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Hearing Disorders: HELP
Articles from Chile
Based on 47 articles published since 2010
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These are the 47 published articles about Hearing Disorders that originated from Chile during 2010-2020.
 
+ Citations + Abstracts
Pages: 1 · 2
1 Editorial Stressing out the ER in aminoglycoside-induced hearing loss. 2015

Garcia-Huerta, P / Rivas, A / Hetz, C. ·1] Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile [2] Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile. · 1] Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile [2] Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile [3] Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA. ·Cell Death Dis · Pubmed #25973682.

ABSTRACT: -- No abstract --

2 Review Ginkgo biloba for the treatment of tinnitus. 2018

Quidel Kramer, Felipe / Ortigoza, Ángela. ·Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. · Proyecto Epistemonikos, Santiago, Chile; Departamento de Medicina Familiar, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: acortigoza@uc.cl. Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile. ·Medwave · Pubmed #30339143.

ABSTRACT: INTRODUCTION: Multiple interventions have been postulated for the treatment of tinnitus, but none has been established as clearly effective. Ginkgo biloba has been proposed among the alternatives. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, and generated a summary of findings table using the GRADE approach. RESULTS AND CONCLUSIONS: We identified three systematic reviews including four primary studies, all corresponding to randomized trials. We concluded the use of Ginkgo biloba probably does not decrease the severity of tinnitus. In addition, it does not reduce the intensity of tinnitus or improve the quality of life of patients.

3 Review Are intratympanic corticosteroids effective for Ménière’s disease? 2017

Chuang-Chuang, Ángela / Baeza, María A. ·Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. Email: angelesbaezaa@gmail.com. Address: Facultad de Medicina, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago Centro, Chile. · Proyecto Epistemonikos, Santiago, Chile; Departamento de Otorrinolaringología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. ·Medwave · Pubmed #28306710.

ABSTRACT: Ménière’s disease affects the inner ear and its main symptoms are vertigo, hearing loss and fluctuating aural symptoms. Nowadays, there are many therapeutic alternatives, being the use of intratympanic corticosteroids one that has become popular. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple databases. We identified four systematic reviews including 15 studies overall, of which seven were randomized trials. We extracted data and generated a summary of findings table using the GRADE approach. We concluded intratympanic corticosteroids probably do not decrease tinnitus, and might not decrease vertigo, hearing loss or aural fullness sensation in Ménière’s disease. Intratympanic corticosteroids probably do not cause important adverse effects.

4 Review Platinum-induced ototoxicity: a review of prevailing ototoxicity criteria. 2017

Waissbluth, Sofia / Peleva, Emilia / Daniel, Sam J. ·Department of Otolaryngology, Pontificia Universidad Católica de Chile, Marcoleta 367, Santiago, Chile. sofia.waissbluth@gmail.com. · King's College London, London, UK. · Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, QC, Canada. ·Eur Arch Otorhinolaryngol · Pubmed #27245751.

ABSTRACT: The antineoplastic agent's cisplatin and carboplatin are widely used as they are highly effective. Unfortunately, ototoxicity is a frequently encountered side effect of platinum-based chemotherapy. Clinically, patients generally develop a progressive, bilateral, and irreversible sensorineural hearing loss. With rising cancer survival rates, a greater proportion of patients are living with the side effects of their chemotherapy treatments. Consequently, the quality of life of cancer survivors has now become a major concern for clinicians. Various classification systems are currently available to grade side effects and provide a guideline for subsequent treatments. An extensive review of the literature revealed that a variety of criteria are used worldwide for grading platinum-induced hearing loss in children and adults, including the National Cancer Institute criteria, Brock's grading system, the American Speech-Hearing-Language Association criteria, the World Health Organization criteria, the Pediatric Oncology Group criteria, and the Muenster classification. Less commonly used criteria include the Chang classification, the Functional Hearing Loss scale, the HIT system (German Hirntumor study grading system), and most recently, the International Society of Pediatric Oncology Boston ototoxicity grading scale. The objective of this review is to evaluate the commonly used ototoxicity criteria and discuss their benefits and limitations.

5 Review Comparison of occupational noise legislation in the Americas: an overview and analysis. 2014

Arenas, Jorge P / Suter, Alice H. ·Institute of Acoustics, University Austral of Chile, Valdivia, Chile. ·Noise Health · Pubmed #25209041.

