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Hearing Disorders: HELP
Articles by Ling Lu
Based on 7 articles published since 2010
(Why 7 articles?)

Between 2010 and 2020, Lin Lu wrote the following 7 articles about Hearing Disorders.
+ Citations + Abstracts
1 Review Non-implantable Artificial Hearing Technology. 2019

Lu, Ling / Zhang, Xiaoli / Gao, Xia. ·Department of Otorhinolaryngology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China. · Department of Otorhinolaryngology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China. xiagaogao@hotmail.com. ·Adv Exp Med Biol · Pubmed #30915706.

ABSTRACT: A hearing aid is a sound-amplifying device used for aiding hearing-impaired individuals and compensating hearing loss. With the development of science and technology, tremendous strides have been made in hearing aid technology. The history of hearing aids can be divided into five eras: acoustic era, carbon era, vacuum tube era, transistor and integrated circuit era, and digital era. It mainly comprises microphone, amplifier, receiver, battery, volume and tone control buttons, and other electroacoustic components, which can be classified into following types: pocket hearing aids, BTE hearing aids, ITE hearing aids, ITE hearing aids, completely/invisible-in-canal hearing aids (CIC and IIC), and other types. Of them, one bone-anchored hearing aid (BAHA) softband is mainly applicable to children under 5 years old who cannot wear bone-anchored hearing aids in congenital bilateral external auditory canal occlusion. BAHA system comprises three components: a titanium implant (fixture screw), an external abutment (bridging screw), and a sound processor consisting of a microphone and a transducer. The following procedures are included in hearing aid fitting: medical history collection, trial, fitting, ear sample taking, hearing aid refitting, evaluation, practical instruction, and follow-up care. Children should be helped to select hearing aid as early as possible, and for those with congenital hearing loss or prelingual deafness, it can be added assessment of speech development while preventing the child from swallowing hearing aids or batteries by mistake. Speech recognition score (SRS) test is very important in elderly patients, because the speech hearing and pure-tone hearing of presbycusis are often inconsistent. After the hearing aid is selected, the effect evaluation and related rehabilitation should be carried out timely.

2 Article Long-Term Late Toxicity, Quality of Life, and Emotional Distress in Patients With Nasopharyngeal Carcinoma Treated With Intensity Modulated Radiation Therapy. 2018

McDowell, Lachlan J / Rock, Kathy / Xu, Wei / Chan, Biu / Waldron, John / Lu, Lin / Ezzat, Shereen / Pothier, David / Bernstein, Lori J / So, Nathaniel / Huang, Shao Hui / Giuliani, Meredith / Hope, Andrew / O'Sullivan, Brian / Bratman, Scott V / Cho, John / Kim, John / Jang, Raymond / Bayley, Andrew / Ringash, Jolie. ·Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. · Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada. · Department of Biostatistics, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada. · Department of Endocrine Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. · Department of Otolaryngology-Head and Neck Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada. · Department of Supportive Care, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada. · Division of Medical Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada. · Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada. Electronic address: jolie.ringash@rmp.uhn.ca. ·Int J Radiat Oncol Biol Phys · Pubmed #30191868.

ABSTRACT: PURPOSE: To report long-term (>4 years) toxicity and quality of life (QoL) among patients with nasopharyngeal carcinoma (NPC) treated with intensity modulated radiation therapy (IMRT) in a nonendemic center. METHODS AND MATERIALS: A cross-sectional cohort study enrolled patients with NPC who were disease-free and ≥4 years after IMRT ± chemotherapy. Physician-reported adverse events (Common Terminology Criteria for Adverse Events, version 4.03) and patient-reported QoL (Functional Assessment of Cancer Therapy-Head and Neck, Functional Assessment of Chronic Illness Therapy-Fatigue), utilities (EuroQOL-5D), head and neck symptoms (MD Anderson Symptom Inventory-Head and Neck), and emotional distress (Hospital Anxiety and Depression Scale) were collected. Consenting patients also underwent endocrine screening and audiometry. RESULTS: Among 107 patients enrolled, median age at enrollment and time since treatment were 57 (32-81) and 7.5 years (4.2-11.1), respectively. Most patients (99%) received 70 Gy in 35 fractions; the majority (93%) received concurrent chemotherapy. Mean scores for the Functional Assessment of Cancer Therapy-Head and Neck, Functional Assessment of Chronic Illness Therapy-Fatigue, and EuroQOL-5D were 105.0 (46-148), 116.6 (44-160), and 0.85 (0.29-1.00), respectively. Dry mouth, mucus, swallowing/chewing, memory, and teeth/gum problems were scored highest on the MD Anderson Symptom Inventory-Head and Neck; mean symptom severity and symptom interference scores were 2.3 and 2.4, respectively. Grade 3 or higher physician-reported adverse events were noted in 50 patients (47%), most frequently hearing problems (46, 43%). Audiometry revealed significant bilateral hearing loss (grade ≥3) in 68 patients (72%). Depression (25%), anxiety (37%), and fatigue (28%) were common and strongly correlated with QoL. Most patients (69%) developed hypothyroidism; 1 patient (1%) developed pituitary dysfunction requiring hormone replacement. V50 >90 and V45 >99 to the thyroid correlated with significantly higher rates of hypothyroidism. CONCLUSIONS: Despite the implementation of IMRT, survivors of NPC still experience many physical symptoms that affect long-term QoL many years after treatment. Depression, anxiety, and fatigue remain common in long-term survivors and are highly correlated with QoL.

