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Hearing Disorders: HELP
Articles by Yuji Nishiwaki
Based on 12 articles published since 2009
(Why 12 articles?)
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Between 2009 and 2019, Yuji Nishiwaki wrote the following 12 articles about Hearing Disorders.
 
+ Citations + Abstracts
1 Article Haemoglobin A1c and hearing impairment: longitudinal analysis using a large occupational health check-up data of Japan. 2018

Nagahama, Satsue / Kashino, Ikuko / Hu, Huanhuan / Nanri, Akiko / Kurotani, Kayo / Kuwahara, Keisuke / Dan, Masashi / Michikawa, Takehiro / Akter, Shamima / Mizoue, Tetsuya / Murakami, Yoshitaka / Nishiwaki, Yuji. ·Department of Environmental and Occupational Health, Toho University Graduate School of Medicine, Tokyo, Japan. · Division of Occupational Health and Promotion, All Japan Labor Welfare Foundation, Tokyo, Japan. · Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan. · Department of Food and Health Sciences International College of Arts and Sciences, Fukuoka Women's University, Fukuoka, Japan. · Department of Nutritional Epidemiology and Shokuiku, National Institutes of Biomedical Innovation, Health and Nutrition, National Institute of Health and Nutrition, Tokyo, Japan. · Graduate School of Public Health, Teikyo University, Tokyo, Japan. · Environmental Epidemiology Section, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Japan. · Department of Medical Statistics, Toho University Graduate School of Medicine, Tokyo, Japan. ·BMJ Open · Pubmed #30224397.

ABSTRACT: OBJECTIVES: The aim of this study was to determine whether haemoglobin A1c (HbA1c) level is associated with the incidence of hearing impairment accounting for smoking status and diabetic condition at baseline. METHODS: Participants were 131 689 men and 71 286 women aged 30-65 years and free of hearing impairment at baseline (2008) who attended Japanese occupational annual health check-ups from 2008 to 2015. We defined low-frequency hearing impairment at a hearing threshold >30 dB at 1 kHz and high frequency at >40 dB at 4 kHz in the better ear in pure-tone audiometric tests. HbA1c was categorised into seven categories. The association between HbA1c and hearing impairment was assessed using the Cox proportional hazards model. RESULTS: On 5 years mean follow-up, high HbA1c was associated with high-frequency hearing impairment. In non-smokers, HbA1c≥8.0% was associated with high-frequency hearing impairment, with a multivariable HR (95% CI) compared with HbA1c 5.0%-5.4% of 1.46 (1.10 to 1.94) in men and 2.15 (1.13 to 4.10) in women. There was no significant association between HbA1c and hearing impairment in smokers. A J-shaped association between HbA1c and high-frequency hearing impairment was observed for participants with diabetes at baseline. HbA1c was not associated with low-frequency hearing impairment among any participants. CONCLUSIONS: HbA1c ≥8.0% of non-smokers and ≥7.3% of participants with diabetes was associated with high-frequency hearing impairment. These findings indicate that appropriate glycaemic control may prevent diabetic-related hearing impairment.

2 Article Markers of Overall Nutritional Status and Incident Hearing Impairment in Community-Dwelling Older Japanese: The Kurabuchi Study. 2016

Michikawa, Takehiro / Nakamura, Takahiro / Imamura, Haruhiko / Mizutari, Kunio / Saito, Hideyuki / Takebayashi, Toru / Nishiwaki, Yuji. ·Environmental Epidemiology Section, Centre for Environmental Health Sciences, National Institute for Environmental Studies, Tsukuba, Japan. · Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan. · Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo, Japan. · Department of Otolaryngology, Head and Neck Surgery, National Defense Medical College, Saitama, Japan. · Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Keio University, Tokyo, Japan. ·J Am Geriatr Soc · Pubmed #27310369.

