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Celiac Disease: HELP
Articles from Salt Lake City
Based on 14 articles published since 2010

These are the 14 published articles about Celiac Disease that originated from Salt Lake City during 2010-2020.
+ Citations + Abstracts
1 Editorial Duodenal Bulb Biopsies Remain Relevant in the Diagnosis of Adult Celiac Disease. 2016

Pace, Laura A / Crowe, Sheila E. ·Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Utah, Salt Lake City, Utah. · Department of Medicine, Division of Gastroenterology, University of California San Diego, La Jolla, California. ·Clin Gastroenterol Hepatol · Pubmed #27565522.

ABSTRACT: -- No abstract --

2 Review The Role of Human Leukocyte Antigen in Celiac Disease Diagnostics. 2018

Lázár-Molnár, Eszter / Snyder, Melissa. ·ARUP Laboratories, Department of Pathology, University of Utah School of Medicine, 500 Chipeta Way, MS 115, Salt Lake City, UT 84108, USA. Electronic address: eszter.lazar-molnar@aruplab.com. · Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. ·Clin Lab Med · Pubmed #30420059.

ABSTRACT: Celiac disease is an autoimmune disease affecting the small intestine, triggered by gluten sensitization in genetically susceptible individuals worldwide. Celiac disease development is strongly linked to the presence of HLA-DQ2 and/or DQ8, which present the immunogenic gluten peptides and trigger the immune response leading to pathogenesis. Because of the variability of clinical symptoms, the disease is often underdiagnosed. Intestinal biopsy and the presence of antibodies to deamidated gliadin and tissue transglutaminase are recommended diagnostic tools. Genetic testing for HLA DQ2 and DQ8 can be used to rule out disease in at-risk populations.

3 Review Diet and psoriasis, part II: celiac disease and role of a gluten-free diet. 2014

Bhatia, Bhavnit K / Millsop, Jillian W / Debbaneh, Maya / Koo, John / Linos, Eleni / Liao, Wilson. ·Department of Dermatology, University of California, San Francisco, California; Rush Medical College, Rush University Medical Center, Chicago, Illinois. · Department of Dermatology, University of California, San Francisco, California; University of Utah School of Medicine, Salt Lake City, Utah. · Department of Dermatology, University of California, San Francisco, California; University of California, Irvine, School of Medicine, Irvine, California. · Department of Dermatology, University of California, San Francisco, California. · Department of Dermatology, University of California, San Francisco, California. Electronic address: liaowi@derm.ucsf.edu. ·J Am Acad Dermatol · Pubmed #24780176.

ABSTRACT: Patients with psoriasis have been shown to have a higher prevalence of other autoimmune diseases including celiac disease, a condition marked by sensitivity to dietary gluten. A number of studies suggest that psoriasis and celiac disease share common genetic and inflammatory pathways. Here we review the epidemiologic association between psoriasis and celiac disease and perform a meta-analysis to determine whether patients with psoriasis more frequently harbor serologic markers of celiac disease. We also examine whether a gluten-free diet can improve psoriatic skin disease.

4 Review Testing for antireticulin antibodies in patients with celiac disease is obsolete: a review of recommendations for serologic screening and the literature. 2013

Nandiwada, Sarada L / Tebo, Anne E. ·Department of Pathology, University of Utah, Salt Lake City, UT, USA. ·Clin Vaccine Immunol · Pubmed #23365209.

ABSTRACT: Celiac disease (CD) is an autoimmune disorder that occurs in genetically susceptible individuals of all ages and is triggered by immune response to gluten and related proteins. The disease is characterized by the presence of HLA-DQ2 and/or -DQ8 haplotypes, diverse clinical manifestations, gluten-sensitive enteropathy, and production of several autoantibodies of which endomysial, tissue transglutaminase, and deamidated gliadin peptide antibodies are considered specific. Although antireticulin antibodies (ARA) have historically been used in the evaluation of CD, these assays lack optimal sensitivities and specificities for routine diagnostic use. This minireview highlights the advances in CD-specific serologic testing and the rationale for eliminating ARA from CD evaluation consistent with recommendations for diagnosis.

5 Article A subset of patients with pemphigoid (herpes) gestationis has serological evidence of celiac disease. 2018

Saffari, Hedieh / Zone, John J / Allen, Marjorie / Leiferman, Kristin M. ·Immunodermatology Laboratory, Department of Dermatology, School of Medicine, University of Utah, Salt Lake City, UT, USA. ·Int J Dermatol · Pubmed #29473148.

