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Hearing Disorders: HELP
Articles by Hideyuki Saito
Based on 16 articles published since 2009
(Why 16 articles?)
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Between 2009 and 2019, Hideyuki Saito wrote the following 16 articles about Hearing Disorders.
 
+ Citations + Abstracts
1 Article Effects of tinnitus treatments on sleep disorders in patients with tinnitus. 2018

Wakabayashi, Satoko / Saito, Hideyuki / Oishi, Naoki / Shinden, Seiichi / Ogawa, Kaoru. ·a Department of Otolaryngology-Head and Neck Surgery , Keio University School of Medicine , Tokyo , Japan. ·Int J Audiol · Pubmed #28906162.

ABSTRACT: OBJECTIVE: To assess the effects of tinnitus treatments on sleep disorders in patients with tinnitus. DESIGN: Subjects completed the Pittsburg Sleep Quality Index (PSQI), Tinnitus Handicap Inventory (THI), Self-rating Depression Scale (SDS), and State Trait Anxiety Inventory (STAI). The questionnaire results and the patients' sex, age, time since the onset of tinnitus, and mean hearing level were examined, and differences between a sleep disorder group and a normal sleep group were examined. Patients completed the questionnaires again after initiating tinnitus treatments (counselling and use of sound generators), and the change in questionnaire scores at follow-up was evaluated. STUDY SAMPLE: Patients (N = 100) with tinnitus who visited Keio University Hospital and started treatment without medication between 2005 and 2008. RESULTS: Sixty-six percent of the patients had sleep disorders. Compared with patients without sleep disorders, patients with sleep disorders had significantly higher SDS and STAI scores at the first visit. The mean PSQI scores showed significant improvement at follow-up. CONCLUSIONS: Sleep disorders in patients with tinnitus improved after tinnitus treatments. Complex interactions between depressive symptoms and anxiety may occur in these patients. The improvement in sleep disorders at follow-up was correlated with improvements in tinnitus severity and state anxiety.

2 Article Markers of Overall Nutritional Status and Incident Hearing Impairment in Community-Dwelling Older Japanese: The Kurabuchi Study. 2016

Michikawa, Takehiro / Nakamura, Takahiro / Imamura, Haruhiko / Mizutari, Kunio / Saito, Hideyuki / Takebayashi, Toru / Nishiwaki, Yuji. ·Environmental Epidemiology Section, Centre for Environmental Health Sciences, National Institute for Environmental Studies, Tsukuba, Japan. · Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan. · Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo, Japan. · Department of Otolaryngology, Head and Neck Surgery, National Defense Medical College, Saitama, Japan. · Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Keio University, Tokyo, Japan. ·J Am Geriatr Soc · Pubmed #27310369.

ABSTRACT: OBJECTIVES: To examine the association between four markers of overall nutritional status (a serum biomarker (albumin) and three anthropometric indices (body mass index (BMI), midarm circumference (MAC), calf circumference (CC))) and incident hearing impairment in older Japanese adults. DESIGN: Community-based prospective cohort study. SETTING: Kurabuchi Town, Gunma Prefecture, Japan. PARTICIPANTS: Individuals aged 65 and older (143 men, 195 women) without hearing impairment at baseline examination (2005-06) who participated in repeated examinations 4 years later (2009-10) (N = 338). MEASUREMENTS: The three anthropometric indices were measured at baseline, and nephelometry was used to assess serum albumin levels. Hearing impairment was defined as failure to hear a 30-dB hearing level signal at 1 kHz and a 40-dB signal at 4 kHz in the better ear on pure-tone audiometry. RESULTS: Over the 4-year period, 16.3% of participants developed hearing impairment. Those with lower marker values had greater risk of hearing impairment than those with higher marker values (multivariable adjusted odds ratio (aOR) = 2.18, 95% confidence interval (CI) = 1.05-4.57 for albumin ≤4.0 g/dL; aOR = 2.72, 95% CI = 1.10-6.71 for BMI <19.0 kg/m(2) ). The pattern of association showed a similar tendency for MAC and CC. Excluding obese participants did not changed the results substantially. CONCLUSION: Further research is needed to determine whether interventions that improve markers of nutritional status may help prevent age-related hearing loss in older adults.