ABSTRACT: OBJECTIVES: To examine the association between four markers of overall nutritional status (a serum biomarker (albumin) and three anthropometric indices (body mass index (BMI), midarm circumference (MAC), calf circumference (CC))) and incident hearing impairment in older Japanese adults. DESIGN: Community-based prospective cohort study. SETTING: Kurabuchi Town, Gunma Prefecture, Japan. PARTICIPANTS: Individuals aged 65 and older (143 men, 195 women) without hearing impairment at baseline examination (2005-06) who participated in repeated examinations 4 years later (2009-10) (N = 338). MEASUREMENTS: The three anthropometric indices were measured at baseline, and nephelometry was used to assess serum albumin levels. Hearing impairment was defined as failure to hear a 30-dB hearing level signal at 1 kHz and a 40-dB signal at 4 kHz in the better ear on pure-tone audiometry. RESULTS: Over the 4-year period, 16.3% of participants developed hearing impairment. Those with lower marker values had greater risk of hearing impairment than those with higher marker values (multivariable adjusted odds ratio (aOR) = 2.18, 95% confidence interval (CI) = 1.05-4.57 for albumin ≤4.0 g/dL; aOR = 2.72, 95% CI = 1.10-6.71 for BMI <19.0 kg/m(2) ). The pattern of association showed a similar tendency for MAC and CC. Excluding obese participants did not changed the results substantially. CONCLUSION: Further research is needed to determine whether interventions that improve markers of nutritional status may help prevent age-related hearing loss in older adults.

3 Article Glycosylated hemoglobin level is associated with hearing impairment in older Japanese: the Kurabuchi Study. 2014

Michikawa, Takehiro / Mizutari, Kunio / Saito, Hideyuki / Takebayashi, Toru / Nishiwaki, Yuji. · ·J Am Geriatr Soc · Pubmed #25039656.

ABSTRACT: OBJECTIVES: To examine the association between glycemic levels (glycosylated hemoglobin (HbA1c)) and hearing impairment in a general older population. DESIGN: Community-based prospective longitudinal cohort study. SETTING: Kurabuchi Town, Gunma Prefecture, Japan. PARTICIPANTS: Residents (N = 831; 350 men, 481 women) aged 65 and older were examined in 2005 and 2006 and analyzed in a cross-sectional study. Residents without hearing impairment at baseline who participated in audiometric re-examinations 4 years later were analyzed (n = 338). MEASUREMENTS: Hearing impairment was defined as failure to hear a 30-dB signal at 1 kHz and a 40-dB signal at 4 kHz in the better ear in pure-tone audiometric tests. RESULTS: Mean HbA1c level (National Glycohemoglobin Standardization Program) was 5.8 ± 0.8% (40 mmol/mol). Odds ratios (ORs) and 95% confidence intervals (CIs) of hearing impairment associated with HbA1c were estimated using a logistic regression model. In the cross-sectional analysis, HbA1c levels were positively associated with hearing impairment (OR per 1.0% increase in HbA1c = 1.30, 95% CI = 1.00-1.68). This association persisted even after excluding 58 participants with a self-reported history of diagnosed diabetes mellitus. Longitudinal analysis revealed the temporality of the discussed association (OR = 1.52, 95% CI = 1.03-2.23). CONCLUSION: The present study provides supportive evidence for a causal link between hyperglycemia and age-related hearing loss.

4 Article Age-related hearing loss and the factors determining continued usage of hearing aids among elderly community-dwelling residents. 2013

Mizutari, Kunio / Michikawa, Takehiro / Saito, Hideyuki / Okamoto, Yasuhide / Enomoto, Chieko / Takebayashi, Toru / Ogawa, Kaoru / Nishiwaki, Yuji. ·Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan ; Division of Otolaryngology, National Center for Child Health and Development, Tokyo, Japan. ·PLoS One · Pubmed #24086287.

