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Hearing Disorders: HELP
Articles from Rikshospitalet Oslo
Based on 6 articles published since 2010

These are the 6 published articles about Hearing Disorders that originated from Rikshospitalet Oslo during 2010-2020.
+ Citations + Abstracts
1 Clinical Trial Hearing Status in Survivors of Childhood Acute Myeloid Leukemia Treated With Chemotherapy Only: A NOPHO-AML Study. 2019

Skou, Anne-Sofie / Olsen, Steen Ø / Nielsen, Lars H / Glosli, Heidi / Jahnukainen, Kirsi / Jarfelt, Marianne / Jónmundsson, Guðmundur K / Malmros, Johan / Nysom, Karsten / Hasle, Henrik / Anonymous6090972. ·Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus. · Departments of Otorhinolaryngology, Head and Neck Surgery, and Audiology. · Department of Pediatric and Adolescent Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway. · Children's Hospital, Helsinki University Central Hospital, Helsinki, Finland. · Department of Pediatric Oncology, The Queen Silvia Children's Hospital, Gothenburg. · Department of Pediatrics, Landspitalinn University Hospital, Reykjavik, Iceland. · Department of Pediatric Oncology, Karolinska University Hospital. · Department of Women´s and Children's Health, Karolinska Institutet, Stockholm, Sweden. · Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark. ·J Pediatr Hematol Oncol · Pubmed #30550508.

ABSTRACT: BACKGROUND: As more children survive acute myeloid leukemia (AML) it is increasingly important to assess possible late effects of the intensive treatment. Hearing loss has only sporadically been reported in survivors of childhood AML. We assessed hearing status in survivors of childhood AML treated with chemotherapy alone according to 3 consecutive NOPHO-AML trials. PROCEDURE: A population-based cohort of children treated according to the NOPHO-AML-84, NOPHO-AML-88, and NOPHO-AML-93 trials included 137 eligible survivors among whom 101 (74%) completed a questionnaire and 99 (72%) had otologic and audiologic examination performed including otoscopy (72%), pure tone audiometry (70%), and tympanometry (60%). Eighty-four of 93 (90%) eligible sibling controls completed a similar questionnaire. RESULTS: At a median of 11 years (range, 4 to 25) after diagnosis, hearing disorders were rare in survivors of childhood AML and in sibling controls, with no significant differences. None had severe or profound hearing loss diagnosed at audiometry. Audiometry detected a subclinical hearing loss ranging from slight to moderate in 19% of the survivors, 5% had low-frequency hearing loss, and 17% had high-frequency hearing loss. CONCLUSIONS: The frequency of hearing disorders was low, and hearing thresholds in survivors of childhood AML were similar to background populations of comparable age.

2 Article Long-term ototoxicity in women after cisplatin treatment for ovarian germ cell cancer. 2017

Skalleberg, Jakob / Solheim, Olesya / Fosså, Sophie D / Småstuen, Milada Cvancarova / Osnes, Terje / Gundersen, Per Ole M / Bunne, Marie. ·Department of Otolaryngology, Head and Neck Surgery, Rikshospitalet, Oslo University Hospital, Norway. · Department of Gynecological Oncology, Radiumhospitalet, Oslo University Hospital, Norway. · National Resource Center for Late Effects after Cancer Treatment, Radiumhospitalet, Oslo University Hospital, Norway. Electronic address: sopfos@ous-hf.no. · Department of Health Science and Biostatistics, Høgskolen i Oslo og Akershus, Norway. · Department of Clinical Pharmacology, St Olav University Hospital, Trondheim, Norway. ·Gynecol Oncol · Pubmed #28202195.

ABSTRACT: OBJECTIVE: Evaluate long-term cisplatin-induced ototoxicity in women treated for malignant ovarian germ cell tumors (MOGCT). METHODS: Seventy-four women treated for MOGCT in Norway (1980-2009) were analyzed: 41 had received cisplatin-based chemotherapy (CBCT) ("Cases") and 33 had no CBCT ("Controls"). Median follow-up was 15years. Hearing was assessed by pure tone audiometry and by the SCIN questionnaire. Air conduction thresholds were reported as absolute hearing thresholds and age-adjusted thresholds. Absolute and age-adjusted hearing loss were defined as thresholds of >20dB at any frequency. Tinnitus was evaluated using the Tinnitus Handicap Inventory. Serum Platinum Concentration (SPC) was determined. RESULTS: Absolute hearing loss was identified in 21 Cases (51%) and 24 Controls (73%). After adjusting for age, only 9 Cases (22%) and 5 Controls (15%) remained. Age-adjusted hearing thresholds at 4, 6 and 8kHz were slightly but significantly higher in Cases compared to Controls. Subjective hearing loss was reported by 27% of Cases and 21% of Controls, who were significantly older. Elevated SPC values were detected up to 20years after CBCT, but SPC did not correlate significantly with age-adjusted hearing loss. The rate of tinnitus was similar in Cases and Controls. CONCLUSION: Long-term MOGCT survivors treated with CBCT have small but significant reductions in age-adjusted hearing thresholds at 4, 6 and 8kHz versus Controls. Approximately one in four women experienced subjective hearing loss. To avoid overestimation of clinically relevant cisplatin-induced ototoxicity, absolute hearing thresholds should be age-adjusted and compared to an age-matched control group.

