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Hearing Disorders: HELP
Articles by Yue Zhang
Based on 7 articles published since 2010
(Why 7 articles?)
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Between 2010 and 2020, Yue Zhang wrote the following 7 articles about Hearing Disorders.
 
+ Citations + Abstracts
1 Article Shape-appearance constrained segmentation and separation of vein and artery in pulsatile tinnitus patients based on MR angiography and flow MRI. 2019

Wang, Yan / Kao, Evan / Zhang, Yue / Tian, Bing / Gong, Jingshan / Faraji, Farshid / Haraldsson, Henrik / Amans, Matthew R / Saloner, David / Liu, Jing. ·Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, United States. · Department of Surgery, University of California San Francisco, CA, United States; Veteran Affairs Medical Center, San Francisco, CA, United States. · Department of Radiology, Changhai Hospital of Shanghai, Shanghai, China. Electronic address: bing.tian@hotmail.com. · Department of Radiology, Shenzhen People's Hospital, Shenzhen, China. · Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, United States; Veteran Affairs Medical Center, San Francisco, CA, United States. ·Magn Reson Imaging · Pubmed #31163188.

ABSTRACT: This study reports on the development and evaluation of a novel segmentation method for extracting the internal jugular vein and the adjacent carotid artery from magnetic resonance (MR) images of patients with pulsatile tinnitus. A narrow band level set method with combined shape and appearance constraints was developed and applied to high-resolution MR images from 17 pulsatile tinnitus patients (age 52 ± 23 years, 10 females). The proposed method was validated by comparing with the manual segmentation as well as by identifying the jugular vein and carotid artery based on 4D flow MRI in which the two types of vessels have opposing flow. Our study showed that the vein and artery are in contact with each other on 30.2% of all the slices. Dice value, Peak signal-to-noise ratio (PSNR), Hausdorff distance and mean sum of square distance (MSSD) between automatic and manual segmentation were 89.13 ± 2.84%, 27.36 ± 2.39%, 17.2 ± 6.9 mm, 7.4 ± 5.5 mm, demonstrating good segmentation accuracy. The average Dice similarity coefficient and the coefficient of variation compared with 4D flow MRI was 91.42 ± 1.63% and 89.28 ± 4.54% for the internal jugular vein and the carotid artery. The present pipeline for automatic internal jugular vein quantification holds promise for efficient image interpretation in large-scale cohort studies.

2 Article Degeneration of saccular hair cells caused by MITF gene mutation. 2019

Du, Yi / Ren, Li-Li / Jiang, Qing-Qing / Liu, Xing-Jian / Ji, Fei / Zhang, Yue / Yuan, Shuo-Long / Wu, Zi-Ming / Guo, Wei-Wei / Yang, Shi-Ming. ·Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Key Laboratory of Hearing Impairment Science, Chinese PLA Medical School, Beijng, China. · Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Key Laboratory of Hearing Impairment Science, Chinese PLA Medical School, Beijng, China. zimingwu@126.com. · Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Key Laboratory of Hearing Impairment Science, Chinese PLA Medical School, Beijng, China. gwent001@163.com. · Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Key Laboratory of Hearing Impairment Science, Chinese PLA Medical School, Beijng, China. shm_yang@163.com. ·Neural Dev · Pubmed #30635004.

ABSTRACT: BACKGROUND: Waardenburg syndrome (WS) is the consequence of an inherited autosomal dominant mutation which causes the early degeneration of intermediate cells of cochlear stria vascularis (SV) and profound hearing loss. Patients with WS may also experience primary vestibular symptoms. Most of the current WS studies did not discuss the relationship between WS and abnormal vestibular function. Our study found that a spontaneous mutant pig showed profound hearing loss and depigmentation. MITF-M, a common gene mutation causes type WS which affect the development of the intermediate cell of SV, was then identified for animal modeling. RESULTS: In this study, the degeneration of vestibular hair cells was found in pigs with MITF-M. The morphology of hair cells in vestibular organs of pigs was examined using electron microscopy from embryonic day E70 to postnatal two weeks. Significant hair cell loss in the mutant saccule was found in this study through E95 to P14. Conversely, there was no hair cell loss in either utricle or semi-circular canals. CONCLUSIONS: Our study suggested that MITF-M gene mutation only affects hair cells of the saccule, but has no effect on other vestibular organs. The study also indicated that the survival of cochlear and saccular hair cells was dependent on the potassium release from the cochlear SV, but hair cells of the utricle and semi-circular canals were independent on SV.

3 Article Adeno-associated virus transformation into the normal miniature pig and the normal guinea pigs cochlea via scala tympani. 2017

Shi, Xunbei / Wu, Nan / Zhang, Yue / Guo, Weiwei / Lin, Chang / Yang, Shiming. ·a Department of Otolaryngology , Affiliated First Hospital, Fujian Medical University , Fuzhou , P.R. China. · b Department of Otolaryngology, Head and Neck Surgery , Institute of Otolaryngology of PLA, Chinese PLA General Hospital , Beijing , P.R. China. ·Acta Otolaryngol · Pubmed #28471702.

