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Hearing Disorders: HELP
Articles by Jan Bulla
Based on 2 articles published since 2010
(Why 2 articles?)

Between 2010 and 2020, Jan Bulla wrote the following 2 articles about Hearing Disorders.
+ Citations + Abstracts
1 Clinical Trial A proof-of-concept study on the combination of repetitive transcranial magnetic stimulation and relaxation techniques in chronic tinnitus. 2016

Kreuzer, Peter M / Poeppl, Timm B / Bulla, Jan / Schlee, Winfried / Lehner, Astrid / Langguth, Berthold / Schecklmann, Martin. ·Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany. peter.kreuzer@medbo.de. · Interdisciplinary Tinnitus Centre of the University of Regensburg, Regensburg, Germany. peter.kreuzer@medbo.de. · Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany. · Interdisciplinary Tinnitus Centre of the University of Regensburg, Regensburg, Germany. · Department of Mathematics, University of Bergen, P.O. Box 7800, 5020, Bergen, Norway. ·J Neural Transm (Vienna) · Pubmed #27315823.

ABSTRACT: Interference of ongoing neuronal activity and brain stimulation motivated this study to combine repetitive transcranial magnetic stimulation (rTMS) and relaxation techniques in tinnitus patients. Forty-two patients were enrolled in this one-arm proof-of-concept study to receive ten sessions of rTMS applied to the left dorsolateral prefrontal cortex and temporo-parietal cortex. During stimulation, patients listened to five different kinds of relaxation audios. Variables of interest were tinnitus questionnaires, tinnitus numeric rating scales, depressivity, and quality of life. Results were compared to results of historical control groups having received the same rTMS protocol (active control) and sham treatment (placebo) without relaxation techniques. Thirty-eight patients completed the treatment, drop-out rates and adverse events were low. Responder rates (reduction in tinnitus questionnaire (TQ) score ≥5 points 10 weeks after treatment) were 44.7 % in the study, 27.8 % in the active control group, and 21.7 % in the placebo group, differing between groups on a near significant level. For the tinnitus handicap inventory (THI), the main effect of group was not significant. However, linear mixed model analyses showed that the relaxation/rTMS group differed significantly from the active control group showing steeper negative THI trend for the relaxation/rTMS group indicating better amelioration over the course of the trial. Deepness of relaxation during rTMS and selection of active relaxation vs. passive listening to music predicted larger TQ. All remaining secondary outcomes turned out non-significant. This combined treatment proved to be a safe, feasible and promising approach to enhance rTMS treatment effects in chronic tinnitus.

2 Article Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort. 2017

Maas, Iris Lianne / Brüggemann, Petra / Requena, Teresa / Bulla, Jan / Edvall, Niklas K / Hjelmborg, Jacob V B / Szczepek, Agnieszka J / Canlon, Barbara / Mazurek, Birgit / Lopez-Escamez, Jose A / Cederroth, Christopher R. ·Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité-Universitätsmedizin Berlin, Berlin, Germany. · Tinnitus Center, Charité-Universitätsmedizin Berlin, Berlin, Germany. · Otology & Neurotology Group CTS495, Department of Genomic Medicine, GENYO - Center for Genomics and Oncological Research-Pfizer, University of Granada, Junta de Andalucía, PTS, Granada, Spain. · Department of Mathematics, University of Bergen, Bergen, Norway. · Experimental Audiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. · Department of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark. · Department of ORL, Head and Neck Surgery, Research Laboratory, Charité-Universitätsmedizin Berlin, Berlin, Germany. · Department of Otolaryngology, Complejo Hospitalario Universidad de Granada (CHUGRA), ibs.granada, Granada, Spain. ·Genet Med · Pubmed #28333916.

ABSTRACT: PURPOSE: Genetic contributions to tinnitus have been difficult to determine due to the heterogeneity of the condition and its broad etiology. Here, we evaluated the genetic and nongenetic influences on self-reported tinnitus from the Swedish Twin Registry (STR). METHODS: Cross-sectional data from the STR was obtained. Casewise concordance rates (the risk of one twin being affected given that his/her twin partner has tinnitus) were compared for monozygotic (MZ) and dizygotic (DZ) twin pairs (N = 10,464 concordant and discordant twin pairs) and heritability coefficients (the proportion of the total variance attributable to genetic factors) were calculated using biometrical model fitting procedures. RESULTS: Stratification of tinnitus cases into subtypes according to laterality (unilateral versus bilateral) revealed that heritability of bilateral tinnitus was 0.56; however, it was 0.27 for unilateral tinnitus. Heritability was greater in men (0.68) than in women (0.41). However, when female pairs younger than 40 years of age were selected, heritability of 0.62 was achieved with negligible effects of shared environment. CONCLUSION: Unlike unilateral tinnitus, bilateral tinnitus is influenced by genetic factors and might constitute a genetic subtype. Overall, our study provides the initial evidence for a tinnitus phenotype with a genetic influence.Genet Med advance online publication 23 March 2017.