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Hearing Disorders: HELP
Articles by Naoki Oishi
Based on 21 articles published since 2009
(Why 21 articles?)
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Between 2009 and 2019, N. Oishi wrote the following 21 articles about Hearing Disorders.
 
+ Citations + Abstracts
1 Review Ototoxicity in dogs and cats. 2012

Oishi, Naoki / Talaska, Andra E / Schacht, Jochen. ·Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, MI 48109-5616, USA. ·Vet Clin North Am Small Anim Pract · Pubmed #23122180.

ABSTRACT: A variety of drugs in veterinary use have side effects that can potentially damage the senses of hearing or balance in animals. A large body of literature exists on the incidence and mechanisms of ototoxicity in experimental animals and in humans, but little is documented in domestic dogs and cats. However, the generality of these adverse actions across species allows one to extrapolate and provide the veterinarian with insight into possible complications of chemotherapy.

2 Review Emerging treatments for noise-induced hearing loss. 2011

Oishi, Naoki / Schacht, Jochen. ·Kresge Hearing Research Institute, Medical Sciences Bldg I, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5616, USA. ·Expert Opin Emerg Drugs · Pubmed #21247358.

ABSTRACT: INTRODUCTION: Approximately 5% of the population worldwide suffers from industrial, military or recreational noise-induced hearing loss (NIHL) at a great economic cost and detriment to the quality of life of the affected individuals. This review discusses pharmacological strategies to attenuate NIHL that have been developed in animal models and that are now beginning to be tested in field trials. AREAS COVERED: The review describes the epidemiology, pathology and pathophysiology of NIHL in experimental animals and humans. The underlying molecular mechanisms of damage are then discussed as a basis for therapeutic approaches to ameliorate the loss of auditory function. Finally, studies in military, industrial and recreational settings are evaluated. Literature was searched using the terms 'noise-induced hearing loss' and 'noise trauma'. EXPERT OPINION: NIHL, in principle, can be prevented. With the current pace of development, oral drugs to protect against NIHL should be available within the next 5-10 years. Positive results from ongoing trials combined with additional laboratory tests might accelerate the time from the bench to clinical treatment.

3 Article Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations. 2018

Akbergenov, Rashid / Duscha, Stefan / Fritz, Ann-Kristina / Juskeviciene, Reda / Oishi, Naoki / Schmitt, Karen / Shcherbakov, Dimitri / Teo, Youjin / Boukari, Heithem / Freihofer, Pietro / Isnard-Petit, Patricia / Oettinghaus, Björn / Frank, Stephan / Thiam, Kader / Rehrauer, Hubert / Westhof, Eric / Schacht, Jochen / Eckert, Anne / Wolfer, David / Böttger, Erik C. ·Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland. · Anatomisches Institut, Universität Zürich, Zürich, Switzerland. · Institut für Bewegungswissenschaften und Sport, ETH Zürich, Zürich, Switzerland. · Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA. · Transfaculty Research Platform Molecular and Cognitive Neurosciences, Universitäre Psychiatrische Kliniken Basel, Basel, Switzerland. · GenOway, Lyon Cedex 07, France. · Neuro- und Ophthalmopathologie, Universitätsspital Basel, Basel, Switzerland. · Functional Genomics Center Zurich, ETH Zürich und Universität Zürich, Zürich, Switzerland. · Institut de biologie moléculaire et cellulaire du CNRS, Université de Strasbourg, Strasbourg, France. · Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland boettger@imm.uzh.ch. ·EMBO Rep · Pubmed #30237157.

ABSTRACT: The 1555 A to G substitution in mitochondrial 12S A-site rRNA is associated with maternally transmitted deafness of variable penetrance in the absence of otherwise overt disease. Here, we recapitulate the suggested A1555G-mediated pathomechanism in an experimental model of mitoribosomal mistranslation by directed mutagenesis of mitoribosomal protein MRPS5. We first establish that the ratio of cysteine/methionine incorporation and read-through of mtDNA-encoded MT-CO1 protein constitute reliable measures of mitoribosomal misreading. Next, we demonstrate that human HEK293 cells expressing mutant V336Y MRPS5 show increased mitoribosomal mistranslation. As for immortalized lymphocytes of individuals with the pathogenic A1555G mutation, we find little changes in the transcriptome of mutant V336Y MRPS5 HEK cells, except for a coordinated upregulation of transcripts for cytoplasmic ribosomal proteins. Homozygous knock-in mutant

4 Article Auditory Related Resting State fMRI Functional Connectivity in Tinnitus Patients: Tinnitus Diagnosis Performance. 2018

Minami, Shujiro B / Oishi, Naoki / Watabe, Takahisa / Uno, Kimiichi / Ogawa, Kaoru. ·National Tokyo Medical Center, National Institute of Sensory Organs. · Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Keio University. · Gaienhigashi Clinic, Tokyo, Japan. ·Otol Neurotol · Pubmed #29210942.