ABSTRACT: The workplace contributes significantly to the total dose of daily noise to which a person is subjected. Therefore, millions of people around the world are exposed to potentially dangerous noise levels and consequently, there is an urgent, global need for legislation to adequately protect the auditory health of workers. Occupational noise legislation has been adopted in many of the countries with different degrees of comprehensiveness and varying levels of sophistication. This paper presents a global view of current legislation on occupational noise in the 22 countries that make up the Americas, that is, Latin America, Canada, and the United States. Upon analysis of the legislation, there are notable differences among countries in the defined values for permissible exposure limit (PEL) and exchange rate. Of the countries that have regulations, the majority (81%) use a PEL of 85 dBA. A PEL of 85 dBA and the 3-dB exchange rate are currently used by 32% of the nations in the Americas. Most nations limit impulsive noise exposure to a peak unweighted sound pressure level of 140 dB (or dBC), while a few use slightly lower limits. However, 27% of the countries in the region still have not established regulations with respect to permissible noise levels and exchange rates. This fact is leaving millions of workers in the Americas unprotected against occupational noise. Provide an overview and analysis of the current legislation on occupational noise in the 22 countries that make up the Americas. The information on legislation, regulations, and standards discussed in this paper were obtained directly from official government sources in each country, the International Labour Organization database, or through various colleagues in each country. (1) There are notable differences among countries in the defined values for PEL and exchange rate. (2) Of the countries that have regulations, the majority (81%) use a PEL of 85 dBA. A PEL of 85 dBA and the 3-dB exchange rate are currently used by 32% of the nations in the Americas. (3) Most nations limit impulsive noise exposure to a peak unweighted sound pressure level of 140 dB (or dBC), while a few use slightly lower limits. (4) 27% of the countries in the region still have not established regulations with respect to permissible noise levels and exchange rates. (5) Millions of workers in the Americas are unprotected against occupational noise.

6 Review [Auditory rehabilitation programmes for adults: what do we know about their effectiveness?]. 2014

Cardemil, Felipe / Aguayo, Lorena / Fuente, Adrian. ·Servicio de Otorrinolaringología, Hospital Barros Luco Trudeau, Universidad de Chile, Santiago, Chile; Programa de Doctorado en Salud Pública, Escuela de Salud Pública, Universidad de Chile, Santiago, Chile. · Programa de Magíster en Salud Pública, Escuela de Salud Pública, Universidad de Chile, Santiago, Chile. · Escuela de Fonoaudiología, Universidad de Chile, Santiago, Chile. Electronic address: afuente@med.uchile.cl. ·Acta Otorrinolaringol Esp · Pubmed #24602838.

ABSTRACT: INTRODUCTION AND OBJECTIVE: Hearing loss ranks third among the health conditions that involve disability-adjusted life years. Hearing aids are the most commonly used treatment option in people with hearing loss. However, a number of auditory rehabilitation programmes have been developed with the aim of improving communicative abilities in people with hearing loss. The objective of this review was to determine the effectiveness of auditory rehabilitation programmes focused on communication strategies. MATERIAL AND METHODS: This was a narrative revision. A literature search using PUBMED was carried out. This search included systematic reviews investigating the effectiveness of auditory training and individual and group auditory rehabilitation programmes with the main focus on counselling and communicative strategies for adults with hearing loss. Each study was analysed in terms of the type of intervention used and the results obtained. RESULTS: Three articles were identified: one article about the effectiveness of auditory training programmes and 2 systematic reviews that investigated the effectiveness of communicative programmes in adults with hearing loss. The "Active Communication Education" programme appears to be an effective group programme of auditory rehabilitation that may be used with older Spanish-speaking adults. CONCLUSIONS: The utility of hearing aid fitting and communicative programmes as rehabilitation options are associated with improvements in social participation and quality of life in patients with hearing loss, especially group auditory rehabilitation programmes, which seem to have good potential for reducing activity limitations and social participation restrictions, and thus for improving patient quality of life.

7 Review [Genetics of congenital deafness]. 2012

Faundes, Víctor / Pardo, Rosa Andrea / Castillo Taucher, Silvia. ·Sección de Genética, Departamento de Medicina, Hospital Clínico Universidad de Chile, Santiago, Chile. vfaundes@ug.uchile.cl ·Med Clin (Barc) · Pubmed #22538062.

ABSTRACT: Congenital deafness is defined as the hearing loss which is present at birth and, consequently, before speech development. It is the most prevalent sensor neural disorder in developed countries, and its incidence is estimated between 1-3 children per 1,000 newborns, of which more than 50% are attributable to genetics causes. Deafness can be classified as syndromic or non-syndromic. In the first case, it is associated with outer ear malformations and/or systemic findings. More than 400 syndromes accompanied of deafness have been described, which represent about 30% of cases of congenital hearing loss. The remaining percentage corresponds to non-syndromic cases: 75-85% are autosomal recessive, 15-24% are autosomal dominant, and 1-2% are X-linked. The evaluation of a child with deafness requires a multidisciplinary collaboration among specialists, who must coordinate themselves and give information to the affected family. The aims of establishing a diagnosis are to predict other manifestations that may suggest some syndrome and to anticipate their management, as well as to perform genetic counseling to parents and affected individuals.