3 Article Targeted next‑generation sequencing identifies two novel COL2A1 gene mutations in Stickler syndrome with bilateral retinal detachment. 2018

Huang, Xinhua / Lin, Ying / Chen, Chuan / Zhu, Yi / Gao, Hongbin / Li, Tao / Liu, Bingqian / Lyu, Cancan / Huang, Ying / Wu, Qingxiu / Li, Haichun / Jin, Chenjin / Liang, Xiaoling / Lu, Lin. ·State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China. · Department of Toxicology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China. ·Int J Mol Med · Pubmed #30015854.

ABSTRACT: Stickler syndrome is a group of inherited connective tissue disorders characterized by distinctive facial and ocular abnormalities, hearing loss and early‑onset arthritis. The aim of the present study was to investigate the genetic changes in two Chinese patients with Stickler syndrome, manifested as bilateral retinal detachment and peripheral retinal degeneration. Complete ophthalmic examinations, including best‑corrected visual acuity, slit‑lamp examination and fundus examination, were performed. Genomic DNA was extracted from leukocytes of the peripheral blood collected from the patients, their unaffected family members and 200 unrelated control subjects from the same population. Next‑generation sequencing of established genes associated with ocular disease was performed. A heterozygous collagen type II α1 chain (COL2A1) mutation c.1310G>C (p.R437P) in exon 21 was identified in Family 1 and a heterozygous COL2A1 mutation c.2302‑1G>A in intron 34 was identified in Family 2. The functional effects of the mutations were assessed by polymorphism phenotyping (PolyPhen) and sorting intolerant from tolerant (SIFT) analysis. The c.1310G>C mutation was predicted to damage protein structure and function, and the c.2302‑1G>A mutation was predicted to result in a splicing defect. The findings of the current study expand the established mutation spectrum of COL2A1, and may facilitate genetic counseling and development of therapeutic strategies for patients with Stickler syndrome.

4 Article [The experimental study on repair of noise-induced hearing loss in guinea pigs by bone marrow NTCSCs transplantation]. 2015

Zhang, Yingying / Liang, Gengtian / Liu, Li / Lu, Ling / Liu, Jinyan. · ·Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi · Pubmed #26647544.

ABSTRACT: OBJECTIVE: To observe the repairing effects of bone marrow transplantation with nerve tissue committed stem cell (NTCSCs) on experimental rats with injury of noise-induced hearing loss. METHOD: Guinea pigs were randomly divided into control group, noise exposure group and the transplanting group. A week after white noise exposure of 110 dB, NTCSCs and PBS were injected into guinea pigs of the noise exposure group and the transplanting group respectively. One week after noise exposure to four weeks continuous administration. ABR thresholds were measured respectively prior to the experiment, 1 week post-noise,1, 2 and 4 weeks post-drugs, The changes of cochlea hair cells were also observed by a scan electron microscope (SEM). RESULT: The ABR threshold shifts in the transplanting group were significantly fewer than that in the noise exposure group. SEM showed that hear hair of the inner and outer hair cells in noise exposure group displayed mess, fusion and imperfections. In the transplanting treatment group, the hair cells displayed slight pathological changes, there wasn't significant differents comparied with normal group. The number of OHCs were relatively stable in the normal group, while the obvious OHC loss was observed in other groups. There was significant difference among the three groups, however, the OHC loss in the transplanting group was no significantly different to that in the noise exposure (P > 0.05). CONCLUSION: The bone marrow NTCSCs which had been transplanted to rat cochlea could reduce the damage of the noise on the hair cell, and thus played a role in repairing the damage of auditory nerve.

5 Article [RAGE, NF-kappaB, p21 expressions in mouse spiral ganglion cells]. 2014

Gao, Xianting / Lin, Chang / Lu, Ling / Liang, Gengtian / Chen, Zhihong / Zhang, Xujing. · ·Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi · Pubmed #24800547.