3 Article Glycosylated hemoglobin level is associated with hearing impairment in older Japanese: the Kurabuchi Study. 2014

Michikawa, Takehiro / Mizutari, Kunio / Saito, Hideyuki / Takebayashi, Toru / Nishiwaki, Yuji. · ·J Am Geriatr Soc · Pubmed #25039656.

ABSTRACT: OBJECTIVES: To examine the association between glycemic levels (glycosylated hemoglobin (HbA1c)) and hearing impairment in a general older population. DESIGN: Community-based prospective longitudinal cohort study. SETTING: Kurabuchi Town, Gunma Prefecture, Japan. PARTICIPANTS: Residents (N = 831; 350 men, 481 women) aged 65 and older were examined in 2005 and 2006 and analyzed in a cross-sectional study. Residents without hearing impairment at baseline who participated in audiometric re-examinations 4 years later were analyzed (n = 338). MEASUREMENTS: Hearing impairment was defined as failure to hear a 30-dB signal at 1 kHz and a 40-dB signal at 4 kHz in the better ear in pure-tone audiometric tests. RESULTS: Mean HbA1c level (National Glycohemoglobin Standardization Program) was 5.8 ± 0.8% (40 mmol/mol). Odds ratios (ORs) and 95% confidence intervals (CIs) of hearing impairment associated with HbA1c were estimated using a logistic regression model. In the cross-sectional analysis, HbA1c levels were positively associated with hearing impairment (OR per 1.0% increase in HbA1c = 1.30, 95% CI = 1.00-1.68). This association persisted even after excluding 58 participants with a self-reported history of diagnosed diabetes mellitus. Longitudinal analysis revealed the temporality of the discussed association (OR = 1.52, 95% CI = 1.03-2.23). CONCLUSION: The present study provides supportive evidence for a causal link between hyperglycemia and age-related hearing loss.

4 Article Age-related hearing loss and the factors determining continued usage of hearing aids among elderly community-dwelling residents. 2013

Mizutari, Kunio / Michikawa, Takehiro / Saito, Hideyuki / Okamoto, Yasuhide / Enomoto, Chieko / Takebayashi, Toru / Ogawa, Kaoru / Nishiwaki, Yuji. ·Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan ; Division of Otolaryngology, National Center for Child Health and Development, Tokyo, Japan. ·PLoS One · Pubmed #24086287.

ABSTRACT: While hearing aids are recommended for people with age-related hearing loss, many with impaired hearing do not use them. In this study, we investigated how many elderly people in the study area needed hearing aids, and the factors that determined continued wearing of the devices. The study area was Kurabuchi Town, Japan, where 1,437 residents (those aged 65 years or over) were eligible for participation in the study; 1,414 participated, of whom, 103 (7.3%) were already using hearing aids at the start of the study. After the primary screening, hearing aids were lent to 68 participants (4.8%) who did not already have one, 38 of whom (60.3% of the borrowers, representing 2.7% of the total aged population) went on to wear the hearing aid continuously. The Hearing Handicap Inventory for the Elderly (HHIE) score was significantly elevated among these 38 participants. This study indicated that hearing aids are of potential benefit to many local residents. Multivariate logistic regression revealed that HHIE scores were associated with the extent of HA usage. The adjusted odds ratio for a 1-unit increase in HHIE score was 1.08 (95% confidence interval: 1.02-1.14). Programs like this, in which people with impaired hearing are identified at the local level and given appropriate assistance, are useful models for future use in societies with aging populations.

5 Article Tinnitus preceded depressive symptoms in community-dwelling older Japanese: a prospective cohort study. 2013

Michikawa, Takehiro / Nishiwaki, Yuji / Saito, Hideyuki / Mizutari, Kunio / Takebayashi, Toru. ·Environmental Epidemiology Section, Center for Environmental Health Sciences, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, Japan. tmichikawa@nies.go.jp ·Prev Med · Pubmed #23384472.