ABSTRACT: BACKGROUND: Pemphigoid (herpes) gestationis (PG) is an uncommon, self-limited disease with other autoimmune associations; however, celiac disease (CD) is not recognized as one. METHODS: From 71 patients' sera submitted for herpes gestationis factor (HGF) testing over a 5-year period, 12 were consistent with PG demonstrating HGF and increased IgG BP180 antibody levels; these sera were tested for IgA and IgG endomysial antibodies (EMA), epithelial basement membrane zone and cell surface antibodies by indirect immunofluorescence, and for IgA and IgG tissue transglutaminase (transglutaminase 2 or TG2) antibodies, IgA epidermal transglutaminase (transglutaminase 3 or TG3) antibodies, IgG BP230, and IgG desmoglein 1 and desmoglein 3 antibodies by enzyme-linked immunosorbent assays (ELISAs). RESULTS: Three of 12 patients' sera with PG (25%) had CD antibodies with positive IgA EMA and increased IgA TG2 antibody levels; two of these had positive IgG EMA, and one other had an increased IgA TG3 antibody level. CONCLUSIONS: A subset of patients with serological findings of PG also has serological evidence of CD, which may have implications in the etiopathogenesis of PG and which reveals important information about the mother's, and possibly her infant's, health.

6 Article Identification of Pediatric Patients With Celiac Disease Based on Serology and a Classification and Regression Tree Analysis. 2017

Ermarth, Anna / Bryce, Matthew / Woodward, Stephanie / Stoddard, Gregory / Book, Linda / Jensen, M Kyle. ·Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah. Electronic address: anna.ermarth@hsc.utah.edu. · Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah. ·Clin Gastroenterol Hepatol · Pubmed #27847281.

ABSTRACT: BACKGROUND & AIMS: Celiac disease is detected using serology and endoscopy analyses. We used multiple statistical analyses of a geographically isolated population in the United States to determine whether a single serum screening can identify individuals with celiac disease. METHODS: We performed a retrospective study of 3555 pediatric patients (18 years old or younger) in the intermountain West region of the United States from January 1, 2008, through September 30, 2013. All patients had undergone serologic analyses for celiac disease, including measurement of antibodies to tissue transglutaminase (TTG) and/or deamidated gliadin peptide (DGP), and had duodenal biopsies collected within the following year. Modified Marsh criteria were used to identify patients with celiac disease. We developed models to identify patients with celiac disease using logistic regression and classification and regression tree (CART) analysis. RESULTS: Single use of a test for serum level of IgA against TTG identified patients with celiac disease with 90% sensitivity, 90% specificity, a 61% positive predictive value (PPV), a 90% negative predictive value, and an area under the receiver operating characteristic curve value of 0.91; these values were higher than those obtained from assays for IgA against DGP or IgG against TTG plus DGP. Not including the test for DGP antibody caused only 0.18% of celiac disease cases to be missed. Level of TTG IgA 7-fold the upper limit of normal (ULN) identified patients with celiac disease with a 96% PPV and 100% specificity. Using CART analysis, we found a level of TTG IgA 3.2-fold the ULN and higher to most accurately identify patients with celiac disease (PPV, 89%). Multivariable CART analysis showed that a level of TTG IgA 2.5-fold the ULN and higher was sufficient to identify celiac disease in patients with type 1 diabetes (PPV, 88%). Serum level of IgA against TTG in patients with versus those without trisomy 21 did not affect diagnosis predictability in CART analysis. CONCLUSIONS: In a population-based study, we found that serum level of IgA against TTG can identify patients with celiac disease with PPVs of about 90%. Predictive values increase greatly when levels are markedly above the ULN or when the assay is used in combination with other variables. Measurement of IgG against TTG or DGP does not increase the accuracy of detection of celiac disease based against TTG IgA levels. There is a low risk of false-positive results from serologic analysis in patients with type I diabetes or persistent increases in antibody against TTG on repeat testing.

7 Article Co-occurrence of eosinophilic esophagitis and potential/probable celiac disease in an adult cohort: a possible association with implications for clinical practice. 2016

Johnson, J B / Boynton, K K / Peterson, K A. ·Department of Medicine, The Health Sciences Center, University of Utah, Salt Lake City, Utah, USA. ·Dis Esophagus · Pubmed #26541352.