ABSTRACT: OBJECTIVE: The purpose of the present study was to investigate functional connectivity in tinnitus patients with and without hearing loss, and design the tinnitus diagnosis performance by resting state functional magnetic resonance imaging (rs-fMRI). SUBJECTS AND METHODS: Nineteen volunteers with normal hearing without tinnitus, 18 tinnitus patients with hearing loss, and 11 tinnitus patients without hearing loss were enrolled in this study. The subjects were evaluated with rs-fMRI, and region of interests (ROIs) based correlation analyses were performed using the CONN toolbox version 16 and SPM version 8. The correlation coefficients from individual level results were converted into beta values. RESULTS: With a beta threshold of more than 0.2, 91% of all possible connections between auditory-related ROIs (Heschl's gyrus, planum temporale, planum polare, operculum, insular cortex, superior temporal gyrus) in the control group remained intact, whereas 83 and 66% of such connections were present in the hearing loss and the normal-hearing tinnitus group. However, between non-auditory-related ROIs, the rates of intact connections at a beta threshold of more than 0.2 were 17% in the control group, and 16 and 15% in the tinnitus groups. When resting state fMRI positive is defined as less than 9% of all possible connections between auditory-related ROIs with a beta threshold of more than 0.7, the sensitivity and specificity of tinnitus diagnosis is 86 and 74%, respectively. CONCLUSIONS: The associations between auditory-related networks are weakened in tinnitus patients, even if they have normal hearing. It is possible that rs-fMRI can be a tool for objective examination of tinnitus, by focusing the auditory-related areas.

5 Article Effects of tinnitus treatments on sleep disorders in patients with tinnitus. 2018

Wakabayashi, Satoko / Saito, Hideyuki / Oishi, Naoki / Shinden, Seiichi / Ogawa, Kaoru. ·a Department of Otolaryngology-Head and Neck Surgery , Keio University School of Medicine , Tokyo , Japan. ·Int J Audiol · Pubmed #28906162.

ABSTRACT: OBJECTIVE: To assess the effects of tinnitus treatments on sleep disorders in patients with tinnitus. DESIGN: Subjects completed the Pittsburg Sleep Quality Index (PSQI), Tinnitus Handicap Inventory (THI), Self-rating Depression Scale (SDS), and State Trait Anxiety Inventory (STAI). The questionnaire results and the patients' sex, age, time since the onset of tinnitus, and mean hearing level were examined, and differences between a sleep disorder group and a normal sleep group were examined. Patients completed the questionnaires again after initiating tinnitus treatments (counselling and use of sound generators), and the change in questionnaire scores at follow-up was evaluated. STUDY SAMPLE: Patients (N = 100) with tinnitus who visited Keio University Hospital and started treatment without medication between 2005 and 2008. RESULTS: Sixty-six percent of the patients had sleep disorders. Compared with patients without sleep disorders, patients with sleep disorders had significantly higher SDS and STAI scores at the first visit. The mean PSQI scores showed significant improvement at follow-up. CONCLUSIONS: Sleep disorders in patients with tinnitus improved after tinnitus treatments. Complex interactions between depressive symptoms and anxiety may occur in these patients. The improvement in sleep disorders at follow-up was correlated with improvements in tinnitus severity and state anxiety.

6 Article Clinical characteristics of patients with tinnitus evaluated with the Tinnitus Sample Case History Questionnaire in Japan: A case series. 2017

Kojima, Takashi / Kanzaki, Sho / Oishi, Naoki / Ogawa, Kaoru. ·Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. · Department of Otorhinolaryngology, Machida Municipal Hospital, Machida-shi, Tokyo, Japan. ·PLoS One · Pubmed #28841656.

