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Hearing Disorders: HELP
Articles from Toronto General Hospital
Based on 4 articles published since 2010

These are the 4 published articles about Hearing Disorders that originated from Toronto General Hospital during 2010-2020.
+ Citations + Abstracts
1 Article Nucleolus vs Nucleus Count for Identifying Spiral Ganglion in Human Temporal Bone. 2018

Di Stadio, Arianna / Ralli, Massimo / Ishai, Reuven / D'Ascanio, Luca / Trabalzini, Franco / Della Volpe, Antonio / Babighian, Gregorio / Ricci, Giampietro. ·University of Perugia, Permanent Temporal Bone Laboratory, Perugia, Italy. · University La Sapienza, Department of Oral and Maxillofacial Sciences, Rome, Italy. · Toronto General Hospital, Otolaryngology Department, Toronto, Canada. · "Carlo Poma" Civil Hospital, Department of Otolaryngology-Head and Neck Surgery, Mantova, Italy. · Meyer Children's Hospital, Otolaryngology unit, Florence, Italy. · Santobono-Posillipon Hospital, Otology and Cochlear Implant Unit, Naples, Italy. · University of Perugia, Otolaryngology Department, Perugia, Italy. ·J Int Adv Otol · Pubmed #30256195.

ABSTRACT: OBJECTIVES: Spiral ganglion (SG) counting is used in experimental studies conducted on age-, noise-, and drug-induced sensorineural hearing loss, as well as in the assessment of cochlear implant performances. Different methods of counting have been reported, but no definite standardization of such procedure has been published. The aim of our study is to identify the best method to count human spiral ganglions (SGs). MATERIALS AND METHODS: By identification of nuclei or nucleoli as described by Schucknect, seven researchers with different experience levels counted SGs in 123 human temporal bones (TBs). Data on time of post-mortem bone removal post-mortem, methods of specimen's fixation, decalcification, and coloration were collected to test their possible influence on human tissue. Percentage, two-tailed t-test, Spearman's test, and one-way ANOVA were used to analyze the data. RESULTS: Nucleoli were identified in 61% of cases, whereas nuclei were recognized in 100% of cases (p<0.005). Nucleoli presence in all four segments in the same temporal bone (TB) was observed in 69 cases (92%), whereas nuclei were identified in all four segments in 103 cases (83.7%) (p<0.001). The junior investigators requested a double check by the seniors in 25 (20.3%) cases for identifying and counting nucleoli, whereas the senior researchers showed no doubts in their identification and count. The only parameter positively affecting nucleoli identification in tissue preparation was bone removal for <12 h with respect to longer post-mortem time (p<0.001). CONCLUSION: We suggest counting nuclei, rather than nucleoli, for spiral ganglion computation because of easier recognition of nuclei, especially in case of investigator's limited experience.

2 Article Long-Term Late Toxicity, Quality of Life, and Emotional Distress in Patients With Nasopharyngeal Carcinoma Treated With Intensity Modulated Radiation Therapy. 2018

McDowell, Lachlan J / Rock, Kathy / Xu, Wei / Chan, Biu / Waldron, John / Lu, Lin / Ezzat, Shereen / Pothier, David / Bernstein, Lori J / So, Nathaniel / Huang, Shao Hui / Giuliani, Meredith / Hope, Andrew / O'Sullivan, Brian / Bratman, Scott V / Cho, John / Kim, John / Jang, Raymond / Bayley, Andrew / Ringash, Jolie. ·Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. · Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada. · Department of Biostatistics, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada. · Department of Endocrine Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. · Department of Otolaryngology-Head and Neck Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada. · Department of Supportive Care, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada. · Division of Medical Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada. · Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada. Electronic address: jolie.ringash@rmp.uhn.ca. ·Int J Radiat Oncol Biol Phys · Pubmed #30191868.