8 Review Mitochondrial diabetes and deafness: possible dysfunction of strial marginal cells of the inner ear. 2011

Olmos, Pablo R / Borzone, Gisella R / Olmos, Juan P / Diez, Alberto / Santos, José L / Serrano, Valentina / Cataldo, Luis R / Anabalón, José L / Correa, Claudio H. ·Department of Nutrition, Diabetes and Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile. polmos@med.puc.cl ·J Otolaryngol Head Neck Surg · Pubmed #21453644.

ABSTRACT: OBJECTIVE: Some patients with the syndrome of mitochondrial diabetes and deafness (MIDD) have a m.3243A>G mutation of the MTTL1 gene encoding transfer ribonucleic acid for the amino acid leucine (tRNALeu(UUR)). One of our MIDD patients inspired us to propose an integrated view on how a single mutation of the mitochondrial deoxyribonucleic acid (DNA) affects both the glucose metabolism and the inner ear physiology. DESIGN: (a) Study of mitochondrial DNA in a patient with MIDD. (b) REVIEW OF THE LITERATURE on the impact of the m.3243A>G mutation on glucose metabolism and on the physiology of the hearing process. SETTINGS: Outpatient diabetes and nutrition department and molecular nutrition laboratory. METHODS: (a) Polymerase chain reaction followed by restriction fragment analysis identified the m.3243A>G mutation. (b) REVIEW OF THE LITERATURE from 1994 to 2009. RESULTS: (a) Molecular study: the m.3243A>G mutation was detected with an appreciable level of heteroplasmy. (b) REVIEW OF THE LITERATURE: the strial marginal cells located near the organ of Corti fulfill two characteristics: they are rich in mitochondria, and their dysfunction may produce neurosensorial deafness by means of a reduction in the potassium ion concentration of the endolymph. CONCLUSIONS: The m.3243A>G mutation not only underlies a dysfunction of the insulin-producing beta cell of the pancreas but also results in a reduction in adenosine triphosphate production of the strial marginal cells of the inner ear, thus diminishing the energy (in the form of potassium ion gradient) needed for the outer hair cells of the organ of Corti to amplify the soundwaves, particularly at high frequencies.

9 Clinical Trial Clinical performance of a new magnetic bone conduction hearing implant system: results from a prospective, multicenter, clinical investigation. 2015

Briggs, Robert / Van Hasselt, Andrew / Luntz, Michal / Goycoolea, Marcos / Wigren, Stina / Weber, Peter / Smeds, Henrik / Flynn, Mark / Cowan, Robert. ·*HEARing Cooperative Research Centre, Melbourne, Australia; †Chinese University of Hong Kong, Hong Kong, China; ‡Bnai Zion Hospital, Haifa, Israel; §Clínica Las Condes, Santiago, Chile; ∥Cochlear Bone Anchored Solutions AB, Mölnlycke, Sweden; and ¶Cochlear Americas, Denver, Colorado, U.S.A. ·Otol Neurotol · Pubmed #25634465.

ABSTRACT: OBJECTIVE: The aim of the investigation was to prospectively evaluate, in a multicenter setting, the clinical performance of a new magnetic bone conduction hearing implant system. METHODS: The test device was the Cochlear Baha Attract System (Cochlear Bone Anchored Solutions AB, Mölnlycke, Sweden). Instead of the skin-penetrating abutment of traditional bone conduction hearing implants, the test device uses an implantable and an external magnet to transmit sound from the sound processor (SP) through intact skin to the skull bone. Twenty-seven adult patients with a conductive or mild mixed hearing loss or single-sided sensorineural deafness were included in the clinical investigation across four investigational sites. The patients were followed for 9 months after implantation. The study evaluated efficacy in terms of hearing performance compared with unaided hearing and with hearing with the SP on a softband. Patient benefit, soft tissue status, device retention, and safety parameters were monitored continuously throughout the investigation. RESULTS: Surgery and healing was uneventful. Statistically significant improvements in audibility and speech understanding in noise and quiet were recorded for the test device compared with preoperative unaided hearing. Speech recognition was similar or better than tests performed with the same SP on a softband. Good soft tissue outcomes were reported, without major pressure-related complications. At the end of the investigation, all patients continued to use and benefit from the device. CONCLUSION: The test device provides good hearing performance in patients with a conductive hearing loss or single-sided sensorineural deafness, with good wearing comfort and minimal soft tissue complications.

10 Article [Health care of people with visual or hearing disabilities]. 2019

Campos, Valeria / Cartes-Velásquez, Ricardo. ·Departamento de Prevención y Salud Pública Odontológica, Facultad de Odontología, Universidad de Concepción, Concepción, Chile. · Universidad Andrés Bello, Concepción, Chile. ·Rev Med Chil · Pubmed #31859896.

