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Celiac Disease: HELP
Articles by Aydan Kansu
Based on 11 articles published since 2010
(Why 11 articles?)
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Between 2010 and 2020, Aydan Kansu wrote the following 11 articles about Celiac Disease.
 
+ Citations + Abstracts
1 Article Variability of anti-human transglutaminase testing in celiac disease across Mediterranean countries. 2017

Smarrazzo, Andrea / Magazzù, Giuseppe / Ben-Hariz, Mongi / Legarda Tamara, Maria / Velmishi, Virtut / Roma, Elefhteria / Kansu, Aydan / Mičetić-Turk, Dušanka / Bravi, Enzo / Stellato, Pio / Arcidiaco, Carmela / Greco, Luigi. ·Andrea Smarrazzo, Pio Stellato, Carmela Arcidiaco, Luigi Greco, Department of Translational Medical Sciences, School of Medicine, Section of Pediatrics, University of Naples "Federico II", 80131 Naples, Italy. ·World J Gastroenterol · Pubmed #28706427.

ABSTRACT: AIM: To verify the precision and accuracy of transglutaminase antibodies (TGA) assays across Mediterranean countries. METHODS: This study involved 8 referral centres for celiac disease (CD) in 7 Mediterranean countries. A central laboratory prepared 8 kits of 7 blinded and randomized serum samples, with a titrated amount of Human TGA IgA. Each sample was analysed three times on three different days, with each centre running a total of 21 tests. The results were included in a blindly coded report form, which was sent to the coordinator centre. The coordinator estimated the mean coefficient of Variation (CoVar = σ/μ), the mean accuracy (Accur = Vobserved - Vreal) and the mean percent variation (Var% = [(Vobserved - Vreal)/Vreal] × 100). RESULTS: The analysis showed that 79.17% of the mean variation fell between -25% and +25% of the expected value, with the accuracy and precision progressively increasing with higher titres of TGA. From values 1.25 times greater than the normal cut-off, the measurements were highly reliable. CONCLUSION: TGA estimation is a crucial step for the diagnosis of CD; given its accuracy and precision, clinicians could be confident in establishing a diagnosis.

2 Article Diagnosis of celiac disease and applicability of ESPGHAN guidelines in Mediterranean countries: a real life prospective study. 2017

Smarrazzo, Andrea / Misak, Zrinjka / Costa, Stefano / Mičetić-Turk, Dušanka / Abu-Zekry, Mona / Kansu, Aydan / Abkari, Abdelhak / Bouziane-Nedjadi, Karim / Ben Hariz, Mongi / Roma, Eleftheria / Velmishi, Virtut / Legarda Tamara, Maria / Attard, Thomas / Djurisic, Veselinka / Greco, Luigi / Magazzù, Giuseppe. ·Department of Translational Medical Sciences, School of Medicine, University "Federico II", Naples, Italy. · European Laboratory for Food Induced Diseases, Naples, Italy. · Children's Hospital Zagreb, Zagreb, Croatia. · Celiac Regional Centre, Pediatric Gastroenterology and Cystic Fibrosis Unit, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy. · Paediatric Department, University Medical Centre, Maribor, Slovenia. · Cairo University Children Hospital, El Cairo, Egypt. · Department of Pediatric Gastroenterology, School of Medicine, Ankara University, Ankara, Turkey. · Centre Hospitalier Universitaire Ibnou Rochd, Casablanca, Morocco. · Faculté de Médecine d'Oran, Oran, Algeria. · Pediatric Unit, Mongi SLIM's Hospital of Tunis, Marsa, Tunisia. · First Department of Pediatrics, University of Athens, Athens, Greece. · Service of Pediatric Gastroenterology "Mother Teresa" Hospital, Tirana, Albania. · Paediatric Gastroenterology Unit, Cruces University Hospital, Bilbao, Spain. · University of Malta, Msida, Malta. · Clinical Center of Montenegro, Podgorica, Montenegro. · Celiac Regional Centre, Pediatric Gastroenterology and Cystic Fibrosis Unit, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy. magazzug@unime.it. ·BMC Gastroenterol · Pubmed #28109250.