ABSTRACT: BACKGROUND: The Tinnitus Sample Case History Questionnaire was determined as a standardized questionnaire for obtaining patient case histories and for characterizing patients into subgroups at the Tinnitus Research Initiative in 2006. In this study, we developed a Japanese version of this questionnaire for evaluating the clinical characteristics of patients with tinnitus. The Japanese version of the questionnaire will be available for evaluating treatments for tinnitus and for comparing data on tinnitus in research centers. AIMS/OBJECTIVES: To evaluate the clinical characteristics of patients with tinnitus in Japan using a newly developed Japanese version of Tinnitus Sample Case History Questionnaire. STUDY DESIGN: This was a prospective study based on patient records. SETTING: University hospitals, general hospitals, and clinics. SUBJECTS AND METHODS: We collected patient data using a Japanese translated version of the Tinnitus Sample Case History Questionnaire. In total, 584 patients who visited our institutions in Japan between August 2012 and March 2014 were included (280 males and 304 females; age 13-92 years; mean age, 60.8). We examined patients after dividing them into two groups according to the presence or absence of hyperacusis. The collected results were compared with those from the Tinnitus Research Initiative database. RESULTS: Compared with the TRI database, there were significantly more elderly female patients and fewer patients with trauma-associated tinnitus. There was a statistically lower ratio of patients with hyperacusis. We found that patients with tinnitus in addition to hyperacusis had greater tinnitus severity and exhibited higher rates of various complications. CONCLUSION: The Japanese version of the Tinnitus Sample Case History Questionnaire developed in this study can be a useful tool for evaluating patients with tinnitus in Japan. The results of this multicenter study reflect the characteristics of patients with tinnitus who require medical care in Japan. Our data provides a preliminary basis for an international comparison of tinnitus epidemiology.

7 Article Assessment of hyperacusis with a newly produced Japanese version of the Khalfa hyperacusis questionnaire. 2017

Oishi, Naoki / Yamada, Hiroyuki / Kanzaki, Sho / Kurita, Akihiro / Takiguchi, Yoichiro / Yuge, Isamu / Asama, Yoji / Masuda, Masatsugu / Ogawa, Kaoru. ·a Department of Otolaryngology, Head and Neck Surgery , Keio University School of Medicine , Tokyo , Japan. · b Department of Otolaryngology , Saitama Red Cross Hospital , Saitama , Japan. · c Department of Otolaryngology , Eiju Sogo Hospital , Tokyo , Japan. · d Department of Otolaryngology , Yuge E.N.T. Clinic , Kanagawa , Japan. · e Department of Otolaryngology , Asama Jibiinkoka Clinic , Ibaragi , Japan. · f Department of Otolaryngology, Head and Neck Surgery , Kyorin University School of Medicine , Tokya , Japan. ·Acta Otolaryngol · Pubmed #28394666.

ABSTRACT: OBJECTIVES: The purpose of this study was to determine the validity and reliability of a Japanese version of the Khalfa hyperacusis questionnaire (KHQ) and proposed a threshold KHQ score for classifying hyperacusis. METHODS: In total, 112 patients with hyperacusis (group A) and 103 patients without hyperacusis (group B). The patients in group A were further classified into the following subgroups: subjects with hyperacusis as their chief complaint (n = 26, group A1) and subjects with hyperacusis accompanied by chief complaints of tinnitus and/or hearing loss (n = 86, group A2). RESULTS: The average total questionnaire score for patients in group A was 11.8 ± 9.7, which was statistically significantly higher than that of patients in group B, 5.7 ± 4.8. Cronbach's coefficients for internal consistency were high for the total score (0.92). The average total scores for groups A1 and A2 were 18.1 ± 11.1 and 9.9 ± 8.4, respectively, and the difference between the groups was statistically significant. CONCLUSIONS: We developed a Japanese version of the KHQ. It showed high reliability and validity; suggesting its usefulness in clinical practice. We propose that a total KHQ score of 16 is an appropriate cutoff for classifying hyperacusis.

8 Article Auditory resting-state functional connectivity in tinnitus and modulation with transcranial direct current stimulation. 2015

Minami, Shujiro B / Oishi, Naoki / Watabe, Takahisa / Uno, Kimiichi / Kaga, Kimitaka / Ogawa, Kaoru. ·a 1 National Institute of Sensory Organs, National Tokyo Medical Center , Tokyo, Japan. · b 2 Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Keio University , Tokyo, Japan. · c 3 Gaienhigashi Clinic , Tokyo, Japan. · d 4 Center for Speech and Hearing Disorders, International University of Health and Welfare , Tokyo, Japan. ·Acta Otolaryngol · Pubmed #26181225.

