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Hearing Disorders: HELP
Articles by Sara Giannantonio
Based on 17 articles published since 2010
(Why 17 articles?)

Between 2010 and 2020, S. Giannantonio wrote the following 17 articles about Hearing Disorders.
+ Citations + Abstracts
1 Article Universal newborn hearing screening in the Lazio region, Italy. 2018

Turchetta, Rosaria / Conti, Guido / Marsella, Pasquale / Orlando, Maria Patrizia / Picciotti, Pasqualina Maria / Frezza, Simonetta / Russo, Francesca Yoshie / Scorpecci, Alessandro / Cammeresi, Maria Gloria / Giannantonio, Sara / Greco, Antonio / Ralli, Massimo. ·Department of Sense Organs, Sapienza University of Rome, Rome, Italy. · Department of Head and Neck Surgery, Institute of Otorhinolaryngology, Catholic University of Sacred Heart, Rome, Italy. · Department of Surgery, Audiology and Otosurgery Unit, Bambino Gesù Pediatric Hospital, Rome, Italy. · Department of Pediatrics, Division of Neonatology, Catholic University of Sacred Heart, Rome, Italy. · Department of Sense Organs, Sapienza University of Rome, Rome, Italy. massimo.ralli@uniroma1.it. ·Ital J Pediatr · Pubmed #30143030.

ABSTRACT: BACKGROUND: The introduction of Universal Newborn Hearing Screening (UNHS) programs has drastically contributed to the early diagnosis of hearing loss in children, allowing prompt intervention with significant results on speech and language development in affected children. UNHS in the Lazio region has been initially deliberated in 2012; however, the program has been performed on a universal basis only from 2015. The aim of this retrospective study is to present and discuss the preliminary results of the UNHS program in the Lazio region for the year 2016, highlighting the strengths and weaknesses of the program. METHODS: Data from screening facilities in the Lazio region for year 2016 were retrospectively analyzed. Data for Level I centers were supplied by the Lazio regional offices; data for Level II and III centers were provided by units that participated to the study. RESULTS: During 2016, a total of 44,805 babies were born in the Lazio region. First stage screening was performed on 41,821 children in 37 different birth centers, with a coverage rate of 93.3%. Of these, 38.977 (93.2%) obtained a "pass" response; children with a "refer" result in at least one ear were 2844 (6.8%). Data from Level II facilities are incomplete due to missing reporting, one of the key issues in Lazio UNHS. Third stage evaluation was performed on 365 children in the three level III centers of the region, allowing identification of 70 children with unilateral (40%) or bilateral (60%) hearing loss, with a prevalence of 1.6/1000. CONCLUSIONS: The analysis of 2016 UNHS in the Lazio region allowed identification of several strengths and weaknesses of the initial phase of the program. The strengths include a correct spread and monitoring of UNHS among Level I facilities, with an adequate coverage rate, and the proper execution of audiological monitoring and diagnosis among Level III facilities. Weakness, instead, mainly consisted in lack of an efficient and automated central process for collecting, monitoring and reporting of data and information.

2 Article A functional and anatomical comparison between two passive transcutaneous bone conduction implants in children. 2018

Giannantonio, Sara / Scorpecci, Alessandro / Pacifico, Concettina / Marsella, Pasquale. ·Audiology and Otosurgery Unit, "Bambino Gesù" Children's Hospital, Rome, Italy. Electronic address: sara.giannantonio@opbg.net. · Audiology and Otosurgery Unit, "Bambino Gesù" Children's Hospital, Rome, Italy. ·Int J Pediatr Otorhinolaryngol · Pubmed #29605355.