ABSTRACT: PURPOSE: To report long-term (>4 years) toxicity and quality of life (QoL) among patients with nasopharyngeal carcinoma (NPC) treated with intensity modulated radiation therapy (IMRT) in a nonendemic center. METHODS AND MATERIALS: A cross-sectional cohort study enrolled patients with NPC who were disease-free and ≥4 years after IMRT ± chemotherapy. Physician-reported adverse events (Common Terminology Criteria for Adverse Events, version 4.03) and patient-reported QoL (Functional Assessment of Cancer Therapy-Head and Neck, Functional Assessment of Chronic Illness Therapy-Fatigue), utilities (EuroQOL-5D), head and neck symptoms (MD Anderson Symptom Inventory-Head and Neck), and emotional distress (Hospital Anxiety and Depression Scale) were collected. Consenting patients also underwent endocrine screening and audiometry. RESULTS: Among 107 patients enrolled, median age at enrollment and time since treatment were 57 (32-81) and 7.5 years (4.2-11.1), respectively. Most patients (99%) received 70 Gy in 35 fractions; the majority (93%) received concurrent chemotherapy. Mean scores for the Functional Assessment of Cancer Therapy-Head and Neck, Functional Assessment of Chronic Illness Therapy-Fatigue, and EuroQOL-5D were 105.0 (46-148), 116.6 (44-160), and 0.85 (0.29-1.00), respectively. Dry mouth, mucus, swallowing/chewing, memory, and teeth/gum problems were scored highest on the MD Anderson Symptom Inventory-Head and Neck; mean symptom severity and symptom interference scores were 2.3 and 2.4, respectively. Grade 3 or higher physician-reported adverse events were noted in 50 patients (47%), most frequently hearing problems (46, 43%). Audiometry revealed significant bilateral hearing loss (grade ≥3) in 68 patients (72%). Depression (25%), anxiety (37%), and fatigue (28%) were common and strongly correlated with QoL. Most patients (69%) developed hypothyroidism; 1 patient (1%) developed pituitary dysfunction requiring hormone replacement. V50 >90 and V45 >99 to the thyroid correlated with significantly higher rates of hypothyroidism. CONCLUSIONS: Despite the implementation of IMRT, survivors of NPC still experience many physical symptoms that affect long-term QoL many years after treatment. Depression, anxiety, and fatigue remain common in long-term survivors and are highly correlated with QoL.

3 Article Pharmacogenomics in diabetes: outcomes of thiamine therapy in TRMA syndrome. 2018

Habeb, Abdelhadi M / Flanagan, Sarah E / Zulali, Mohamed A / Abdullah, Mohamed A / Pomahačová, Renata / Boyadzhiev, Veselin / Colindres, Lesby E / Godoy, Guillermo V / Vasanthi, Thiruvengadam / Al Saif, Ramlah / Setoodeh, Aria / Haghighi, Amirreza / Haghighi, Alireza / Shaalan, Yomna / Anonymous540937 / Hattersley, Andrew T / Ellard, Sian / De Franco, Elisa. ·Paediatric Department, Prince Mohammed bin Abdulaziz Hospital, National Guard Ministry, P.O. Box 40740, Al Madinah, 41511, Kingdom of Saudi Arabia. amhabeb@hotmail.com. · Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK. · Paediatric Department, College of Medicine, Taibah University, Madinah, Kingdom of Saudi Arabia. · Paediatric Department, Khartoum University, Khartoum, Sudan. · Department of Paediatrics, Charles University, Medical Faculty and University Hospital Pilsen, Pilsen, Czech Republic. · Medical University, Varna, Bulgaria. · Hospital María De Especialidades Pediatricas, Tegucigalpa, Honduras. · Kanchi Kamakoh Child Trust Hospital, Chennai, India. · Paediatric Department, Maternity and Children's Hospital, Dammam, Kingdom of Saudi Arabia. · Growth & Development Research Centre, University of Tehran, Medical Sciences, Tehran, Iran. · Toronto General Hospital, University of Toronto, Toronto, ON, Canada. · Department of Genetics and Medicine, Harvard Medical School, Boston, MA, USA. · Broad Institutes of Harvard and MIT, Cambridge, MA, USA. · Partners HealthCare Laboratory for Molecular Medicine, Cambridge, MA, USA. · Faculty of Medicine, Cairo University, Cairo, Egypt. · Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK. e.de-franco@exeter.ac.uk. ·Diabetologia · Pubmed #29450569.