ABSTRACT: OBJECTIVE: Most studies of the association between tinnitus and depression have been cross-sectional, making it difficult to draw any conclusions about the directionality of the association. This study aimed to clarify whether tinnitus precedes the development of depressive symptoms in a general older population. METHODS: Residents of Kurabuchi Town, Gunma Prefecture, Japan (239 men, 296 women: ≥65years) without depressive symptoms were given health examinations in 2005-2006. Information on tinnitus was obtained via a questionnaire. Depressive symptoms were then assessed in a face-to-face home visit interviews carried out once in 2007 and once in 2008 according to the Geriatric Depression Scale 15-item version (GDS15). RESULTS: Among the men, the 2.5-year incidence of depressive symptoms (GDS15≥6) was higher in those with tinnitus than in those without (20.5% vs. 9.5%). In the multi-adjusted model, tinnitus was significantly associated with an increased risk of depressive symptoms (relative risk=2.07; 95% confidence interval=1.01-4.25). Among the women, no associations were found. CONCLUSION: In the present study, tinnitus was independently associated with the risk of depressive symptoms developing in men, but not in women. We believe primary care providers and public health staff should recognize tinnitus as a risk factor for depressive symptoms.

6 Article A psychometric validation of the Japanese versions of new questionnaires on tinnitus (THI-12, TRS, TRSw, TSS, and TSSw). 2013

Wasano, Koichiro / Kanzaki, Sho / Sakashita, Tetsushi / Takahashi, Mariko / Inoue, Yasuhiro / Saito, Hideyuki / Fujioka, Masato / Watabe, Takahisa / Watanabe, Reiko / Sunami, Kishiko / Kato, Shoko / Kabaya, Kayoko / Shinden, Seiichi / Ogawa, Kaoru. ·Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan. wasano@a5.keio.jp ·Acta Otolaryngol · Pubmed #23320814.

ABSTRACT: CONCLUSION: The Japanese version of the Tinnitus Handicap Inventory-12 (THI-12), Tinnitus Rating Scale (TRS), TRS 1-week version (TRSw), Tinnitus Severity Scale (TSS), and TSS 1-week version (TSSw), which were developed in this study, showed high reliability and validity, suggesting their usefulness in clinical practice. Based on the THI severity grades, we propose that the severity grades of THI-12 (draft) are categorized into four groups: 0-4 points, 5-9 points, 10-14 points, and 15-24 points. OBJECTIVES: We developed Japanese versions of new questionnaires for evaluating the level of psychological distress and difficulty in activities of daily living due to tinnitus, and performed their psychometric validation to determine the reliability and validity. The THI-12 is an assessment consisting of 12 items, each of which is rated on a 3-point scale that was created by reducing the number of questions from the 25 items of the THI. The TRS, TRSw, TSS, and TSSw, which were self-evaluation questionnaires of tinnitus on an 11-grade integer Likert scale from 0 to10 points, were used as additional instruments to assess tinnitus severity and distress. METHODS: The subjects were healthy adults, and patients with subjective tinnitus who were examined at the Otolaryngology Department of Keio University Hospital, Osaka City University Hospital, or Nagoya City University Hospital with a chief complaint of tinnitus between September 2010 and January 2011. In all, 38 healthy adult subjects and 113 patients with subjective tinnitus were included. We examined the reproducibility and the internal consistency for reliability. We also examined the relationship with the available scales (THI and Hospital Anxiety and Depression Scale, HADS) and group divergence for validity. RESULTS: The psychometric validation showed high reliability and validity of the THI-12, TRS, TRSw, TSS, and TSSw.

7 Article Effects of tinnitus retraining therapy involving monaural noise generators. 2013

Oishi, Naoki / Shinden, Seiichi / Kanzaki, Sho / Saito, Hideyuki / Inoue, Yasuhiro / Ogawa, Kaoru. ·Department of Otolaryngology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan. o-ishi@mub.biglobe.ne.jp ·Eur Arch Otorhinolaryngol · Pubmed #22331257.