ABSTRACT: OBJECTIVE: To compare anatomical and functional outcomes of two passive transcutaneous bone conduction implant systems: Sophono™ and BAHA Attract™. MATERIALS AND METHODS: Twenty patients, affected by bilateral conductive hearing loss, underwent unilateral transcutaneous bone conduction implant surgery. Ten children received a Sophono™ implant (6 males, 4 females, mean age 11 years, mean unaided Pure Tone Average (PTA) 0.25-4kHz = 69.70dB HL) and 10 a BAHA Attract™ system (7 males, 3 females, mean age 19 years, mean unaided PTA0.25-4kHz = 66.40dB HL). The following outcomes were considered: incidence of local complications, hearing aid benefit, hearing aid gain and changes in quality of life (QOL), as measured by the Glasgow Children's Benefit Inventory (GCBI). RESULTS: One patient in the Sophono group experienced magnet-related skin decubitus, while two patients (one per group) had skin hyperemia in the area overlying the magnet. The mean BAHA-aided threshold was 23.70dB, whereas the mean Sophono-aided threshold was 31.60dB. The mean gain was significantly different for lower frequencies, the BAHA having better functional outcomes. All patients reported an improvement in their QOL. CONCLUSION: Given the lower thickness of the internal magnet, the Sophono™ system might be more suitable for younger children, whereas BAHA offered better functional results. Both systems can be considered valid and safe options for the functional rehabilitation of conductive hearing loss in children, provided that precautions are observed, such as a gradual use of the device and use of the least powerful magnets in the first months after the activation.

3 Article EEG activity as an objective measure of cognitive load during effortful listening: A study on pediatric subjects with bilateral, asymmetric sensorineural hearing loss. 2017

Marsella, Pasquale / Scorpecci, Alessandro / Cartocci, Giulia / Giannantonio, Sara / Maglione, Anton Giulio / Venuti, Isotta / Brizi, Ambra / Babiloni, Fabio. ·Audiology and Otosurgery Unit, Bambino Gesù Pediatric Hospital, Italy. · Audiology and Otosurgery Unit, Bambino Gesù Pediatric Hospital, Italy. Electronic address: alessandroscorpecci@yahoo.it. · Department of Molecular Medicine, "Sapienza" University of Rome, Italy. · BrainSigns srl, Rome, Italy. · Department of Developmental and Social Psychology, "Sapienza" University of Rome, Italy. ·Int J Pediatr Otorhinolaryngol · Pubmed #28688548.

ABSTRACT: OBJECTIVES: Deaf subjects with hearing aids or cochlear implants generally find it challenging to understand speech in noisy environments where a great deal of listening effort and cognitive load are invested. In prelingually deaf children, such difficulties may have detrimental consequences on the learning process and, later in life, on academic performance. Despite the importance of such a topic, currently, there is no validated test for the assessment of cognitive load during audiological tasks. Recently, alpha and theta EEG rhythm variations in the parietal and frontal areas, respectively, have been used as indicators of cognitive load in adult subjects. The aim of the present study was to investigate, by means of EEG, the cognitive load of pediatric subjects affected by asymmetric sensorineural hearing loss as they were engaged in a speech-in-noise identification task. METHODS: Seven children (4F and 3M, age range = 8-16 years) affected by asymmetric sensorineural hearing loss (i.e. profound degree on one side, mild-to-severe degree on the other side) and using a hearing aid only in their better ear, were included in the study. All of them underwent EEG recording during a speech-in-noise identification task: the experimental conditions were quiet, binaural noise, noise to the better hearing ear and noise to the poorer hearing ear. The subjects' Speech Recognition Thresholds (SRT) were also measured in each test condition. The primary outcome measures were: frontal EEG Power Spectral Density (PSD) in the theta band and parietal EEG PSD in the alpha band, as assessed before stimulus (word) onset. RESULTS: No statistically significant differences were noted among frontal theta power levels in the four test conditions. However, parietal alpha power levels were significantly higher in the "binaural noise" and in the "noise to worse hearing ear" conditions than in the "quiet" and "noise to better hearing ear" conditions (p < 0.001). SRT scores were consistent with task difficulty, but did not correlate with alpha and theta power level variations. CONCLUSION: This is the first time that EEG has been applied to children with sensorineural hearing loss with the purpose of studying the cognitive load during effortful listening. Significantly higher parietal alpha power levels in two of three noisy conditions, compared to the quiet condition, are consistent with increased cognitive load. Specifically, considering the time window of the analysis (pre-stimulus), parietal alpha power levels may be a measure of cognitive functions such as sustained attention and selective inhibition. In this respect, the significantly lower parietal alpha power levels in the most challenging listening condition (i.e. noise to the better ear) may be attributed to loss of attention and to the subsequent fatigue and "withdrawal" from the task at hand.

