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Celiac Disease: HELP
Articles by Andrew Hale
Based on 1 article published since 2010
(Why 1 article?)

Between 2010 and 2020, Andrew Hale wrote the following article about Celiac Disease.
+ Citations + Abstracts
1 Article Patients with common variable immunodeficiency paradoxically have increased rates of autoimmune disorders. 2017

Susheela, Ammu Thampi / Hale, Andrew. ·Division of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. · Department of Infectious Diseases, University of Vermont Medical Center and Larner College of Medicine, Boston, Massachusetts, USA. ·BMJ Case Rep · Pubmed #29030367.

ABSTRACT: Common variable immunodeficiency (CVID), characterised by disordered B cell function, is one of the most common primary immunodeficiency disorders. Patients with CVID are at lifelong risk of recurrent infections, particularly of the respiratory and gastrointestinal tracts. Paradoxically, given their immunocompromised state, patients with CVID are also at significantly increased risk of autoimmune disorders, which are seen in almost 25% of cases. The authors report a 24-year-old female patient with CVID, manifested as severe hypogammaglobulinaemia with recurrent sinopulmonary infections and enterocolitis, who presented with transaminitis, chronic diarrhoea and haematemesis. No infectious aetiologies were identified. She was diagnosed with coeliac disease after a small bowel biopsy and positive response to gluten-free diet. Haematemesis was attributed to portal hypertension due to liver cirrhosis, which was confirmed via liver biopsy. Coeliac disease can be a cause of diarrhoea in patients with immunodeficiency disorders and is often underdiagnosed. It can also be the underlying source of liver disease and is an often under-recognised cause of cirrhosis. The case presented emphasises the paradoxical and challenging relationship that patients with CVID face between immunodeficiency and autoimmune disorders, and also highlights that coeliac disease is an under-recognised cause of liver disease.