ABSTRACT: While hearing aids are recommended for people with age-related hearing loss, many with impaired hearing do not use them. In this study, we investigated how many elderly people in the study area needed hearing aids, and the factors that determined continued wearing of the devices. The study area was Kurabuchi Town, Japan, where 1,437 residents (those aged 65 years or over) were eligible for participation in the study; 1,414 participated, of whom, 103 (7.3%) were already using hearing aids at the start of the study. After the primary screening, hearing aids were lent to 68 participants (4.8%) who did not already have one, 38 of whom (60.3% of the borrowers, representing 2.7% of the total aged population) went on to wear the hearing aid continuously. The Hearing Handicap Inventory for the Elderly (HHIE) score was significantly elevated among these 38 participants. This study indicated that hearing aids are of potential benefit to many local residents. Multivariate logistic regression revealed that HHIE scores were associated with the extent of HA usage. The adjusted odds ratio for a 1-unit increase in HHIE score was 1.08 (95% confidence interval: 1.02-1.14). Programs like this, in which people with impaired hearing are identified at the local level and given appropriate assistance, are useful models for future use in societies with aging populations.

5 Article Tinnitus preceded depressive symptoms in community-dwelling older Japanese: a prospective cohort study. 2013

Michikawa, Takehiro / Nishiwaki, Yuji / Saito, Hideyuki / Mizutari, Kunio / Takebayashi, Toru. ·Environmental Epidemiology Section, Center for Environmental Health Sciences, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, Japan. tmichikawa@nies.go.jp ·Prev Med · Pubmed #23384472.

ABSTRACT: OBJECTIVE: Most studies of the association between tinnitus and depression have been cross-sectional, making it difficult to draw any conclusions about the directionality of the association. This study aimed to clarify whether tinnitus precedes the development of depressive symptoms in a general older population. METHODS: Residents of Kurabuchi Town, Gunma Prefecture, Japan (239 men, 296 women: ≥65years) without depressive symptoms were given health examinations in 2005-2006. Information on tinnitus was obtained via a questionnaire. Depressive symptoms were then assessed in a face-to-face home visit interviews carried out once in 2007 and once in 2008 according to the Geriatric Depression Scale 15-item version (GDS15). RESULTS: Among the men, the 2.5-year incidence of depressive symptoms (GDS15≥6) was higher in those with tinnitus than in those without (20.5% vs. 9.5%). In the multi-adjusted model, tinnitus was significantly associated with an increased risk of depressive symptoms (relative risk=2.07; 95% confidence interval=1.01-4.25). Among the women, no associations were found. CONCLUSION: In the present study, tinnitus was independently associated with the risk of depressive symptoms developing in men, but not in women. We believe primary care providers and public health staff should recognize tinnitus as a risk factor for depressive symptoms.

6 Article Sunlight exposure may be a risk factor of hearing impairment: a community-based study in Japanese older men and women. 2013

Michikawa, Takehiro / Nishiwaki, Yuji / Asakura, Keiko / Hillebrand, Greg / Miyamoto, Kukizo / Ono, Masaji / Kinjo, Yoshihide / Akiba, Suminori / Takebayashi, Toru. ·Environmental Epidemiology Section, Center for Environmental Health Sciences, National Institute for Environmental Studies, Onogawa, Tsukuba, Ibaraki, Japan. tmichikawa@nies.go.jp ·J Gerontol A Biol Sci Med Sci · Pubmed #22492021.