4 Article Music perception improves in children with bilateral cochlear implants or bimodal devices. 2017

Polonenko, Melissa J / Giannantonio, Sara / Papsin, Blake C / Marsella, Pasquale / Gordon, Karen A. ·Archie's Cochlear Implant Laboratory, Department of Otolaryngology, The Hospital for Sick Children, Room 6D08, Toronto M5G 1X8, Canada. · Audiology and Otosurgery Unit, Bambino Gesù Pediatric Hospital, Piazza di Sant'Onofrio 4, 00165, Rome, Italy. ·J Acoust Soc Am · Pubmed #28679263.

ABSTRACT: The objectives of this study were to determine if music perception by pediatric cochlear implant users can be improved by (1) providing access to bilateral hearing through two cochlear implants or a cochlear implant and a contralateral hearing aid (bimodal users) and (2) any history of music training. The Montreal Battery of Evaluation of Musical Ability test was presented via soundfield to 26 bilateral cochlear implant users, 8 bimodal users and 16 children with normal hearing. Response accuracy and reaction time were recorded via an iPad application. Bilateral cochlear implant and bimodal users perceived musical characteristics less accurately and more slowly than children with normal hearing. Children who had music training were faster and more accurate, regardless of their hearing status. Reaction time on specific subtests decreased with age, years of musical training and, for implant users, better residual hearing. Despite effects of these factors on reaction time, bimodal and bilateral cochlear implant users' responses were less accurate than those of their normal hearing peers. This means children using bilateral cochlear implants and bimodal devices continue to experience challenges perceiving music that are related to hearing impairment and/or device limitations during development.

5 Article Bimodal Stimulation in Prelingually Deaf Children: Lessons from a Cross-sectional Survey. 2016

Scorpecci, Alessandro / Giannantonio, Sara / Pacifico, Concettina / Marsella, Pasquale. ·Audiology and Otosurgery Unit, Bambino Gesù Pediatric Hospital, Rome, Italy alessandro.scorpecci@opbg.net. · Audiology and Otosurgery Unit, Bambino Gesù Pediatric Hospital, Rome, Italy. ·Otolaryngol Head Neck Surg · Pubmed #27484236.

ABSTRACT: OBJECTIVE: (1) To survey the use of bimodal stimulation by prelingually deaf children receiving unilateral cochlear implantation and (2) to investigate demographic and audiologic factors explaining the use of bimodal stimulation. STUDY DESIGN: Cross-sectional survey. SETTING: Tertiary care institution. SUBJECTS AND METHODS: The study included 44 unilaterally implanted prelingually deaf children from a single institution, with a minimum follow-up of 1 year. During routine follow-up visits, an examiner interviewed parents on their children's use of bimodal stimulation. At the same time, residual hearing and hearing aid gain in the contralateral ear were assessed. RESULTS: Approximately half of patients (52%) used bimodal stimulation. On average, bimodal users showed better mean unaided and aided thresholds than nonbimodal users (P < .001). A mean 250- to 500-Hz unaided threshold ≤90 dB HL in the contralateral, nonimplanted ear was associated with a higher probability of bimodal use (P = .008). Parental satisfaction with the contralateral hearing aid was inversely correlated with mean 125- to 500-Hz and 1000- to 4000-Hz unaided thresholds (P < .001) and mean 250- to 500-Hz and 1000- to 4000-Hz aided thresholds (P < .001). CONCLUSIONS: A mean 250- to 500-Hz unaided threshold ≤90 dB HL is associated with a higher probability of bimodal use by prelingually deaf children. Better residual hearing is associated with a higher degree of parental satisfaction with the contralateral hearing aid. This information could be useful to counsel parents of prelingually deaf children, when deciding between bimodal stimulation and simultaneous bilateral cochlear implantation.