ABSTRACT: Visual or hearing disabilities account for 20% of people reporting some sort of disability. We performed a literature review about the interaction that people with visual or hearing disabilities have with the health care system. We found that these people report a lower quality of life and have a higher frequency of physical and psychological ailments. They also have difficulties to obtain an adequate health care and report a paucity of trained professionals to take care of them.

11 Article [Alport syndrome. Report of two cases]. 2019

Jones, Alex / Gallegos, Manuel / Díaz, Ignacio / Reyes, Magdalena / Zacharias, Sergio. ·Fundación Oftalmológica de Los Andes, Santiago, Chile. · Hospital Dr. Sótero del Río, Santiago, Chile. ·Rev Med Chil · Pubmed #31344217.

ABSTRACT: Alport syndrome is an inherited progressive form of glomerular disease that is often associated with sensorineural hearing loss and ocular abnormalities. We report two men with Alport syndrome. Both had chronic kidney disease and consulted for long-term loss of visual acuity. One had auditory abnormalities. On the ophthalmological examination, both had anterior lenticonus and one had dot or fleck retinopathy. Those findings are described in up to 50% and 70% of men with X-linked Alport syndrome, respectively. Both patients had a family history of Alport syndrome or suggestive signs and symptoms.

12 Article Jet fuel exposure and auditory outcomes in Australian air force personnel. 2019

Fuente, Adrian / Hickson, Louise / Morata, Thais C / Williams, Warwick / Khan, Asaduzzaman / Fuentes-Lopez, Eduardo. ·School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia. adrian.fuente@umontreal.ca. · Centre de recherche de l'Institut universitaire de gériatrie de Montréal, Montreal, Quebec, Canada. adrian.fuente@umontreal.ca. · School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia. · National Institute for Occupational Safety and Health, Cincinnati, OH, USA. · National Acoustic Laboratories, Sydney, NSW, Australia. · Carrera de Fonoaudiología, Departamento de Ciencias de la Salud, Pontificia Universidad Católica de Chile, Santiago, Chile. ·BMC Public Health · Pubmed #31151392.

ABSTRACT: BACKGROUND: Animal data suggest that jet fuels such as JP-8 are associated with hearing deficits when combined with noise and that the effect is more pronounced than with noise exposure alone. Some studies suggest peripheral dysfunction while others suggest central auditory dysfunction. Human data are limited in this regard. The aim of this study was to investigate the possible chronic adverse effects of JP-8 combined with noise exposure on the peripheral and central auditory systems in humans. METHODS: Fifty-seven participants who were current personnel from the Royal Australian Air Force were selected. Based on their levels of exposure to jet fuels, participants were divided into three exposure groups (low, moderate, high). Groups were also categorised based on their noise exposure levels (low, moderate, high). All participants were evaluated by tympanometry, pure-tone audiometry (1-12 kHz), distortion product otoacoustic emissions (DPOAEs), auditory brainstem response (ABR), words-in-noise, compressed speech, dichotic digit test, pitch pattern sequence test, duration pattern sequence test and adaptive test of temporal resolution. All auditory tests were carried out after the participants were away from the Air Force base for a minimum of two weeks, thus two weeks without jet fuel and noise exposure. RESULTS: Jet fuel exposure was significantly associated with hearing thresholds at 4 and 8 kHz; average hearing thresholds across frequencies in the better ear; DPOAEs at 2.8, 4 and 6 kHz; ABR wave V latency in the right ear; compressed speech and words-in-noise. Further analyses revealed that participants with low exposure level to jet fuels showed significantly better results for the aforementioned procedures than participants with moderate and high exposure levels. All results were controlled for the covariates of age and noise exposure levels. CONCLUSIONS: The results suggest that jet fuel exposure, when combined with noise exposure, has an adverse effect on audibility in humans. Taking all the test results into consideration, jet fuel exposure combined with noise exposure specifically seems to affect the peripheral hearing system in humans.

13 Article Positive pressure therapy for Ménière’s disease. 2019

Holmberg, Jorge / de Amesti, Martín / Rosenbaum, Andrés / Winter, Matías. ·Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. · Proyecto Epistemonikos, Santiago, Chile; Departamento de Otorrinolaringología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. · Proyecto Epistemonikos, Santiago, Chile; Departamento de Otorrinolaringología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: mwinterd@gmail.com. Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile. ·Medwave · Pubmed #30985738.