ABSTRACT: OBJECTIVE: To investigate the expression of the miniature pig cochlea after AAV1 transfect into the cochlea via round window membrane (RWM). METHODS: Twenty miniature pigs are equally divided into four experimental groups. Twelve miniature pigs are equally divided into four control groups. Each pig was transfected with the AAV1 in the experimental group via RWM and each pig was transduced with the artificial perilymph in the control group. The expression of green fluorescent protein (GFP) was observed at 2 weeks, 3 weeks and 4 weeks, respectively. Likewise, AAV1 was delivered into the guinea pigs cochleas using the same method, and the results were compared with that of the miniature pigs. RESULTS: The expression was mainly in the inner hair cells of the miniature pig. The expression of GFP began to appear at 2 weeks, reached the peak at 3 weeks. It also expressed in Hensen's cells, inner pillar cells, outer pillar cells, spiral limbus, and spiral ligament. In the meanwhile, AAV1 was delivered into guinea pig cochlea via the same method, and AAV1 was also expressed in the inner hair cells. But the expression peaked at 2 weeks, and the efficiency of the inner hair cell transfection was higher than that of the pig. CONCLUSION: AAV1 can be transformed into miniature pig cochlea via scala tympani by the RWM method efficiently.

4 Article A de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs. 2016

Chen, Lei / Guo, Weiwei / Ren, Lili / Yang, Mingyao / Zhao, Yaofeng / Guo, Zongyi / Yi, Haijin / Li, Mingzhou / Hu, Yiqing / Long, Xi / Sun, Boyuan / Li, Jinxiu / Zhai, Suoqiang / Zhang, Tinghuan / Tian, Shilin / Meng, Qingyong / Yu, Ning / Zhu, Dan / Tang, Guoqing / Tang, Qianzi / Ren, Liming / Liu, Ke / Zhang, Shihua / Che, Tiandong / Yu, Zhengquan / Wu, Nan / Jing, Lan / Zhang, Ran / Cong, Tao / Chen, Siqing / Zhao, Yiqiang / Zhang, Yue / Bai, Xiaoqing / Guo, Ying / Zhao, Lidong / Zhang, Fengming / Zhao, Hui / Zhang, Liang / Hou, Zhaohui / Zhao, Jiugang / Li, Jianan / Zhang, Lijuan / Sun, Wei / Zou, Xiangang / Wang, Tao / Ge, Liangpeng / Liu, Zuohua / Hu, Xiaoxiang / Wang, Jingyong / Yang, Shiming / Li, Ning. ·State Key Laboratory for Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China. · Key Laboratory of Pig Industry Sciences (Ministry of Agriculture), Chongqing Academy of Animal Science, Chongqing, 402460, China. · Department of Otolaryngology, Head & Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, 100853, China. · Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, 625014, China. · Department of Communicative Disorders and Sciences, Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York, USA. · Key Laboratory of Pig Industry Sciences (Ministry of Agriculture), Chongqing Academy of Animal Science, Chongqing, 402460, China. kingyou@vip.sina.com. · Department of Otolaryngology, Head & Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, 100853, China. yangsm301@263.net. · State Key Laboratory for Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China. ninglcau@cau.edu.cn. ·BMC Biol · Pubmed #27349893.

ABSTRACT: BACKGROUND: Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation of novel cis-regulatory elements (CREs) is much rarer than genomic events that alter existing CREs such as transposition, promoter switching or co-option. Only one case of de novo generation has been reported to date, in fish and without involvement of phenotype alteration. Yet, this event likely occurs in other animals and helps drive genetic/phenotypic variation. RESULTS: Using a porcine model of spontaneous hearing loss not previously characterized we performed gene mapping and mutation screening to determine the genetic foundation of the phenotype. We identified a mutation in the non-regulatory region of the melanocyte-specific promoter of microphthalmia-associated transcription factor (MITF) gene that generated a novel silencer. The consequent elimination of expression of the MITF-M isoform led to early degeneration of the intermediate cells of the cochlear stria vascularis and profound hearing loss, as well as depigmentation, all of which resemble the typical phenotype of Waardenburg syndrome in humans. The mutation exclusively affected MITF-M and no other isoforms. The essential function of Mitf-m in hearing development was further validated using a knock-out mouse model. CONCLUSIONS: Elimination of the MITF-M isoform alone is sufficient to cause deafness and depigmentation. To our knowledge, this study provides the first evidence of a de novo CRE in mammals that produces a systemic functional effect.