ABSTRACT: We describe an adult cohort with eosinophilic esophagitis (EoE) and evidence of celiac disease (CD), propose a change in diagnostic practice to better characterize these conditions, and hypothesize new directions for research. Pediatric studies postulate association between gluten sensitivity and EoE. However, few publications describe the prevalence, detection, or therapeutic and pathophysiologic implications of such association in adults. Retrospective chart review was done on patients diagnosed with EoE from 2009 to 2010 at University of Utah Hospitals and Clinics. Data included sex, age, presentation, duodenal pathology, tissue transglutaminase immunoglobulin A antibody (TTG) positivity, human leukocyte antigen (HLA) type (when indicated), and gross and microscopic Esophagogastroduodenoscopy (EGD) findings. Duodenal biopsy, TTG results, and HLA type were correlated. Endoscopy was repeated after gluten-free diet. Forty-four of 75 patients were followed in EoE specialty clinic with duodenal biopsy and TTG testing per protocol. Six EoE patients had potential or probable CD. No sex or age differences were noted between those with findings of CD and EoE and those with EoE alone. Six patients with findings of CD and EoE followed gluten-free diet. Five underwent repeat endoscopy. Three had resolution of esophageal eosinophilia. Potential or probable CD was commonly found in adults with EoE. Diagnosis of CD may be challenging due to nonspecific symptoms and insufficient duodenal biopsy and serologic testing. Furthermore, gluten-free diet resolved EoE findings in some patients, suggesting possible shared pathophysiology in some cases of EoE and CD. TTG testing and adequate duodenal biopsy may further direct clinical care for EoE patients, and studies are needed to elucidate mechanisms linking EoE and CD.

8 Article Parent experiences raising young people with type 1 diabetes and celiac disease. 2015

Erickson, Kerri / Freeborn, Donna / Roper, Susanne Olsen / Mandleco, Barbara / Anderson, Ashley / Dyches, Tina. ·Family Nurse Practitioner, Intermountain Healthcare, Salt Lake City, UT. · College of Nursing, Brigham Young University, Provo, UT. · School of Family Life, Brigham Young University, Provo, UT. · College of Nursing, Brigham Young University, Provo, UT. Electronic address: Barbara-Mandleco@byu.edu. · University Medical Center at Texas Tech University, Lubbock, TX. · McKay School of Education, Brigham Young University, Provo, UT. ·J Pediatr Nurs · Pubmed #25305541.

ABSTRACT: Authors of this qualitative descriptive study interviewed 30 parents concerning their experiences raising a child or adolescent with type 1 diabetes (T1D) and celiac disease (CD). Analysis revealed six themes: (a) health complications of T1D, (b) challenges of daily disease management, (c) financial concerns, (d) the young person's emotional/mental health, (e) experiences with healthcare providers, and (f) experiences with people outside the family and at school. Results suggest nurses need to be sensitive to challenges young people living with T1D and CD and their parents face, conduct ongoing assessments, and provide time during interactions to adequately address concerns.

9 Article Celiac disease serum markers and recurrent pregnancy loss. 2013

Sharshiner, Rita / Romero, Stephanie T / Bardsley, Tyler R / Branch, D Ware / Silver, Robert M. ·The Department of Obstetrics and Gynecology, University of Utah, Utah 30 North 1900 East #2B200, Salt Lake City, UT 84132, USA. Electronic address: Rita.sharshiner@hsc.utah.edu. ·J Reprod Immunol · Pubmed #24176553.

ABSTRACT: Celiac disease has been associated with numerous unfavorable health outcomes, including pregnancy complications such as infertility, preterm birth, and preeclampsia. However, the association between celiac disease and recurrent pregnancy loss (RPL) remains uncertain. Our purpose was to compare serum markers of celiac disease in women with and without RPL. Therefore, we performed a case-control study of 116 women with unexplained recurrent pregnancy loss and 116 age-matched controls. Maternal sera were analyzed for immunoglobulin A (IgA) and immunoglobulin G (IgG) tissue transglutaminase (tTG) antibodies and endomysial (EM) antibodies. Groups were similar with regard to age, race and ethnicity, and BMI. One case and one control tested positive (≥20 Units) for IgA tTG antibodies and mean levels of IgA tTG antibodies were similar in cases and controls (5.5±2.86 versus 6.0±12.45; p=0.16). No cases or controls were positive for IgG tTG antibodies. However, cases had higher levels of IgG tTG antibody compared with controls (4.0±2.40 versus 3.3±1.30; p=0.0064). One subject (a control) tested positive for IgA EM antibodies and no subjects tested positive for IgG EM antibodies. In conclusion, positive results for tTG and EM antibodies were similar in women with and without RPL. Given these results, testing for occult celiac disease is not recommended in the evaluation of women with idiopathic RPL.

10 Article Using patients like my patient for clinical decision support: institution-specific probability of celiac disease diagnosis using simplified near-neighbor classification. 2013

Shirts, Brian H / Bennett, Sterling T / Jackson, Brian R. ·Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA, shirtsb@uw.edu. ·J Gen Intern Med · Pubmed #23645451.