ABSTRACT: BACKGROUND: We assessed how the diagnosis of Celiac Disease (CD) is made and how the new ESPGHAN guidelines can be applied in children from countries with different resources. METHODS: A real life prospective study was performed in 14 centres of 13 different Mediterranean countries. Participants were asked to apply the usual diagnostic work-up for CD according to their diagnostic facilities. RESULTS: There were 1974 patients enrolled in the study, mean age 4 years, 10 months; 865 male, 1109 female. CD was confirmed in 511 (25.9%) and was unconfirmed in 1391 (70.5%) patients; 14 patients were diagnosed as having CD according to the new ESPGHAN guidelines, 43 patients were classified as having potential CD. In all participating countries the diagnosis of CD relied on histology of duodenal biopsy; in 5 countries, HLA, and in one country endomysial antibodies (EMA) were not available. Symptoms did not add a significant increase to the pre-test probability of serological tests. The positive predictive value of tissue transglutaminase type 2 (tTG) antibodies performed with different kits but all corresponding to those recommended by ESPGHAN was 96.1% (95% CI 94-97.9%) in presence of tTG > 10xULN. In 135 patients with tTG >10xULN, HLA genotyping was performed and in all it was compatible with CD. CONCLUSIONS: The results of our study show that CD diagnosis still relies on intestinal biopsy in the Mediterranean area. New ESPGHAN criteria are not applicable in 5 countries due to lack of resources needed to perform HLA genotyping and, in one country, EMA assay. Further simplification of the new ESPGHAN guidelines might be made according to what preliminarily the present results suggest if confirmed by new prospective studies.

3 Article Neurological findings spectrum in Celiac disease. 2016

Aksoy, Erhan / Tıraş-Teber, Serap / Kansu, Aydan / Deda, Gülhis / Kartal, Ayşe. ·Department of Pediatric Neurology, Dr. Sami Ulus Maternity and Childrens' Health and Diseases Training and Research Hospital, Ankara, Turkey. · Division of Pediatric Gastroenterology, Ankara University Faculty of Medicine, Ankara, Turkey. · Division of Pediatric Neurology, Department of Pediatrics, Selçuk University Faculty of Medicine, Konya, Turkey. ·Turk J Pediatr · Pubmed #28266186.

ABSTRACT: We aimed to provide early diagnosis by determining possible Celiac disease related subclinical or symptomatic neurological abnormalities in children in order to decrease risk of mortality and morbidity. Children with Celiac disease were assessed with neurological examination, neurophysiological tests and neuroimaging. A total of 65 patients were included in the study. The neurological examination was abnormal in 4 patients. There were EEG abnormalities in 5 patients, VEP was abnormal in 7 patients, BAER was abnormal in 1 patient, ENMG was abnormal in 8 patients, and there were abnormal findings on neuroimaging in 2 patients. The Celiac disease related neurological complications that manifest in adulthood usually lay their foundations in childhood. Therefore, it must be kept in mind that subclinical neurological abnormalities may be related to Celiac disease, and Celiac disease may be the underlying cause in the patients with overt neurological abnormalities in childhood.

4 Article Carotid intima-media thickness and arterial stiffness as early markers of atherosclerosis in pediatric celiac disease. 2016

Demir, Arzu Meltem / Kuloğlu, Zarife / Yaman, Aytaç / Fitöz, Suat / Nergizoğlu, Gökhan / Kansu, Aydan. ·Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey. · Department of Radiology, Ankara University Faculty of Medicine, Ankara, Turkey. · Department of Nephrology, Ankara University Faculty of Medicine, Ankara, Turkey. ·Turk J Pediatr · Pubmed #27976558.

ABSTRACT: The association between pediatric celiac disease (CD) and atherosclerosis is unknown. Our aim was to investigate whether pediatric CD patients have an increased risk of atherosclerosis. We evaluated the premature atherosclerosis by pulse wave velocity (PWV) and carotid intima-media thickness (cIMT). A total of 37 CD patients (20 girls, mean age 13±3.3 years) and 36 healthy age and sex matched controls were enrolled. Mean duration of CD was 47.1±32.3 months and 40.5% of patients had positive tissue transglutaminase antibody (tTg) IgA. Total cholesterol level was lower in CD (p=0.026) and cIMT was lower in tTg IgA antibody negative CD (p=0.030). cIMT was significantly correlated with tTg IgA antibody positivity (r=0.336; p=0.042). Adherence to strict gluten-free diet is associated with decreased cIMT, suggesting that gluten withdrawal seems to have a beneficial effect on premature atherosclerosis.

