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Celiac Disease: HELP
Articles by R. Meza-Romero
Based on 1 article published since 2010
(Why 1 article?)
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Between 2010 and 2020, R. Meza-Romero wrote the following article about Celiac Disease.
 
+ Citations + Abstracts
1 Article Single-chain recombinant HLA-DQ2.5/peptide molecules block α2-gliadin-specific pathogenic CD4+ T-cell proliferation and attenuate production of inflammatory cytokines: a potential therapy for celiac disease. 2011

Huan, J / Meza-Romero, R / Mooney, J L / Vandenbark, A A / Offner, H / Burrows, G G. ·Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA. ·Mucosal Immunol · Pubmed #20736999.

ABSTRACT: Celiac disease (CD) is a disorder of the small intestine caused by intolerance to wheat gluten and related proteins in barley and rye. CD4(+) T cells have a central role in CD, recognizing and binding complexes of HLA-DQ2.5 bearing gluten peptides that have survived digestion and that are deamidated by tissue transglutaminase (TG2), propagating a cascade of inflammatory processes that damage and eventually destroy the villous tissue structures of the small intestine. In this study, we present data showing that recombinant DQ2.5-derived molecules bearing covalently tethered α2-gliadin-61-71 peptide have a remarkable ability to block antigen-specific T-cell proliferation and inhibited proinflammatory cytokine secretion in human DQ2.5-restricted α2-gliadin-specific T-cell clones obtained from patients with CD. The results from our in vitro studies suggest that HLA-DQ2.5-derived molecules could significantly inhibit and perhaps reverse the intestinal pathology caused by T-cell-mediated inflammation and the associated production of proinflammatory cytokines.