ABSTRACT: BACKGROUND: Oxidative stress is an important factor in the pathology of age-related hearing loss. Recent animal studies have reported that ultraviolet radiation in sunlight is related to systemic induction of oxidative stress. Chronic sun exposure leads to photodamaged skin, which is manifested as facial skin wrinkling and hyperpigmentation. We hypothesized that sunlight exposure, as assessed by the severity of facial skin photodamage, might be associated with hearing impairment through an oxidative stress mechanism. To examine this, we performed a cross-sectional analysis by using the baseline data from a community-based cohort study of older Japanese. METHODS: A total of 805 residents (342 men and 463 women) aged 65 years or older living in Kurabuchi Town, Gunma prefecture, Japan, were examined between 2005 and 2006. Facial skin condition was quantified by image analysis of standardized facial images. Hearing impairment was defined as a failure to hear a 30-dB signal at 1 kHz and a 40-dB signal at 4 kHz in the better ear in pure-tone audiometric tests. RESULTS: In men, facial wrinkle was positively associated with hearing impairment (for highest vs lowest: multivariate-adjusted odds ratio, 2.16; 95% confidence interval, 1.00-4.66; p for trend = .01). Stratified analysis by age, educational level, smoking status, sunscreen or foundation use, and diabetes showed results similar to those for men as a whole. This association was particularly pronounced in men with the low levels of antioxidants and without occupational noise exposure. We observed no apparent association in women. CONCLUSIONS: The results support the hypothesis that chronic sun exposure is a risk factor of hearing impairment.

7 Article Self-reported hearing loss in older adults is associated with future decline in instrumental activities of daily living but not in social participation. 2012

Yamada, Mutsuko / Nishiwaki, Yuji / Michikawa, Takehiro / Takebayashi, Toru. ·Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan. ·J Am Geriatr Soc · Pubmed #22726063.

ABSTRACT: OBJECTIVES: To investigate whether self-reported hearing loss in older adults is associated with a decline in their ability to perform instrumental activities of daily living (IADL) or a decline in social participation. DESIGN: Prospective follow-up. SETTING: Community. PARTICIPANTS: One thousand two hundred fifty-four adults aged 65 to 98. MEASUREMENTS: Self-reported hearing loss, IADL, and social participation were evaluated through home-visit surveys. Self-reported hearing loss was measured according to responses to the question, "Do you have difficulty hearing and understanding what a person says to you in a quiet room if they speak normally to you, even when wearing your hearing aid?" Levels of IADL and social participation were measured using the subscales of the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC). RESULTS: Of the 921 participants with a perfect baseline IADL score and valid follow-up scores, 105 also self-reported hearing loss at baseline. Of this group, 44.8% (total n = 105) reported a decline in their IADL score over the 3-year follow-up period. After adjusting for major confounders, a statistically significant difference in experiencing an IADL decline over the 3-year period was found between those with hearing loss at baseline and those without (odds ratio (OR) = 1.79, 95% confidence interval (CI) = 1.12-2.87). Self-reported hearing loss at baseline did not have a statistically significant effect on decline in social participation (OR = 1.05, 95% CI = 0.63-1.76) over the 3-year follow-up period. CONCLUSION: Self-reported hearing loss was associated with a decline in IADL, but not with social participation.

8 Article Impact of hearing difficulty on dependence in activities of daily living (ADL) and mortality: a 3-year cohort study of community-dwelling Japanese older adults. 2011

Yamada, Mutsuko / Nishiwaki, Yuji / Michikawa, Takehiro / Takebayashi, Toru. ·Department of Preventive Medicine and Public Health, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. ·Arch Gerontol Geriatr · Pubmed #20546947.

ABSTRACT: Studies have associated hearing impairment with adverse health outcomes, but the actual impact of hearing difficulty has been barely investigated. We investigated among older adults (i) the prevalence of hearing difficulty, (ii) the association of hearing difficulty with a composite outcome of dependence in activities of daily living (ADL) and death, and (iii) the population attributable risk fraction (PAF) of hearing difficulty. In 2005, a home-visit survey of 1364 Japanese older adults aged ≥65 (participation proportion=95.5%) was conducted to evaluate self-reports of hearing difficulty. Over 3 years, 99.4% of the initial sample was followed. Outcomes were measured by incidence of death or dependence in ADL. In the sample, the prevalence of hearing difficulty was 17.7% (age ≥65) and 25.7% (age ≥75). Hearing difficulty at high levels was associated with a composite outcome of dependence in ADL and mortality (adjusted odds ratio=OR and 95% confidence interval=95% CI=6.19 (1.92-19.92)) as well as with each outcome independently. Improving the hearing difficulty from high to moderate or no difficulty would reduce the composite outcome in 4.3% (age ≥65) and in 6.3% (age ≥75) of the target population. In conclusion, hearing difficulty was common, was associated with and had substantial impact on adverse health outcomes.