5 Article Classification chaos in coeliac disease: Does it really matter? 2016

Özakıncı, Hilal / Kırmızı, Ayça / Savaş, Berna / Kalkan, Çağdaş / Soykan, İrfan / Çetinkaya, Hülya / Kuloğlu, Zarife / Kansu, Aydan / Gürkan, Ödül Eğritaş / Dalgıç, Buket / Şentürk, Zeynep / Ensari, Arzu. ·Departments of Pathology, Ankara University Medical School, 06100, Sıhhıye, Ankara, Turkey. · Departments of Gastroenterology, Ankara University Medical School, 06100, Sıhhıye, Ankara, Turkey. · Departments of Paediatric Gastroenterology, Ankara University Medical School, 06100, Sıhhıye, Ankara, Turkey. · Departments of Paediatric Gastroenterology, Gazi University Medical School, 06560, Yenimahalle, Ankara, Turkey. · Departments of Biostatistics, Ankara University Medical School, 06100, Sıhhıye, Ankara, Turkey. · Departments of Pathology, Ankara University Medical School, 06100, Sıhhıye, Ankara, Turkey. Electronic address: ensariarzu@gmail.com. ·Pathol Res Pract · Pubmed #27637158.

ABSTRACT: The spectrum of mucosal pathology in coeliac disease (CD), initially defined by Marsh in 1992 has been subjected to several modifications in the following years by Oberhuber, then by Corazza and Villanaci, and finally by Ensari. The present study, aimed to end the ongoing confusion regarding the classification of mucosal pathology in CD by applying all the classifications proposed so far on a large series of cases. A total of 270 duodenal biopsies taken from the distal duodenum of patients with a diagnosis of CD were included in the study. All biopsies were classified according to Marsh, Oberhuber, Corazza Villanaci, and Ensari classification schemes. For statistical analyses cases were divided into three groups: Group 1 included type 1 lesions in Marsh, Ensari, and Oberhuber and grade A in Corazza Villanaci classifications. Group 2 comprised of type 2 lesions in Marsh and Ensari classifications together with type2, type 3a and 3b lesions in Oberhuber classification and grade B1 lesions in Corazza Villanaci classification. Group 3 included type 3 lesions in Marsh and Ensari classifications, and type 3c lesions in Oberhuber, and grade B2 lesions in Corazza Villanaci classifications. The kappa value was 1.00 (excellent) for group 1, 0.53 (fair) for group 2 and 0.78 (excellent) for group 3 (p<0.0001). These results suggest that any of the above classification system would serve similar purposes in the diagnosis of CD. Therefore, it is advisable that the pathologist should use the simplest reliable scheme.

6 Article Yield of coeliac screening in abdominal pain-associated functional gastrointestinal system disorders. 2015

Kansu, Aydan / Kuloğlu, Zarife / Demir, Arzu / Yaman, Aytaç / Anonymous2480832. ·Pediatric Gastroenterology, School of Medicine, Ankara University, Ankara, Turkey. ·J Paediatr Child Health · Pubmed #26041019.

ABSTRACT: AIM: Chronic abdominal pain (CAP) in childhood is common and in the majority functional. While CAP is one of the complaints of coeliac disease (CD), whether CAP as a sole complaint is indicative of CD is unclear. Our aim was to evaluate the relationship between CAP and CD. METHODS: The study was conducted on 1047 children (61.1% female, mean age 9.6 ± 4.1 years) with CAP. Patients were evaluated according to the Rome III criteria. Patients with alarm symptoms and conditions known to be associated with CD were excluded. Patients were screened for CD using a rapid tissue transglutaminase (tTG) test; positive cases were tested by tTG ELISA, and duodenal biopsies were obtained if tTG was above the normal limit. RESULTS: Functional dyspepsia (FD), irritable bowel syndrome (IBS) and functional abdominal pain (FAP) were diagnosed in 384 (36.7%), 274 (26.2%) and 389 (37.2%) patients, respectively. In 13 patients, the tTG rapid test was positive; 10 were also positive for tTG by ELISA and histopathological evaluations diagnosed CD in all 10 patients. The overall prevalence of CD was 0.95% (2.2%, 0.5% and 0.5% in patients with IBS, FD and FAP, respectively). The prevalence of CD in patients with IBS was higher than expected but with borderline statistical significance (P = 0.053). CONCLUSIONS: CD is found as common in children with FD and FAP as in the general population. CD was more commonly diagnosed in IBS patients with borderline statistical significance. We suggest that particular attention be paid to children with IBS.

