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Hearing Disorders: HELP
Articles by Ming-Kun Han
Based on 3 articles published since 2010
(Why 3 articles?)
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Between 2010 and 2020, Mingkun Han wrote the following 3 articles about Hearing Disorders.
 
+ Citations + Abstracts
1 Article Molecular mechanisms underlying the protective effects of hydrogen-saturated saline on noise-induced hearing loss. 2017

Chen, Liwei / Han, Mingkun / Lu, Yan / Chen, Daishi / Sun, Xuejun / Yang, Shiming / Sun, Wei / Yu, Ning / Zhai, Suoqiang. ·a Department of Otolaryngology Head and Neck Surgery , Chinese PLA General Hospital , Beijing , China. · b Department of Otolaryngology Head and Neck Surgery , Affiliated Fuzhou First Hospital of Fujian Medical University , Fujian , China. · c Department of Neurosurgery Erlangen , Medical Faculty of the Friedrich Alexander University of Erlangen-Numberg , Erlangen , Germany. · d Department of Diving Medicine, Faculty of Naval Medicine , Second Military Medical University , Shanghai , China. · e Department of Communicative Disorders and Sciences , University at Buffalo The State University of New York , Buffalo , NY , USA. ·Acta Otolaryngol · Pubmed #28549396.

ABSTRACT: OBJECTIVES: This study aimed to explore the molecular mechanism of the protective effects of hydrogen-saturated saline on NIHL. METHODS: Guinea pigs were divided into three groups: hydrogen-saturated saline; normal saline; and control. For saline administration, the guinea pigs were given daily abdominal injections 3 d before and 1 h before noise exposure. ABR were tested to examine cochlear physiology changes. The changes of 8-hydroxy-desoxyguanosine (8-HOdG), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), intercellular cell adhesion molecule-1 (ICAM-1) and high mobility group box-1 protein (HMGB1) in the cochlea were also examined. RESULTS: The results showed that pre-treatment with hydrogen-saturated saline could significantly attenuate noise-induced hearing loss. The concentration of 8-HOdG was also significantly decreased in the hydrogen-saturated saline group compared with the normal saline group. After noise exposure, the concentrations of IL-1, IL-6, TNF-α, and ICAM-1 in the cochlea of guinea pigs in the hydrogen-saturated saline group were dramatically reduced compared to those in the normal saline group. The concentrations of HMGB-1 and IL-10 in the hydrogen-saturated saline group were significantly higher than in those in the normal saline group immediately and at 7 d after noise exposure. CONCLUSIONS: This study revealed for the first time the protective effects of hydrogen-saturated saline on noise-induced hearing loss (NIHL) are related to both the anti-oxidative activity and anti-inflammatory activity.

2 Article A 2017

Du, Wan / Han, Ming-Kun / Wang, Da-Yong / Han, Bing / Zong, Liang / Lan, Lan / Yang, Ju / Shen, Qi / Xie, Lin-Yi / Yu, Lan / Guan, Jing / Wang, Qiu-Ju. ·Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. ·Chin Med J (Engl) · Pubmed #28051029.

ABSTRACT: BACKGROUND: The molecular genetic research showed the association between X-linked hearing loss and mutations in POU3F4. This research aimed to identify a POU3F4 mutation in a nonsyndromic X-linked recessive hearing loss family. METHODS: A series of clinical evaluations including medical history, otologic examinations, family history, audiologic testing, and a high-resolution computed tomography scan were performed for each patient. Bidirectional sequencing was carried out for all polymerase chain reaction products of the samples. Moreover, 834 controls with normal hearing were also tested. RESULTS: The pedigree showed X-linkage recessive inheritance pattern, and pathogenic mutation (c.499C>T) was identified in the proband and his family member, which led to a premature termination prior to the entire POU domains. This mutation co-segregated with hearing loss in this family. No mutation of POU3F4 gene was found in 834 controls. CONCLUSIONS: A nonsense mutation is identified in a family displaying the pedigree consistent with X-linked recessive pattern in POU3F4 gene. In addition, we may provide molecular diagnosis and genetic counseling for this family.

3 Article Phenotype-genotype correlation in 295 Chinese deaf subjects with biallelic causative mutations in the GJB2 gene. 2011

Zhao, Fei-Fan / Ji, Yu-Bin / Wang, Da-Yong / Lan, Lan / Han, Ming-Kun / Li, Qian / Zhao, Yali / Rao, Shaoqi / Han, Dongyi / Wang, Qiu-Ju. ·Department of Otorhinolaryngology/Head and Neck Surgery, Chinese People's Liberation Army Institute of Otolaryngology, Chinese People's Liberation Army General Hospital, Beijing, China. ·Genet Test Mol Biomarkers · Pubmed #21488715.

ABSTRACT: AIMS: The connexin 26 coding gene (GJB2) is the primary causative gene for nonsyndromic sensorineural hearing impairment (NSSHI). More than 100 mutations in this gene have been reported to be linked to hearing impairment (HI), from mild to profound hearing loss. To precisely estimate the impact of GJB2 mutations in the Chinese population, a cross-sectional study was performed to analyze the auditory data of Chinese patients with NSSHI. RESULTS: Two hundred ninety-five unrelated patients with NSSHI with biallelic mutations in GJB2 were recruited from seven provinces in Northern China from 2004 to 2008. The levels of HI and average pure tone audiometry were compared across different genotypes by χ(2) testing. The subjects with the genotypes of combined truncating mutations had more cases of severe HI than the subjects with a genotype of several nontruncating mutations. It was also revealed that subjects carrying either c.[79G>A; 341A>G]+[79G>A; 341A>G] or c.[109G>A]+[79G>A; 341A>G] had significantly fewer cases of severe HI than the reference group of homozygous c.235delC, whereas the subjects carrying c.[235delC]+[176_191del16] had more cases of severe HI than the homozygous c.235delC group. CONCLUSIONS: This is the first study to clarify the correlations between different GJB2 biallelic genotypes and NSSHI phenotype in the Chinese population. The Chinese subjects with two truncating mutations in GJB2 were shown to correlate with more severe HI.