currently used for genome editing. We will highlight applications of these technologies in studies of genetic disorders and discuss issues pertaining to applications of CRISPR/Cas9 in auditory systems implicated in genetic hearing loss.

20 Review Salivary gland choristoma of the middle ear. 2015

Chen, Shubin / Li, Yongxin. ·Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China 100005. ·Ear Nose Throat J · Pubmed #25651359.

ABSTRACT: Salivary gland choristoma of the middle ear is a rare entity. It is believed to be a developmental abnormality that may be associated with anomalies of adjacent structures. We describe the case of a 6-year-old girl who had a salivary gland choristoma in the middle ear that was associated with an ossicular chain anomaly and a facial nerve anomaly. We discuss the clinical features and management of this condition, and we review the literature.

21 Review [Application of next generation sequencing in gene identification and genetic diagnosis of hereditary hearing loss]. 2014

Huijun, Yuan / Yu, Lu. ·Institute of Otolaryngology, Chinese PLA General Hospital, Beijing 100853, China. ·Yi Chuan · Pubmed #25567869.

ABSTRACT: More than 50% cases with hearing loss are caused by genetic defects. With the development of genomics technology, molecular genetics of hearing loss has become a cutting-edge field under investigation in otology. The next generation sequencing has provided a new model originated from sequencing data to genetic disease study, and has made a revolutionary change in the strategy of gene identification for genetic diseases. Due to the application of next generation sequencing technology, gene identification of hearing loss has been accelerated in recent years, and moreover, the new technology and strategy were explored to clinical application. In this review, we briefly introduce the current situation of hereditary hearing loss research, and the application and perspective of next generation sequencing in this field.

22 Review Chinese herbal medicine for idiopathic sudden sensorineural hearing loss: a systematic review of randomised clinical trials. 2013

Su, C-X / Yan, L-J / Lewith, G / Liu, J-P. ·Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; School of Nursing, Beijing University of Chinese Medicine, Beijing, China. ·Clin Otolaryngol · Pubmed #24209508.

ABSTRACT: BACKGROUND: Idiopathic sudden sensorineural hearing loss has great impact on quality of life. Many clinical trials using Chinese herbal medicine for idiopathic sudden sensorineural hearing loss have been conducted and reported beneficial results. However, there is no critical appraised evidence on efficacy and safety of Chinese herbal medicine for idiopathic sudden sensorineural hearing loss to inform clinical use. OBJECTIVE OF REVIEW: To assess the beneficial effect and safety of Chinese herbal medicine for idiopathic sudden sensorineural hearing loss. TYPE OF REVIEW: Systematic review of randomised clinical trials. SEARCH STRATEGY: Seven electronic databases and two trial registries were searched for all eligible trials from inception to January 2013. EVALUATION METHOD: Two authors independently selected trials and extracted data. The Cochrane risk of bias tool was utilised to assess the methodological quality of the included trials. revman 5.2 software was applied for data analysis with effect estimate presented as risk ratio and mean difference with its 95% confidence interval. RESULTS: Forty-one randomised clinical trials involving 3560 participants were identified. Five kinds of Chinese herbal medicine were trialed. All trials compared conventional therapies of steroids, vasodilators, anticoagulants, nutritional supplements or hyperbaric oxygen with or without herbal medicine. No trial was identified that compared herbal medicine alone with placebo. No trial was identified that blinded the participants or the observers to their herbal medication. Only one trial adequately reported its method of randomisation. No trial reported the sample size calculated to show an effect. All trials had material other defects giving a high likelihood of bias. Because of the overall poor quality of all 41 trials, it was concluded that there was no level-one evidence to support the use of Chinese herbal medicine, alone or in addition to conventional therapies, to improve the hearing in adults with idiopathic sudden sensorineural hearing loss. Two trials reported adverse effects, and no severe adverse effects were found in the Chinese herbal medicine groups. CONCLUSIONS: The existing evidence for the beneficial effect and safety of Chinese herbal medicine for idiopathic sudden sensorineural hearing loss comes from methodologically poor studies and therefore cannot be reliably used to support their clinical use. We identify a justification to further investigate the effect and safety of Chinese herbal medicine for people with idiopathic sudden sensorineural hearing loss in rigorously designed randomised trials.

23 Review Effectiveness of repetitive transcranial magnetic stimulation for chronic tinnitus: a systematic review. 2012

Peng, Zhe / Chen, Xiu-Qi / Gong, Shu-Sheng. ·Department of Otolaryngology, Head and Neck Surgery, Capital Medical University, Beijing, China. ·Otolaryngol Head Neck Surg · Pubmed #22941756.

