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Hearing Disorders: HELP
Articles by Pasquale Capaccio
Based on 3 articles published since 2010
(Why 3 articles?)
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Between 2010 and 2020, P. Capaccio wrote the following 3 articles about Hearing Disorders.
 
+ Citations + Abstracts
1 Article MR Imaging in Sudden Sensorineural Hearing Loss. Time to Talk. 2017

Conte, G / Di Berardino, F / Sina, C / Zanetti, D / Scola, E / Gavagna, C / Gaini, L / Palumbo, G / Capaccio, P / Triulzi, F. ·From the Postgraduation School of Radiodiagnostics (G.C.) giorgioconte.unimed@gmail.com. · Audiology (F.D.B., D.Z.). · Neuroradiology (C.S., E.S., C.G., F.T.). · Otolaryngology (L.G., P.C.) Units, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico. · School of Medicine (G.P.). · Department of Pathophysiology and Transplantation (F.T.), Università degli Studi di Milano, Milan, Italy. ·AJNR Am J Neuroradiol · Pubmed #28546251.

ABSTRACT: Sudden sensorineural hearing loss is defined as acute hearing loss of the sensorineural type of at least 30 dB over 3 contiguous frequencies that occurs within a 72-hour period. Although many different causative factors have been proposed, sudden sensorineural hearing loss is still considered "idiopathic" in 71%-85% of cases, and treatments are empiric, not based on etiology. MR imaging implemented with a 3D FLAIR sequence has provided new insights into the etiology of sudden sensorineural hearing loss. Herein, we review the current management trends for patients with sudden sensorineural hearing loss, from the initial clinical diagnosis to therapeutic strategies and diagnostic work-up. We focused primarily on MR imaging assessment and discuss the relevance that MR imaging findings might have for patient management, pointing out different perspectives for future clinical research.

2 Article Thrombin generation in patients with idiopathic sudden sensorineural hearing loss. 2014

Tripodi, Armando / Capaccio, Pasquale / Pignataro, Lorenzo / Chantarangkul, Veena / Menegatti, Marzia / Bamonti, Fabrizia / Clerici, Marigrazia / De Giuseppe, Rachele / Peyvandi, Flora. ·Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di Milano and IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy. Electronic address: armando.tripodi@unimi.it. · Department of Biomedical, Surgical and Dental Sciences, University of Milan, Università degli Studi di Milano and IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy. · Department of Clinical Sciences and Community Health, Università degli Studi di Milano and IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy. · Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di Milano and IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy. · Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Pathophysiology and Transplantation, Università degli Studi di Milano and IRCCS Ca' Granda Maggiore Hospital Foundation, Milano, Italy. · Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Department of Hematology-Oncology and BMT Unit, IRCCS Cà Granda Maggiore Hospital Foundation, Milan, Italy. ·Thromb Res · Pubmed #24690481.

ABSTRACT: INTRODUCTION: The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unknown. Systemic hemostasis derangement causing local vascular occlusion might be one of the pathogenetic mechanisms. MATERIAL AND METHODS: Forty-one patients with ISSNHL and 48 healthy subjects were investigated. We measured thrombin generation in the presence or absence of thrombomodulin in platelet-poor or platelet-rich plasma by means of a home-made method based on calibrated automated thrombin generation, which should mimic much more closely than any other conventional coagulation test the balance of coagulation operating in vivo. DNA analyses for the most common prothrombotic genotypes such as factor V Leiden, prothrombin G20210A, MTHFR or platelet GPIIIa A1/A2 were also carried out in patients and controls. RESULTS: Patients generated as much thrombin as controls both in platelet-rich and platelet-poor plasma and the frequency of the most common prothrombotic genotypes were similar in patients and controls. CONCLUSIONS: The results suggest that the pathogenesis of ISSNHL is not due to systemic blood hypercoagulability. Other culprits such as local vascular abnormalities, viral infections, immune-mediated mechanisms or abnormalities of inner ear and central nervous system should be advocated to explain ISSNHL.

3 Article Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss. 2012

Capaccio, Pasquale / Pignataro, Lorenzo / Gaini, Lorenzo M / Sigismund, Paolo E / Novembrino, Cristina / De Giuseppe, Rachele / Uva, Valentina / Tripodi, Armando / Bamonti, Fabrizia. ·Dipartimento di Scienze Specialistiche e Chirurgiche, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, Italy. ·Eur Arch Otorhinolaryngol · Pubmed #21706323.

ABSTRACT: An impaired cochlear perfusion seems to be an important etiopathogenetic event in idiopathic sudden sensorineural hearing loss (ISSNHL). Recently, oxidative stress has been proposed as risk factors of microvascular damage. This observational study aimed to evaluate the possible role of oxidative stress in ISSNHL. In thirty-nine ISSNHL patients and seventy healthy subjects serum reactive oxygen species concentrations (ROS) and total antioxidant capacity (TAC) were measured by spectrophotometric methods on F.R.E.E. analyzer (Diacron International, Italy). Moreover, a global oxidative stress index (Oxidative-INDEX), reflecting both oxidative and antioxidant counterparts, was also calculated. 25/39 patients showed oxidative stress due to ROS levels significantly higher than controls (348.2 ± 84.8 vs. 306.75 ± 46.7 UCarr; p = 0.001). The Oxidative-INDEX was significantly higher in patients than in controls (0.75 ± 2.4 vs. -0.0007 ± 1.28 AU, p = 0.03). As oxidative stress is a key determinant in endothelial dysfunction, our findings could suggest vascular impairment involvement in ISSNHL etiopathogenesis.