7 Article A point-of-care test for facing the burden of undiagnosed celiac disease in the Mediterranean area: a pragmatic design study. 2014

Costa, Stefano / Astarita, Luca / Ben-Hariz, Mongi / Currò, Giovanni / Dolinsek, Jernej / Kansu, Aydan / Magazzu', Giuseppe / Marvaso, Stefania / Micetic-Turku, Dusanka / Pellegrino, Salvatore / Primavera, Giuseppe / Rossi, Pasqualino / Smarrazzo, Andrea / Tucci, Francesca / Arcidiaco, Carmela / Greco, Luigi. ·Celiac Regional Center, Pediatric Gastroenterology and Cystic Fibrosis Unit, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy. stefan.costa@gmail.com. · European Laboratory for Food Induced Diseases, University of Naples Federico II, Naples, Italy. luca_astarita@hotmail.com. · Pediatric Unit, Mongi SLIM's Hospital of Tunis, Marsa, Tunisia. mongi.benhariz@rns.tn. · Celiac Regional Center, Pediatric Gastroenterology and Cystic Fibrosis Unit, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy. giovanni.curro75@gmail.com. · University Medical Centre Pediatric Department, Ljubljanska, Maribor, Slovenia. jernej.dolinsek@ukc-mb.si. · Faculty of Medicine, Department of Pediatric Gastroenterology, Ankara University, Ankara, Turkey. aydankansu@gmail.com. · Celiac Regional Center, Pediatric Gastroenterology and Cystic Fibrosis Unit, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy. magazzug@unime.it. · Celiac Regional Center, Pediatric Gastroenterology and Cystic Fibrosis Unit, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy. stefaniamarvaso@tiscali.it. · University Medical Centre Pediatric Department, Ljubljanska, Maribor, Slovenia. dusanka.turk13@gmail.com. · Celiac Regional Center, Pediatric Gastroenterology and Cystic Fibrosis Unit, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy. salvatorepellegrino2014@gmail.com. · National Health System, Azienda Sanitaria Locale 6, Associazione Culturale Pediatri, Palermo, Italy. beppeprimavera@virgilio.it. · Directorate General for European and International Relations, Ministry of Health, Rome, Italy. p.rossi@sanita.it. · European Laboratory for Food Induced Diseases, University of Naples Federico II, Naples, Italy. and1_mlk@hotmail.it. · European Laboratory for Food Induced Diseases, University of Naples Federico II, Naples, Italy. ftucci84@gmail.com. · European Laboratory for Food Induced Diseases, University of Naples Federico II, Naples, Italy. margherita@unina.it. · European Laboratory for Food Induced Diseases, University of Naples Federico II, Naples, Italy. ydongre@unina.it. · Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy. ydongre@unina.it. ·BMC Gastroenterol · Pubmed #25518884.

ABSTRACT: BACKGROUND: We aimed at assessing the factors that can influence results of the dissemination of an already validated, new generation commercial Point-of-Care Test (POCT) for detecting celiac disease (CD), in the Mediterranean area, when used in settings where it was designed to be administered, especially in countries with poor resources. METHODS: Pragmatic study design. Family pediatricians at their offices in Italy, nurses and pediatricians in Slovenia and Turkey at pediatricians', schools and university primary care centers looked for CD in 3,559 (1-14 yrs), 1,480 (14-23 yrs) and 771 (1-18 yrs) asymptomatic subjects, respectively. A new generation POCT detecting IgA-tissue antitransglutaminase antibodies and IgA deficiency in a finger-tip blood drop was used. Subjects who tested positive and those suspected of having CD were referred to a Celiac Centre to undergo further investigations in order to confirm CD diagnosis. POCT Positive Predictive Value (PPV) at tertiary care (with Negative Predictive Value) and in primary care settings, and POCT and CD rates per thousand in primary care were estimated. RESULTS: At tertiary care setting, PPV of the POCT and 95% CI were 89.5 (81.3-94.3) and 90 (56-98.5) with Negative Predictive Value 98.5 (94.2-99.6) and 98.7% (92-99.8) in children and adults, respectively. In primary care settings of different countries where POCT was performed by a different number of personnel, PPV ranged from 16 to 33% and the CD and POCT rates per thousand ranged from 4.77 to 1.3 and from 31.18 to 2.59, respectively. CONCLUSIONS: Interpretation of POCT results by different personnel may influence the performance of POC but dissemination of POCT is an urgent priority to be implemented among people of countries with limited resources, such as rural populations and school children.