ABSTRACT: OBJECTIVE: This systematic review aimed to assess the effectiveness of repetitive transcranial magnetic stimulation (rTMS) treatment for chronic tinnitus. Data Sources Relevant electronic databases and a reference list of articles published up to January 2012 were searched. Randomized controlled clinical trials of all types of rTMS treatment for patients with chronic tinnitus were included. REVIEW METHODS: A literature search was conducted with structured criteria to select studies evaluated for systematic review. RESULTS: Five trials (160 participants) were included in this review. Repetitive transcranial magnetic stimulation treatment showed benefits in the short term, but the long-term effects are questionable. The Tinnitus Handicap Inventory (THI) and the visual analog scale (VAS) were the major assessment methods used. After active TMS stimulation, the reduction in the THI total score and VAS was significant compared with baseline at the first time point assessed and in the short term (2 weeks and 4 weeks). The longest follow-up time was 26 weeks after treatment, and the shortest follow-up time was 2 weeks. No severe side effects were reported from the use of rTMS. Differences in age, hearing level, duration of tinnitus of the included patients, and the condition of sham treatment may influence the effect. CONCLUSION: Repetitive transcranial magnetic stimulation could be a new therapeutic tool for the treatment of chronic tinnitus, and thus far we have not been able to demonstrate any substantial risk from rTMS treatment. However, the long-term effects of rTMS treatment for tinnitus are not clear and will require further study.

24 Review Aberrant internal carotid artery causing objective pulsatile tinnitus and conductive hearing loss. 2012

Song, Yue-Shuai / Yuan, Yong-Yi / Wang, Guo-Jian / Dai, Pu / Han, Dong-Yi. ·Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China. ·Acta Otolaryngol · Pubmed #22779753.

ABSTRACT: Aberrant internal carotid artery (ICA) in the middle ear is a rare, dangerous vascular anomaly and conservative follow-up was usually adopted in most reported cases. Here we report the case of an 8-year-old girl with symptoms of objective pulsatile tinnitus and conductive hearing loss in the right ear. Otoscopic examination, computed tomography, and conventional angiography were performed. An aberrant ICA combined with a 'third mobile window' was suspected preoperatively and confirmed at exploratory surgery of the middle ear. The aberrant ICA was treated, and the pulsatile tinnitus disappeared and hearing recovered after the surgery. This case suggests that surgery is practical to relieve troublesome tinnitus and hearing loss in appropriate cases with aberrant ICA.

25 Clinical Trial Outcomes of the Baha Attract System combined with auricle reconstruction in mandarin speaking patients with bilateral microtia-atresia. 2019

Fan, Xinmiao / Chen, Yu / Niu, Xiaomin / Wang, Yibei / Fan, Yue / Chen, Xiaowei. ·a Department of Otolaryngology , Peking Union Medical College Hospital , Beijing , PR China. · b Department of Radiology , Peking Union Medical College Hospital , Beijing , PR China. ·Acta Otolaryngol · Pubmed #30806113.

ABSTRACT: BACKGROUND: A transcutaneous bone-conduction hearing device (tBCHD), the Baha Attract System has been recently introduced to China, and very few studies have assessed the efficacy of this system in speakers of mandarin. OBJECTIVES: This study aims to analyze the functional and cosmetic outcomes of this system. MATERIALS AND METHODS: This prospective study included 11 patients (nine males, two females), of mean age 16 years (range 9-32 years). Seven patients were conducted the implantation simultaneously with auricle reconstruction, and the other four were before it. Auditory results were compared between unaided patients and implanted patients. Subjective satisfaction was analyzed using three questionnaires. RESULTS: The mean sound field thresholds were 65.9 ± 5.1 dB SPL unaided and 30.9 ± 4.7 dB SPL with an implanted Baha Attract System, resulting in a mean hearing gain of 35.0 ± 6.7 dB. The mean WRS scores were 47.8 ± 8.7% unaided and 92.1 ± 2.0% with the Baha Attract System, resulting in a mean improvement of 47.8 ± 8.7%. No adverse events were reported and questionnaires showed good patients satisfaction. CONCLUSIONS: The transcutaneous Baha Attract System is effective in mandarin speaking patients, and the combination of hearing rehabilitation and auricle reconstruction surgery is promising for patients with bilateral microtia-atresia.

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