5 Article Inner hair cell ribbon synapse plasticity might be molecular basis of temporary hearing threshold shifts in mice. 2015

Wang, Haolin / Zhao, Ning / Yan, Kaisheng / Liu, Xiuli / Zhang, Yue / Hong, Zhijun / Wang, Mingyu / Yin, Qing / Wu, Feifeng / Lei, Yu / Li, Xiaoyan / Shi, Lin / Liu, Ke. ·Department of Otorhinolaryngology, The First Affiliated Hospital, Dalian Medical University Dalian 116013, China. · Department of Otorhinolaryngology, The First Affiliated Hospital, China Medical University Shenyang 110001, China. · Department of Otolaryngology, Head & Neck Surgery, The Institute of Otolaryngology, Chinese PLA General Hospital 28 Fuxing Road, BeiJing, 100853, China. ·Int J Clin Exp Pathol · Pubmed #26339457.

ABSTRACT: Recent studies have reported that noise exposure at relatively low intensities can cause temporary threshold shifts (TTS) in hearing. However, the mechanism underlying the TTS is still on debate. Here, we report that an acoustic stimulation (100 dB SPL, white noise) induced TTS in mice, with the maximal ABR threshold elevations seen on the 4(th) day after noise exposure. On the other hand, there were no significant morphological changes in the cochlea. Further, there were paralleled changes of pre-synaptic ribbons in both the number and postsynaptic density (PSDs) during this noise exposure. The numbers of presynaptic ribbon, postsynaptic density (PSDs), and colocalized puncta correlated with the shifts of ABR thresholds. Moreover, a complete recovery of ABR thresholds and synaptic puncta was seen on the 14(th) day after the noise stimulations. Thus, our study may indicate that noise exposure can cause a decline in cochlear ribbon synapses and result in consequent hearing loss. The reduction of synaptic puncta appears reversible and may contribute to hearing restoration in mice after noise exposure.

6 Article Noise induced reversible changes of cochlear ribbon synapses contribute to temporary hearing loss in mice. 2015

Shi, Lin / Liu, Ke / Wang, Haolin / Zhang, Yue / Hong, Zhijun / Wang, Mingyu / Wang, Xiaoyu / Jiang, Xuejun / Yang, Shiming. ·a 1 Department of Otorhinolaryngology, The First Affiliated Hospital, China Medical University , Shenyang 110001, PR China. · c 3 Department of Otorhinolaryngology, The First Affiliated Hospital, Dalian Medical University , Dalian 116013, PR China. · b 2 Department of Otolaryngology, Head & Neck Surgery, The Institute of Otolaryngology, Chinese PLA General Hospital , 28 Fuxing Road, Beijing, 100853, PR China. ·Acta Otolaryngol · Pubmed #26139555.

ABSTRACT: CONCLUSION: Noise exposure can cause a decline in cochlear ribbon synapses and result in consequent hearing loss. The reduction of synaptic puncta appears reversible and may contribute to hearing restoration in mice after noise exposure. OBJECTIVE: To detect whether noise induced reversible changes of cochlear ribbon synapses contribute to temporary hearing loss in C57BL/6J mice. METHODS: The mice were assigned randomly to five groups and exposed to white noise at 110 dB SPL for 2 h except the control group. ABR thresholds were acquired before noise exposure (control), immediately following exposure (Day 0), or on Days 4, 7, or 14 after noise exposure. Light microscopy, scanning emission microscopy, and whole mounts examination was utilized to study whether there is morphology change of outer hair cells (OHC), inner hair cells (IHC), or spiral ganglion cells (SGN) due to the 110 dB white noise. Moreover, experimental approaches, including immunostaining and confocal microcopy, were used to detect whether ribbon synapses were the primary targets of noise-induced temporary hearing loss. RESULT: Exposure to 110 dB white noise for 2 h induced TTS in mice, with the maximal ABR threshold elevations seen on the 4(th) day after noise exposure. There were no significant morphological changes in the cochlea. Paralleled changes of pre-synaptic ribbons in both the number and post-synaptic density (PSDs) during this noise exposure were detected. The number of pre-synaptic ribbon, post-synaptic density (PSDs), and co-localized puncta correlated with the shifts of ABR thresholds. Moreover, a complete recovery of ABR thresholds and synaptic puncta was seen on the 14(th) day after the noise stimulations.

7 Article Chinese deaf and hard of hearing adolescents' awareness of thematic and taxonomic relations among ordinary concepts represented by pictures and written words. 2012

Li, Degao / Gao, Kejuan / Zhang, Yue / Wu, Xueyun. ·School of International Studies, Zhejiang University, Hangzhou, China. ·Am Ann Deaf · Pubmed #22524093.

ABSTRACT: Inspired by a previous study of Korean deaf and hard of hearing adolescents, the researchers conducted a priming task of living-nonliving categorization with a sample of Chinese deaf and hard of hearing adolescents. The sample in this study had significantly lower accuracy levels for the thematically related items than for the taxonomically related items and significantly larger differences in reaction times than a group of hearing adolescents when stimuli were changed from pictures to written words. However, they were not significantly different from the hearing adolescents in their performance with the taxonomically related written words. Furthermore, unlike the hearing adolescents, they did not have significantly different reaction times as the result of changes in positions of stimulus presentations.