8 Article Celiac disease in the Mediterranean area. 2014

Tucci, Francesca / Astarita, Luca / Abkari, Abdelhak / Abu-Zekry, Mona / Attard, Thomas / Ben Hariz, Mongi / Bilbao, José Ramon / Boudraa, Ghazalia / Boukthir, Samir / Costa, Stefano / Djurisic, Veselinka / Hugot, Jean-Pierre / Irastorza, Iñaki / Kansu, Aydan / Kolaček, Sanja / Magazzù, Giuseppe / Mičetić-Turk, Dušanka / Misak, Zrinjka / Roma, Eleftheria / Rossi, Pasqualino / Terzic, Selma / Velmishi, Virtut / Arcidiaco, Carmela / Auricchio, Renata / Greco, Luigi. ·European Laboratory for Food Induced Diseases, University of Naples Federico II, Naples 80131, Italy. ydongre@unina.it. ·BMC Gastroenterol · Pubmed #24517104.

ABSTRACT: BACKGROUND: The World Gastroenterology Organization recommends developing national guidelines for the diagnosis of Celiac Disease (CD): hence a profile of the diagnosis of CD in each country is required. We aim to describe a cross-sectional picture of the clinical features and diagnostic facilities in 16 countries of the Mediterranean basin. Since a new ESPGHAN diagnostic protocol was recently published, our secondary aim is to estimate how many cases in the same area could be identified without a small intestinal biopsy. METHODS: By a stratified cross-sectional retrospective study design, we examined clinical, histological and laboratory data from 749 consecutive unselected CD children diagnosed by national referral centers. RESULTS: The vast majority of cases were diagnosed before the age of 10 (median: 5 years), affected by diarrhea, weight loss and food refusal, as expected. Only 59 cases (7.8%) did not suffer of major complaints. Tissue transglutaminase (tTG) assay was available, but one-third of centers reported financial constraints in the regular purchase of the assay kits. 252 cases (33.6%) showed tTG values over 10 times the local normal limit. Endomysial antibodies and HLA typing were routinely available in only half of the centers. CD was mainly diagnosed from small intestinal biopsy, available in all centers. Based on these data, only 154/749 cases (20.5%) would have qualified for a diagnosis of CD without a small intestinal biopsy, according to the new ESPGHAN protocol. CONCLUSIONS: This cross-sectional study of CD in the Mediterranean referral centers offers a puzzling picture of the capacities to deal with the emerging epidemic of CD in the area, giving a substantive support to the World Gastroenterology Organization guidelines.

9 Article Burden of celiac disease in the Mediterranean area. 2011

Greco, Luigi / Timpone, Laura / Abkari, Abdelhak / Abu-Zekry, Mona / Attard, Thomas / Bouguerrà, Faouzi / Cullufi, Paskal / Kansu, Aydan / Micetic-Turk, Dusanka / Mišak, Zrinjka / Roma, Eleftheria / Shamir, Raanan / Terzic, Selma. ·European Laboratory for Food Induced Diseases, Federico II University of Naples, 80131 Naples, Italy. ydongre@unina.it ·World J Gastroenterol · Pubmed #22174546.