9 Article Prevalence and factors associated with tinnitus: a community-based study of Japanese elders. 2010

Michikawa, Takehiro / Nishiwaki, Yuji / Kikuchi, Yuriko / Saito, Hideyuki / Mizutari, Kunio / Okamoto, Michiko / Takebayashi, Toru. ·Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan. ·J Epidemiol · Pubmed #20501961.

ABSTRACT: BACKGROUND: The prevalence of tinnitus is reported to be high in older Western populations, and several risk factors have been suggested. However, community-based evidence on prevalence is limited and, to our knowledge, there is no such information from older non-Western populations. The purpose of this study was to determine the prevalence and factors associated with tinnitus in community-dwelling Japanese elders. METHODS: In this community-based cross-sectional study, 1320 residents of Kurabuchi Town aged 65 years or older (584 men and 736 women; participation proportion = 98.7%) were interviewed at home in 2006, and information on tinnitus and factors associated with tinnitus was collected. We estimated the prevalence of tinnitus by age group and sex and used a logistic regression model to investigate associated factors. RESULTS: The prevalence of tinnitus was 18.6% (men: 18.0%; women: 19.0%); there were no statistically significant differences by age group or sex. Hearing difficulty, depressive mood, prescribed medication, past/current history of coronary heart disease, and knee joint pain requiring medical consultation were associated with tinnitus. CONCLUSIONS: These findings suggest that tinnitus is common in Japanese aged over 65 years. Because the factors associated with tinnitus in this cross-sectional study are potentially modifiable, they should be thoroughly investigated in a longitudinal study.

10 Article Hearing handicap predicts the development of depressive symptoms after 3 years in older community-dwelling Japanese. 2010

Saito, Hideyuki / Nishiwaki, Yuji / Michikawa, Takehiro / Kikuchi, Yuriko / Mizutari, Kunio / Takebayashi, Toru / Ogawa, Kaoru. ·Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Keio University, Tokyo, Japan. ·J Am Geriatr Soc · Pubmed #20002512.

ABSTRACT: OBJECTIVES: To examine the association between hearing handicap and depressive symptoms in older community-dwelling Japanese. DESIGN: Community-based cohort study. SETTING: Kurabuchi Town, Gunma Prefecture, Japan. PARTICIPANTS: Five hundred eighty residents (261 men, 319 women) aged 65 and older without depressive symptoms. MEASUREMENTS: In a baseline examination performed in 2005/06, participants answered the 10-item screening version of the Hearing Handicap Inventory for Elderly (HHIE-S). They were divided into two groups according to their scores: a group with no hearing handicap (HHIE-S scores of < or =8) and a hearing handicap group (HHIE-S scores of > or =10). The Geriatric Depression Scale was used to identify depressive symptoms in face-to-face home visit interviews conducted in 2008, and the association between hearing handicap and depressive symptoms was assessed using logistic regression. RESULTS: The incidence of depressive symptoms was 19.6% in the group with a hearing handicap and 8.0% in the group without a hearing handicap. When compared with the subjects without hearing handicap, subjects with a hearing handicap had a multiadjusted odds ratio of depressive symptoms of 2.45 (95% confidence interval=1.26-4.77). The association remained significant even when hearing impairment measured with pure-tone audiometry was added to the multiadjusted model. CONCLUSION: A hearing handicap can predict future depressive symptoms in older community-dwelling people.

11 Article Gender-specific associations of vision and hearing impairments with adverse health outcomes in older Japanese: a population-based cohort study. 2009

Michikawa, Takehiro / Nishiwaki, Yuji / Kikuchi, Yuriko / Nakano, Makiko / Iwasawa, Satoko / Asakura, Keiko / Milojevic, Ai / Mizutari, Kunio / Saito, Hideyuki / Ishida, Susumu / Okamura, Tomonori / Takebayashi, Toru. ·Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan. di065051@sc.itc.keio.ac.jp ·BMC Geriatr · Pubmed #19930597.