6 Article Prelingual auditory-perceptual skills as indicators of initial oral language development in deaf children with cochlear implants. 2016

Pianesi, Federica / Scorpecci, Alessandro / Giannantonio, Sara / Micardi, Mariella / Resca, Alessandra / Marsella, Pasquale. ·Audiology-Otology Unit and Cochlear Implant Referral Center, "Bambino Gesù" Pediatric Hospital, Rome, Italy. · Audiology-Otology Unit and Cochlear Implant Referral Center, "Bambino Gesù" Pediatric Hospital, Rome, Italy. Electronic address: alessandroscorpecci@yahoo.it. ·Int J Pediatr Otorhinolaryngol · Pubmed #26857317.

ABSTRACT: OBJECTIVES: To assess when prelingually deaf children with a cochlear implant (CI) achieve the First Milestone of Oral Language, to study the progression of their prelingual auditory skills in the first year after CI and to investigate a possible correlation between such skills and the timing of initial oral language development. METHODS: The sample included 44 prelingually deaf children (23 M and 21 F) from the same tertiary care institution, who received unilateral or bilateral cochlear implants. Achievement of the First Milestone of Oral Language (FMOL) was defined as speech comprehension of at least 50 words and speech production of a minimum of 10 words, as established by administration of a validated Italian test for the assessment of initial language competence in infants. Prelingual auditory-perceptual skills were assessed over time by means of a test battery consisting of: the Infant Toddler Meaningful Integration Scale (IT-MAIS); the Infant Listening Progress Profile (ILiP) and the Categories of Auditory Performance (CAP). RESULTS: On average, the 44 children received their CI at 24±9 months and experienced FMOL after 8±4 months of continuous CI use. The IT-MAIS, ILiP and CAP scores increased significantly over time, the greatest improvement occurring between baseline and six months of CI use. On multivariate regression analysis, age at diagnosis and age at CI did not appear to bear correlation with FMOL timing; instead, the only variables contributing to its variance were IT-MAIS and ILiP scores after six months of CI use, accounting for 43% and 55%, respectively. CONCLUSION: Prelingual auditory skills of implanted children assessed via a test battery six months after CI treatment, can act as indicators of the timing of initial oral language development. Accordingly, the period from CI switch-on to six months can be considered as a window of opportunity for appropriate intervention in children failing to show the expected progression of their auditory skills and who would have higher risk of delayed oral language development.

7 Article Mental workload estimations in unilateral deafened children. 2015

Cartocci, Giulia / Maglione, Anton Giulio / Vecchiato, Giovanni / Di Flumeri, Gianluca / Colosimo, Alfredo / Scorpecci, Alessandro / Marsella, Pasquale / Giannantonio, Sara / Malerba, Paolo / Borghini, Gianluca / Arico, Pietro / Babiloni, Fabio. · ·Conf Proc IEEE Eng Med Biol Soc · Pubmed #26736593.

ABSTRACT: Despite of technological innovations, noisy environments still constitute a challenging and stressful situation for words recognition by hearing impaired subjects. The evaluation of the mental workload imposed by the noisy environments for the recognition of the words in prelingually deaf children is then of paramount importance since it could affect the speed of the learning process during scholar period.The aim of the present study was to investigate different electroencephalographic (EEG) power spectral density (PSD) components (in theta 4-8 Hz - and alpha - 8-12 Hz - frequency bands) to estimate the mental workload index in different noise conditions during a word recognition task in prelingually deaf children, a population not yet investigated in relation to the workload index during auditory tasks. A pilot study involving a small group of prelingually deaf children was then subjected to EEG recordings during an auditory task composed by a listening and a successive recognition of words with different noise conditions. Results showed that in the pre-word listening phase frontal EEG PSD in theta band and the ratio of the frontal EEG PSD in theta band and the parietal EEG PSD in alpha band (workload index; IWL) reported highest values in the most demanding noise condition. In addition, in the phase preceding the word forced-choice task the highest parietal EEG PSD in alpha band and IWL values were reported at the presumably simplest condition (noise emitted in correspondence of the subject's deaf ear). These results could suggest the prominence of EEG PSD theta component activity in the pre-word listening phase. In addition, a more challenging noise situation in the pre-choice phase would be so "over-demanding" to fail to enhance both the alpha power and the IWL in comparison to the already demanding "simple" condition.

