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Celiac Disease: HELP
Articles by Amnon Sonnenberg
Based on 3 articles published since 2010
(Why 3 articles?)

Between 2010 and 2020, Amnon Sonnenberg wrote the following 3 articles about Celiac Disease.
+ Citations + Abstracts
1 Article Associations of Microscopic Colitis With Other Lymphocytic Disorders of the Gastrointestinal Tract. 2018

Sonnenberg, Amnon / Turner, Kevin O / Genta, Robert M. ·Division of Gastroenterology, Portland VA Medical Center and Oregon Health & Science University, Portland, Oregon. Electronic address: sonnenbe@ohsu.edu. · Miraca Life Sciences, Irving, Texas. · Miraca Life Sciences, Irving, Texas; Baylor College of Medicine, Houston, Texas. ·Clin Gastroenterol Hepatol · Pubmed #29535059.

ABSTRACT: BACKGROUND & AIMS: Lymphocytic disorders of the upper and lower gastrointestinal tract seem to cluster in patients. We aimed to assess the frequency of comorbid occurrence of lymphocytic disorders in patients with microscopic colitis (MC). METHODS: We collected data from the Miraca Life Sciences Database, a large national electronic repository of histopathologic records of patients throughout the United States. In a population of 228,506 patients who underwent bidirectional endoscopy from January 2008 through July 2016, we studied the comorbid occurrence of celiac disease, duodenal intraepithelial lymphocytosis, lymphocytic gastritis, and lymphocytic esophagitis among 3456 patients with MC. Associations were described in terms of their odds ratios (OR) and 95% CIs. RESULTS: Any type of lymphocytic disorder occurred in 13.7% of patients with MC and 5.9% of patients without MC. The ORs of lymphocytic disorders in patients with MC were: 2.56 (95% CI, 2.32-2.82) for any type of lymphocytic disorder, 3.07 (95% CI, 1.25-7.52) for lymphocytic esophagitis, 15.05 (95% CI, 12.31-18.41) for lymphocytic gastritis, 1.73 (95% CI, 1.53-21.96) for duodenal intraepithelial lymphocytosis, and 6.06 (95% CI, 5.06-7.25) for celiac disease. Comorbidities were more common in patients with lymphocytic than collagenous colitis, with an OR of 1.74 (95% CI, 1.42-2.13). Patients with MC with comorbidities were significantly younger and had a lower proportion of men than patients with MC patients without comorbidities. Diarrhea was the predominant symptoms in all patients MC, irrespective of comorbidities. CONCLUSION: In a retrospective study, we identified lymphocytic disorders of the upper gastrointestinal tract that are significantly more common in patients with than without MC. These associations suggest the existence of an underlying etiology that is common to all lymphocytic disorders and that affects the upper and lower gastrointestinal tract.

2 Article Decreased risk of celiac disease in patients with Helicobacter pylori colonization. 2013

Lebwohl, Benjamin / Blaser, Martin J / Ludvigsson, Jonas F / Green, Peter H R / Rundle, Andrew / Sonnenberg, Amnon / Genta, Robert M. · ·Am J Epidemiol · Pubmed #24124196.

ABSTRACT: The prevalence of celiac disease (CD) has increased in recent decades without a clear explanation. The "hygiene hypothesis" theorizes that decreased exposure to bacterial antigens may trigger autoimmunity. We aimed to determine whether Helicobacter pylori infection and CD were associated among patients undergoing upper gastrointestinal endoscopy. We performed a cross-sectional study of patients who underwent esophagogastroduodenoscopy with submission of gastric and duodenal biopsies to Miraca Life Sciences, Inc. (Irving, Texas), a US commercial pathology laboratory, during a 4.5-year period (January 2008-June 2012). We compared the prevalence of H. pylori in CD patients with that in persons without CD. We performed multiple logistic regression analysis, adjusting odds ratios for patient age, gender, and racial, ethnic, and socioeconomic factors. Among 136,179 patients, a total of 2,689 (2.0%) had CD. H. pylori prevalence was significantly lower in patients with CD (4.4%) than in those without CD (8.8%; P < 0.0001). After adjustment for the above covariates, this inverse relationship remained strong (adjusted odds ratio (OR) = 0.48, 95% confidence interval (CI): 0.40, 0.58). The relationships were similar in men (unadjusted OR = 0.51, 95% CI: 0.38, 0.69) and women (unadjusted OR = 0.46, 95% CI: 0.36, 0.58) and in all age groups. We conclude that H. pylori presence and CD are inversely associated, a relationship that persists after adjustment for socioeconomic factors. Future studies should address whether H. pylori modulates immune responses to ingested gluten.

3 Minor Re: "Decreased risk of celiac disease in patients with Helicobacter pylori colonization". The authors reply. 2014

Lebwohl, Benjamin / Blaser, Martin J / Ludvigsson, Jonas F / Green, Peter H / Rundle, Andrew / Sonnenberg, Amnon / Genta, Robert M. ·Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY. ·Am J Epidemiol · Pubmed #24699781.

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