ABSTRACT: BACKGROUND: Several epidemiological studies have shown that self-reported vision and hearing impairments are associated with adverse health outcomes (AHOs) in older populations; however, few studies have used objective sensory measurements or investigated the role of gender in this association. Therefore, we examined the association of vision and hearing impairments (as measured by objective methods) with AHOs (dependence in activities of daily living or death), and whether this association differed by gender. METHODS: From 2005 to 2006, a total of 801 residents (337 men and 464 women) aged 65 years or older of Kurabuchi Town, Gunma, Japan, participated in a baseline examination that included vision and hearing assessments; they were followed up through September 2008. Vision impairment was defined as a corrected visual acuity of worse than 0.5 (logMAR = 0.3) in the better eye, and hearing impairment was defined as a failure to hear a 30 dB hearing level signal at 1 kHz in the better ear. Information on outcomes was obtained from the town hall and through face-to-face home visit interviews. We calculated the risk ratios (RRs) of AHOs for vision and hearing impairments according to gender. RESULTS: During a mean follow-up period of 3 years, 34 men (10.1%) and 52 women (11.3%) had AHOs. In both genders, vision impairment was related to an elevated risk of AHOs (multi-adjusted RR for men and women together = 1.60, 95% CI = 1.05-2.44), with no statistically significant interaction between the genders. In contrast, a significant association between hearing impairment and AHOs (multi-adjusted RR = 3.10, 95% CI = 1.43-6.72) was found only in the men. CONCLUSION: In this older Japanese population, sensory impairments were clearly associated with AHOs, and the association appeared to vary according to gender. Gender-specific associations between sensory impairments and AHOs warrant further investigation.

12 Article Serum levels of retinol and other antioxidants for hearing impairment among Japanese older adults. 2009

Michikawa, Takehiro / Nishiwaki, Yuji / Kikuchi, Yuriko / Hosoda, Kanae / Mizutari, Kunio / Saito, Hideyuki / Asakura, Keiko / Milojevic, Ai / Iwasawa, Satoko / Nakano, Makiko / Takebayashi, Toru. ·DMSc, Department of Preventive Medicine and Public Health, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. ·J Gerontol A Biol Sci Med Sci · Pubmed #19349590.

ABSTRACT: BACKGROUND: The objective of this study was to assess the relation between serum levels of retinol and other antioxidants and hearing impairment in Japanese older adults. METHODS: This is a community-based cross-sectional study comprising 762 residents aged 65 years or older in Kurabuchi, Gumma, Japan. We measured serum retinol and other antioxidants (alpha- and gamma-tocopherols, and carotenoids including beta-cryptoxanthin, alpha- and beta-carotenes, lycopene, and lutein plus zeaxanthin) by high-performance liquid chromatography and divided each measurement into quartiles. Hearing impairment was defined as a failure to hear a 30-dB hearing level (HL) signal at 1 kHz and a 40-dB HL signal at 4 kHz in the better ear in pure-tone audiometric tests. The odds ratios (OR) for hearing impairment were calculated for each of the upper three quartiles of retinol and other antioxidant levels relative to the lowest quartile. RESULTS: Crude analysis showed that serum levels of retinol and provitamin A carotenoids (beta-cryptoxanthin, and alpha- and beta-carotenes) were inversely related to the prevalence of hearing impairment. The multiadjusted ORs (95% confidence intervals) for the highest quartile of retinol and the provitamin A family (combinations of provitamin A carotenoids) compared with the lowest were 0.51 (0.26-1.00) and 0.53 (0.27-1.02), respectively. A dose-response relationship was observed for retinol (p = .03) and provitamin A (p = .09). CONCLUSION: Increased serum levels of retinol and provitamin A carotenoids were clearly associated with a decreased prevalence of hearing impairment.