ABSTRACT: The aim of this study was to assess how tinnitus retraining therapy (TRT) employing monaural noise generators (NGs) affects tinnitus patients. Ninety-five patients with chronic tinnitus were included in this study. All received directive counseling and monaural NGs without any other combination treatment. Effects were evaluated with the Tinnitus Handicap Inventory (THI) 6, 12, and 24 months after the start of treatment. Multiple regression analysis was used to evaluate factors associated with improvement of THI scores. We observed a significant improvement in the average THI scores, which ranged from 59 at baseline to 36 after 6 months and were stable up to 24 months. Severely distressed (SD) patients experienced more benefits from the therapy than moderately distressed (MD) patients. Multiple regression analysis revealed that the presence of transient anxiety symptoms, measured by the state section of the State Trait Anxiety Inventory at the beginning of treatment, were associated the most to a decline in THI scores in SD patients. Pure-tone average at three mid frequencies was a negatively contributing factor. Analysis of MD patients did not provide a good model. In conclusion, TRT employing monaural NGs was an effective intervention especially for SD patients, although plateau of the effects after 6 months may be indicative of limitation of applying NGs monoaurally. Reducing the patients' hearing handicap may reinforce the effects of TRT in SD patients. Additional evaluation and interventions for both SD and MD patients might be needed.

8 Article Influence of depressive symptoms, state anxiety, and pure-tone thresholds on the tinnitus handicap inventory in Japan. 2011

Oishi, Naoki / Shinden, Seiichi / Kanzaki, Sho / Saito, Hideyuki / Inoue, Yasuhiro / Ogawa, Kaoru. ·Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan. o-ishi@mub.biglobe.ne.jp ·Int J Audiol · Pubmed #21495790.

ABSTRACT: OBJECTIVE: To assess factors that contribute to Tinnitus Handicap Inventory (THI) scores in Japan. DESIGN: Case series with chart review. STUDY SAMPLE: Two hundred and eighty-five tinnitus patients at tertiary referral center, who completed the Japanese version of the THI, the Self-rating Depression Scale (SDS), and the State Trait Anxiety Inventory (STAI). RESULTS: In multiple regression analysis, the SDS score contributed the most to the THI score. The state section of the STAI score and pure tone average (PTA) at four high frequencies also contributed significantly, but to lesser degrees. The other following factors were not statistically significant: age, gender, time from the onset of tinnitus to the first clinical visit, PTA at three mid frequencies, and trait section of the STAI score. This model may account for approximately 45% of THI score variability. CONCLUSIONS: The THI scores may be influenced by depressive symptoms, state anxiety, and pure tone thresholds in Japan.

9 Article Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus. 2011

Minami, Shujiro B / Shinden, Seiichi / Okamoto, Yasuhide / Watada, Yukiko / Watabe, Takahisa / Oishi, Naoki / Kanzaki, Sho / Saito, Hideyuki / Inoue, Yasuhiro / Ogawa, Kaoru. ·National Institute of Sensory Organs, National Tokyo Medical Center, 2-5-1 Higashigaoka, Tokyo, Japan. shujirominami@mac.com ·Auris Nasus Larynx · Pubmed #20971587.

ABSTRACT: OBJECTIVE: There is compelling evidence that tinnitus is associated with functional alterations in the central nervous system. Repetitive transcranial magnetic stimulation (rTMS) is a potent tool for modifying neural activity at the stimulated area and at a distance along the functional anatomical connections. Depending on the stimulation parameters, cortical networks can be functionally disturbed or modulated in their activities. Low-frequency rTMS has been shown to result in a decrease in cortical excitability. The technique can alleviate tinnitus by modulating the excitability of neurons in the auditory cortex. We aimed to investigate the effects of low-frequency rTMS in patients and determine the factors that predict a beneficial outcome with rTMS treatment. METHODS: Sixteen patients (male 10, female 6) with chronic tinnitus underwent low-frequency (1Hz) rTMS (intensity: 110% motor threshold; number of stimuli: 1200) to the left auditory cortex. The treatment outcome was assessed with a visual analog scale (VAS) of loudness, annoyance and duration, loudness balance test, and tinnitus handicap inventory (THI). Therapeutic success was studied according to the patients' clinical characteristics. RESULTS: A significant reduction in the VAS (loudness and annoyance) occurred immediately after rTMS, with a gradual return to pretreatment levels after 7 days. The tinnitus patients with sudden deafness were significant resistant to rTMS treatment compared with those diagnosed with age-related hearing loss. CONCLUSION: These results support the potential of rTMS as a new therapeutic tool for the treatment of chronic tinnitus. Because this study was performed with a small sample size and showed high interindividual variability in treatment effects, further development of the technique is needed before it can be recommended for clinical applications.