ABSTRACT: INTRODUCTION: Ménière's disease is a disorder of the inner ear characterized by episodes of spontaneous vertigo, fluctuating hearing loss and tinnitus. Positive pressure therapy has been used to reduce the intensity and frequency of episodes, but it is not clear whether it is actually effective. METHODS: We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. RESULTS AND CONCLUSIONS: We identified five systematic reviews including 22 studies overall, of which five were randomized trials. We concluded positive pressure therapy probably leads to slightly worse hearing and makes little or no difference in the intensity of vertigo. In addition, we are uncertain whether positive pressure therapy improves functionality or decreases vertigo attacks as the certainty of the evidence has been assessed as very low.

14 Article [Meningitis and hypoacusia due to swine meat handling]. 2018

Moraga, Juan / Fica, Alberto / Navarrete, Braulio / Henríquez, Ruby / Navarrete-Asenjo, Claudio. ·Universidad Austral de Chile, Chile. · Hospital Base de Valdivia, Chile. ·Rev Chilena Infectol · Pubmed #31095197.

ABSTRACT: Zoonotic meningitis by Streptococcus suis has been described occasionally in Chile and linked to pig farmers in the south of the country. We report a female case that developed acute bacterial meningitis by this agent, two days after handling a piece of raw swine meat. She did not participate on swine breeding nor visited farms. Diagnosis was obtained by CSF culture. A severe hearing loss and not recovered despite corticosteroids use and antimicrobial treatment, without others complications. Meningitis by S. suis is emerging as a new pathogen and linked to swine in different forms. Hypoacusis happens frequently with this agent.

15 Article [Hereditary thrombocytopenia associated with a mutation in the MYH-9 gene. Report of one case]. 2018

Conte, Guillermo / López, Miguel / Alarcón, Pablo. ·Sección Hematología Hospital Clínico, Universidad de Chile, Santiago, Chile. · Escuela de Postgrado, Facultad de Medicina, Universidad de Chile, Chile. · Sección Genética Hospital Clínico, Universidad de Chile, Santiago, Chile. ·Rev Med Chil · Pubmed #30725031.

ABSTRACT: We report a 51-year-old female who had a first episode of thrombocytopenia at 23 years of age during a pregnancy. At the age of fifty, a hysterectomy was indicated due to a metrorrhagia: a platelet count of 21,000/ul was detected. She was treated with eltrombopag with a good response. The family history of the patient revealed the presence of thrombocytopenia in several family members. Suspecting a hereditary thrombocytopenia, a genetic study revealed a mutation in the MYH-9 gene. This mutation can be suspected when there is a family history of thrombocytopenia with autosomal dominant inheritance, macrothrombocytopenia and in this particular case, due to the response to thrombopoietin receptor agonist, eltrombopag.

16 Article Elderly who refuse to use hearing aids: an analysis of the causes. 2018

Carrasco-Alarcón, Pablo / Morales, Camilo / Bahamóndez, Mónica Chicuy / Cárcamo, Diego Alarcón / Schacht, Ángela Cayul. ·Departamento de Procesos Terapéuticos, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco, Chile. ·Codas · Pubmed #30304099.

ABSTRACT: PURPOSE: The present research sought to describe the elements that interfere with the use of hearing aids in the elderly beneficiaries of a hearing aid delivery from Chile in a Family Health Center. METHODS: A descriptive, cross-sectional study was conducted with 24 beneficiary users, with application of a closed-question questionnaire prepared by the researchers. RESULTS: A 75% adherence to the use of hearing aids is reported. There was a difference of 3.8 h in the use between adherents and non-adherents and in the frequency of use. The main reasons for not using the hearing aids are discomfort due to mold and noise. CONCLUSION: It is necessary to provide quality education during the implementation process, as well as to address the technical difficulties related to atrial adjustment and calibration of the hearing aid in order to increase adherence.

17 Article Incidence and associated risk factors for platinum-induced ototoxicity in pediatric patients. 2018

Waissbluth, Sofia / Del Valle, Álvaro / Chuang, Angela / Becker, Ana. ·Department of Otolaryngology, Complejo Asistencial Dr. Sotero Del Rio, Santiago, Chile. Electronic address: sofia.waissbluth@mail.mcgill.ca. · Department of Otolaryngology, Complejo Asistencial Dr. Sotero Del Rio, Santiago, Chile. · Department of Pediatric Hematology-Oncology, Complejo Asistencial Dr. Sotero Del Rio, Santiago, Chile. ·Int J Pediatr Otorhinolaryngol · Pubmed #29958605.