ABSTRACT: CONCLUSIONS: The functional connectivity (FC) between the right and left auditory cortex is weak in tinnitus patients. Transcranial direct current stimulation (tDCS) over the auditory cortex has potential as a tool to modulate auditory-based FC. OBJECTIVE: This study investigated the effects of applying tDCS in tinnitus patients, and searched for modulation of brain networks in resting-state functional magnetic resonance imaging (rs-fMRI) through an analysis of FC with the stimulated brain region. SUBJECTS AND METHODS: Nine male patients with chronic tinnitus and 10 male volunteers with normal hearing were enrolled. The subjects were evaluated with rs-fMRI immediately before and after tDCS. The tinnitus patients filled out the self-evaluation questionnaires designed to measure tinnitus conditions before tDCS treatment and 1 week afterwards. RESULTS: The FC between the right and left auditory cortex was significantly weaker in tinnitus patients than in controls. After tDCS treatment, in the tinnitus group, the primary auditory cortex showed a reduction in the amount of statistically significant connectivity with the somatosensory area and motor area, but maintained strong significant connectivity (p < 0.005) with the auditory area and insular cortex. In contrast, in the control group, there remained strong significant connectivity between the primary auditory cortex and the somatosensory area, motor area, insular cortex, and auditory area.

9 Article XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death. 2015

Oishi, N / Duscha, S / Boukari, H / Meyer, M / Xie, J / Wei, G / Schrepfer, T / Roschitzki, B / Boettger, E C / Schacht, J. ·Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA. · Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland. · 1] Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA [2] Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland. · Functional Genomics Center Zurich, ETH Zürich, Universität Zürich, Zürich, Switzerland. ·Cell Death Dis · Pubmed #25973683.

ABSTRACT: Here we study links between aminoglycoside-induced mistranslation, protein misfolding and neuropathy. We demonstrate that aminoglycosides induce misreading in mammalian cells and assess endoplasmic reticulum (ER) stress and unfolded protein response (UPR) pathways. Genome-wide transcriptome and proteome analyses revealed upregulation of genes related to protein folding and degradation. Quantitative PCR confirmed induction of UPR markers including C/EBP homologous protein, glucose-regulated protein 94, binding immunoglobulin protein and X-box binding protein-1 (XBP1) mRNA splicing, which is crucial for UPR activation. We studied the effect of a compromised UPR on aminoglycoside ototoxicity in haploinsufficient XBP1 (XBP1(+/-)) mice. Intra-tympanic aminoglycoside treatment caused high-frequency hearing loss in XBP1(+/-) mice but not in wild-type littermates. Densities of spiral ganglion cells and synaptic ribbons were decreased in gentamicin-treated XBP1(+/-) mice, while sensory cells were preserved. Co-injection of the chemical chaperone tauroursodeoxycholic acid attenuated hearing loss. These results suggest that aminoglycoside-induced ER stress and cell death in spiral ganglion neurons is mitigated by XBP1, masking aminoglycoside neurotoxicity at the organismal level.

10 Article [Long-term effects of tinnitus retraining therapy involving monaural noise generators]. 2014

Inagaki, Yozo / Oishi, Naoki / Kanzaki, Sho / Wakabayashi, Satoko / Fujioka, Masato / Watabe, Takahisa / Watanabe, Reiko / Wasano, Koichiro / Yamada, Hiroyuki / Kojima, Takashi / Shinden, Seiichi / Ogawa, Kaoru. · ·Nihon Jibiinkoka Gakkai Kaiho · Pubmed #24720159.

ABSTRACT: We have previously reported on the effects of tinnitus retraining therapy (TRT) involving monaural noise generators (NGs) up to 24 months after the start of treatment (Eur Arch Otorhinolaryngol. 2013 Feb; 270(2) : 443-8.) but very few reports exist about the long-term effects of TRT for periods of over 2 years. The aim of this study was to report the effects of TRT involving monaural NGs more than 24 months after the start of treatment. Thirty-three patients with chronic tinnitus were included in this study. All received directive counseling and monaural NGs without any other combination treatment. Effects were evaluated with the Tinnitus Handicap Inventory (THI) at their final visits to our clinic (average 31 months after the start of treatment). The average THI scores significantly improved from 55.3 +/- 19.7 at baseline to 33.5 +/- 23.3 at their final visits. Seventeen patients (52%) improved by more than 20 points from the baseline. Eleven patients who were treated with TRT for more than 3 years were individually observed in a detailed manner. Some of them experienced aggravation of their symptoms after 2 years' successful treatments. This study suggests that, although TRT seems effective more than 2 years after the start of treatment, the clinical course of each patient can vary and we need to follow them periodically depending on their situations and symptoms.