8 Article Alpha EEG Frontal Asymmetries during Audiovisual Perception in Cochlear Implant Users. A Study with Bilateral and Unilateral Young Users. 2015

Maglione, A G / Scorpecci, A / Malerba, P / Marsella, P / Giannantonio, S / Colosimo, A / Babiloni, F / Vecchiato, G. ·Giovanni Vecchiato, PhD, Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy, E-mail: giovanni.vecchiato@uniroma1.it. ·Methods Inf Med · Pubmed #25969145.

ABSTRACT: OBJECTIVES: The aim of the present study is to investigate the variations of the electroencephalographic (EEG) alpha rhythm in order to measure the appreciation of bilateral and unilateral young cochlear implant users during the observation of a musical cartoon. The cartoon has been modified for the generation of three experimental conditions: one with the original audio, another one with a distorted sound and, finally, a mute version. METHODS: The EEG data have been recorded during the observation of the cartoons in the three experimental conditions. The frontal alpha EEG imbalance has been calculated as a measure of motivation and pleasantness to be compared across experimental populations and conditions. RESULTS: The EEG frontal imbalance of the alpha rhythm showed significant variations during the perception of the different cartoons. In particular, the pattern of activation of normal-hearing children is very similar to the one elicited by the bilateral implanted patients. On the other hand, results related to the unilateral subjects do not present significant variations of the imbalance index across the three cartoons. CONCLUSION: The presented results suggest that the unilateral patients could not appreciate the difference in the audio format as well as bilaterally implanted and normal hearing subjects. The frontal alpha EEG imbalance is a useful tool to detect the differences in the appreciation of audiovisual stimuli in cochlear implant patients.

9 Article A case-control study on proinflammatory genetic polymorphisms on sudden sensorineural hearing loss. 2015

Cadoni, Gabriella / Gaetani, Eleonora / Picciotti, Pasqualina M / Arzani, Dario / Quarta, Miriam / Giannantonio, Sara / Paludetti, Gaetano / Boccia, Stefania. ·Department of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy. ·Laryngoscope · Pubmed #25345762.

ABSTRACT: OBJECTIVES/HYPOTHESIS: Sudden sensorineural hearing loss (SSNHL) is strictly related to inner ear vascular injuries and recently to some atherosclerotic risk factors. The pathogenic role of inflammatory molecules in atherosclerosis is well established. However, there is little knowledge about the potential role of inflammatory cytokines and adhesion molecules on SSNHL etiology. STUDY DESIGN: The aim of this study was to evaluate the role of proinflammatory genetic polymorphisms of the MCP-1 (CCL2), E-selectin, and interleukin (IL)-6 gene in SSNHL patients. METHODS: We evaluated the frequency and distribution of selected single nucleotide polymorphisms of the MCP-1 (CCL2), E-selectin, and IL-6 gene in 87 SSNHL patients and 107 healthy controls. RESULTS: Our results did not show significant difference between the compared groups for MCP-1 and E-selectin genes, whereas a significant difference was reported for the IL-6 gene (P < .0001). CONCLUSIONS: The main finding of our study is that the 174G/G polymorphism (with a wider distribution of wt/wt genotype in SSNHL patients than in the healthy controls) of the IL-6 gene is significantly associated with the risk of SSNHL, which is consistent with a previous finding on serum levels of IL-6 in SSNHL. It is possible that the variant acts as a triggering agent of different lipidemia-related phenotypes. Both the -174G/G polymorphism and elevated IL-6 levels in SSNHL patients could suggest that IL-6 plays a role in the inner ear involvement by atherosclerotic inflammatory events.