10 Article Prevalence and factors associated with tinnitus: a community-based study of Japanese elders. 2010

Michikawa, Takehiro / Nishiwaki, Yuji / Kikuchi, Yuriko / Saito, Hideyuki / Mizutari, Kunio / Okamoto, Michiko / Takebayashi, Toru. ·Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan. ·J Epidemiol · Pubmed #20501961.

ABSTRACT: BACKGROUND: The prevalence of tinnitus is reported to be high in older Western populations, and several risk factors have been suggested. However, community-based evidence on prevalence is limited and, to our knowledge, there is no such information from older non-Western populations. The purpose of this study was to determine the prevalence and factors associated with tinnitus in community-dwelling Japanese elders. METHODS: In this community-based cross-sectional study, 1320 residents of Kurabuchi Town aged 65 years or older (584 men and 736 women; participation proportion = 98.7%) were interviewed at home in 2006, and information on tinnitus and factors associated with tinnitus was collected. We estimated the prevalence of tinnitus by age group and sex and used a logistic regression model to investigate associated factors. RESULTS: The prevalence of tinnitus was 18.6% (men: 18.0%; women: 19.0%); there were no statistically significant differences by age group or sex. Hearing difficulty, depressive mood, prescribed medication, past/current history of coronary heart disease, and knee joint pain requiring medical consultation were associated with tinnitus. CONCLUSIONS: These findings suggest that tinnitus is common in Japanese aged over 65 years. Because the factors associated with tinnitus in this cross-sectional study are potentially modifiable, they should be thoroughly investigated in a longitudinal study.

11 Article Long-term prognosis of low-frequency hearing loss and predictive factors for the 10-year outcome. 2010

Oishi, Naoki / Inoue, Yasuhiro / Saito, Hideyuki / Kanzaki, Sho / Kanzaki, Jin / Ogawa, Kaoru. ·Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan. o-ishi@mub.biglobe.ne.jp ·Otolaryngol Head Neck Surg · Pubmed #20304279.

ABSTRACT: OBJECTIVES: To determine the long-term prognosis of low-frequency hearing loss and predictive factors for the 10-year outcome of low-frequency hearing loss. STUDY DESIGN: Case series with chart review. SETTING: Tertiary referral center. SUBJECTS AND METHODS: From 1979 to 1998, 466 consecutive patients with low-frequency hearing loss received initial treatment at the Hearing and Tinnitus Clinic of Keio University Hospital. Of the 49 eligible patients, pure-tone threshold data obtained over a period of 10 years after onset of low-frequency hearing loss were available for analysis. To determine the progression of hearing loss, we analyzed audiometric pattern changes. We also examined how the following factors affected 10-year prognosis: sex, age, side of hearing loss, accompanying dizziness, pre-therapeutic hearing thresholds at low frequencies, initial therapy results, and fluctuation of hearing during the first year after onset. RESULTS: High- and pan-frequency hearing loss increased as time progressed. About half of the cases developed high- or pan-frequency hearing loss within 10 years of onset. Audiometric patterns measured at 10 years significantly correlated with those measured at one (r = 0.57), three (r = 0.73), and five years (r = 0.85). The 10-year prognosis significantly correlated with only two factors: initial therapy results (r = 0.49) and fluctuation of hearing during the first year (r = 0.43). CONCLUSIONS: About half of the cases in our study developed high- or pan-frequency hearing loss within 10 years of onset of low-frequency hearing loss. The initial therapy results and fluctuation of hearing during the first year may indicate the long-term prognosis of patients presenting with low-frequency hearing loss.

12 Article Hearing handicap predicts the development of depressive symptoms after 3 years in older community-dwelling Japanese. 2010

Saito, Hideyuki / Nishiwaki, Yuji / Michikawa, Takehiro / Kikuchi, Yuriko / Mizutari, Kunio / Takebayashi, Toru / Ogawa, Kaoru. ·Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Keio University, Tokyo, Japan. ·J Am Geriatr Soc · Pubmed #20002512.