11 Article Tumor necrosis factor-alpha-mutant mice exhibit high frequency hearing loss. 2013

Oishi, Naoki / Chen, Jun / Zheng, Hong-Wei / Hill, Kayla / Schacht, Jochen / Sha, Su-Hua. ·Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI, 48109-5616, USA. ·J Assoc Res Otolaryngol · Pubmed #23996384.

ABSTRACT: Exogenous tumor necrosis factor-alpha (TNF-α) plays a role in auditory hair cell death by altering the expression of apoptosis-related genes in response to noxious stimuli. Little is known, however, about the function of TNF-α in normal hair cell physiology. We, therefore, investigated the cochlear morphology and auditory function of TNF-α-deficient mice. Auditory evoked brainstem response showed significantly higher thresholds, especially at higher frequencies, in 1-month-old TNF-α(-/-) mice as compared to TNF-α(+/-) and wild type (WT); hearing loss did not progress further from 1 to 4 months of age. There was no difference in the gross morphology of the organ of Corti, lateral wall, and spiral ganglion cells in TNF-α(-/-) mice compared to WT mice at 4 months of age, nor were there differences in the anatomy of the auditory ossicles. Outer hair cells were completely intact in surface preparations of the organ of Corti of TNF-α(-/-) mice, and synaptic ribbon counts of TNF-α(-/-) and WT mice at 4 months of age were similar. Reduced amplitudes of distortion product otoacoustic emissions, however, indicated dysfunction of outer hair cells in TNF-α(-/-) mice. Scanning electron microscopy revealed that stereocilia were sporadically absent in the basal turn and distorted in the middle turn. In summary, our results demonstrate that TNF-α-mutant mice exhibit early hearing loss, especially at higher frequencies, and that loss or malformation of the stereocilia of outer hair cells appears to be a contributing factor.

12 Article Intra-tympanic delivery of short interfering RNA into the adult mouse cochlea. 2013

Oishi, Naoki / Chen, Fu-Quan / Zheng, Hong-Wei / Sha, Su-Hua. ·Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109-5616, USA. ·Hear Res · Pubmed #23183031.

ABSTRACT: Trans-tympanic injection into the middle ear has long been the standard for local delivery of compounds in experimental studies. Here we demonstrate the advantages of the novel method of intra-tympanic injection through the otic bone for the delivery of compounds or siRNA into the adult mouse cochlea. First, a fluorescently-conjugated scrambled siRNA probe was applied via intra-tympanic injection into the middle ear cavity and was detected in sensory hair cells and nerve fibers as early as 6 h after the injection. The fluorescent probe was also detected in other cells of the organ of Corti, the lateral wall, and in spiral ganglion cells 48 h after the injection. Furthermore, intra-tympanic delivery of Nox3 siRNA successfully reduced immunofluorescence associated with Nox3 in outer hair cells 72 h after injection by 20%. Drug or siRNA delivery via intra-tympanic injection does not compromise the tympanic membrane or interfere with noise-induced hearing loss, while trans-tympanic injections significantly altered the cochlear response to noise exposure. In summary, intra-tympanic injection through the otic bone into the middle ear cavity provides a promising approach for delivery of compounds or siRNA to cochlear hair cells of adult mice, relevant for the study of mechanisms underlying inner ear insults and, specifically, noise-induced hearing loss.

13 Article Effects of tinnitus retraining therapy involving monaural noise generators. 2013

Oishi, Naoki / Shinden, Seiichi / Kanzaki, Sho / Saito, Hideyuki / Inoue, Yasuhiro / Ogawa, Kaoru. ·Department of Otolaryngology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan. o-ishi@mub.biglobe.ne.jp ·Eur Arch Otorhinolaryngol · Pubmed #22331257.

ABSTRACT: The aim of this study was to assess how tinnitus retraining therapy (TRT) employing monaural noise generators (NGs) affects tinnitus patients. Ninety-five patients with chronic tinnitus were included in this study. All received directive counseling and monaural NGs without any other combination treatment. Effects were evaluated with the Tinnitus Handicap Inventory (THI) 6, 12, and 24 months after the start of treatment. Multiple regression analysis was used to evaluate factors associated with improvement of THI scores. We observed a significant improvement in the average THI scores, which ranged from 59 at baseline to 36 after 6 months and were stable up to 24 months. Severely distressed (SD) patients experienced more benefits from the therapy than moderately distressed (MD) patients. Multiple regression analysis revealed that the presence of transient anxiety symptoms, measured by the state section of the State Trait Anxiety Inventory at the beginning of treatment, were associated the most to a decline in THI scores in SD patients. Pure-tone average at three mid frequencies was a negatively contributing factor. Analysis of MD patients did not provide a good model. In conclusion, TRT employing monaural NGs was an effective intervention especially for SD patients, although plateau of the effects after 6 months may be indicative of limitation of applying NGs monoaurally. Reducing the patients' hearing handicap may reinforce the effects of TRT in SD patients. Additional evaluation and interventions for both SD and MD patients might be needed.