ABSTRACT: OBJECTIVES: Platinum-based chemotherapy is effective against a variety of pediatric malignancies. Unfortunately, the use of cisplatin and carboplatin can lead to permanent and progressive sensorineural hearing loss which can affect the quality of life of cancer survivors. The objectives of this study were to evaluate the incidence of platinum-induced ototoxicity in children and analyze potential risk factors. METHODS: Prospective cohort study. All pediatric patients receiving chemotherapy with cisplatin and/or carboplatin from 01/2012 until 10/2017 were included. Hearing evaluations were performed before every chemotherapy cycle, and following the end of chemotherapy, with auditory brainstem response, otoacoustic emissions and/or audiometry. Demographics, cumulative doses, cranial irradiation and exposure to other ototoxic agents were analyzed. RESULTS: Twenty-eight patients were included, with a mean age of 7.2 years at the beginning of chemotherapy (range 5 months-15 years 2 months); twenty-one patients received cisplatin, four received carboplatin, and three received both agents. Twelve patients had cranial irradiation and seven received another ototoxic medication. The most frequent malignancies were germ cell tumors, medulloblastoma and gliomas. Sensorineural hearing loss occurred in 28.6% of the patients with a mean follow-up period of 21.5 months (range: 1-53 months). All patients evaluated with audiometry had ≥ Chang 2b ototoxicity. Risk factors include age less than 5 years, cranial irradiation, and cisplatin cumulative dose greater than 400 mg/m CONCLUSION: Sensorineural hearing loss is a potential side effect of platinum-based chemotherapy. Pediatric patients receiving cisplatin chemotherapy with a cumulative dose exceeding 400 mg/m

18 Article [A medical biography of Ludwig van Beethoven]. 2018

Miranda, Marcelo. ·Clínica Las Condes, Santiago, Chile. ·Rev Med Chil · Pubmed #29806682.

ABSTRACT: Much emphasis has been given to the deafness of Ludwig van Beethoven and its potential causes. However, when analyzing several symptoms reported by himself throughout his life in many letters and his final illness, a common etiology emerges. This article reports the medical history of this artist, based on authoritative scientific sources.

19 Article Active Transcutaneous Bone Conduction Implant: Middle Fossa Placement Technique in Children With Bilateral Microtia and External Auditory Canal Atresia. 2018

Der, Carolina / Bravo-Torres, Sofía / Pons, Nicolás. ·Otorhinolaryngology Department, Dr. Luis Calvo Mackenna Children's Hospital. · School of Medicine, Clínica Alemana Universidad del Desarrollo. · School of Rehabilitation Sciences, Universidad Andrés Bello. · Hospital del Salvador, Universidad de Chile, Dr. Luis Calvo Mackenna Children's Hospital, Santiago, Chile. ·Otol Neurotol · Pubmed #29664868.

ABSTRACT: AIM: The aim of this study is to present the middle fossa technique (MFT) as an alternative for patients who cannot undergo traditional surgery for active transcutaneous bone conduction implants (ATBCI) due to their altered anatomy or desire for future aesthetic reconstruction. DESIGN: A case series descriptive study was designed. The MFT was developed. Preoperative and postoperative information from 24 patients with external auditory canal atresia (EACA) and implanted with ATBCI was reviewed. RESULTS: A total of 24 children with bilateral EACA received implants in the middle cranial fossa. Their average age was 12. Of these patients, eight had an associated congenital disorder: Goldenhar Syndrome, Treacher Collins Syndrome or the Pierre Robin Sequence. The average follow-up was at 17 months (ranging from between 2- and 36 mo) and there were no major complications. Four patients showed skin erythema at the processor site after turn on, which was solved by lowering the magnet strength. One patient had a scalp hematoma that required puncture drainage. The hearing thresholds went down on average from 66.5 to 25.2 dB 1 month after turn on. Speech recognition improved respectively from 29.4% without and 78.9% with a bone conduction hearing aid to 96.4%. CONCLUSION: MFT placement of the ATBCI was proven to be safe and effective and a viable option for treating pediatric patients with EACA who cannot receive implants at the sinodural angle or in the retrosigmoidal position because of their altered anatomy and/or desire for future aesthetic reconstruction.

20 Article The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels. 2018

García, Isaac E / Villanelo, Felipe / Contreras, Gustavo F / Pupo, Amaury / Pinto, Bernardo I / Contreras, Jorge E / Pérez-Acle, Tomás / Alvarez, Osvaldo / Latorre, Ramon / Martínez, Agustín D / González, Carlos. ·Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile. · Laboratory of Molecular Physiology and Biophysics, Facultad de Odontología, Universidad de Valparaíso, Valparaíso, Chile. · Computational Biology Laboratory, Fundación Ciencia & Vida, Santiago, Chile. · Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ. · Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile. · Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile ramon.latorre@uv.cl. · Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile agustin.martinez@uv.cl. ·J Gen Physiol · Pubmed #29643172.