3 Article The impact of ethnicity on cochlear implantation in Norwegian children. 2017

Amundsen, Viktoria Vedeler / Wie, Ona Bø / Myhrum, Marte / Bunne, Marie. ·Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 1078 Blindern, N-0316 Oslo, Norway. Electronic address: viktoriavamundsen@gmail.com. · Department of Special Needs Education, Faculty of Education, University of Oslo, P.O. Box 1140 Blindern, N-0318 Oslo, Norway; Department of Otorhinolaryngology, Division of Head and Neck Surgery, Oslo University Hospital Rikshospitalet, P.O. Box 4950, N-0424 Oslo, Norway. Electronic address: o.b.wie@isp.uio.no. · Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 1078 Blindern, N-0316 Oslo, Norway; Department of Otorhinolaryngology, Division of Head and Neck Surgery, Oslo University Hospital Rikshospitalet, P.O. Box 4950, N-0424 Oslo, Norway. Electronic address: marte.myhrum@medisin.uio.no. · Department of Otorhinolaryngology, Division of Head and Neck Surgery, Oslo University Hospital Rikshospitalet, P.O. Box 4950, N-0424 Oslo, Norway. Electronic address: marie.bunne@ous-hf.no. ·Int J Pediatr Otorhinolaryngol · Pubmed #28109494.

ABSTRACT: OBJECTIVES: To explore the impact of parental ethnicity on cochlear implantation in children in Norway with regard to incidence rates of cochlear implants (CIs), comorbidies, age at onset of profound deafness (AOD), age at first implantation, uni- or bilateral CI, and speech recognition. METHOD: This retrospective cohort study included all children (N = 278) aged <18 years in Norway who received their first CI during the years 2004-2010. RESULTS: 86 children (30.9%) in our study sample had parents of non-Nordic ethnicity, of whom 46 were born in Nordic countries with two non-Nordic parents. Compared with the background population, children with non-Nordic parents were 1.9 times more likely to have received CI than Nordic children (i.e., born in Nordic countries with Nordic parents). When looking at AOD, uni-vs. bilateral CIs, and comorbidities, no significant differences were found between Nordic children and children with a non-Nordic ethnicity. Among children with AOD <1 year (n = 153), those born in non-Nordic countries with two non-Nordic parents (n = 6) and adopted non-Nordic children (n = 6) received their first CI on average 14.9 and 21.1 months later than Nordic children (n = 104), respectively (p = 0.006 and 0.005). Among children with AOD <1 year, those born in Nordic countries with two non-Nordic parents (n = 31) received their CI at an older age than Nordic children, but this difference was not significant after adjusting for calendar year of implantation and excluding comorbidity as a potential cause of delayed implantation. The mean age at implantation for children with AOD <1 year dropped 2.3 months/year over the study period. The mean monosyllable speech recognition score was 84.7% for Nordic children and 76.3% for children born in Norway with two non-Nordic parents (p = 0.002). CONCLUSIONS: The incidence of CI was significantly higher in children with a non-Nordic vs. a Nordic ethnicity, reflecting a higher incidence of profound deafness. Children born in Norway have equal access to CIs regardless of their ethnicity, but despite being born and receiving care in Norway, prelingually deaf children with non-Nordic parents are at risk of receiving CI later than Nordic children. Moreover, prelingually deaf children who arrive in Norway at an older age may be at risk for a worse prognosis after receiving a CI due to lack of auditory stimulation in early childhood, which is critical for language development and late implantation; this is a serious issue with regard to deafness among refugees.

4 Article Insertion Depth in Cochlear Implantation and Outcome in Residual Hearing and Vestibular Function. 2016

Nordfalk, Karl Fredrik / Rasmussen, Kjell / Hopp, Einar / Bunne, Marie / Silvola, Juha Tapio / Jablonski, Greg Eigner. ·Oslo University Hospital-Rikshospitalet, Oslo, Norway. ·Ear Hear · Pubmed #26524566.