14 Article Influence of depressive symptoms, state anxiety, and pure-tone thresholds on the tinnitus handicap inventory in Japan. 2011

Oishi, Naoki / Shinden, Seiichi / Kanzaki, Sho / Saito, Hideyuki / Inoue, Yasuhiro / Ogawa, Kaoru. ·Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan. o-ishi@mub.biglobe.ne.jp ·Int J Audiol · Pubmed #21495790.

ABSTRACT: OBJECTIVE: To assess factors that contribute to Tinnitus Handicap Inventory (THI) scores in Japan. DESIGN: Case series with chart review. STUDY SAMPLE: Two hundred and eighty-five tinnitus patients at tertiary referral center, who completed the Japanese version of the THI, the Self-rating Depression Scale (SDS), and the State Trait Anxiety Inventory (STAI). RESULTS: In multiple regression analysis, the SDS score contributed the most to the THI score. The state section of the STAI score and pure tone average (PTA) at four high frequencies also contributed significantly, but to lesser degrees. The other following factors were not statistically significant: age, gender, time from the onset of tinnitus to the first clinical visit, PTA at three mid frequencies, and trait section of the STAI score. This model may account for approximately 45% of THI score variability. CONCLUSIONS: The THI scores may be influenced by depressive symptoms, state anxiety, and pure tone thresholds in Japan.

15 Article Pure tone auditory thresholds can change according to duration of interrupted tones in patients with psychogenic hearing loss. 2011

Oishi, Naoki / Inoue, Yasuhiro / Hori, Akemi / Yakushimaru, Reiko / Kohno, Naoyuki / Ogawa, Kaoru. ·Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan. o-ishi@mub.biglobe.ne.jp ·Acta Otolaryngol · Pubmed #21254959.

ABSTRACT: CONCLUSION: Pure tone auditory thresholds can change according to duration of interrupted tones in patients with mild to severe psychogenic hearing loss (PHL). OBJECTIVES: To examine how the duration of stimulus tones affects the hearing thresholds of patients with PHL. METHODS: Twelve patients with PHL (21 ears) were enrolled in this study. We initially measured their hearing thresholds using interrupted tones with a duration of 2 s and equal length of on-time and off-time, 225 ± 35 ms, respectively. After a 10 min interval, we measured their hearing thresholds using the same interrupted tones conditions lasting 5 s. The average threshold gains (2 s thresholds minus 5 s thresholds) were compared to those of 15 control subjects with normal hearing (25 ears), 15 patients with cochlear hearing loss (23 ears), and 4 patients with retrocochlear lesions (4 ears). Patients with profound PHL (4 patients, 6 ears) were analyzed separately. RESULTS: The average threshold gain of PHL patients (excluding profound PHL patients) at all frequencies was 18.3 dB, which was significantly larger than that of other groups: 0.3 dB (profound PHL patients), 3.8 dB (controls with normal hearing), 3.0 dB (patients with cochlear hearing loss), and 3.2 dB (patients with retrocochlear lesions).

16 Article Severe progressive sensorineural hearing loss improved after removal of large jugular foramen schwannoma. 2011

Oishi, Naoki / Kohno, Naoyuki / Shiokawa, Yoshiaki. ·Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan. o-ishi@mub.biglobe.ne.jp ·Auris Nasus Larynx · Pubmed #20971588.