ABSTRACT: Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, we investigate the biophysical properties of the syndromic mutant Cx26G12R (G12R). Unlike wild-type Cx26, G12R macroscopic hemichannel currents do not saturate upon depolarization, and deactivation is faster during hyperpolarization, suggesting that these channels have impaired fast and slow gating. Single G12R hemichannels show a large increase in open probability, and transitions to the subconductance state are rare and short-lived, demonstrating an inoperative fast gating mechanism. Molecular dynamics simulations indicate that G12R causes a displacement of the N terminus toward the cytoplasm, favoring an interaction between R12 in the N terminus and R99 in the intracellular loop. Disruption of this interaction recovers the fast and slow voltage-dependent gating mechanisms. These results suggest that the mechanisms of fast and slow gating in connexin hemichannels are coupled and provide a molecular mechanism for the gain-of-function phenotype displayed by the syndromic G12R mutation.

21 Article Are diuretics effective for Ménière`s disease? 2018

Rosenbaum, Andrés / Winter, Matías. ·Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. · Proyecto Epistemonikos, Santiago, Chile; Departamento de Otorrinolaringología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: mwinterd@gmail.com. Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Centro de Innovación UC Anacleto Angelini, Avda. Vicuña Mackenna 4860, Macul, Santiago, Chile. ·Medwave · Pubmed #29624570.

ABSTRACT: INTRODUCTION: Ménière`s disease is an inner ear disorder characterized by episodes of spontaneous vertigo, fluctuating hearing loss and tinnitus. Diuretics have been widely used for the treatment of attacks, but there is controversy about their effectiveness. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. RESULTS AND CONCLUSIONS: We identified three systematic reviews including nineteen studies overall, of which four were randomized trials. We concluded it is not clear whether diuretics lead to a symptomatic improvement of vertigo or an objective decrease in hearing loss in patients with Ménière`s disease, because the certainty of the evidence is very low.

22 Article Long term platinum-induced ototoxicity in pediatric patients. 2018

Waissbluth, Sofia / Chuang, Angela / Del Valle, Álvaro / Cordova, Marcela. ·Department of Otolaryngology, Complejo Asistencial Dr. Sotero Del Rio, Santiago, Chile. Electronic address: sofia.waissbluth@mail.mcgill.ca. · Department of Otolaryngology, Complejo Asistencial Dr. Sotero Del Rio, Santiago, Chile. · Department of Pediatric Hematology-Oncology, Complejo Asistencial Dr. Sotero Del Rio, Santiago, Chile. ·Int J Pediatr Otorhinolaryngol · Pubmed #29501316.

ABSTRACT: OBJECTIVES: Platinum-based chemotherapy treatments are effective against a variety of pediatric malignancies. However, its use can lead to permanent hearing loss. The aim of this study was to evaluate the long-term effect of platinum chemotherapy on hearing and evaluate its progression. METHODS: Prospective cohort study. All records of pediatric patients receiving platinum-based chemotherapy between 2001 and 2006 were reviewed. Demographics and audiograms performed before, during, and following chemotherapy were analyzed. An updated audiogram and a video head impulse test were performed. A hearing ability questionnaire was also completed. RESULTS: Thirty-nine patients met the inclusion criteria. Of these, 12 patients were included in the study; 14 were deceased, 8 had incomplete data and 5 were excluded for other reasons. Median age at chemotherapy was 4.3 years (range 10 months-14.2 years). Seven patients had received cisplatin, two received carboplatin and three received both agents. Five had also received cranial irradiation. With a median follow-up time of 11.9 years, 58.3% had developed hearing loss and two patients wore bilateral hearing aids; 67% of the patients with hearing loss had worsening of their hearing in the long-term. All patients referred difficulties in various subscales measured by the questionnaire. Three patients had decreased vestibulo-ocular reflex gains. CONCLUSION: Platinum-induced hearing loss in pediatric patients can be progressive and debilitating. A long term audiometric follow-up of at least 10 years is suggested for these patients.

23 Article Acute Deafness: A Rare Complication of Shunting. 2018

Martinez-Perez, Rafael / Montivero, Agustin / Rayo, Natalia / Ramirez, Marco / Naudy, Cristian / Mura, Jorge. ·Division of Skull Base and Vascular Neurosurgery, National Institute of Neurosurgery Dr Asenjo, Universidad de Chile, Santiago, Chile; Department of Neurosurgery, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain. Electronic address: rafa11safin@hotmail.com. · Division of Skull Base and Vascular Neurosurgery, National Institute of Neurosurgery Dr Asenjo, Universidad de Chile, Santiago, Chile. · Western University, London, Ontario, Canada. ·World Neurosurg · Pubmed #29477699.