ABSTRACT: AIM: To estimate the burden of undiagnosed celiac disease (CD) in the Mediterranean area in terms of morbidity, mortality and health cost. METHODS: For statistics regarding the population of each country in the Mediterranean area, we accessed authoritative international sources (World Bank, World Health Organization and United Nations). The prevalence of CD was obtained for most countries from published reports. An overall prevalence rate of 1% cases/total population was finally estimated to represent the frequency of the disease in the area, since none of the available confidence intervals of the reported rates significantly excluded this rate. The distribution of symptoms and complications was obtained from reliable reports in the same cohort. A standardized mortality rate of 1.8 was obtained from recent reports. Crude health cost was estimated for the years between symptoms and diagnosis for adults and children, and was standardized for purchasing power parity to account for the different economic profiles amongst Mediterranean countries. RESULTS: In the next 10 years, the Mediterranean area will have about half a billion inhabitants, of which 120 million will be children. The projected number of CD diagnoses in 2020 is 5 million cases (1 million celiac children), with a relative increase of 11% compared to 2010. Based on the 2010 rate, there will be about 550,000 symptomatic adults and about 240,000 sick children: 85% of the symptomatic patients will suffer from gastrointestinal complaints, 40% are likely to have anemia, 30% will likely have osteopenia, 20% of children will have short stature, and 10% will have abnormal liver enzymes. The estimated standardized medical costs for symptomatic celiac patients during the delay between symptom onset and diagnosis (mean 6 years for adults, 2 years for children) will be about €4 billion (€387 million for children) over the next 10 years. A delay in diagnosis is expected to increase mortality: about 600,000 celiac patients will die in the next 10 years, with an excess of 44.4% vs age- and sex-matched controls. CONCLUSION: In the near future, the burden of CD will increase tremendously. Few Mediterranean countries are able to face this expanding epidemic alone.

10 Article Celiac disease and autoimmune thyroid disease in children with type 1 diabetes mellitus: clinical and HLA-genotyping results. 2010

Ergür, Ayça Törel / Oçal, Gönül / Berberoğlu, Merih / Adıyaman, Pelin / Sıklar, Zeynep / Aycan, Zehra / Evliyaoğlu, Olcay / Kansu, Aydan / Girgin, Nurten / Ensari, Arzu. ·Department of Pediatric Endocrinology, Faculty of Medicine, Ufuk University, Ankara, Turkey. aycaergur@superonline.com ·J Clin Res Pediatr Endocrinol · Pubmed #21274314.

ABSTRACT: OBJECTIVE: Increased prevalence of celiac disease (CD) and autoimmune thyroid disorders (ATD) in patients with Type 1 diabetes mellitus (T1D) has been widely reported. Such an association may lead to adverse effects on the growth, bone metabolism and fertility, and response to therapy may become difficult. The aim of this study was to evaluate the clinical findings and HLA typing results in patients with T1D associated with CD or ATD. METHODS: The association of CD and ATD was evaluated in 38 children with T1D aged 1.5-16.8 years who had been followed for 48.3±28 months. Diagnosis of CD was based on positivity for serum endomysial IgA antibody and histopathological findings of intestinal biopsy specimens. Thyroid autoimmunity was assessed by antithyroglobulin and antithyroid peroxidase antibodies and with diagnostic ultrasonographic findings. RESULTS: ATD was detected in 31.5%, and CD-in 7.8% of T1D patients. Subjects with CD showed either no symptoms or suggestive problems such as short stature, hepatosteatosis, pubertal delay and difficulties in the control of diabetes. Patients with ATD had no clinical symptoms. DQ8 was the most prominent finding in CD. CONCLUSIONS: It is essential that patients with T1D, regardless of presence or absence of symptoms, should be investigated for CD and ATD.

11 Minor A Successful HSCT in a Girl with Novel LRBA Mutation with Refractory Celiac Disease. 2016

Sari, Sinan / Dogu, Figen / Hwa, Vivian / Haskologlu, Sule / Dauber, Andrew / Rosenfeld, Ron / Polat, Meltem / Kuloglu, Zarife / Kansu, Aydan / Dalgic, Buket / Ikinciogullari, Aydan. ·Department of Pediatric Gastroenterology, Gazi University Faculty of Medicine, 06500, Besevler, Ankara, Turkey. drsinansari@gmail.com. · Department of Pediatric Allergy/Immunology, Ankara University Faculty of Medicine, Ankara, Turkey. · Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. · Oregon Health & Science University, Portland, OR, USA. · Pediatric Infectious Disease, Gazi University Faculty of Medicine, Ankara, Turkey. · Pediatric Gastroenterology, Ankara University Faculty of Medicine, Ankara, Turkey. · Department of Pediatric Gastroenterology, Gazi University Faculty of Medicine, 06500, Besevler, Ankara, Turkey. ·J Clin Immunol · Pubmed #26686526.

ABSTRACT: -- No abstract --