ABSTRACT: AIMS/HYPOTHESIS: Diabetes is one of the cardinal features of thiamine-responsive megaloblastic anaemia (TRMA) syndrome. Current knowledge of this rare monogenic diabetes subtype is limited. We investigated the genotype, phenotype and response to thiamine (vitamin B METHODS: We studied 32 individuals with biallelic SLC19A2 mutations identified by Sanger or next generation sequencing. Clinical details were collected through a follow-up questionnaire. RESULTS: We identified 24 different mutations, of which nine are novel. The onset of the first TRMA symptom ranged from birth to 4 years (median 6 months [interquartile range, IQR 3-24]) and median age at diabetes onset was 10 months (IQR 5-27). At presentation, three individuals had isolated diabetes and 12 had asymptomatic hyperglycaemia. Follow-up data was available for 15 individuals treated with thiamine for a median 4.7 years (IQR 3-10). Four patients were able to stop insulin and seven achieved better glycaemic control on lower insulin doses. These 11 patients were significantly younger at diabetes diagnosis (p = 0.042), at genetic testing (p = 0.01) and when starting thiamine (p = 0.007) compared with the rest of the cohort. All patients treated with thiamine became transfusion-independent and adolescents achieved normal puberty. There were no additional benefits of thiamine doses >150 mg/day and no reported side effects up to 300 mg/day. CONCLUSIONS/INTERPRETATION: In TRMA syndrome, diabetes can be asymptomatic and present before the appearance of other features. Prompt recognition is essential as early treatment with thiamine can result in improved glycaemic control, with some individuals becoming insulin-independent. DATA AVAILABILITY: SLC19A2 mutation details have been deposited in the Decipher database ( https://decipher.sanger.ac.uk/ ).

4 Article Increase in use of protective earplugs by Rock and Roll concert attendees when provided for free at concert venues. 2015

Cha, Jieun / Smukler, Simon R / Chung, Yuan / House, Ron / Bogoch, Isaac I. ·a * Department of Medicine , University of Toronto , Toronto, Ontario , Canada. · b Department of Occupational and Environmental Health , St. Michael's Hospital , Toronto , Ontario , Canada. · c Divisions of General Internal Medicine and Infectious Diseases, Toronto General Hospital , Toronto, Ontario , Canada. ·Int J Audiol · Pubmed #26609734.

ABSTRACT: OBJECTIVE: To determine the prevalence of hearing protection use among attendees of Rock and Roll concerts at baseline and in concerts where earplugs are provided for free at concert venue entrances. DESIGN: Six concerts performed at two music venues in Toronto, Canada were evaluated. Study personnel observed and recorded the use of hearing protection at three concerts where no earplugs were distributed, and three concerts where earplugs were provided for free at the concert venue entrance. STUDY SAMPLE: A total of 955 individuals over the age of 18 were observed at six concerts. Six hundred and thirty-seven individuals (64% male) were observed at concerts where no earplugs were provided, and 318 individuals (68% male) were observed at concerts where free earplugs were provided. RESULTS: Multivariate logistic regression demonstrated a significant increase in hearing protection usage at concerts where earplugs were provided for free at the concert venue entrance, odds ratio 7.27 (95% CI: 3.24-16.30). CONCLUSION: The provision of free earplugs at concert venues may be a simple and inexpensive intervention that could be a component of a larger public health campaign to prevent non-occupational noise-induced hearing loss.