ABSTRACT: BACKGROUND: Interpretation of a diagnostic test result requires knowing what proportion of patients with a "similar" result has the condition in question. This information is often not readily available from the medical literature, or may be based on different clinical populations that make it nonapplicable. In certain settings, where correlated screening parameters and diagnostic data are available in electronic medical records, a representation of diagnostic test performance on "patients like my patient" can be obtained. OBJECTIVE: We sought to integrate patient demographic and physician practice information using a simplified nearest neighbor algorithm. We used this method to illustrate the relationship between tTG IgA test result and duodenal biopsy for celiac disease in a local diagnostic context. PARTICIPANTS: We used a data set of 1,461 paired tissue transglutaminase (tTG) IgA and definitive duodenal biopsy results from Intermountain Healthcare with data on patient age and ordering physician specialty. This was split into a discovery set of 1,000 and a validation set of 461 paired results. MAIN MEASURES: Accuracy of the local discovery data set in predicting probability of positive duodenal biopsy and confidence intervals around predicted probability in the test data compared to probabilities of positive biopsy implied from published logistic regression and from published sensitivity and specificity studies. KEY RESULTS: The near-neighbor method could estimate probability of clinical outcomes with predictive performance equivalent to other methods while adjusting probability estimates and confidence intervals to fit specific clinical situations. CONCLUSIONS: Data from clinical encounters obtained from electronic medical records can yield prediction estimates that are tailored to the individual patient, local population, and healthcare delivery processes. Local analysis of diagnostic probability may be more clinically meaningful than probabilities inferred from published studies. This local utility may come at the expense of external validity and generalizability.

11 Article Cystic fibrosis and celiac disease: both can occur together. 2011

Pohl, John F / Judkins, Jordan / Meihls, Suzanne / Lowichik, Amy / Chatfield, Barbara A / McDonald, Catherine M. ·University of Utah, Salt Lake City, USA. john.pohl@imail.org ·Clin Pediatr (Phila) · Pubmed #22121140.

ABSTRACT: -- No abstract --

12 Article Sclerosing mesenteritis in a child with celiac disease. 2011

Sampert, Catherine / Lowichik, Amy / Rollins, Michael / Inman, C J / Bohnsack, John / Pohl, John F. ·Department of Pediatric Gastroenterology, Primary Children's Medical Center, University of Utah School of Medicine, Salt Lake City, UT 84113-1103, USA. ·J Pediatr Gastroenterol Nutr · Pubmed #21572343.

ABSTRACT: -- No abstract --

13 Article Celiac disease and HLA typing using real-time PCR with melting curve analysis. 2011

Profaizer, T / Eckels, D / Delgado, J C. ·Histocompatibility & Immunogenetics Laboratory, University of Utah School of Medicine, Salt Lake City, UT 84132-1904, USA. tracie.profaizer@hsc.utah.edu ·Tissue Antigens · Pubmed #21521178.

ABSTRACT: Celiac disease (CD) is an autoimmune disease characterized by chronic diarrhea, inflammatory lesions of small bowel and nutritional malabsorption. CD is strongly associated with the presence of HLA-DQB*02, DQB*03:02 and DQA*05. The absence of any one of these three human leukocyte antigen (HLA) alleles rules out the diagnosis of CD in suspected patients. Here, we describe a novel method to detect the presence of these specific HLA alleles using real-time polymerase chain reaction (PCR) with melting curve analysis. Compared with current HLA typing assays, the real-time PCR method is faster, requires fewer handling steps and provides 100% sensitivity and specificity for typing of HLA-DQB*02, DQB*03:02 and DQA*05 alleles.

14 Minor Markers of non-coeliac wheat sensitivity in patients with myalgic encephalomyelitis/chronic fatigue syndrome. 2019

Uhde, Melanie / Indart, Alyssa C / Yu, Xuechen B / Jang, Sophie S / De Giorgio, Roberto / Green, Peter H R / Volta, Umberto / Vernon, Suzanne D / Alaedini, Armin. ·Department of Medicine, Columbia University Medical Center, New York, New York, USA. · Celiac Disease Center, Columbia University Medical Center, New York, New York, USA. · Institute of Human Nutrition, Columbia University Medical Center, New York, New York, USA. · Departments of Medical and Surgical Sciences and Digestive System, Centro di Ricerca Biomedica Applicata (C.R.B.A.), University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy. · Bateman Horne Center, Salt Lake City, Utah, USA. ·Gut · Pubmed #29550784.

ABSTRACT: -- No abstract --