ABSTRACT: We report a very rare case of hearing improvement after removal of the intracranial part of a jugular foramen schwannoma (JFS) presenting with chronic and severe progressive sensorineural hearing loss (SNHL). The patient presented with progressive hearing impairment in his right ear, lasting 2 years. The patient's pure tone audiogram revealed severe SNHL. His speech discrimination score (SDS) was 0%. Auditory-evoked brain responses (ABRs) comprised only I waves following 30-100dB stimulation, although distortion-product otoacoustic emissions (DPOAEs) had good responses. These test results indicated that his hearing impairment was retrocochlear SNHL. Magnetic resonance imaging revealed within the right jugular foramen a large intracranial-extracranial tumor that compressed the brainstem. The intracranial part of the tumor was resected through retrosigmoidal craniotomy, and the tumor was pathologically diagnosed as a schwannoma. Several months after the operation, the patient's auditory thresholds improved to a level consistent with mild SNHL, ABR V waves emerged following 60-90dB stimulation, and SDS improved significantly to 95%. This case demonstrates that hearing improvement can be achieved after surgery for JFS presenting with severe and chronic progressive SNHL, and that good DPOAE responses and the presence of ABR I waves may be predictors of postoperative hearing recovery in JFS.

17 Article Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus. 2011

Minami, Shujiro B / Shinden, Seiichi / Okamoto, Yasuhide / Watada, Yukiko / Watabe, Takahisa / Oishi, Naoki / Kanzaki, Sho / Saito, Hideyuki / Inoue, Yasuhiro / Ogawa, Kaoru. ·National Institute of Sensory Organs, National Tokyo Medical Center, 2-5-1 Higashigaoka, Tokyo, Japan. shujirominami@mac.com ·Auris Nasus Larynx · Pubmed #20971587.

ABSTRACT: OBJECTIVE: There is compelling evidence that tinnitus is associated with functional alterations in the central nervous system. Repetitive transcranial magnetic stimulation (rTMS) is a potent tool for modifying neural activity at the stimulated area and at a distance along the functional anatomical connections. Depending on the stimulation parameters, cortical networks can be functionally disturbed or modulated in their activities. Low-frequency rTMS has been shown to result in a decrease in cortical excitability. The technique can alleviate tinnitus by modulating the excitability of neurons in the auditory cortex. We aimed to investigate the effects of low-frequency rTMS in patients and determine the factors that predict a beneficial outcome with rTMS treatment. METHODS: Sixteen patients (male 10, female 6) with chronic tinnitus underwent low-frequency (1Hz) rTMS (intensity: 110% motor threshold; number of stimuli: 1200) to the left auditory cortex. The treatment outcome was assessed with a visual analog scale (VAS) of loudness, annoyance and duration, loudness balance test, and tinnitus handicap inventory (THI). Therapeutic success was studied according to the patients' clinical characteristics. RESULTS: A significant reduction in the VAS (loudness and annoyance) occurred immediately after rTMS, with a gradual return to pretreatment levels after 7 days. The tinnitus patients with sudden deafness were significant resistant to rTMS treatment compared with those diagnosed with age-related hearing loss. CONCLUSION: These results support the potential of rTMS as a new therapeutic tool for the treatment of chronic tinnitus. Because this study was performed with a small sample size and showed high interindividual variability in treatment effects, further development of the technique is needed before it can be recommended for clinical applications.

18 Article Long-term prognosis of low-frequency hearing loss and predictive factors for the 10-year outcome. 2010

Oishi, Naoki / Inoue, Yasuhiro / Saito, Hideyuki / Kanzaki, Sho / Kanzaki, Jin / Ogawa, Kaoru. ·Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan. o-ishi@mub.biglobe.ne.jp ·Otolaryngol Head Neck Surg · Pubmed #20304279.

ABSTRACT: OBJECTIVES: To determine the long-term prognosis of low-frequency hearing loss and predictive factors for the 10-year outcome of low-frequency hearing loss. STUDY DESIGN: Case series with chart review. SETTING: Tertiary referral center. SUBJECTS AND METHODS: From 1979 to 1998, 466 consecutive patients with low-frequency hearing loss received initial treatment at the Hearing and Tinnitus Clinic of Keio University Hospital. Of the 49 eligible patients, pure-tone threshold data obtained over a period of 10 years after onset of low-frequency hearing loss were available for analysis. To determine the progression of hearing loss, we analyzed audiometric pattern changes. We also examined how the following factors affected 10-year prognosis: sex, age, side of hearing loss, accompanying dizziness, pre-therapeutic hearing thresholds at low frequencies, initial therapy results, and fluctuation of hearing during the first year after onset. RESULTS: High- and pan-frequency hearing loss increased as time progressed. About half of the cases developed high- or pan-frequency hearing loss within 10 years of onset. Audiometric patterns measured at 10 years significantly correlated with those measured at one (r = 0.57), three (r = 0.73), and five years (r = 0.85). The 10-year prognosis significantly correlated with only two factors: initial therapy results (r = 0.49) and fluctuation of hearing during the first year (r = 0.43). CONCLUSIONS: About half of the cases in our study developed high- or pan-frequency hearing loss within 10 years of onset of low-frequency hearing loss. The initial therapy results and fluctuation of hearing during the first year may indicate the long-term prognosis of patients presenting with low-frequency hearing loss.