10 Article Adaptation of cochlear implant fitting to various telecommunication systems: a proposal for a 'telephone map'. 2014

Giannantonio, Sara / Di Nardo, Walter / Schinaia, Lorenzo / Paludetti, Gaetano. ·Head and Neck Department, Catholic University of the Sacred Heart , Rome , Italy. ·Acta Otolaryngol · Pubmed #24865302.

ABSTRACT: CONCLUSIONS: Despite the innovations in cochlear implant (CI) technology in recent years, some auditory tasks remain difficult for CI recipients. This work proposes the creation of specific maps for telephone communication (via conventional phone and via Internet protocol, VoIP). In light of our preliminary results, we believe that our experimental maps might improve conventional telephone and Internet communications for CI recipients. OBJECTIVES: This study aimed to: (1) analyze the spectro-temporal characteristics of the signals; (2) evaluate speech recognition scores using two different types of telephone communication; and (3) change some map parameters on the basis of the previous signal analysis, to obtain a specific map for telephone use. METHODS: Eleven Cochlear™ Nucleus® CI recipients were tested for bisyllabic word recognition in quiet using reproduced voice and transmitted voice via conventional telephone and Skype® using the habitual-ACE (SLB) map, and two experimental maps (F- and V-Map). RESULTS: The results showed a worsening of word recognition scores with SLB-Map via telephone (30.5%) and VoIP (18.6%) compared with those achieved with the same map in an anechoic booth. In the experimental listening conditions, 65% and 54% of patients performed better with F- and V-Map, respectively, up to a maximum of performance improvement by 35% via telephone and 25% via VoIP.

11 Article Role of auditory brain function assessment by SPECT in cochlear implant side selection. 2013

Di Nardo, W / Giannantonio, S / Di Giuda, D / De Corso, E / Schinaia, L / Paludetti, G. ·Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy. ·Acta Otorhinolaryngol Ital · Pubmed #23620636.

ABSTRACT: Pre-surgery evaluation, indications for cochlear implantation and expectations in terms of post-operative functional results remain challenging topics in pre-lingually deaf adults. Our study has the purpose of determining the benefits of Single Photon Emission Tomography (SPECT) assessment in pre-surgical evaluation of pre-lingually deaf adults who are candidates for cochlear implantation. In 7 pre-lingually profoundly deaf patients, brain SPECT was performed at baseline conditions and in bilateral simultaneous multi-frequency acoustic stimulation. Six sagittal tomograms of both temporal cortices were used for semi-quantitative analysis in each patient. Percentage increases in cortical perfusion resulting from auditory stimulation were calculated. The results showed an inter-hemispherical asymmetry of the activation extension and intensity in the stimulated temporal areas. Consistent with the obtained brain activation data, patients were implanted preferring the side that showed higher activation after acoustic stimulus. Considering the increment in auditory perception performances, it was possible to point out a relationship between cortical brain activity shown by SPECT and hearing performances, and, even more significant, a correlation between post-operative functional performances and the activation of the most medial part of the sagittal temporal tomograms, corresponding to medium-high frequencies. In light of these findings, we believe that brain SPECT could be considered in the evaluation of deaf patients candidate for cochlear implantation, and that it plays a major role in functional assessment of the auditory cortex of pre-lingually deaf subjects, even if further studies are necessary to conclusively establish its utility. Further developments of this technique are possible by using trans-tympanic electrical stimulation of the cochlear promontory, which could give the opportunity to study completely deaf patients, whose evaluation is objectively difficult with current audiological methods.

12 Article Noninvasive management of cochlear implant's inner magnet displacement after magnetic resonance. 2013

Di Nardo, Walter / Giannantonio, Sara / Schinaia, Lorenzo / De Corso, Eugenio / Paludetti, Gaetano. ·Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy. ·Laryngoscope · Pubmed #23086709.