ABSTRACT: OBJECTIVES: To examine the association between hearing handicap and depressive symptoms in older community-dwelling Japanese. DESIGN: Community-based cohort study. SETTING: Kurabuchi Town, Gunma Prefecture, Japan. PARTICIPANTS: Five hundred eighty residents (261 men, 319 women) aged 65 and older without depressive symptoms. MEASUREMENTS: In a baseline examination performed in 2005/06, participants answered the 10-item screening version of the Hearing Handicap Inventory for Elderly (HHIE-S). They were divided into two groups according to their scores: a group with no hearing handicap (HHIE-S scores of < or =8) and a hearing handicap group (HHIE-S scores of > or =10). The Geriatric Depression Scale was used to identify depressive symptoms in face-to-face home visit interviews conducted in 2008, and the association between hearing handicap and depressive symptoms was assessed using logistic regression. RESULTS: The incidence of depressive symptoms was 19.6% in the group with a hearing handicap and 8.0% in the group without a hearing handicap. When compared with the subjects without hearing handicap, subjects with a hearing handicap had a multiadjusted odds ratio of depressive symptoms of 2.45 (95% confidence interval=1.26-4.77). The association remained significant even when hearing impairment measured with pure-tone audiometry was added to the multiadjusted model. CONCLUSION: A hearing handicap can predict future depressive symptoms in older community-dwelling people.

13 Article Effects of selective serotonin reuptake inhibitor on treating tinnitus in patients stratified for presence of depression or anxiety. 2010

Oishi, Naoki / Kanzaki, Sho / Shinden, Seiichi / Saito, Hideyuki / Inoue, Yasuhiro / Ogawa, Kaoru. ·Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan. o-ishi@mub.biglobe.ne.jp ·Audiol Neurootol · Pubmed #19851065.

ABSTRACT: We evaluated the effects of a selective serotonin reuptake inhibitor, paroxetine, on treating tinnitus.Tinnitus patients stratified for the presence of depression and anxiety were studied retrospectively. Fifty-six patients were observed for more than 6 months. They were initially treated with paroxetine only at a dose of 10 mg/day for 2-4 weeks; thereafter, the dose was increased to 20 mg/day. Tinnitus distress was evaluated with the Tinnitus Handicap Inventory (THI) and with visual analog scales (VASs) for tinnitus loudness and annoyance. Depression and anxiety were measured with the Self-Rating Depression Scale (SDS) and the trait section of the State-Trait Anxiety Inventory (STAI). The patients were grouped according to their SDS and STAI scores, and each variable was compared at baseline and the 6-month follow-up. Changes among these variables were also examined to determine whether reduced tinnitus distress was related to the improvement of depression or anxiety. Patients with both depression and anxiety showed better results (decrease in THI, VASs, SDS and STAI scores) than patients with anxiety alone, or patients without depression and anxiety. In patients with depression and anxiety, changes in tinnitus variables and changes in depression and anxiety scores were strongly correlated. In other patients, however, changes in tinnitus variables and changes in depression and anxiety scores were not correlated. These results suggest that paroxetine is effective in treating distressed tinnitus patients with depression and anxiety by reducing their tinnitus severity as well as their depression and anxiety.

14 Article Burow's solution-induced acute sensorineural hearing loss: report of two cases. 2010

Oishi, Naoki / Inoue, Yasuhiro / Saito, Hideyuki / Ogawa, Kaoru. ·Department of Otolaryngology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan. o-ishi@mub.biglobe.ne.jp ·Auris Nasus Larynx · Pubmed #19850426.

ABSTRACT: This is the report of rare cases to show the potential ototoxicity of Burow's solution in clinical use. We encountered two cases of acute sensorineural hearing loss occurring after the administration of 8% Burow's solution (pH 2.93) into the tympanic cavities. Prior to treatment, both cases presented with tympanic membrane perforations in the posterior and inferior portions and a small amount of serous discharge. Fortunately, hearing loss recovered almost completely except for high tones within a few weeks. These two case reports demonstrate that the ototoxicity of Burow's solution should be considered when it is used to treat otitis media accompanied by tympanic membrane perforation.