ABSTRACT: OBJECTIVE: To research advanced glycation end-product receptors (RAGE), NF-kappaB, p21 expressions in C57BL/6j mice cochlea spiral ganglion cells(SGC) ,and then to investigate the presbycusis pathogenesis. METHOD: To take C57BL/6J mice:2 month 25,and 10 month 25. Histological sections were observed the SGC. RAGE, NF-kappaB, p21 were immunohistochemical in the SGC,with IPP6 to IOD. RESULT: (1) The count SGCs of 10 month-old was obviously decreased comparing to 2 month-old, the count of 2 month SGC is 39 +/- 5, 10 month group is 20 +/- 6, P < 0.01; (2) RAGE, NF-kappaB, p21 expressed in spiral ganglion cell,different place with different age,and the means optical density in the 10 month are higher than the 2 month, respectively. The IOD of RAGE expression in 2 month SGC: 0.179 +/- 0.025, 10 month IOD: 0.308 +/- 0.050; The IOD of NF-kappaB expression in 2 month SGC: 0.181 +/- 0.045, 10 month IOD: 0.335 +/- 0.120; The IOD of p21 expression in 2 month SGC: 0.160 +/- 0.023, 10 month IOD: 0.365 +/- 0.031, compare with 2 group, respectively, P < 0.05, and the difference has statistics sense. CONCLUSION: RAGE,NF-kappaB, p21 expressions are in SGCs and increases with the aging of SGCs, suppose RAGE, NF-kappaB, p21 may participate in the process of presbycusis pathogenesis.

6 Article [A primary study of bone conduction hearing loss in adults with otitis media with effusion]. 2010

Dai, Yanhong / She, Wandong / Lu, Ling / Chen, Jie / Wang, Junguo / Ma, Xiaofeng / Jiang, Ping / Yang, Ye. ·Department of Otolaryngology-Head and Neck Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China. ·Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi · Pubmed #21322927.

ABSTRACT: OBJECTIVE: To study the bone conductive hearing loss in adults of otitis media with effusion (OME). METHOD: Fifty adults of OME treated in our hospital, from Mar. 2009 to Feb. 2010, were enrolled for analyzing bone conduction hearing loss (BCHL) before auripuncture and after auripuncture, the difference between which were compared in 51 ears. BCT of pre auripuncture 24 subjects, BCT of post-auripuncture 22 subjects, and BCT recovered from OME 9 subjects compared with the contralateral ear respectively. High and extend high frequency (8, 10, 12, 16 kHz) air conduction threshold (ACT) after recover from OME was compared to the normal contralateral ear in 4 adults. RESULT: BCT improved significantly after auripuncture at the frequencies (0.5-4.0 kHz), and the improvements in 4.0 kHz are more than that in 0.5 kHz significantly (P<0.05). In the unilateral OME subjects, BCT, of post auripuncture and recovered from OME, nearly recovered to the same level as the contralateral ear in most cases. While high and extend-high frequency (8, 10, 12, 16 kHz) ACT elevated in 3 of 4 patients recovered from OME. CONCLUSION: Both effusion in middle ear and injury in inner ear could result in the elevation of BCT. Elevation of BCT at regular frequencies (0.5-4.0 kHz) is frequently associated with the effusion in middle ear, while these frequencies were insensitive in the early inner ear injury. The high and extend high frequency ACT elevation may be sensitive for the early sensorineural hearing loss. As the disease prolonged, sensorineural hearing loss of the lower frequencies (0.5-4.0 kHz) could be detected of OME patient.

7 Retraction Experimental study of local inner ear gene therapy for controlling autoimmune sensorineural hearing loss. 2014

Tan, Chang-qiang / Gao, Xia / Cai, Wen-jun / Qian, Xiao-yun / Lu, Ling / Huang, He. ·State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, No. 5 Xinmofan Road, Nanjing, Jiangsu 210009, China. · Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Jiangsu 210008, China. · Department of Otolaryngology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu 210009, China. ·Biomed Res Int · Pubmed #24804196.

ABSTRACT: This study aimed to investigate the efficacy of gene therapy for treating autoimmune sensorineural hearing loss (ASHL) via local administration of a recombinant adenovirus vector containing the Fas ligand or interleukin IL-10 gene. Guinea pigs were divided into four groups, with different microinjections in the scala tympani. Group A were injected with FasL-EGFP, B with IL-10-EGFP, C with EGFP, and D with artificial perilymph. Seven days later, auditory brain-stem response (ABR) was tested, and the temporal bone was stained and observed by light microscopy. The spiral ligament and basement membrane were observed using transmission electron microscopy. FasL and IL-10 expression were examined using immunofluorescence histochemistry. Immunohistochemical analysis showed that the recombinant adenovirus vector in Groups A, B, and C can transfect the stria vascularis, the spiral ligament, the organ of Corti, the spiral ganglion, the region surrounding the small blood vessel in the modiolus, and the cochlear bone wall. Compared with those in Groups C and D, the ABR wave III mean thresholds were significantly lower and the inner ear immunoinflammatory responses in Groups A and B were significantly alleviated. Inhibition of immunoinflammatory response alleviated immunoinflammatory injury and auditory dysfunction. This technique shows potential as a novel therapy for ASHL.