ABSTRACT: MRI is a widespread and greatly helpful diagnostic tool, yet its use on cochlear implant patients is restricted by the presence of an inner magnet. We report on a case of magnet dislodgment after 1.5T MRI in a 31-year-old female with a Hi-Res 90K cochlear implant. In this case, it was possible to implement an alternative, totally noninvasive approach based on an external manual repositioning rather than a surgical procedure of the displaced magnet.

13 Article Investigation on the music perception skills of Italian children with cochlear implants. 2012

Scorpecci, Alessandro / Zagari, Felicia / Mari, Giorgia / Giannantonio, Sara / D'Alatri, Lucia / Di Nardo, Walter / Paludetti, Gaetano. ·ENT Department A. Gemelli Hospital, Catholic University of the Sacred Heart, Rome, Italy. alessandroscorpecci@yahoo.it ·Int J Pediatr Otorhinolaryngol · Pubmed #22835928.

ABSTRACT: OBJECTIVE: To compare the music perception skills of a group of Italian-speaking children with cochlear implants to those of a group of normal hearing children; to analyze possible correlations between implanted children's musical skills and their demographics, clinical characteristics, phonological perception, and speech recognition and production abilities. METHODS: 18 implanted children aged 5-12 years and a reference group of 23 normal-hearing subjects with typical language development were enrolled. Both groups received a melody identification test and a song (i.e. original version) identification test. The implanted children also received a test battery aimed at assessing speech recognition, speech production and phoneme discrimination. RESULTS: The implanted children scored significantly worse than the normal hearing subjects in both musical tests. In the cochlear implant group, phoneme discrimination abilities were significantly correlated with both melody and song identification skills, and length of device use was significantly correlated with song identification skills. CONCLUSIONS: Experience with device use and phonological perception had a moderate-to-strong correlation to implanted children's music perception abilities. In the light of these findings, it is reasonable to assume that a rehabilitation program specifically aimed at improving phonological perception could help pediatric cochlear implant recipients better understand the basic elements of music; moreover, a training aimed at improving the comprehension of the spectral elements of music could enhance implanted children's phonological skills.

14 Article Cytomegalovirus DNA retrieval in the inner ear fluids of a congenitally deaf child one month after primary infection: a case report. 2011

Di Nardo, Walter / Cattani, Paola / Scorpecci, Alessandro / Giannantonio, Sara / D'Onghia, Sara / Fadda, Giovanni / Paludetti, Gaetano. ·Department of Otorhinolaryngology, Catholic University of Sacred Heart, Rome, Italy. ·Laryngoscope · Pubmed #21305557.

ABSTRACT: In the present article we report cytomegalovirus (CMV) DNA localization in the inner ear of a 15-month-old deaf boy 1 month after a virologically documented primary infection. CMV DNA retrieval was possible thanks to polymerase chain reaction analysis of the perilymph collected at cochlear implant surgery. To the authors' knowledge this is the first demonstration of CMV persistence in the cochlea of an immunocompetent subject after an acquired infection.

15 Article Improving melody recognition in cochlear implant recipients through individualized frequency map fitting. 2011

Di Nardo, Walter / Scorpecci, Alessandro / Giannantonio, Sara / Cianfrone, Francesca / Paludetti, Gaetano. ·Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, A. Gemelli University Hospital, Largo Gemelli, 8, 00168, Rome, Italy. ·Eur Arch Otorhinolaryngol · Pubmed #20635091.

ABSTRACT: Recent research has shown that music perception remains very difficult for most cochlear implant (CI) users, who generally report being unsatisfied with the quality of music listening through the CI. In particular, the appreciation of the spectral features of music, which include pitch, melody and timbre, is widely known to be poorer than its rhythmic patterns. One of the possible causes for this may be the misalignment between the conventional frequency band allocation to the electrodes of the array (frequency-place function) and the distribution of pitch percepts generated by electrode stimulation along the array (electrode-pitch function). In this paper the authors investigate whether mismatch correction through individualized fitting of the processor's frequency maps can improve music understanding in ten Nucleus™ cochlear implant users, by comparing scores obtained with experimental and old map; both maps were tested before, immediately after and 1 month after the fitting through a music test battery designed for the purpose of the study.