15 Article Gender-specific associations of vision and hearing impairments with adverse health outcomes in older Japanese: a population-based cohort study. 2009

Michikawa, Takehiro / Nishiwaki, Yuji / Kikuchi, Yuriko / Nakano, Makiko / Iwasawa, Satoko / Asakura, Keiko / Milojevic, Ai / Mizutari, Kunio / Saito, Hideyuki / Ishida, Susumu / Okamura, Tomonori / Takebayashi, Toru. ·Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan. di065051@sc.itc.keio.ac.jp ·BMC Geriatr · Pubmed #19930597.

ABSTRACT: BACKGROUND: Several epidemiological studies have shown that self-reported vision and hearing impairments are associated with adverse health outcomes (AHOs) in older populations; however, few studies have used objective sensory measurements or investigated the role of gender in this association. Therefore, we examined the association of vision and hearing impairments (as measured by objective methods) with AHOs (dependence in activities of daily living or death), and whether this association differed by gender. METHODS: From 2005 to 2006, a total of 801 residents (337 men and 464 women) aged 65 years or older of Kurabuchi Town, Gunma, Japan, participated in a baseline examination that included vision and hearing assessments; they were followed up through September 2008. Vision impairment was defined as a corrected visual acuity of worse than 0.5 (logMAR = 0.3) in the better eye, and hearing impairment was defined as a failure to hear a 30 dB hearing level signal at 1 kHz in the better ear. Information on outcomes was obtained from the town hall and through face-to-face home visit interviews. We calculated the risk ratios (RRs) of AHOs for vision and hearing impairments according to gender. RESULTS: During a mean follow-up period of 3 years, 34 men (10.1%) and 52 women (11.3%) had AHOs. In both genders, vision impairment was related to an elevated risk of AHOs (multi-adjusted RR for men and women together = 1.60, 95% CI = 1.05-2.44), with no statistically significant interaction between the genders. In contrast, a significant association between hearing impairment and AHOs (multi-adjusted RR = 3.10, 95% CI = 1.43-6.72) was found only in the men. CONCLUSION: In this older Japanese population, sensory impairments were clearly associated with AHOs, and the association appeared to vary according to gender. Gender-specific associations between sensory impairments and AHOs warrant further investigation.

16 Article Serum levels of retinol and other antioxidants for hearing impairment among Japanese older adults. 2009

Michikawa, Takehiro / Nishiwaki, Yuji / Kikuchi, Yuriko / Hosoda, Kanae / Mizutari, Kunio / Saito, Hideyuki / Asakura, Keiko / Milojevic, Ai / Iwasawa, Satoko / Nakano, Makiko / Takebayashi, Toru. ·DMSc, Department of Preventive Medicine and Public Health, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. ·J Gerontol A Biol Sci Med Sci · Pubmed #19349590.

ABSTRACT: BACKGROUND: The objective of this study was to assess the relation between serum levels of retinol and other antioxidants and hearing impairment in Japanese older adults. METHODS: This is a community-based cross-sectional study comprising 762 residents aged 65 years or older in Kurabuchi, Gumma, Japan. We measured serum retinol and other antioxidants (alpha- and gamma-tocopherols, and carotenoids including beta-cryptoxanthin, alpha- and beta-carotenes, lycopene, and lutein plus zeaxanthin) by high-performance liquid chromatography and divided each measurement into quartiles. Hearing impairment was defined as a failure to hear a 30-dB hearing level (HL) signal at 1 kHz and a 40-dB HL signal at 4 kHz in the better ear in pure-tone audiometric tests. The odds ratios (OR) for hearing impairment were calculated for each of the upper three quartiles of retinol and other antioxidant levels relative to the lowest quartile. RESULTS: Crude analysis showed that serum levels of retinol and provitamin A carotenoids (beta-cryptoxanthin, and alpha- and beta-carotenes) were inversely related to the prevalence of hearing impairment. The multiadjusted ORs (95% confidence intervals) for the highest quartile of retinol and the provitamin A family (combinations of provitamin A carotenoids) compared with the lowest were 0.51 (0.26-1.00) and 0.53 (0.27-1.02), respectively. A dose-response relationship was observed for retinol (p = .03) and provitamin A (p = .09). CONCLUSION: Increased serum levels of retinol and provitamin A carotenoids were clearly associated with a decreased prevalence of hearing impairment.