19 Article Effects of selective serotonin reuptake inhibitor on treating tinnitus in patients stratified for presence of depression or anxiety. 2010

Oishi, Naoki / Kanzaki, Sho / Shinden, Seiichi / Saito, Hideyuki / Inoue, Yasuhiro / Ogawa, Kaoru. ·Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan. o-ishi@mub.biglobe.ne.jp ·Audiol Neurootol · Pubmed #19851065.

ABSTRACT: We evaluated the effects of a selective serotonin reuptake inhibitor, paroxetine, on treating tinnitus.Tinnitus patients stratified for the presence of depression and anxiety were studied retrospectively. Fifty-six patients were observed for more than 6 months. They were initially treated with paroxetine only at a dose of 10 mg/day for 2-4 weeks; thereafter, the dose was increased to 20 mg/day. Tinnitus distress was evaluated with the Tinnitus Handicap Inventory (THI) and with visual analog scales (VASs) for tinnitus loudness and annoyance. Depression and anxiety were measured with the Self-Rating Depression Scale (SDS) and the trait section of the State-Trait Anxiety Inventory (STAI). The patients were grouped according to their SDS and STAI scores, and each variable was compared at baseline and the 6-month follow-up. Changes among these variables were also examined to determine whether reduced tinnitus distress was related to the improvement of depression or anxiety. Patients with both depression and anxiety showed better results (decrease in THI, VASs, SDS and STAI scores) than patients with anxiety alone, or patients without depression and anxiety. In patients with depression and anxiety, changes in tinnitus variables and changes in depression and anxiety scores were strongly correlated. In other patients, however, changes in tinnitus variables and changes in depression and anxiety scores were not correlated. These results suggest that paroxetine is effective in treating distressed tinnitus patients with depression and anxiety by reducing their tinnitus severity as well as their depression and anxiety.

20 Article Burow's solution-induced acute sensorineural hearing loss: report of two cases. 2010

Oishi, Naoki / Inoue, Yasuhiro / Saito, Hideyuki / Ogawa, Kaoru. ·Department of Otolaryngology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan. o-ishi@mub.biglobe.ne.jp ·Auris Nasus Larynx · Pubmed #19850426.

ABSTRACT: This is the report of rare cases to show the potential ototoxicity of Burow's solution in clinical use. We encountered two cases of acute sensorineural hearing loss occurring after the administration of 8% Burow's solution (pH 2.93) into the tympanic cavities. Prior to treatment, both cases presented with tympanic membrane perforations in the posterior and inferior portions and a small amount of serous discharge. Fortunately, hearing loss recovered almost completely except for high tones within a few weeks. These two case reports demonstrate that the ototoxicity of Burow's solution should be considered when it is used to treat otitis media accompanied by tympanic membrane perforation.

21 Article Acute-onset unilateral psychogenic hearing loss in adults: report of six cases and diagnostic pitfalls. 2009

Oishi, Naoki / Kanzaki, Sho / Kataoka, Chinatsu / Tazoe, Mami / Takei, Yasuhiko / Nagai, Keiichi / Kohno, Naoyuki / Ogawa, Kaoru. ·Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan. ·ORL J Otorhinolaryngol Relat Spec · Pubmed #19851081.

ABSTRACT: We encountered 6 rare cases of acute-onset unilateral psychogenic hearing loss in adults. All were women in their 20s and 30s. Three cases had severe hearing impairment characterized by hearing loss at every frequency; 2 cases had profound hearing impairment, and 1 case had low-frequency hearing impairment. Of the 6 cases, 3 had a history of hearing loss, and 1 had a history of psychogenic visual disturbance. All 6 cases were initially diagnosed as having idiopathic sudden sensorineural hearing loss; all subsequently received steroid therapy. Three cases were not diagnosed as being psychogenic in origin until otoacoustic emissions and auditory brain responses were performed. Although the presence of distinctive clinical features (age, gender, and past history) is important for suspecting psychogenic hearing loss, objective audiological tests such as otoacoustic emissions are essential for diagnosing some cases. Compared to the existing reports of similar cases, our cases had a poorer prognosis (only 2 cases were cured).