ABSTRACT: BACKGROUND: Mild hearing loss following shunting has been described; however, severe auditory impairment associated with ventriculoperitoneal (VP) shunt is an uncommon, rarely reported phenomenon. Treatment options and pathophysiologic considerations are discussed in this case report. CASE DESCRIPTION: A 27-year-old man who was treated for an eighth cranial nerve schwannoma with complete resection and a VP shunt 10 years previously presented to the emergency department with acute severe hearing loss and headache. Imaging showed diminished size of the ventricles and dural contrast enhancement. The previous shunt was replaced with a programmable antisiphoning VP shunt. The patient's hearing and headache improved 48 hours later, as demonstrated in serial audiograms. CONCLUSIONS: Hearing loss is an underestimated complication of shunting that in some cases may progress to severe impairment and deafness. Patients with a VP shunt who experience hearing loss should undergo further evaluation and possibly adjustment of shunt settings.

24 Article Active transcutaneous bone conduction implant: audiological results in paediatric patients with bilateral microtia associated with external auditory canal atresia. 2018

Bravo-Torres, Sofía / Der-Mussa, Carolina / Fuentes-López, Eduardo. ·a Unidad de Otorrinolaringologia, Servicio de Cirugia , Hospital Dr. Luis Calvo Mackenna , Santiago , Chile. · b Carrera de Fonoaudiologia , Facultad de Ciencias de la Rehabilitacion, Universidad Andres Bello , Santiago , Chile. · c Clinica Alemana de Santiago , Facultad de Medicina Universidad del Desarrollo , Santiago , Chile. · d Programa de Doctorado en Salud Pública, Escuela de Salud Pública , Universidad de Chile , Santiago , Chile , and. · e Carrera de Fonoaudiología, Departamento de Ciencias de la Salud, Facultad de Medicina , Pontificia Universidad Católica de Chile , Santiago , Chile. ·Int J Audiol · Pubmed #28857620.

ABSTRACT: OBJECTIVE: To describe, in terms of functional gain and word recognition, the audiological results of patients under 18 years of age implanted with the active bone conduction implant, Bonebridge™. DESIGN: Retrospective case studies conducted by reviewing the medical records of patients receiving implants between 2014 and 2016 in the public health sector in Chile. STUDY SAMPLE: All patients implanted with the Bonebridge were included (N = 15). Individuals who had bilateral conductive hearing loss, secondary to external ear malformations, were considered as candidates. RESULTS: The average hearing threshold one month after switch on was 25.2 dB (95%CI 23.5-26.9). Hearing thresholds between 0.5 and 4 kHz were better when compared with bone conduction hearing aids. Best performance was observed at 4 kHz, where improvements to hearing were observed throughout the adaptation process. There was evidence of a significant increase in the recognition of monosyllables. CONCLUSIONS: The Bonebridge implant showed improvements to hearing thresholds and word recognition in paediatric patients with congenital conductive hearing loss.

25 Article Prevalence and associated factors of hearing aid use among older adults in Chile. 2017

Fuentes-López, Eduardo / Fuente, Adrian / Cardemil, Felipe / Valdivia, Gonzalo / Albala, Cecilia. ·a Doctorado en Salud Pública, Escuela de Salud Pública , Universidad de Chile , Santiago , Chile. · b Facultad de Medicina, UDA Ciencias de la Salud, Carrera de Fonoaudiología , Pontificia Universidad Católica de Chile , Santiago , Chile. · c École d'Orthophonie et d'Audiologie, Faculté de Médecine , Université de Montréal , Montréal , Canada. · d Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal , Montréal , Canada. · e Servicio de Otorrinolaringología , Hospital San Juan de Dios - Universidad de Chile , Santiago , Chile. · f Departamento de Otorrinolaringología , Clínica Las Condes , Santiago , Chile. · g Departamento de Salud Pública, Facultad de Medicina , Pontificia Universidad Católica de Chile , Santiago , Chile , and. · h Instituto de Nutrición y Tecnología de los Alimentos , Universidad de Chile , Santiago , Chile. ·Int J Audiol · Pubmed #28639872.

ABSTRACT: OBJECTIVE: The aim of this study was to determine the prevalence of use of hearing aids by older adults in Chile and the influence of some variables such as education level, income level and geographic area of residence on the prevalence of hearing aids. DESIGN: A national cross-sectional survey which was carried out in 2009. STUDY SAMPLE: A representative sample of 4766 Chilean older adults aged 60 years and above. RESULTS: The percentage of older adults in Chile who self-reported hearing problems and used hearing aids was 8.9%. Such prevalence increased for adults living in urban areas and for those who knew about the new Chilean programme of universal access to health services (AUGE). For older adults who did not know about this programme, significant associations between the use of hearing aids and the variables of age, geographic area of residence, and income level were found. CONCLUSIONS: People's knowledge about AUGE programme may positively influence the use of hearing aids, although a direct effect cannot be attributed.

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