16 Article Serum fatty acids and cardiovascular risk factors in sudden sensorineural hearing loss: a case-control study. 2010

Cadoni, Gabriella / Scorpecci, Alessandro / Cianfrone, Francesca / Giannantonio, Sara / Paludetti, Gaetano / Lippa, Silvio. ·Institutes of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy. ·Ann Otol Rhinol Laryngol · Pubmed #20336917.

ABSTRACT: OBJECTIVES: We analyzed the relationships between sudden sensorineural hearing loss (SSNHL) and serum levels of fatty acids, total cholesterol, low-density lipoproteins (LDLs), and the antioxidant coenzyme Q10. METHODS: Forty-three patients with SSNHL and 43 healthy subjects were enrolled in the study. The main outcome measures were serum levels of fatty acids, coenzyme Q10, total cholesterol, and LDLs. RESULTS: On univariate logistic regression analysis, high levels of total cholesterol (p < 0.001), LDLs (p = 0.024), behenic acid (p < 0.001), docosahexaenoic acid (p < 0.001), linolenic acid (p = 0.017), and oleic acid (p < 0.001) and low levels of coenzyme Q10 (p < 0.001) and nervonic acid (p < 0.001) were associated with an elevated risk of SSNHL. On multivariate analysis, only hypercholesterolemia (p = 0.15) and low levels of coenzyme Q10 (p = 0.02) and nervonic acid (p = 0.005) were significantly associated with SSNHL. CONCLUSIONS: This is the first report of low serum levels of nervonic acid as an independent risk factor for SSNHL. Considering that hypercholesterolemia, high serum levels of LDL, and low serum levels of the antioxidant coenzyme Q10 were associated with SSNHL as well, we hypothesize that saturated fatty acids may play a role in determining the dysmetabolic state in a subset of SSNHL patients. Together, these findings suggest that not only total cholesterol and LDL levels, but also fatty acid determination, may help identify SSNHL patients with cardiovascular risk factors.

17 Article Cochlear implant patients' speech understanding in background noise: effect of mismatch between electrode assigned frequencies and perceived pitch. 2010

Di Nardo, W / Scorpecci, A / Giannantonio, S / Cianfrone, F / Parrilla, C / Paludetti, G. ·Department of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy. ·J Laryngol Otol · Pubmed #20202276.

ABSTRACT: OBJECTIVE: To assess the electrode pitch function in a series of adults with postlingually implanted cochlear implants and with contralateral residual hearing, in order to investigate the correlation between the degree of frequency map mismatch and the subjects' speech understanding in quiet and noisy conditions. DESIGN: Case series. SUBJECTS: Seven postlingually deafened adults with cochlear implants, all with detectable contralateral residual hearing. Subjects' electrode pitch function was assessed by means of a pitch-matching test, in which they were asked to match an acoustic pitch (pure tones delivered to the non-implanted ear by an audiometer) to a perceived 'pitch' elicited by stimulation of the cochlear implant electrodes. A mismatch score was calculated for each subject. Speech recognition was tested using lists of sentences presented in quiet conditions and at +10, 0 and 5 dB HL signal-to-noise ratio levels (i.e. noise 10 dB HL lower than signal, noise as loud as signal and noise 5 dB HL higher than signal, respectively). Correlations were assessed using a linear regression model, with significance set at p < 0.05. RESULTS: All patients presented some degree of mismatch between the acoustic frequencies assigned to their implant electrodes and the pitch elicited by stimulation of the same electrode, with high between-individual variability. A significant correlation (p < 0.005) was found between mismatch and speech recognition scores at +10 and 0 dB HL signal-to-noise ratio levels (r2 = 0.91 and 0.89, respectively). CONCLUSION: The mismatch between frequencies allocated to electrodes and the pitch perceived on stimulation of the same electrodes could partially account for our subjects' difficulties with speech understanding in noisy conditions. We suggest that these subjects could benefit from mismatch correction, through a procedure allowing individualised reallocation of frequency bands to electrodes.