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Hearing Disorders: HELP
Articles by Jing-Yi Huang
Based on 1 article published since 2009
(Why 1 article?)
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Between 2009 and 2019, Jing-Yi Huang wrote the following article about Hearing Disorders.
 
+ Citations + Abstracts
1 Article Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss. 2014

Brown, Kevin D / Maqsood, Sadia / Huang, Jing-Yi / Pan, Yong / Harkcom, William / Li, Wei / Sauve, Anthony / Verdin, Eric / Jaffrey, Samie R. ·Department of Otolaryngology-Head and Neck Surgery, Weill Medical College, Cornell University, New York, NY 10065, USA. Electronic address: kevin_d_brown@med.unc.edu. · Department of Otolaryngology-Head and Neck Surgery, Weill Medical College, Cornell University, New York, NY 10065, USA. · Gladstone Institutes, University of California, San Francisco, San Francisco, CA 94941, USA. · Department of Pharmacology, Weill Medical College, Cornell University, New York, NY 10065, USA. · Gladstone Institutes, University of California, San Francisco, San Francisco, CA 94941, USA. Electronic address: eric.verdin@gladstone.ucsf.edu. · Department of Pharmacology, Weill Medical College, Cornell University, New York, NY 10065, USA. Electronic address: srj2003@med.cornell.edu. ·Cell Metab · Pubmed #25470550.

ABSTRACT: Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD(+)) exhibits axon-protective effects in cultured neurons; however, its ability to block degeneration in vivo has been difficult to establish due to its poor cell permeability and serum instability. Here, we describe a strategy to increase cochlear NAD(+) levels in mice by administering nicotinamide riboside (NR), a recently described NAD(+) precursor. We find that administration of NR, even after noise exposure, prevents noise-induced hearing loss (NIHL) and spiral ganglia neurite degeneration. These effects are mediated by the NAD(+)-dependent mitochondrial sirtuin, SIRT3, since SIRT3-overexpressing mice are resistant to NIHL and SIRT3 deletion abrogates the protective effects of NR and expression of NAD(+) biosynthetic enzymes. These findings reveal that administration of NR activates a NAD(+)-SIRT3 pathway that reduces neurite degeneration caused by noise exposure.