ABSTRACT: OBJECTIVES: It has long been known that cochlear implantation may cause loss of residual hearing and vestibular function. Different insertion depths may cause varying degrees of intracochlear trauma in the apical region of the cochlea. The present study investigated the correlation between the insertion depth and postoperative loss of residual hearing and vestibular function. DESIGN: Thirty-nine adults underwent unilateral cochlear implantation. One group received a Med-El +Flex electrode array (24 mm; n = 4), 1 group received a Med-El +Flex electrode array (28 mm; n = 18), and 1 group received a Med-El +Flex electrode array (31.5 mm; n = 17). Residual hearing, cervical vestibular-evoked myogenic potentials, videonystagmography, and subjective visual vertical/horizontal were explored before and after surgery. The electrode insertion depth and scalar position were examined with high-resolution rotational tomography after implantation in 29 subjects. RESULTS: There was no observed relationship between the angular insertion depth (405° to 708°) and loss of low-frequency pure-tone average. Frequency-specific analysis revealed a weak relationship between the angular insertion depth and loss of hearing at 250 Hz (R= 0.20; p = 0.02). There was no statistically significant difference in the residual hearing and vestibular function between the +Flex and the +Flex electrode array. Eight percent of the cases had vertigo after surgery. The electrode arrays were positioned inside the scala tympani and not scala vestibuli in all subjects. In 18% of the cases, the +Flex electrode array was not fully inserted. CONCLUSIONS: The final outcome in residual hearing correlates very weakly with the angular insertion depth for depths above 405°. Postoperative loss of vestibular function did not correlate with the angular insertion depth or age at implantation. The surgical protocol used in this study seems to minimize the risk of postoperative vertigo symptoms.

5 Article Unilateral deafness in adults: effects on communication and social interaction. 2010

Wie, Ona B / Pripp, Are Hugo / Tvete, Ole. ·Department of Otolaryngology, Oslo University Hospital, Rikshospitalet, Norway. ·Ann Otol Rhinol Laryngol · Pubmed #21140638.

ABSTRACT: OBJECTIVES: The aim of this study was to explore the self-reported consequences of profound unilateral deafness regarding communication and social interaction and to compare subjects' speech perception scores to those of normal-hearing individuals who were rendered temporarily unilaterally deaf. METHODS: Cross-sectional data from 30 individuals with unilateral deafness and 30 individuals with normal hearing (age, 14 to 75 years) were obtained through structured interviews and tests of audiovisual, auditory-only, and visual-only speech perception. RESULTS: In individuals with permanent unilateral deafness, 93% reported that hearing loss affected communication. Eighty-seven percent reported problems with speech perception in noisy settings. Other consequences were feelings of exclusion, reduced well-being, and extensive use of speech perception strategies. Inducing temporary unilateral deafness (through short-term blocking of one ear) in normal-hearing subjects produced similar effects on speech perception (27% score) as those experienced by unilaterally deaf subjects (25% score). CONCLUSIONS: Individuals with unilateral deafness experienced a significant disability in auditory function that affected their communication and social interaction. The major challenges were communicating in situations with background noise, in poor acoustic surroundings, and with limited access to speech-reading or direct listening. Under certain listening conditions, long-standing unilateral deafness seemed to yield no advantage over temporary deafness on one side.

6 Article Causes of hearing impairment in the Norwegian paediatric cochlear implant program. 2010

Siem, Geir / Fagerheim, Toril / Jonsrud, Christoffer / Laurent, Claude / Teig, Erik / Harris, Sten / Leren, Trond P / Früh, Andreas / Heimdal, Ketil. ·Department of Otolaryngology, Faculty Division Rikshospitalet, University of Oslo, Norway. geir@siem.no ·Int J Audiol · Pubmed #20553101.

ABSTRACT: Severe to profound hearing impairment (HI) is estimated to affect around 1/2000 young children. Advances in genetics have made it possible to identify several genes related to HI. This information can cast light upon prognostic factors regarding the outcome in cochlear implantation, and provide information both for scientific and genetic counselling purposes. From 1992 to 2005, 273 children from 254 families (probands) were offered cochlear implants in Norway. An evaluation of the causes of HI, especially regarding the genes GJB2, GJB6, SLC26A4, KCNQ1, KCNE1, and the mutation A1555G in mitochondrial DNA was performed in 85% of the families. The number of probands with unknown cause of HI was thus reduced from 120 to 68 (43% reduction). Ninety-eight (46%) of the probands had an identified genetic etiology of their HI. A relatively high prevalence of Jervell and Lange-Nielsen syndrome was found. The main causes of severe and profound HI were similar to those found in other European countries. GJB2 mutations are a common cause of prelingual HI in Norwegian cochlear implanted children.